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Construction method of delayed reward, advantage and disadvantage tradeoff decision-making behavioral model

A construction method and behavioral technology, which is applied in the field of construction of behavioral models for delaying rewards and trade-offs, and can solve problems such as indistinguishability

Pending Publication Date: 2021-09-14
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the key difficulty is that these behavioral paradigms cannot distinguish the three most important cognitive components in CBD: cost, benefit, and cost-benefit conflict.
Many scientific questions cannot be answered, for example, which cognitive component is represented by the selective changes in neuronal firing activity observed during CBD

Method used

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  • Construction method of delayed reward, advantage and disadvantage tradeoff decision-making behavioral model
  • Construction method of delayed reward, advantage and disadvantage tradeoff decision-making behavioral model
  • Construction method of delayed reward, advantage and disadvantage tradeoff decision-making behavioral model

Examples

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Embodiment 1

[0041] A method for constructing a decision-making behavioral model for delaying rewards and weighing pros and cons, comprising the following steps:

[0042] 1) Training stage:

[0043] Water cut-off period: choose about 25 grams of C57BL / 6 mice, cut off water for 2 days (no water for 48 hours), and feed rat food normally.

[0044] Adaptation period: the mice are placed in the operation box to move freely. At this stage, the lever does not extend into the operation box. Each time the mouse licks the water spout, a reward is triggered (4 μl of water from the water spout). The training time is 30 minutes a day, repeated for 3 days , this stage allows mice to establish the link between licking the mouth and reward.

[0045]Continuous strengthening training period: the mice are placed in the operation box to move freely, and each test starts with the levers on both sides being stretched out randomly. 4 μl of water comes out of the water spout, and the mouse gets a reward. The in...

Embodiment 2

[0060] Study on Adenosine A Using the Constructed Behavioral Model 2A receptor (Adenosine A 2A Receptor,A 2A R) Regulatory effect on the behavioral model of delayed reward trade-off decision-making.

[0061] Choose about 25 grams of A 2A R (loxp / loxp) Transgenic mice were injected with AAV8-Cre-zsGreen virus into the DMS brain regions on both sides, and control mice were injected with AAV8-zsGreen control virus. Two weeks after viral expression, mice began training. Such as Figure 4 As shown, the left picture is the control group, the right picture is the experimental group, and the red mark A 2A R, Green marks the virus injection site.

[0062] Figure 5 DMS brain area A 2A The influence diagram of R on mice’s ability to weigh pros and cons in the decision-making behavioral model of delayed reward pros and cons. In subtasks 1 and 2, there was no statistical difference in the behavioral performance of mice in the experimental group and the control group, indicating t...

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Abstract

The invention discloses a method for constructing a decision-making behavioral model for delaying rewards, benefits and disadvantages, and belongs to the field of animal behavioral experiments. The construction method comprises the following steps: a training stage, a preference test and elimination stage, an advantage and disadvantage choice establishment stage and a choice test stage; through the method, a mouse finally selects a signal with high value, and thus construction of the delayed reward, advantage and disadvantage trade-off decision behavioral model is completed. According to the method, a perfect and fine behavioral model is provided for research of an advantage and disadvantage balancing choice mechanism, and tests show that the construction method is high in success rate and stable in model.

Description

technical field [0001] The invention relates to the field of animal behavior experiments, in particular to a method for constructing a decision-making behavioral model of delayed reward pros and cons. Background technique [0002] Value-based decision making is an important prerequisite for the survival of all living things. It refers to the process in which an individual encodes and compares the value of the "decision input" before the behavior is executed, and selects the highest value. Weighing the costs and benefits of behavior is crucial to daily decision-making. For example, to go to a certain place to complete a task, choose to take a taxi or walk. Choosing to take a taxi saves time, but the price is to pay the corresponding economic cost, while choosing to walk is a time cost increase. Choices like this are very common in everyday life. The decision-making problem based on "cost-benefit trade off" is a common concern of economics and neuroscience. [0003] In the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06N5/00G06N3/00
CPCG06N5/00G06N3/006
Inventor 王琴陈江帆孙晓婷刘闽
Owner WENZHOU MEDICAL UNIV
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