19 results about "Mechanical pain" patented technology

The invention relates to the technical field of medical information, and provides a human body pain evaluation method and device based on finite element simulation, equipment and a medium, and the method comprises the steps: building an individual three-dimensional tissue finite element model of a target object; finite element simulation is carried out through the individual three-dimensional tissue finite element model of the target object, and a stress-strain distribution result is obtained; calculating a mechanical pain stimulation index based on the mechanical pain threshold value and the stress-strain distribution result of each type of tissue; obtaining an established threshold mapping relation between the mechanical pain stimulation index and subjective pain evaluation of the target object; calculating an individual pain stimulation index of the target object based on the individual pain threshold and the stress-strain distribution result; performing visualization processing on the spatial distribution result of the individual pain stimulation index to generate a pain heat map; the pain heat map is used for reflecting the spatial distribution and intensity grade of the pain risk. According to the invention, objective evaluation of pain can be realized without depending on continuous subjective input.

The invention provides sinomenine in preparation of a medicine for treating chronic pain of rheumatoid arthritis and application of the sinomenine in preparation of the medicine for treating the chronic pain of the rheumatoid arthritis, and aims at solving the problems that an existing medicine for resisting the rheumatoid arthritis is limited in action target spot and poor in treatment effect. The sinomenine takes a histamine receptor H1R on a nervous system dorsal root ganglion M1 type macrophage as the action target spot; the target spot is intervened to regulate and control polarization of macrophages, reduce expression of histamine H1R in M1 type macrophages and inhibit infiltration of the macrophages, so that chronic pain, including crymodynia, mechanical pain, heat pain and the like, of rheumatoid arthritis is effectively relieved; the sinomenine combined action target can improve pain and arthritis symptoms of a model mouse, reduce the level of inflammatory factors and inhibit LPS-induced macrophage migration and H1R expression, and the sinomenine pharmaceutical composition has various dosage forms, has unique action target and mechanism, has a remarkable treatment effect, and can be used for preparing medicines for treating chronic infectious diseases. The compound is expected to become a novel non-opioid anti-rheumatoid arthritis chronic pain medicine.

A transdermal patch for delivering lidocaine for pain relief comprises a backing layer, an adhesive layer, and a composition containing lidocaine in an amount ranging from about 1% to about 10% by weight and heparin as a non-anticoagulant permeation enhancer in an amount ranging from about 1% to about 50% by weight. The heparin enhances permeation of lidocaine through the skin without exerting systemic anticoagulant effects by temporarily disrupting lipid bilayers in the stratum corneum to create microchannels for increased diffusion of lidocaine molecules. The patch provides effective relief for multiple pain types including neuropathic pain, inflammatory pain, ischemic pain, post-surgical pain, nociplastic pain, mechanical pain, and compressive pain. The transdermal patch is configured to provide sustained release of lidocaine for periods ranging from about 8 hours to about 24 hours, reducing pain by at least 50% with minimal systemic absorption.

The invention discloses application of isotoosendanin in preparation of a medicine for relieving neuropathic pain and application of TRPV1 and Nav1.7 as medicine targets of the isotoosendanin, and relates to the technical field of biological medicine. The medicine prepared from the isotoosendanin can inhibit the expression of dorsal root ganglion (DRG) neurons TRPV1 and Nav1.7 protein; the medicine prepared from the isotoosendanin can inhibit the reduction of mechanical pain threshold and crymodynia threshold; the neuropathic pain comprises pain after selective injury of sciatic nerve branches; the TRPV1 and Nav1.7 are used as drug targets to be applied to preparation of the neuropathic pain relieving drug taking the isotoosendanin as an effective component. The isotoosendanin plays a role in relieving neuropathic pain, and the isotoosendanin can be used for inhibiting the expression of TRPV1 and Nav1.7; the isotoosendanin can be used for treating neuropathic pain by inhibiting expression of TRPV1 and Nav1.7 channel proteins, and a new thought is provided for preparing the neuropathic pain medicine.

