Medicine composition for treating melancholia using glycyrrhiza, Chinese date as raw material and preparation method thereof

A composition and technology for depression, applied in the field of preparation of pharmaceutical compositions, can solve problems such as decreased libido and increased suicide rate

Inactive Publication Date: 2009-06-10
戚郁芬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the antidepressants already on the market have side effects of varying degrees, such as: increased suicide rate, headache, dizziness, dizziness, insomnia, drowsiness, tinnitus, dry mouth, anorexia, increased appetite, weight gain, blood pressure rise, gastrointestinal Discomfort, nausea, nausea, vomiting, indigestion, diarrhea, constipation, leg pain, skin rash, tremor, cramps, sweating, edema, decreased libido, impotence, etc.

Method used

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  • Medicine composition for treating melancholia using glycyrrhiza, Chinese date as raw material and preparation method thereof
  • Medicine composition for treating melancholia using glycyrrhiza, Chinese date as raw material and preparation method thereof
  • Medicine composition for treating melancholia using glycyrrhiza, Chinese date as raw material and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0046] With the preparation method that comprises the following steps, make the pharmaceutical composition for the treatment of depression of the present invention:

[0047] (a) after crushing 2-32 parts by weight of licorice, first add water to soak at room temperature, then extract by water extraction and alcohol precipitation, and then concentrate and dry the extracted supernatant to obtain a licorice extract containing glycyrrhizic acid;

[0048] (b) Crush 2-42 parts by weight of Chinese jujube and then heat and extract with water to obtain a first extract, which is separated and purified by column chromatography to obtain a second extract, wherein the second extract the jujube cyclic adenosine monophosphate concentration of the extract is higher than the jujube cyclic adenosine monophosphate concentration of the first extract; and

[0049] (c) Mix and pulverize the licorice extract obtained in step (a) and step (b) and the second jujube extract to obtain the pharmaceutica...

Embodiment 1

[0083] see figure 1 , is a schematic flow chart of the method for preparing the pharmaceutical composition of Example 1 of the present invention. In Figure 1, crush 4 kg of licorice root, soak it in water for 12 hours, extract it by heating, precipitate it with alcohol, and dry it to obtain 0.8 kg of licorice extract containing 10% glycyrrhizic acid; crush 2 kg of jujube, soak it in water at room temperature, and then Extract by water extraction and alcohol precipitation method to obtain jujube extract, then use two columns of macroporous resin OU-2 and ME-2 to successively apply column adsorption and separation, and dry to obtain 6 g of jujube extract containing 1% jujube cAMP; The extracts obtained in the above steps are mixed and pulverized evenly to obtain the pharmaceutical composition of the present invention.

Embodiment 2

[0085] see figure 2 , is a schematic flow chart of the method for preparing the pharmaceutical composition of Example 2 of the present invention. exist figure 2 , directly mix and pulverize prepared 4 g of glycyrrhetinic acid and 1 g of jujube extract containing 10 mg of jujube cAMP to obtain the pharmaceutical composition of the present invention.

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Abstract

The invention discloses a group of pharmaceutical compositions for treating melancholia made from the raw materials including licorice and jujube. The invention further discloses the preparation method of the pharmaceutical compositions. Experiments proves that: the pharmaceutical composition of the invention can obviously reduce the tail suspension time and the reserpine induced temperature of the tested mice, which proves that it achieves anti-melancholia function.

Description

technical field [0001] The invention relates to a group of medicinal compositions for treating depression made from licorice and jujube as raw materials, which can be used as medicine, nutritional agent and health food. The present invention also relates to a preparation method of the above-mentioned pharmaceutical composition for treating depression. Background technique [0002] Depression is a common disease. According to statistics, about 25% of women in the general population have experienced depression in their lifetime, and about 10% of men have experienced depression (Zhang Chunxing: "Modern Psychology") . According to the data provided by the World Health Organization (WHO): the incidence rate of depression in the world is about 11%. It will rise to become the second most common disease in the world. [0003] In the prior art, antidepressant drugs are mainly Prozac, Cylot, Zoloft, etc. (5-HT, NE, DA reuptake inhibitors such as SSRI, SNRI, NDRI, etc.), and their m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/00A61P25/20A61K31/7076C07H1/08
Inventor 张作光
Owner 戚郁芬
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