Myrrh target area for treatment of gynecological tumor and preparation method and application thereof

A technology for effective parts and gynecological tumors, applied in the application field of preparing anti-gynecological tumor drugs, can solve the problems of undisclosed gynecological tumor disease treatment, complex composition, large dosage, etc., and achieve good inhibitory and killing effects and dosage The effect of low, high content of active ingredients

Inactive Publication Date: 2010-10-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Chinese invention patents 200410058013.0, 200410018778.1, 200710163373.0, 200710016109.4 and 200910118808.9 all disclose the anti-tumor Chinese medicine compound containing myrrh, which has complex composition and large dosage, and has not disclosed the treatment for gynecological tumor diseases. Modern chemical composition research shows that myrrh The main chemical compone

Method used

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  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof
  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof
  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof

Examples

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Example Embodiment

[0030] Example 1 Preparation of effective parts of myrrh

[0031] Take the crude myrrh powder, heat and reflux with 6 times the amount of 95% ethanol for three times, combine the extracts, recover the ethanol at 60℃, 700mmHg, concentrate to almost no ethanol flavor, add 0.8 times the weight of crude drug to water suspension, and then add the same amount Extract 3 times with petroleum ether (60°C-90°C), combine the petroleum ether extracts, and concentrate to obtain the effective part of myrrh with a yield of 15.40%.

[0032] Take 0.2g of the effective part of myrrh above, add 0.01g of starch, 0.5g of lactose, 0.5g of microcrystalline cellulose, 0.02g of magnesium stearate and 0.01g of talc, and mix the above ingredients uniformly to form granules with 20-80 mesh Sieve, dry at 40-80°C, and press to obtain tablets.

Example Embodiment

[0033] Example 2 Preparation of effective parts of myrrh

[0034] Take the crude myrrh powder and add 8 times the amount of 85% ethanol to soak and extract for 8 hours, filter to obtain the filtrate, add 8 times the amount of 85% ethanol to the filter residue, soak and extract for 8 hours, filter, combine the filtrate, and recover at 60℃, 700mmHg Ethanol was concentrated to almost no ethanol taste, and 0.8 times the weight of crude drug was added to suspend in water, and then the same amount of ether (60°C to 90°C) was added to extract 3 times, and the ether solvent was recovered to obtain the effective part of myrrh. The yield was about 16.56%.

[0035] Take 0.2g of the above myrrh effective part extract, add 0.01g starch, 0.5g lactose, 0.5g microcrystalline cellulose, 0.02g magnesium stearate and 0.01g talc, mix the above ingredients evenly, sieving and granulating, Dry at 40~80℃ to make granules.

Example Embodiment

[0036] Example 3 Preparation of effective parts of myrrh

[0037] (1) Take myrrh, crush it through a 20-mesh sieve, use pure ethanol with 50% myrrh as an entrainer, and extract with supercritical carbon dioxide. The extraction temperature is 30°C, the extraction pressure is 30Mpa, and the extraction time is 2 hours. Obtain the carbon dioxide extract, and recover the concentrate under reduced pressure below 60°C for use;

[0038] (2) Take the supercritical carbon dioxide extraction concentrate obtained in step (1) and add 8 times the amount of water to suspend, then add 3 times the amount of ether to extract 3 times, combine the ether extracts and concentrate to obtain the effective part of myrrh. The yield is about Is 23.38%. .

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Abstract

The invention discloses a myrrh target area for treatment of gynecological tumors and a preparation method and application thereof. The preparation method comprises the following steps: extracting with alcohol for myrrh and other solvents through supercritical fluid extraction, impregnation or reflux extraction to obtain alcohol extract; concentrating, suspending the concentrate with water, extracting with ether, petroleum ether, n-hexane or other low-polar solvents to obtain low-polar solvents extract; and concentrating, thereby obtaining the myrrh target area with 0-5 weight percent of diterpene and 0-30 weight percent of diterpenoid resin acid components. The invention combines the modern extraction and separation and the pharmacological activity screening to determine the optimal target area, the active ingredients of the prepared target area are clearer, the contents of the active ingredients are high and the results of in vitro anti-tumor experiments show that the myrrh target area provided by the invention has the function of inhibiting and killing multiple kinds of gynecological tumors with low dosage, and is expected to be developed as the novel traditional Chinese medicine with significant treatment effect and fewer low adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the effective part of myrrh, its preparation method and its application in the preparation of anti-gynecological tumor drugs. Background technique [0002] Gynecological tumors are major diseases that endanger women's health and are common diseases of women of childbearing age. Common malignant tumors include endometrial cancer, cervical cancer, breast cancer, ovarian cancer, etc. Common benign tumors include uterine fibroids, ovarian cysts, etc. . Today, nearly 15 million women in developed countries are diagnosed with cancer every year, 50% of which occur in reproductive organs, and 80% occur in postmenopausal women. The morbidity and mortality of cervical cancer in my country account for about one-third of the world. [0003] Treatment of gynecological tumors The treatment options routinely adopted by domestic and foreign medical circles are...

Claims

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Application Information

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IPC IPC(8): A61K36/328A61P35/00
Inventor 宿树兰段金廒唐于平钱大玮华永庆
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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