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Chinese medicine compound effective part with effect of treating arthritis

A technology for effective parts and arthritis, which is applied in the field of preparation of drugs for the treatment of rheumatoid arthritis, can solve problems such as adverse reactions, complex composition of medicinal flavors, and large dosage, and achieve low adverse reactions, convenient clinical administration, and high activity. Ingredient-specific effects

Active Publication Date: 2015-03-18
南京百草和康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current traditional Chinese medicine compound preparations have complex tastes, large dosages, and certain adverse reactions.

Method used

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  • Chinese medicine compound effective part with effect of treating arthritis
  • Chinese medicine compound effective part with effect of treating arthritis
  • Chinese medicine compound effective part with effect of treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for the effective part of a traditional Chinese medicine compound with the effect of treating arthritis, the preparation method of which is:

[0031] (1) Weigh 10 parts of frankincense and 10 parts of myrrh in proportion, crush them to a particle size of 40 mesh, mix them, and decoct them with water for extraction twice. Add 8 times the amount of medicinal materials for the second time and decoct in water for 1 hour, combine the decoctions from the two decoctions, concentrate to 1g crude drug / ml, and obtain a concentrated solution;

[0032] (2) Use 95% ethanol to adjust the concentrated solution obtained in step (1) to 80% ethanol concentration, leave it for 12 hours, filter the precipitate, take the supernatant, concentrate to 5kg, and obtain the concentrate;

[0033] (3) Take the concentrate obtained in step (2) and put it on a D101 macroporous adsorption resin column. After standing for 12 hours, carry out gradient elution with pure water and ethanol with a ...

Embodiment 2

[0037] A method for the effective part of a traditional Chinese medicine compound with the effect of treating arthritis, the preparation method of which is:

[0038] (1) Take 35 parts of frankincense and 25 parts of myrrh, mix them, grind them to a particle size of 40 mesh, and extract 3 times with 60% ethanol under reflux. For the first time, add 8 times the amount of 60% ethanol and reflux for 2 hours. Add 6 times the amount of 60% ethanol for the first time and reflux for 2 hours, add 6 times the amount of 60% ethanol for the third time and reflux for 1.5 hours, combine the extracts, concentrate under reduced pressure at 50-70 ° C to obtain 5 kg of concentrated solution;

[0039] (2) Add ethanol to the concentrated solution obtained in step (1), so that the concentration of ethanol reaches 90%, place the precipitate, separate the supernatant, concentrate, and obtain the concentrate;

[0040] (3) Put the concentrate obtained in step (2) on a D102 type macroporous adsorption ...

Embodiment 3

[0044] A method for the effective part of a traditional Chinese medicine compound with the effect of treating arthritis, the preparation method of which is:

[0045] (1) Take 50 parts of frankincense and 50 parts of myrrh, mix them, crush them to a particle size of 40 mesh, and extract them twice with 80% ethanol under reflux. For the first time, add 80 times the amount of 80% ethanol and reflux for 2 hours. Add 8 times the amount of 80% ethanol to reflux for 1.5 hours, combine the extracts, and concentrate under reduced pressure at 50-70°C to obtain 7 kg of concentrated solution;

[0046] (2) Add ethanol to the concentrated solution obtained in step (1), so that the concentration of ethanol reaches 90%, place the precipitate, separate the supernatant, concentrate, and obtain the concentrate;

[0047] (3) Take the concentrate obtained in step (2) and put it on the AB-8 type macroporous adsorption resin column. After standing for 12 hours, carry out gradient elution with pure w...

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Abstract

The invention discloses a Chinese medicine compound effective part with an effect of treating arthritis. The effective part is prepared via the steps as follows: 10-50 parts of frankincense and 10-50 parts of myrrh are abstracted via water or alcohol, impurities are removed via alcohol deposition, and the frankincense and the myrrh are placed on a macropore adsorption resin column, and eluted and purified with alcohol gradient with optimized concentrate. The effective part is refined and prepared via modern analytical apparatuses and pharmacological experiments section and according to Chinese medicine theories, the pathogenesis of rheumatic and rheumatoid arthritis. Shown by the experiment result, the Chinese medicine compound effective part provided by the invention has the good effects of antiphlogosis, pain easing, immunization regulation and the like, can be used for treating rheumatic and rheumatoid arthritis, proliferative arthritis, and inflammation pain diseases, is clear in ingredient, low in clinical dosage and lower in adverse reaction, and possibly can be developed as a new generation of medicine for treating the arthritis.

Description

Technical field: [0001] The invention relates to an effective part of a compound traditional Chinese medicine, in particular to an effective part of a traditional Chinese medicine capable of preventing and treating rheumatoid arthritis and its application in preparing medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic systemic autoimmune disease characterized by joint synovitis. Synovitis persists and recurs, which can lead to the destruction of cartilage and bone in the joint, dysfunction of the joint, and even disability. Vasculitis lesions involve various organs of the whole body, so the disease is also called rheumatoid disease. Its etiology is not yet clear, and its main clinical manifestations are chronic, symmetrical, polysynovial arthritis and extra-articular lesions, and it is an autoimmune inflammatory disease. This disease is mainly in the small joints such as hand, wrist, foot, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/328A61P19/02A61P29/00
Inventor 宿树兰段金廒钱大玮成俊
Owner 南京百草和康医药科技有限公司
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