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Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof

An antidepressant and extract technology, which is applied in the field of antidepressant traditional Chinese medicine combination extract and its preparation, can solve the problems of large toxic and side effects, resistance to western medicine, etc.

Inactive Publication Date: 2016-06-15
JILIN TONGHUA BOXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicines for treating various types of depression mainly include tricyclic antidepressants (abbreviated as TCAs, divided into imazines, purines, dibenzodes, etc.), monoamine oxidase inhibitors (abbreviated as MAOIs, such as iprohydrazine, etc.) ) and 5-HT reuptake inhibitors (referred to as SSRI, such as fluoxetine, etc.), but Western medicines generally have disadvantages such as drug resistance and large toxic and side effects. It is natural antidepressants that have become a research hotspot in this field

Method used

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  • Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof
  • Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof
  • Traditional Chinese medicine combined extract with anti-depression effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 140g of Salvia miltiorrhiza, 100g of Chuanxiong, 100g of kudzu root, 100g of earthworm, 100g of red peony, 70g of safflower, 10g of turmeric, 100g of Polygonum multiflorum, 100g of Alisma, 100g of wolfberry, 70g of jujube seed, 100g of polygala, 100g of iris, Knee 100g, licorice 70g. Add the weighed traditional Chinese medicine to 10 times of water, heat and reflux to extract 3 times, each time for 1 hour, filter, and combine the filtrate to obtain the Chinese medicine combination extract with antidepressant effect; concentrate the obtained filtrate to a relative density of 1.10 (60°C) The clear paste is spray-dried to obtain the extract extract; according to the following composition by weight percentage: 2% sodium starch glycolate, 10% microcrystalline cellulose, 5% starch, 0.5% magnesium stearate, and the balance is the extract extract . The dry powder of the above-mentioned substances is fully mixed, granulated by dry method, passed through an 80-mesh sieve, a...

Embodiment 2

[0026] Experimental study on the main pharmacodynamics of antidepressants in mice.

[0027] 1. Effects on Depressive Behavior in Behavioral Hopelessness Model Mice

[0028] Fluoxetine hydrochloride capsules, Shanghai Zhongxi Pharmaceutical Co., Ltd.; experimental tablet: the tablet prepared in Example 1, 0.42g per tablet (equivalent to about 0.6g of crude drug amount).

[0029] Clean-grade Kunming mice, half male and half female, weighing 18-22g, were kept in separate cages, maintained a 12-hour circadian rhythm, room temperature was 24±1°C, free to drink and eat, and the mice were randomly divided into five groups, 10 in each group, male and female Half, respectively: blank group (physiological saline, 0.1ml / kg, i.g.), test tablet dosage group, positive control group (fluoxetine, 10mg / kg, i.g.), each group of animals was administered continuously for 7 days.

[0030] Calculated according to the amount of crude drug, the dosage for a 70kg person per day is 5.4g, and each tabl...

Embodiment 3

[0077] Take 100g of salvia miltiorrhiza, 150g of Chuanxiong, 80g of kudzu root, 80g of earthworm, 120g of red peony root, 100g of safflower, 10g of turmeric, 150g of Radix Polygoni Multiflori, 80g of Alisma, 80g of wolfberry, 100g of jujube seed, 60g of polygalaceae, 150g of calamus nine-section, Knee 80g, licorice 100g. Add the weighed traditional Chinese medicine to 12 times of water, heat and reflux extract 3 times, each time for 1.5 hours, filter, and combine the filtrate to obtain the Chinese medicine combination extract with antidepressant effect; concentrate the obtained filtrate to a relative density of 1.15 (60°C) The clear paste is spray-dried to obtain the extract extract; it is composed according to the following weight percentage: 3% sodium starch glycolate, 9% microcrystalline cellulose, 6% starch, 0.3% magnesium stearate, and the balance is the extract extract . The dry powder of the above-mentioned substances is fully mixed, granulated by dry method, passed th...

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Abstract

The invention discloses a traditional Chinese medicine combined extract with an anti-depression effect as well as a preparation method and application thereof and belongs to the technical field of traditional Chinese medicinal preparations. The traditional Chinese medicine combined extract with the anti-depression effect is prepared from salviae miltiorrhizae, ligusticum wallichii, kudzuvine root and earthworm in certain parts by weight. The traditional Chinese medicine combined extract is scientific in compatibility and reasonable in preparation; experiments show that the traditional Chinese medicine combined extract or traditional Chinese medicine tablets thereof can obviously reduce the dead time of mouse tail suspension and forced swimming of a behavioural despair model, and open-field test results show that the autonomic activity of a mouse is not influenced while the dead time is reduced; and meanwhile, the traditional Chinese medicine combined extract also can obviously resist mouse body temperature decrease caused by reserpine and obviously improve the mouse head shaking frequency induced by 5-hydroxytryptophane, so that the traditional Chinese medicine combined extract has the anti-depression effect, plays a role by changing the monoaminergic level in the brain, and has an application prospect of being developed into an anti-depression drug.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine combination extract with antidepressant effect and its preparation method and application. Background technique [0002] Depression is a disease characterized by depressed mood, which is often ignored because it cannot cause direct harm to the body. Currently, depression is one of the 15 leading causes of disability in developed countries. According to the data of the United States, about 11 million people in the United States suffer from clinical depression every year, and the suicide rate of patients with clinical depression is 10-15%. Affected by this disease, the annual loss is about 20 billion US dollars. Domestic survey data show that the suicide rate of depression is about 20 times higher than that of the general population. It can be seen that depression is a great threat to human health. It i...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/30A61P25/24A61K35/62
CPCA61K36/537A61K9/282A61K35/62A61K36/21A61K36/28A61K36/286A61K36/484A61K36/488A61K36/65A61K36/69A61K36/704A61K36/71A61K36/725A61K36/815A61K36/884A61K36/9066A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 宋爱群曲立军董守光
Owner JILIN TONGHUA BOXIANG PHARMA
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