36 results about "Reference dose" patented technology

A computer-based method for generating an improved radiation therapy treatment plan for a treatment volume having a target and an organ-at-risk. The method includes a step of accessing an existing radiation therapy treatment plan from a memory of a computer, a dose distribution of the existing radiation therapy treatment plan serving as a reference dose distribution; and performing machine parameter optimization on the existing radiation therapy treatment plan with the computer by pursuing an optimization goal to minimize doses to the organ-at-risk, thereby generating the improved radiation therapy treatment plan.

The invention discloses a cloud-computing based dose verification system and method of tumor radiotherapy. The system comprises a user terminal equipment, a cloud computing server, a local therapy planning system, a computer, an HDFS data storage server and a medical linear accelerator. According to the system and method, EPID information collection is separated from dose analysis and comparison, and part which needs computing and analyzing is transferred to the server based on cloud computer; the equipment at the user end only makes therapy plans, collects, pre-processes and transmits EPID images and receives and display analysis results; and Gamma analysis between to-be-compared dose distribution and reference dose distribution is accelerated. The parallel operation mechanism of cloud computing is used, so that planning dose verification of tumor radiotherapy can be greatly accelerated, time of clinical dosimeter verification is reduced, and the efficiency of radiotherapy is improved.

A charged-particle beam exposure apparatus for exposing a member to be exposed to a charged particle beam with a pattern includes memories (902-905) for storing a plurality of control data for controlling reference dose data of the charged particle beam in accordance with the incident position of the charged particle beam on the member to be exposed, a selector (907) for selecting any one of the plurality of control data stored in the memories, and an exposure unit for controlling the reference dose data of the charged particle beam for each irradiation position on the basis of the control data selected by the selector, thereby exposing the member to be exposed with the pattern. The charged-particle beam exposure apparatus rapidly performs proper proximity effect correction to expose the member to be exposed with the pattern.

A computer Chinese medicine prognosis disease inferring and prescription derivation system based on mathematics of Yin-yang and five elements comprises an existing disease symptom input module, a prognosis disease deducing-judging module, a medicament selecting module and a medicament database, wherein the medicament database stores the name, nature and taste, functions, mainly-treated symptoms, reference doses of each medicament as well as application-treatment correlation of each medicament with each visceral organ and symptom; the existing disease symptom input module provides an existing disease selection menu, so that a user can input a corresponding diseased visceral organ and the symptom by clicking the options of the existing disease selection menu according to the existing diagnostic result; the prognosis disease deducing-judging module transforms the diseased visceral organ and the symptom into existing disease semantic logic operators and conducts derivation operation thereon to obtain the un-diseased visceral organ and symptom expressed by prognosis disease semantic logic operators; and the medicament selection module obtains the diseased and un-diseased visceral organs and symptoms and selects medicaments according to the application-treatment correlation of each medicament with each visceral organ and symptom. The system realizes the standardization and automation of prognosis disease inferring and prescription derivation.

An X-ray imaging apparatus includes an estimation unit (208) that estimates a cumulative exposure dose of X-rays irradiated onto an object, a remaining exposure tolerance dose calculation unit (213) that calculates a remaining exposure tolerance dose using a difference between a tolerated maximum exposure dose and the cumulative exposure dose, an X-ray irradiation tolerance period calculation unit (206) that calculates an X-ray irradiation tolerance period using a difference between a predetermined scheduled X-ray irradiation period and an actual irradiation period of X-rays irradiated onto the object, an X-ray irradiation reference dose calculation unit (212) that calculates an X-ray irradiation reference dose per unit time that will form a basis of X-ray irradiation based on the remaining exposure tolerance dose and the X-ray irradiation tolerance period, and a control unit (211); that controls X-ray irradiation onto the object by setting an X-ray irradiation dose per unit time within the X-ray irradiation tolerance period based on the X-ray irradiation reference dose.

A computer-based method for generating an improved radiation therapy treatment plan for a treatment volume having a target and an organ-at-risk. The method includes a step of accessing an existing radiation therapy treatment plan from a memory of a computer, a dose distribution of the existing radiation therapy treatment plan serving as a reference dose distribution; and performing machine parameter optimization on the existing radiation therapy treatment plan with the computer by pursuing an optimization goal to minimize doses to the organ-at-risk, thereby generating the improved radiation therapy treatment plan.

