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Antidepressant composition and preparing process thereof

A composition and technology for depression, applied in the field of compositions of active ingredients of natural plants, can solve the problems of difficulty in formulating quality control standards, insufficient drug efficacy, complex components, etc., and achieve reduction of absolute immobility time and significant drug efficacy. , the effect of a reasonable formula

Inactive Publication Date: 2006-11-08
NANJING UNIV
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  • Summary
  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0007] The above-mentioned traditional Chinese medicine compound has slow onset of action, relatively complex components, and insufficient efficacy, making it difficult to formulate and implement strict quality control standards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of embodiment 1 pharmaceutical composition, its steps are:

[0026] (1) Take dried Magnolia officinalis, infiltrate with saturated lime water until the percolation liquid has no phenolic reaction, adjust the pH of the percolation liquid to 1-3 with 6M HCl, and wash the precipitate to obtain the magnolol component with a yield of 1.2% ;

[0027] (2) Take the dried Poria cocos sclerotia, extract three times with 10 times the volume of water, combine the extracts, add 95% ethanol after concentration until the ethanol concentration is 80%, and the resulting precipitate is Poria cocos polysaccharide, with a yield of 80.1%;

[0028] (3) Take dried ginger and extract it three times with conventional steam, the yield is 1.0%.

[0029] (4) Take 0.4 g of magnolol active ingredient, 10 g of pachymansin and 1 g of ginger oil, wrap ginger oil with β-cyclodextrin, and mix to obtain the composition MPG.

Embodiment 2

[0030] Effects of Example 2 Composition on Behavioral and Biochemical Indexes of Desperate Model Mice

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating depression, which is composed of three active ingredients of magnolol, pachymansin and ginger oil; or composed of two active ingredients of magnolol and pachyan Composition, the dosage is 0.1-1g of magnolol component, 3.5-14g of polysaccharide, and 0.2-3.5g of ginger oil. The preparation method is as follows: according to the above weight proportion, ginger oil is included with beta-cyclodextrin and then mixed to obtain MPG and MP pharmaceutical compositions respectively. The composition can be used to prepare medicine for treating depression, and has the advantages of stable curative effect, safety and reliability, simple process, easy production and the like.

Description

1. Technical field: [0001] The present invention relates to the composition of natural plant active ingredients, its preparation method and medicinal application, especially relates to the preparation of the composition of magnolol, pachymansin and (or) ginger oil as a medicine for treating depression. 2. Background technology: [0002] Depression refers to an affective disorder syndrome characterized by low mood. The main clinical manifestations are depressed mood, fatigue, anhedonia, thinking and movement retardation, accompanied by anxiety, sleep disturbance, loss of appetite, despair and suicidal delusions. Depression is a common and frequently-occurring disease that endangers the physical and mental health of all human beings. According to the World Health Organization psychiatric epidemic survey report, the prevalence of depression in the world is as high as 3-5%, the suicide rate of patients with major depression is as high as 15-18%, and the lifetime attack rate is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/575A61K36/076A61P25/24
Inventor 孔令东王业民
Owner NANJING UNIV
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