The invention belongs to the technical field of crossing of neuroscience and biomedical engineering, and particularly relates to a device for rat spinal cord electrical stimulation and mechanical pain assessment, which comprises a supporting device, a plurality of breeding boxes are uniformly arranged on the supporting device, the bottoms of the breeding boxes are arranged to be net-shaped bottom surfaces, and the net-shaped bottom surfaces are arranged on the supporting device. The net-shaped bottom surface is used for a mechanical pain detection pen to test the mechanical pain behavior of a rat, a fixing plate is arranged on one side of the supporting device, an electrical stimulator is arranged on the fixing plate, the electrical stimulator is connected with a converter, the converter is connected with multiple sets of in-vitro extension wires, the in-vitro extension wires are connected with positive and negative electrodes in the rat, and the positive and negative electrodes are connected with a battery. The in-vitro extension wire and the electrical stimulator are connected only through the converter, the structure is compact, operation is easy and convenient, the rat can freely move in the breeding box, compared with a traditional fixing frame for fixing the rat, stress in the rat moving process is avoided, spinal cord electrical stimulation experiments and pain behavioral evaluation can be conducted at the same time, and the experiment efficiency is improved.

The invention provides a preparation method of a traditional Chinese medicine dispersion liquid containing self-assembled nanoparticles, which comprises the following steps: mixing fructus piperis longi, rhizoma corydalis, radix angelicae, ligusticum wallichii, ligusticum and indigo naturalis, crushing, sieving to obtain a traditional Chinese medicine crushed material, adding purified water, carrying out ultrasonic extraction and suction filtration to obtain a traditional Chinese medicine extracting solution, centrifuging, removing precipitate, filtering supernate by a filter membrane, and drying to obtain the traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles. And carrying out ultrafiltration centrifugation, sucking liquid in the tube, and carrying out high-speed centrifugation to obtain the traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles. The invention also provides application of the traditional Chinese medicine dispersion liquid. The prepared traditional Chinese medicine dispersion liquid containing the self-assembled nanoparticles can relieve rat migraine caused by nitroglycerin, can remarkably improve the mechanical pain threshold and the heat pain threshold of model rats and remarkably promote callback of inflammatory factors and migraine markers in brain tissues of chronic migraine rats, and is used for preparing drugs for improving migraine through nasal administration.

The invention discloses a method for researching the action mechanism of saikoside D on paclitaxel-induced peripheral neuropathy, and relates to the technical field of disease mechanism research and drug development. Comprising the following steps: performing continuous administration through intraperitoneal injection of paclitaxel, and establishing a paclitaxel-induced peripheral neuropathy animal model; a von Frey cellosilk experiment and a cold and hot plate experiment are adopted for behavioral detection, and mechanical pain threshold and cold and hot pain sense changes are evaluated; the morphological structure change of the sciatic nerve myelin sheath is observed through Luxol Fast Blue staining; and the expression level of the myelin sheath basic protein in the sciatic nerve is detected by using immunofluorescence staining and Western blotting technologies. According to the invention, a closed-loop research system is formed from animal model construction to molecular mechanism verification; based on behavioral detection, histological analysis and multiple dimensions of a molecular biological technology, the data reliability is ensured, and the curative effect of saikoside D can be comprehensively evaluated.

The present invention discloses the use of agents that promote DOCK11 expression as drugs for treating neuropathic pain. This study found that mice with neuropathic pain experience significant mechanical allodynia and thermal hyperalgesia, and that DOCK11 expression is closely associated with mechanical and thermal allodynia in CCI mice. Overexpression of a DOCK11 vector can effectively promote DOCK11 expression in the spinal cord and significantly suppress neuropathic pain. These findings provide potential therapeutic targets for the clinical treatment of neuropathic pain.

The invention relates to the technical field of nano materials, and discloses a composite nano material as well as a preparation method and application thereof. The composite nano material is of a core-shell structure and comprises BiVO4 nano particles as a core; the MnO2 layer is coated on the surfaces of the BiVO4 nano particles; and the alendronate is used for modifying the outer part of the MnO2 layer. The composite nanomaterial can obviously inhibit the growth of bone tumors, has a good analgesic effect on mechanical pain and cold and heat pain, and has no obvious side effect after treatment. The pharmaceutical preparation provided by the invention has the advantages that the raw materials are easy to obtain, and the pharmaceutical preparation has a good application prospect in preparation of drugs with dual effects of resisting tumors and relieving pain.