The invention discloses a public dose evaluation method based on a probability theory in radiation environment evaluation. The method comprises the following steps of analyzing and determining an irradiation path, the irradiation path comprising inhaled air internal irradiation, air immersion external irradiation, surface sediment external irradiation, internal irradiation of food-in animal and plant products and dose evaluation, and selecting a representative personal annual effective dose according to the result of the dose evaluation. According to the method, in the public dose estimation process, all the public within the illuminated range are considered, a reasonable personal annual effective dose is selected as a reference dose value, the value serves as an evaluation index in radiation environment evaluation, the conservative property of the evaluation index is further enhanced, and therefore the safety of the public and the environment is guaranteed.

A method is provided for evaluating a procedure for determining an aggregate radiotherapy dose received in the course of a radiotherapy treatment. The method includes: defining a deformable model of at least one organ to be treated and of at least one neighboring organ, generating a series of simulated images, interpretable by the procedure to be evaluated, with aid of the model; comparing the aggregate dose calculated by the procedure to be evaluated, applied to at least one of the simulated images, with a reference aggregate dose, so as to deliver at least one item of information representative of the quality of the procedure, the reference aggregate dose being obtained by taking into account anatomical deformations applied to the organs, so as to determine a reference dose actually received at each treatment session by the organs, as a function of their actual shape and / or actual position during this session.

An X-ray CT apparatus that transmits X-rays toward a subject on the basis of a set scan condition and reconstructs images from detected X-rays that passes through the subject, including a scan plan setting unit configured to set the scan condition, a reference dose storage unit configured to store reference dose information, including an relation between an attribute information about a plurality of kinds of subjects and reference doses to be referenced for an exposure dose, and an exposure dose calculation unit configured to calculate the exposure dose corresponding to the set scan condition in accordance with the timing of setting of the scan condition.

In a X-ray imaging apparatus an estimation unit estimates a cumulative exposure dose of X-rays irradiated onto an object, and a remaining exposure tolerance dose calculation unit calculates a remaining exposure tolerance dose using a difference between a tolerated maximum exposure dose and the cumulative exposure dose. A X-ray irradiation tolerance period calculation unit calculates an X-ray irradiation tolerance period using a difference between a predetermined scheduled X-ray irradiation period and an actual irradiation period of X-rays irradiated onto the object, an X-ray irradiation reference dose calculation unit calculates reference dose per unit time that will form a basis for irradiation based on the remaining exposure tolerance dose and the X-ray irradiation tolerance period, and a control unit that controls X-ray irradiation of the object by setting dose per unit time within the X-ray irradiation tolerance period based on the reference dose.

A simple metric, the mean absolute dose deviation (“MADD”), for characterizing dose-volume histograms (“DVH”) is disclosed. The MADD facilitates the use and the comparison of DVHs. The MADD is defined as the average of absolute differences between all points of a DVH and a dose point of a specified reference dose range. The MADD is a generalized metric free from distribution assumptions, and it is directly applicable to all types of structures.

The invention discloses a radiation therapy dose comparison display method and system. By obtaining the reference dose value corresponding to each different dose data of the coordinate point of the cursor on the CT image position, the isodose lines corresponding to each different dose data are respectively identified. The reference isodose line closest to the corresponding reference dose value, calculate the distance between each reference isodose line and the coordinate point of the cursor on the CT image position, and use the reference isodose line with the smallest distance as the contrast isodose line, Hide the isodose line of the cursor on the CT image, the dose value in the isodose line is the same as the dose value of the contrast isodose line, other isodose lines other than the isodose line or / and highlight the dose value in the isodose line and the contrast, etc. A dose line is an isodose line with the same dose values. In this way, the doctor can observe at a glance the isodose line with the same dose value in the isodose line corresponding to the CT image position and the dose value of the contrast isodose line and compare it, so as to obtain the optimal radiotherapy plan more accurately.

A charged particle beam writing method includes acquiring a pair of a reference dose and a backscatter coefficient for proximity effect correction using a first settling time, acquiring a first relation between a temperature rise amount and a critical dimension variation amount using a second settling time shorter than the first settling time, the backscatter coefficient and the reference dose acquired, calculating a temperature correction parameter depending on a temperature rise amount, for correcting a dose, by using the first relation, and a second relation on a dose and a pattern critical dimension in a case of using the first settling time, calculating a beam irradiation dose by the reference dose and a dose coefficient obtained from the backscatter coefficient of the pair acquired, and the temperature correction parameter, and writing a pattern with a beam based on the dose calculated using the second settling time.

