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Use of hypericum sampsonii hance xanthone compounds in antidepressant drug preparation

A technology of oxalanones and compounds, applied in the field of application of Yuanbao oxalanones in the preparation of antidepressant drugs

Inactive Publication Date: 2013-04-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about the use of Xanone compounds of Yuanbao Xanone for antidepressant

Method used

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  • Use of hypericum sampsonii hance xanthone compounds in antidepressant drug preparation
  • Use of hypericum sampsonii hance xanthone compounds in antidepressant drug preparation
  • Use of hypericum sampsonii hance xanthone compounds in antidepressant drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of xanone compound

[0016] (1) Preparation of extracting liquid: After pulverizing the medicinal material of Yuanbao herb, put it into the extraction tank, heat extraction with 40-90% ethanol for 2-3 times, each time the amount of solvent is about 8-10 times of the amount of crude drug, each extraction time for 1 to 2 hours, and combine the extracts;

[0017] (2) Refining, concentrating and drying: Concentrate the above extract, degrease the concentrate with petroleum ether, extract with ethyl acetate, concentrate under reduced pressure to obtain the ethyl acetate part;

[0018] (3) Separation and purification: dissolve the above-mentioned ethyl acetate part in water, apply macroporous adsorption resin, and elute with water, 20%, 40%, 60% and 80% ethanol system respectively, wherein 80% of the eluting part is used SephadexLH-20 gel column chromatography is purified, and 80% methanol-water is the elution system, obtains 1-hydroxyl-7-methox...

Embodiment 2

[0026] Example 2: Effects of Xanone Compounds on the Immobility Time of Tail Suspension Depression Model Mice

[0027] Mouse tail suspension experiment (Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological Experimental Methodology, 3rd Edition [M]. Beijing: People's Medical Publishing House, 2002: 807): ICR mice, male and female, 6-8 weeks old , weighing 20±2g, provided by the Experimental Animal Center of the Second Military Medical University of the Chinese People's Liberation Army. Breeding room temperature 18-22 ℃, relative humidity 60%-75%, artificial mixed feed feeding. Randomly divided into: blank control group, positive control group (imipramine 20mg / kg·d), high-dose drug group (60mg / kg·d) and low-dose drug group (15mg / kg·d), 10 small animals in each group Rats were administered continuously for 7 days, and the animals had free access to food and water during the experiment. One hour after the last administration, the tail of the mouse was fixed with a clip about 1 cm f...

Embodiment 3

[0032] Example 3: Effects of Xanone Compounds on the Immobility Time of Mice in Forced Swimming

[0033] Forced mouse swimming test (Xu Shuyun, Bian Rulian, Chen Xiu. Pharmacological Experimental Methodology, 3rd Edition [M]. Beijing: People's Medical Publishing House, 2002: 807): ICR mice, male and female, 6-8 weeks old , weighing 20±2g, provided by the Experimental Animal Center of the Second Military Medical University of the Chinese People's Liberation Army. Breeding room temperature 18-22 ℃, relative humidity 60%-75%, artificial mixed feed feeding. Randomly divided into: blank control group, positive control group (imipramine 20mg / kg·d), high-dose drug group (60mg / kg·d) and low-dose drug group (15mg / kg·d), 10 small animals in each group Rats were administered continuously for 7 days, and the animals had free access to food and water during the experiment. 1 hour after the last administration, the mouse was placed in a container with a diameter of about 14 cm, a water de...

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Abstract

The present invention discloses a new medical use of hypericum sampsonii hance xanthone compounds. Pharmacodynamics researches show that xanthone compounds such as 1-hydroxy-7-methoxy xanthone and 1,3,5-trihydroxy xanthone in the hypericum sampsonii hance can significantly shorten immobility times in tail suspension and immobility times in forced swimming of mice, and have good antidepressant activity, such that the xanthone compounds can be used for preparing antidepressant drugs or food. With the present invention, a new source is provided for seeking antidepressant drugs or food.

Description

technical field [0001] The present invention relates to the new medical application of Yuanbao xanone compounds, in particular to the use of Yuanbao xanone compounds 1-hydroxy-7-methoxyxanone and 1,3,5-trihydroxyxanone in the preparation of antidepressants or food applications. Background technique [0002] Global mental illness has increasingly become a prominent social problem, and depression ranks first among all kinds of mental illness, accounting for 47% of the burden of mental illness. According to the statistics of the World Health Organization, the global incidence of depression is about 11%. Currently, there are as many as 120 million people with depression worldwide. Depression has become the fourth major disease that threatens human health. It is estimated that by 2020, depression may become the second largest disease after heart disease, and depression is becoming a serious global problem. Depression is a common disease that endangers human physical and mental ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/24A23L1/30
Inventor 秦路平辛文波郑承剑张宏
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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