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Medicine composition for treating depression with formulation of Rg1, Rb1 and glycyrrhizic acid and preparation method thereof

A composition, technology of glycyrrhizic acid, applied in drug combination, medical preparations containing active ingredients, food science, etc., can solve problems such as increasing suicide rate

Inactive Publication Date: 2010-11-24
张作光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antidepressants already on the market have side effects of varying degrees, such as: increased suicide rate, headache, dizziness, dizziness, insomnia, drowsiness, tinnitus, dry mouth, anorexia, increased appetite, weight gain, blood pressure rise, gastrointestinal Discomfort, nausea, nausea, vomiting, indigestion, diarrhea, constipation, leg pain, skin rash, tremor, cramps, sweating, edema, decreased libido, impotence, etc.

Method used

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  • Medicine composition for treating depression with formulation of Rg1, Rb1 and glycyrrhizic acid and preparation method thereof
  • Medicine composition for treating depression with formulation of Rg1, Rb1 and glycyrrhizic acid and preparation method thereof
  • Medicine composition for treating depression with formulation of Rg1, Rb1 and glycyrrhizic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] according to figure 1 The medicine of Example 1 of the present invention was prepared. according to figure 1 100 g of ginsenoside Rg1 with a purity of 90%, 100 g of ginsenoside Rb1 with a purity of 90%, and 100 g of glycyrrhizic acid with a purity of 90% are directly mixed and pulverized to obtain 300 g of the drug example 1 of the present invention. .

Embodiment 2

[0036] according to figure 2 The medicine of Example 1 of the present invention was prepared. according to figure 2100g of ginsenoside Rg1 with a purity of 92%, 100g of ginsenoside Rb1 with a purity of 95%, and 100g of glycyrrhizic acid with a purity of 93%, together with 20g of starch, 10g of lactose, and 10g of micropowder silica gel. Mix and pulverize to make 1,000 capsules, to obtain Drug Example 2 of the present invention.

Embodiment 3

[0038] according to figure 1 The medicine of Example 3 of the present invention was prepared. according to figure 1 100 g of ginsenoside Rg1 with a purity of 95%, 50 g of ginsenoside Rb1 with a purity of 92%, and 50 g of glycyrrhetic acid with a purity of 91% are directly mixed and pulverized to obtain 200 g of pharmaceutical example 3 of the present invention.

[0039] Specific experimental example

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PUM

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Abstract

The invention discloses a medicine composition for treating depression, which is prepared from panaxoside Rg1, Rb1 and glycyrrhizic acid (glycyrrhetinic acid), and a preparation method of the medicine composition. Proven by a test, the medicine composition can obviously reduce the tail suspension and immobility time during forced swimming, can rapidly arouse the CAMP-PKA access of a hippocampus and improves the expressions of CREB and BDNF. Accordingly, the medicine composition can be used for treating depression acted on the body.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating depression prepared by using ginsenosides Rg1, Rb1 and glycyrrhizic acid (or glycyrrhetic acid) as raw materials, which can be used as medicine, nutritional agent and health food. The present invention also relates to the preparation method of the above-mentioned pharmaceutical composition for treating depression. Background technique [0002] Depression is a common disease. According to statistics, about 25% of women in the general population have experienced depression in their lifetime, and about 10% of men have experienced depression (Zhang Chunxing: "Modern Psychology") . According to the data provided by the World Health Organization (WHO): the incidence of depression in the world is about 11%, and there are currently about 340 million mental depression patients in the world, and this number is still on the rise. The survey found that in the next 20 years, depression It will bec...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/56A61P25/24A23L1/29A23L33/00
CPCA61K36/484A61K31/704A61K31/192A61K36/258A61K45/06A61P25/24A61K2300/00
Inventor 张作光
Owner 张作光
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