The invention discloses a radiotherapy plan design simulation and three-dimensional dose distribution testing device. The device can accurately determine the spatial positions of points A and B by positioning marking beads and marking bead fixing plates. In X-ray films or CT images, both It can develop accurately, and it is convenient to accurately determine the reference point for dose calculation; by changing the placement position of the dome applicator fixing plate and changing the length of the positioning hole in the uterine cavity applicator fixing plate, the effective lengths of 4 and 6 can be placed respectively. , 8cm uterine cavity applicator, can simulate and design various typical plans for tumor brachytherapy. Through the dosimetry films placed in the uterine cavity source applicator fixing plate and other different positions in the inner cavity through the film fixing plate, the dose distribution of parallel planes within the main range of irradiation of the entire treatment plan with an interval of 1-2mm can be obtained, and the The dose distribution of all planes is compared with the dose distribution of the planned system design, that is, the three-dimensional dose distribution test and verification in space is realized.

A simple metric, the mean absolute dose deviation (“MADD”), for characterizing dose-volume histograms (“DVH”) is disclosed. The MADD facilitates the use and the comparison of DVHs. The MADD is defined as the average of absolute differences between all points of a DVH and a dose point of a specified reference dose range. The MADD is a generalized metric free from distribution assumptions, and it is directly applicable to all types of structures.

The invention provides a radiation-sensitive gene marker and its application in different types of radiation dose monitoring. The radiosensitive gene markers include Mgmt, Bax, Thyn1 and Phlda3. The dose-response curve constructed based on the expression level of the radiation-sensitive gene marker can effectively determine the range of the radiation dose, so as to effectively monitor the dose of different types of radiation exposure, and then accurately indicate the different types of radiation exposure based on biological effects. Reference dose for nuclear radiation damage assessment.

The invention provides a radiation-sensitive gene marker and its application in X-ray radiation dose monitoring. The radiosensitive gene markers include three up-regulated gene markers and two down-regulated gene markers; the up-regulated gene markers include Phlda3, Fgg and Kng1; the down-regulated gene markers include Ptprb and Kti. The dose-response curve constructed based on the expression level of the radiation-sensitive gene marker can effectively determine the range of radiation dose, thereby effectively monitoring the level of X-ray exposure dose, and then accurately prompting the reference dose of X-ray exposure based on biological effects , for nuclear radiation damage assessment.

In order to provide an X-ray CT apparatus or the like capable of performing reconstruction so that the image quality is the same in the entire interval when reconstructing an image using projection data mixed in a low-dose irradiation interval and a high-dose irradiation interval, the X-ray CT apparatus (1) An image quality improvement table (3) indicating an effect level of image quality improvement for a plurality of image quality improvement processes is held in a storage device (123). In the case of performing imaging while modulating the X-ray irradiation dose based on given radiation dose modulation data, the image processing device (122) acquires a reference radiation dose as a reference of image quality, and for the projection data to be the object of image reconstruction , obtain the dose of X-ray irradiation during shooting from the radiation dose modulation data, and the image processing device (122) refers to the image quality improvement table (3) according to the ratio of these radiation dose values ​​to determine the image used to obtain the image quality as a reference In the quality improvement process, the determined image quality improvement process is performed on the projection data to be reconstructed.

The invention discloses an extraction method and application of chroogomphus rutilus polysaccharide with anti-motion sickness effects. The polysaccharide takes chroogomphus rutilus as a raw material, and is prepared by a water extraction and alcohol precipitation method. The chroogomphus rutilus polysaccharide is used for prevention and treatment of motion sickness, and the results show that very good anti-motion sickness effects can be provided when 200mg / kg of chroogomphus rutilus polysaccharide is given to the stomach by behavioral experiments and hormone level tests. The motion sickness symptoms such as visceral discomfort, incontinence, piloerection and tremor can be obviously reduced, and the level of 5-HT in serum can be reduced, and the motilin level is improved; and most importantly, rats are in good spirits, has no low spirits and other side effect symptoms. The 200mg / kg of chroogomphus rutilus polysaccharide is an ideal dose for the polysaccharide anti-motion sickness. The extraction method provides a novel material and a reference dose for further development of novel anti-motion sickness drugs with efficient, non-toxic and non-side effects.