31 results about "Behavioral experiment" patented technology

The present invention enables testing the effect of one or more test agent(s) on one or more animal(s) of a group of animals, preferably insects, to identify agents that affect behavioral properties of the animals. The invention is comprised of the steps of providing animals suitable for testing, bringing those animals into contact with the test agent(s), moving the animals from a growth container to isolate them, prepare and separate the animals for singulation, relocated the animals to a behavior arena, subject the animals to behavioral tracking to assess their behavioral state, and removing the animals from the behavioral tracking to facilitate iterative analysis of further groups. The invention enables a method for preparing a therapeutic compound for the treatment of an animal disease.

The invention discloses a nuclear reactor fuel rod simulating electric heating device and an assembly process. The device comprises a simulation jacket and simulation fuel element pellets, each simulation fuel element pellet is provided with 16 through holes axially extending along the simulation fuel element pellet, thermocouple wire anodes are mounted in part of the through holes, thermocouple wire cathodes are mounted in part of the through holes, and inert gas is stored in the rest through holes. Electric heating rods are mounted in an inner cavity of each simulation fuel element pellet, and a plurality of external wall temperature thermocouples are mounted on the outer side of the simulation jacket. The electric heating device is used for laboratory simulation of nuclear reactor fuel rods to carry out high-temperature degradation and reflooding behavioral experiments of fuel rods for pressurized water reactors under severe accident conditions. A working medium is an aqueous medium, a steam medium or an inert gas medium, a working pressure is 5MPa, a long-term working temperature is 1800 DEG C, and a short-term working temperature is 2400 DEG C.

The invention discloses a wireless infrared remote control optogenetic system. An infrared emitting end comprises a power supply driving board, infrared emitting tube lamp strips, a signal source and a 5V power supply; and an infrared receiving end comprises an infrared receiving pipe, a 3.7V lithium battery, a comparison circuit and blue light emitting diodes. The lighting and extinguishing of the infrared emitting tube lamp strips are controlled through controlling on-off states of the power supply by virtue of a signal source, so that the infrared emitting tube lamp strips are basically equally bright and can synchronously shine or go out; and the infrared receiving pipe is used for receiving infrared signals of infrared emitting tubes of the infrared emitting tube lamp strips, the lighting and extinguishing of blue infrared emitting diodes are controlled through the comparison circuit, and optical signals of the blue light emitting diodes are guided into biological cells through optical fibers, thereby realizing effective photic stimulation. The wireless infrared remote control optogenetic system can be remotely and wirelessly operated and controlled in an experimental box and is small in volume, high in integration level and compact in structure; and remote control signals of the signal source can be accurately and timely responded, and the infrared remote control range is wide, so that the free activities of mice in a large scope are not influenced, and the system is beneficial to the large-scale behavioral experiments.

The invention discloses a multipurpose psychology behavior scale entry system, and mainly aims to solve the various problems of traditional behavioral experiment design, experimental information collection and data compilation. The multipurpose psychology behavior scale entry system mainly comprises the following steps that an experiment scale combining scheme is customized; the scheme is loaded, preparation work is conducted to implement an experiment; the experiment is started, and individual information of tested people are input; scale entry is finished by the tested people according to prompts; whether the input meets requirements is judged; the entry of the information of tested people is finished; the information output is stored; input scale files are loaded; grouping scales and grouping threshold values are set; grouping statistical results are output. According to the multipurpose psychology behavior scale entry system, the various problems in the process of collecting traditional psychology behavior scales can be almost solved, working efficiency of scientific researchers is effectively improved, and effectiveness of experimental information is improved.

The invention discloses a full-automatic rat maze behavior training system mainly composed of a maze body, a maze inner chamber, a maze control circuit, a power source, a PC1 interface data acquisition card, and a computer. The system is characterized in that the maze body is a double-square-shaped maze composed of four maze single chambers. The maze inner chamber is positioned at the center of the double-square-shaped maze. The maze control circuit and the power source are arranged in the maze inner chamber. The maze control circuit is connected with the computer through the PC1 interface data acquisition card. A host computer control software module is arranged in the computer. The system has the advantages of low research and development cost, high practicality, simple operation, stable and reliable working, high expandability, and simple system structure. With the system, rat / mouse behavior training experiment complexity can be greatly reduced, experiment result reliability can be improved, and rat / mouse behavior training experiment automation can be realized. The system can be well applied into behavioral experiments of other animals.

