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Myrrh target area for treatment of gynecological tumor and preparation method and application thereof

A technology for effective parts and gynecological tumors, applied in the application field of preparing anti-gynecological tumor drugs, can solve the problems of undisclosed gynecological tumor disease treatment, complex composition, large dosage, etc., and achieve good inhibitory and killing effects and dosage The effect of low, high content of active ingredients

Inactive Publication Date: 2010-10-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese invention patents 200410058013.0, 200410018778.1, 200710163373.0, 200710016109.4 and 200910118808.9 all disclose the anti-tumor Chinese medicine compound containing myrrh, which has complex composition and large dosage, and has not disclosed the treatment for gynecological tumor diseases. Modern chemical composition research shows that myrrh The main chemical components are resin, volatile oil and gum, and its main active components include myrrh sesquiterpenoids, diterpenoids, triterpenoids and other compounds. In addition, it also contains a small amount of bitter substances, myrrhic acid and oxidase and other components. It is of great value to explore the efficacy of myrrh extract and to research and develop anti-tumor active parts of myrrh

Method used

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  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof
  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof
  • Myrrh target area for treatment of gynecological tumor and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of effective fraction of myrrh

[0031] Take the coarse powder of myrrh, heat and reflux extract three times with 6 times the amount of 95% ethanol, combine the extracts, recover ethanol at 60°C and 700mmHg, concentrate until almost no ethanol smell, add 0.8 times the weight of the crude drug to suspend, and then add an equal amount The petroleum ether (60 ℃~90 ℃) was extracted 3 times, and the petroleum ether extract was combined and concentrated to obtain the effective fraction of myrrh with a yield of 15.40%.

[0032] Take 0.2g of the above effective part of myrrh, add 0.01g of starch, 0.5g of lactose, 0.5g of microcrystalline cellulose, 0.02g of magnesium stearate and 0.01g of talcum powder, mix the above ingredients evenly and make granules through 20-80 mesh Sieve, dry at 40-80°C, and compress into tablets to obtain tablets.

Embodiment 2

[0033]Example 2 Preparation of effective fraction of myrrh

[0034] Take the crude powder of myrrh and add 8 times the amount of 85% ethanol to immerse and extract for 8 hours, filter to obtain the filtrate, add 8 times the amount of 85% ethanol to the filter residue and immerse and extract for 8 hours, filter, combine the filtrates, and recover at 60 ° C and 700 mmHg Ethanol, concentrated until there is no ethanol smell, add 0.8 times the weight of the crude drug in water to suspend, then add the same amount of ether (60 ° C ~ 90 ° C) to extract 3 times, recover the ether solvent, and obtain the effective part of myrrh. The yield is about 16.56%.

[0035] Take 0.2g of the above effective part extract of myrrh, add 0.01g of starch, 0.5g of lactose, 0.5g of microcrystalline cellulose, 0.02g of magnesium stearate and 0.01g of talcum powder, mix the above ingredients evenly, sieve and granulate, Dry at 40-80°C to make granules.

Embodiment 3

[0036] Example 3 Preparation of effective fraction of myrrh

[0037] (1) Get myrrh, pulverize and cross 20 mesh sieves, make entrainer with 50% pure ethanol of myrrh, adopt supercritical carbon dioxide method to extract, extraction temperature is 30 ℃, and extraction pressure is 30Mpa, and extraction time is 2 hours, Obtain the carbon dioxide extract, recover under reduced pressure below 60°C to obtain the concentrate, and set aside;

[0038] (2) Get the supercritical carbon dioxide extraction concentrate that step (1) obtains and add 8 times of amount of water to suspend, then add 3 times of amount of ether to extract 3 times, merge the ether extract, concentrate, and obtain the effective part of myrrh, with a yield of about was 23.38%. .

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Abstract

The invention discloses a myrrh target area for treatment of gynecological tumors and a preparation method and application thereof. The preparation method comprises the following steps: extracting with alcohol for myrrh and other solvents through supercritical fluid extraction, impregnation or reflux extraction to obtain alcohol extract; concentrating, suspending the concentrate with water, extracting with ether, petroleum ether, n-hexane or other low-polar solvents to obtain low-polar solvents extract; and concentrating, thereby obtaining the myrrh target area with 0-5 weight percent of diterpene and 0-30 weight percent of diterpenoid resin acid components. The invention combines the modern extraction and separation and the pharmacological activity screening to determine the optimal target area, the active ingredients of the prepared target area are clearer, the contents of the active ingredients are high and the results of in vitro anti-tumor experiments show that the myrrh target area provided by the invention has the function of inhibiting and killing multiple kinds of gynecological tumors with low dosage, and is expected to be developed as the novel traditional Chinese medicine with significant treatment effect and fewer low adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the effective part of myrrh, its preparation method and its application in the preparation of anti-gynecological tumor drugs. Background technique [0002] Gynecological tumors are major diseases that endanger women's health and are common diseases of women of childbearing age. Common malignant tumors include endometrial cancer, cervical cancer, breast cancer, ovarian cancer, etc. Common benign tumors include uterine fibroids, ovarian cysts, etc. . Today, nearly 15 million women in developed countries are diagnosed with cancer every year, 50% of which occur in reproductive organs, and 80% occur in postmenopausal women. The morbidity and mortality of cervical cancer in my country account for about one-third of the world. [0003] Treatment of gynecological tumors The treatment options routinely adopted by domestic and foreign medical circles are...

Claims

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Application Information

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IPC IPC(8): A61K36/328A61P35/00
Inventor 宿树兰段金廒唐于平钱大玮华永庆
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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