A polypeptide derivative, which is characterized by comprising a polypeptide chain and a palmitic acid group modified on the polypeptide chain, and having a structure as represented by the following general formula I or general formula II: general formula I: C-X2, wherein in general formula I, X2 is absent, as well as any amino acid or any peptide segment, and C is modified with one palmitic acid group; and general formula II: X1-C-X3, wherein in general formula II, X1 and X3 are any amino acid or any peptide segment, and C is modified with two palmitic acid groups. The polypeptide derivative is capable of specifically binding to PIEZO2 and lowering a tactile threshold, thereby enhancing the effect of a PIEZO2-targeting agonist. A pharmaceutical composition containing the polypeptide derivative, when administered to mice, can effectively lower the mechanical pain threshold, thereby improving tactile sensitivity; and when administered to humans, the pharmaceutical composition can enhance the pleasure of human sexual activity.

The utility model belongs to but not limited to the technical field of animal experiment equipment, and discloses a three-degree-of-freedom mechanical arm automatic mouse von Frey pain detector which comprises an integrated experiment box, and a metal grid plate is arranged in the integrated experiment box and divides the integrated experiment box into an upper layer and a lower layer; the upper layer is a light-transmitting transparent experiment box, is separated by a hard opaque partition plate, is used for placing an experiment mouse and is provided with a visible light camera, and the lower layer is a light-proof camera obscura, and is provided with a three-degree-of-freedom mechanical arm and an infrared camera; a von Frey mechanical stimulation needle is arranged on the three-degree-of-freedom mechanical arm, and a high-precision pressure sensor is arranged at the von Frey mechanical stimulation needle. The utility model provides experimental equipment with high precision and high automation level, and by accurately controlling the mechanical pain stimulation to the experimental mouse, the accurate quantitative determination of the pain response threshold of the mouse or the rat is realized, so that objective, accurate and repeatable experimental data is provided.

The invention relates to the technical field of biological medicines, in particular to application of a CCR1 / 5 inhibitor Met-RANTES in inhibition of pathological pain of trigeminal nerves. According to the invention, CCR1 / 5 is taken as a therapeutic target of chronic pain, and a medicine which is remarkable in analgesic effect, small in side effect and capable of relieving chronic pain and improving pain mood is developed by combining the pharmacological function of an inhibitor Met-RANTES of CCR1 / 5. The Met-RANTES inhibits a central nervous system chemokine receptor CCRR1 / 5 in a targeted manner in a regular nasal administration manner, so that pathological mechanical pain-sensitive response and accompanying negative emotion caused by chronic compression of trigeminal nerves can be remarkably relieved, and pain feeling is relieved. In addition, the analgesic effect of the drug combination of the Met-RANTES and the carbamazepine is more obvious than that of the drug combination of the Met-RANTES and the carbamazepine which are independently used. The nasal delivery mode enables the medicine to directly reach the central nervous system, and reduces side effects of the whole body.

The invention relates to the technical field of animal experiment devices, in particular to an automatic animal mechanical pain threshold value detection device and method.The automatic animal mechanical pain threshold value detection device comprises a box body, an iron gauze and a needling mechanism are arranged in the box body, the iron gauze is horizontally arranged on the side wall of the box body, and the needling mechanism is located under the iron gauze and used for applying pressure to stimulate the pelma of an experimental animal; a translation mechanism is further arranged in the box body, the needling mechanism is installed on the translation mechanism, and the translation mechanism is used for driving the needling mechanism to move along the horizontal plane of the box body. The needling mechanism comprises a guide cylinder with two open ends, a pressure sensing device and a driving device; the translation mechanism is sleeved with the guide cylinder, the pressure sensing device is installed in the guide cylinder, and the pressure sensing device is used for fixing the cellosilk and can sense the change of the pressure value between the foot bottom of an animal and the cellosilk. The device not only can automatically detect the mechanical pain threshold value of the animal, but also can quickly replace the cellosilk and reliably fix the cellosilk, so that the pain threshold value detection efficiency is greatly improved.