The invention relates to an information display format and function layout method for an intelligent control production line system. The complex and massive information which needs to be displayed inan information network of the intelligent control production line system is firstly extracted; classification and grouping are carried out based on aspects such as the information processing process of a person, visual cognition behaviors, frequencies and importance, and connotation and significance are known; a subsystem which needs to be displayed is subjected to visual icon design according toan icon design process and a principle; a behavioral experiment is used to optimize and improve the icon design; the hierarchy relationship, the function relationship, the position relationship, the affiliation relationship and the like among the massive information in the intelligent control system are found out, and function layout is carried out on the system according to a layout method; an eye movement experiment is performed to acquire quantitative data of behavior and physiology indicators of the user under different test tasks, a final function layout mode is obtained through data result optimization, and a referable information display format and function layout mode is provided for the intelligent control system.

The invention relates to new application of a dcf1 gene. A wild type mouse (serving as contrast) and a mouse with the dcf1 deleted are mainly adopted; western blotting is used for detecting reducing of myelin basic protein; immunohistochemistry and a transmission electron microscope are used for observing changing of the form of a myelin sheath; and then a behavioral experiment is used for showing that the mouse with the dcf1 deleted can simulate clinical symptoms of multiple sclerosis, then the mouse with the dcf1 deleted is subjected to rescue, and it is discovered that the dcf1 can cause myelin sheath remodeling and regeneration.

The invention provides medical application of brain and heart beneficial tablets in treatment of Alzheimer's disease, and has the outstanding medical treatment effect. A mice is feed with a brain andheart beneficial tablet water solution, the brain and heart beneficial tablets are proved to have the efficacy of preventing and treating Alzheimer's disease through behavioral experiments (mine test,jump platform test, Y maze test and water maze test), immunohistochemical,serum and cortical brain ELISA measuring and western blot, forming of Abeta plaque in the brain can be reduced, and the pathologic condition of Alzheimer's disease can be improved by adjusting the oxidative stress and cholinergic system.

The invention discloses a behavioral experiment device and method for animal auditory association matching. The device comprises a shell, a shading plate, a detecting component, a plurality of turningplates, a sound producing component and a control component and is characterized in that a plurality of partitions are arranged in the shell to separate the space in the shell into multiple cavities,a separation plate is arranged in each cavity to separate the cavity into an experiment cavity and a food cavity, the shell is provided with a plurality of hand stretching openings, each hand stretching opening is communicated with one experiment cavity, a food taking opening is arranged in each separation plate to communicate the corresponding experiment cavity and the corresponding food cavity,the shading plate is slidably arranged on the shell and used for shading the lateral wall, with the hand stretching openings, of the shell, each turning plate correspond to one food taking opening, and the sound producing component is used for providing sound stimulation for an experimental animal. The behavioral experiment device can well quantitatively analyze the association matching relationbetween animal auditory sense and behaviors so as to accurately analyze the function of the temporal lobe in the brain area.

The invention relates to a construction method and an application of a conditional ivermectin receptor (IVMR) transgenic mouse model, and belongs to the technical fields of conditional animal model construction method and application. Under the action of a Cre recombinase, all cells (especially cerebral neurons) of the mouse model can conditionally express the ivermectin receptor IVMR, and the excitability of the neurons expressing the ivermectin receptor IVMR can be down-regulated by applying a drug ivermectin (IVM). Compared with the prior art, the technical method (including a drug administration mode, and targetedly using a transgenic mouse for specific expression of Cre) does not has any brain damage on the mouse. Influence of the used drug ivermectin IVM on animals has a sufficiently long half-life period, and animal behavioral experiments are suitably carried out. In addition, the half-life period is relatively stable, the experiments can be again carried out after drug failure, and before-and-after comparison experiments are conveniently carried out on the same animal.

The invention relates to the technical field of animal experiment devices, and discloses a marmoset behavioral experiment box which comprises a box body and an insertion plate, an insertion opening is formed in a top plate of the box body, the insertion plate can be inserted into the box body through the insertion opening or pulled out of the box body, when the insertion plate is inserted into the box body, the box body is divided into two sub-box bodies by the insertion plate in the length direction of the box body, and when the insertion plate is pulled out of the box body, the two sub-box bodies communicate with each other. According to the marmoset behavioral experiment box, only two adjacent sub-box bodies are arranged, no middle sub-box body exists, the invalid experiment time caused by long-time staying of marmosets in the middle sub-box body is shortened, and therefore, the experiment efficiency and effectiveness are improved; and besides, separation and communication between the two sub-box bodies are achieved in the mode that the inserting plate is inserted and pulled up and down, it can be guaranteed that a passage between the two sub-box bodies is wider, the freedom of back-and-forth movement of the marmosets between the two sub-box bodies is improved, opening and closing can be achieved under the condition that the activity space of the marmosets is not affected, and interference to the marmosets is reduced.

The invention discloses an animal bound type acute anxiety model and belongs to the technical field of animal behavior research, and the model is designed for solving a problem of a poor binding effect of an animal to be tested of an existing device. The animal bound type acute anxiety model comprises a binding plate and an upper cover which is detachably fastened on the binding plate, and a cavity for containing the animal to be tested is formed between the upper cover and the binding plate after fastening. A connection structure is arranged between the upper cover and the binding plate, and the connection structure binds the upper cover and the binding plate when the upper cover covers the binding plate. The animal bound type acute anxiety model has a good animal binding effect, a purpose of binding the animal to be tested such as a rat to establish an acute anxiety model in a behavioral experiment is realized, the model is efficient, convenient, safe and sanitary, an obtained experiment result has high accuracy, and the application range is wide.

The invention provides a smoke interaction method in an evacuation environment based on virtual reality, comprising the following steps: connecting hardware equipment, automatic control equipment anda VR scene software system, and establishing a model; and according to the distance, displayed by the VR scene software system, between the user and the smoke particle system, controlling the automatic control equipment to output the output heat of the smoke so as to realize the interactive operation of the smoke in the evacuation environment based on virtual reality. According to the method, a smell player is connected to a virtual subway station fire experiment scene; the method can be used for HTC VIVE and KAT running machines, automatic control over smoke in a virtual scene in a real physical environment is achieved, man-machine interaction based on an olfactory channel is provided, the method can be used for carrying out a fire evacuation behavior experiment and collecting behavior experiment data, and perception authenticity and real-time performance are achieved. The invention further provides a smoke interaction device in the evacuation environment based on virtual reality.

The invention belongs to the technical field of DNA (deoxyribonucleic acid) recombination of bioengineering and relates to the technical field of bioengineering, particularly to a 52KD subtype BACE1 for APP (amyloid protein precursor) pathological cutting and A-beta formation recombined on the basis of BACE1 alternatively slicing mechanism. ELISA (enzyme linked immunosorbent assay) detects that the 52KD subtype BACE1 achieves promoting effects on generation of A-beta1-40 and A-beta1-42, and behavioral experiments verifies the damage effects of the 52KD subtype BACE1 on memory of AD (Alzheimer's disease) rats, and pathological experiments proves the promoting effects of the 52KD subtype BACE1 on formation of A-beta in brain. The 52KD subtype BACE1 provides basis and clues for diagnosis of AD, deep research of molecular targets and development of drugs.

The invention relates to the technical field of animal experiment devices, in particular to a telescopic shading and sound insulation animal behavioral experiment box which comprises a frame and a plurality of sealing plates, the frame is formed by splicing a plurality of rod pieces, the length of the rod pieces can be adjusted, and the frame is provided with a top opening, a bottom opening and a plurality of side openings; the top opening, the bottom opening and the side openings are sealed and covered with the sealing plates correspondingly, the size of the sealing plates can be adjusted along with adjustment of the length of the rod pieces, and the sealing plates can shield light and insulate sound. According to the animal behavior experiment closed box, the length of the rod piece is set to be adjustable, and the size of the sealing plate is set to be adjustable along with the length of the rod piece, so that the size of the animal behavior experiment closed box can be adjusted, the requirements of different behavioral paradigms can be met, and the universality and convenience of the animal behavior experiment box body are improved; in addition, all the sealing plates are arranged to be capable of shading and insulating sound, and the influence of external environment changes on experiment results in the experiment process is reduced.

The invention discloses an extraction method and application of chroogomphus rutilus polysaccharide with anti-motion sickness effects. The polysaccharide takes chroogomphus rutilus as a raw material, and is prepared by a water extraction and alcohol precipitation method. The chroogomphus rutilus polysaccharide is used for prevention and treatment of motion sickness, and the results show that very good anti-motion sickness effects can be provided when 200mg / kg of chroogomphus rutilus polysaccharide is given to the stomach by behavioral experiments and hormone level tests. The motion sickness symptoms such as visceral discomfort, incontinence, piloerection and tremor can be obviously reduced, and the level of 5-HT in serum can be reduced, and the motilin level is improved; and most importantly, rats are in good spirits, has no low spirits and other side effect symptoms. The 200mg / kg of chroogomphus rutilus polysaccharide is an ideal dose for the polysaccharide anti-motion sickness. The extraction method provides a novel material and a reference dose for further development of novel anti-motion sickness drugs with efficient, non-toxic and non-side effects.