The invention provides application of esketamine in preparation of hyperalgesia drugs, and relates to the technical field of clinical medicine. Clinical tests and animal experiments are combined, it is systematically proved that sub-anesthetic dose esketamine can effectively relieve diabetic hyperalgesia, and a novel molecular action mechanism of esketamine is disclosed. Preliminary tests and animal experiments show that the scheme can significantly improve the mechanical pain threshold and reduce the pain score, and the effect is exact. In mechanism, it is clarified for the first time that esketamine regulates and controls downstream PI3K / Akt / GSK-3beta signal channels by inhibiting excessive activation of an NMDA receptor, and abnormal expression and membrane transport of a GLuR1 receptor are reduced, so that central sensitization is reversed. The scheme has the advantages of quick response, no opioid drug dependence, clear mechanism and the like, provides a new safe, effective and clear-target analgesic strategy for clinical treatment of diabetes-related neuropathic pain, and has good transformation and application prospects.

This invention discloses the pharmaceutical use of schisandrin B in the preparation of analgesic drugs, wherein the analgesia is for the treatment or prevention of chemotherapy-induced neuropathic pain, and the analgesic drug can reduce mechanical and cold hyperalgesia in a chemotherapy-induced neuropathic pain model. Pharmacodynamic studies of this invention demonstrate that oral administration of schisandrin B can reduce chemotherapy-induced neuropathic pain, thereby effectively exerting an analgesic effect, and can be used as a therapeutic or preventative analgesic drug.

The invention discloses application of a bletilla striata glycoside compound, a composition containing the bletilla striata glycoside compound and a preparation method of the bletilla striata glycoside compound. The invention provides an application of a compound or a pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating one, two or three of osteoarthritis, pain and cartilage injury. It is found for the first time that the bletilla striata extract or the bletilla striata glycoside and the like can obviously improve the mechanical pain threshold value of an arthritis pain model animal and inhibit inflammatory reaction and the like, and along with secondary administration, the improvement effect on the mechanical pain threshold is enhanced again. Meanwhile, the load-bearing difference value of the two feet of the posterior limbs of the model animal can be obviously reduced, and it is shown that the rhizoma bletillae extract or the bletilla striata glycoside has the effect of preventing and / or treating osteoarthritis and / or pain, and particularly has the good treatment effect on inflammatory response and / or pain of bone joints caused by bone joint injuries (such as meniscus injuries and ligament injuries).

Disclosed in the present invention are use of a Bletilla striata glycoside compound, a composition containing same, and a preparation method therefor. The present invention provides use of a compound or a pharmaceutically acceptable salt thereof in the preparation of a drug for preventing and / or treating osteoarthritis and / or pain. It has been discovered for the first time that a Bletilla striata extract or a Bletilla striata glycoside can significantly increase the mechanical pain threshold of arthritis pain model animals and inhibit inflammatory responses, etc., and with re-administration, the improvement effect on the mechanical pain threshold is enhanced again. Moreover, the bipedal weight-bearing difference between the hind limbs of the model animals can also be significantly reduced, showing that the Bletilla striata extract or the Bletilla striata glycoside has the effect of preventing and / or treating osteoarthritis and / or pain, especially having a good therapeutic effect on the inflammatory responses and / or pain in the bone joints caused by bone joint injury.

The polypeptide derivative of the present application is characterized by comprising a polypeptide chain and a palmitic acid group modified on the polypeptide chain, and having the structure shown in the following general formula I or general formula II; the general formula I is C-X2, wherein X2 in the general formula I is nothing, any amino acid or any peptide segment, and C is modified with one palmitic acid group; the general formula II is X1-C-X3; wherein X1 and X3 in the general formula II are any amino acid or any peptide segment, and C is modified with two palmitic acid groups. The polypeptide derivative in the present application can specifically bind to Piezo2 and reduce the tactile threshold, thereby playing a role in enhancing the Piezo2 target agonist. The pharmaceutical composition adopts the above polypeptide derivative, and when applied to mice, can effectively reduce the mechanical pain threshold, thereby improving the tactile sensitivity; when applied to humans, can improve the pleasure of human sexual life.

The utility model relates to biological experiment instrument technical field especially, more particularly to a kind of mechanical pain sensitivity marking adapter, comprising: adapter main body, the adapter main body is the cylindrical shape for the convenience grip, the adapter main body top end detachably fixed installation is used to stimulate mouse sole mechanical stimulation component, the adapter main body inner portion is separately provided with bluetooth module and processor, the adapter main body outer wall one side is provided with button, marking instruction is sent to processor by pressing button, processor will transmit computer by bluetooth module with marking record is completed on computer, the utility model provides a kind of mechanical pain sensitivity marking adapter, and the result credibility is high only one person operation.