The invention provides a method for experimenting on the behavior of fruit flies, which includes the following steps: providing an experimental device, the experimental device has a light-transmitting space, and an LED lattice is arranged on the outer surface of the light-transmitting space; In the light space; the display of the LED dot matrix is ​​controlled by the computer; the behavior of the fruit fly is studied by recording the display of the LED dot matrix and the behavior of the fruit fly. The fruit fly behavior experiment method and device of the present invention use advanced LED display technology, and the image refresh rate of the LED dot matrix is ​​greater than 200 Hz, which is higher than the sampling frequency of insect compound eyes close to 200 Hz. The device provides stimuli of different colors, graphics and motion patterns to the fruit flies, so as to observe the behavior of the fruit flies. The display of the LED dot matrix is ​​realized through computer synchronous control, which further improves the effect of the experiment.

The invention discloses a method for judging fatigue failure of titanium alloy under load at room temperature, and belongs to the technical field of fatigue failure of titanium alloy. This method is to use optical microscope and scanning electron microscope to observe the fracture after fatigue failure and the secondary cracks in the longitudinal section of the fracture, and make a comprehensive judgment based on the fatigue crack initiation position on the fracture, the characteristics of the initiation area, and the secondary crack morphology of the longitudinal section. of. The invention has the advantage that it can accurately identify the failure caused by the load fatigue behavior in the titanium alloy and the strength of the load fatigue effect during the failure process. Through the establishment of relevant evaluation standards, it can provide reference for the laboratory research on the fatigue behavior of titanium alloys under load, the evaluation of the load effect of titanium alloys and the analysis of fracture failure.

The invention relates to a heterocyclic compound for treating Alzheimer disease and a preparation method thereof. The heterocyclic compound has a good effect of inhibiting the activity of acetyl cholinesterase; as proved by a behavioral experiment research of a senescence-accelerated mouse (SAM-P / 8), the heterocyclic compound can effectively improve the memory function of the SAM-P / 8 mouse, so that the heterocyclic compound can be used for treating cognitive dysfunction and / or neural degeneration dementia with abnormal protein aggregation, particularly the Alzheimer disease.

The invention discloses an experimental test device for the fire spread characteristic of a thermoplastic material. The experimental test device is characterized in that a molten liquid solidifying system is arranged at the lower part of a tested sample; the dropping molten liquid of the thermoplastic tested sample can be cooled in real time in an experiment; the pool fire formed by the molten liquid is decoupled from the fire spread phenomenon of the tested sample to facilitate intensive study on the coupling action mechanism between the fire spread phenomenon on solid surface and the pool fire at the lower part in the fire spread process of the thermoplastic material; the samples can be arranged freely according to the required layer number and arrangement mode, and thus the layer number, thickness, structure and surface conditions of the samples can be unrestrictedly adjusted according to the test need; the testable samples are more diverse than those of an existing experimental device, and the device is more flexible to use. The device disclosed by the invention has the advantages of reasonable structure, easily available materials, stable working performance and simplicity in operation, and can realize repeated operation and meet the needs of large-scale industrial production.

The invention provides an expressway exit ramp upstream road side road directing information optimization design method based on a driving simulation experiment platform. The method comprises steps of based on summarization of research statuses and results at home and abroad, organically integrating real measurement data and driving simulation; carrying out analysis on effects on traffic operation in expressway intercrossed regions imposed by road side directing information; verifying the feasibility of a driving simulator through two indexes of a lane change position and a lane change insertion gap which can be acquired in the real measurement data and the driving simulation experiment; on this basis, constructing a traffic flow micro behavior experiment platform to acquire related parameter indexes which are hard to acquire in the real measurement data; using the experiment platform to analyze effects on passing efficiency and safety in the intercrossed regions imposed by the design of the road side directing information; and finally providing the expressway exit ramp upstream road side road directing information optimization design method.

The invention discloses a method for constructing a decision-making behavioral model for delaying rewards, benefits and disadvantages, and belongs to the field of animal behavioral experiments. The construction method comprises the following steps: a training stage, a preference test and elimination stage, an advantage and disadvantage choice establishment stage and a choice test stage; through the method, a mouse finally selects a signal with high value, and thus construction of the delayed reward, advantage and disadvantage trade-off decision behavioral model is completed. According to the method, a perfect and fine behavioral model is provided for research of an advantage and disadvantage balancing choice mechanism, and tests show that the construction method is high in success rate and stable in model.

The invention relates to a health-care product for improving memory and brain function and a making method. The health-care product comprises the following components in part by weight: 20 to 30 parts of soybean phosphatidylserine, 10 to 25 parts of tea amino acid extract, 10 to 20 parts of watermelon extract, 10 to 20 parts of white peony root extract, 5 to 15 parts of wine extract, and 10 to 20 parts of pine bark extract. Compared with the prior art, the soybean phosphatidylserine, the tea amino acid extract, the watermelon extract, the wine extract, the white peony root extract and the pine bark extract have an obvious promoting effect on long-term potentiation (LTP) of a hippocampus CA1; and electrophysiological and behavioral experiments show that the health-care product has the function of improving learning memory.

The invention relates to a heterocyclic compound for treating Alzheimer disease and a preparation method thereof. The heterocyclic compound has a good effect of inhibiting the activity of acetyl cholinesterase; as proved by a behavioral experiment research of a senescence-accelerated mouse (SAM-P / 8), the heterocyclic compound can effectively improve the memory function of the SAM-P / 8 mouse, so that the heterocyclic compound can be used for treating cognitive dysfunction and / or neural degeneration dementia with abnormal protein aggregation, particularly the Alzheimer disease.

The invention discloses application of propofol to improvement of a cognitive function of a mouse by promoting formation of a brain-developing dopamine neural network. The application has the beneficial effects that the influence of the propofol effect on the formation of the neural network of the suckling mouse and the change of long-term neural functions (including learning memory and emotionalanxiety) are deeply tracked through technologies such as cell tracing and omnibearing behavioral experiments, so that the application has important clinical significance and social value.

The invention relates to a light-independent magnetic-sensed behavioral experiment system, which is composed of a frame, a selection system, an illumination system and a coil system. The frame is made by synthetic glass and provides support for whole equipment. In the illumination system, light is emitted by a cold light source in a lamp cylinder, after filtering by different wave bands of optical filters, the required illumination condition can be promoted. Two completely same solenoid coils in the coil system are always in different magnetic field states. By adjusting current intensity and direction of the solenoid coils, the magnetic field condition required by experiment is generated. The experiment objects select behavior tendency under same illumination condition and different environment magnetic fields in a T-shaped pipe and an experiment pipe in the selection system.

The invention belongs to the technical field of DNA recombination in bioengineering, relates to the technical field of bioengineering and particularly relates to a 47KD subtype BACE1 which is recombined from a gene based on a BACE1 alternative splicing mechanism and is capable of antagonizing APP pathological incision and inhibiting Abeta. The promotion effects of the 47KD subtype BACE1 to Abeta1-40 and Abeta1-42 are detected by virtue of an ELISA experiment, the correction effect of the 47KD subtype BACE1 on the memory impairment of an AD mouse is verified by virtue of a behavioral experiment, and finally, the correction effect of the 47KD subtype BACE1 on the formation of Abeta in a brain is verified by virtue of a pathological experiment. According to the 47KD subtype BACE1, the basis and the clues are provided for the deep research on AD molecular targets and the research and development of AD drugs.

The invention relates to a construction method and an application of a conditional ivermectin receptor (IVMR) transgenic mouse model, and belongs to the technical fields of conditional animal model construction method and application. Under the action of a Cre recombinase, all cells (especially cerebral neurons) of the mouse model can conditionally express the ivermectin receptor IVMR, and the excitability of the neurons expressing the ivermectin receptor IVMR can be down-regulated by applying a drug ivermectin (IVM). Compared with the prior art, the technical method (including a drug administration mode, and targetedly using a transgenic mouse for specific expression of Cre) does not has any brain damage on the mouse. Influence of the used drug ivermectin IVM on animals has a sufficiently long half-life period, and animal behavioral experiments are suitably carried out. In addition, the half-life period is relatively stable, the experiments can be again carried out after drug failure, and before-and-after comparison experiments are conveniently carried out on the same animal.

The invention relates to a health-care product for improving memory and brain function and a making method. The health-care product comprises the following components in part by weight: 20 to 30 parts of soybean phosphatidylserine, 10 to 25 parts of tea amino acid extract, 10 to 20 parts of watermelon extract, 10 to 20 parts of white peony root extract, 5 to 15 parts of wine extract, and 10 to 20 parts of pine bark extract. Compared with the prior art, the soybean phosphatidylserine, the tea amino acid extract, the watermelon extract, the wine extract, the white peony root extract and the pine bark extract have an obvious promoting effect on long-term potentiation (LTP) of a hippocampus CA1; and electrophysiological and behavioral experiments show that the health-care product has the function of improving learning memory.