The invention relates to the technical field of medical drugs, in particular to a muscle and bone cold compress gel, and comprises the following components: water, glycerol, a saffron crocus extract and a motherwort extract, asarum extract, cortex eucommiae extract, artemisia argyi extract and garden balsam stem extract, the pseudo-ginseng extract, the lycopodium clavatum extract and the radix aconiti carmichaeli extract, rhizoma gastrodiae extract, ligusticum wallichii extract and myrrh extract, fructus rosae laevigatae extract, radix cyathulae extract, cynomorium songaricum extract and angelica sinensis extract, an cyperus rotundus extract, borneol, azone, vanillin butyl ether and ethanol, propylene glycol, bisabolol, caprylyl hydroxyvaleric acid, 1-2-hexanediol, PPG-26 n-butyl alcohol polyether t26 and PEG. The 40 hydrogenated castor oil has the effects of relieving swelling and pain, promoting blood circulation to remove blood stasis and the like, and is directly applied to lesionsin an external application mode., the treatment effect is good, the treatment effect is fast, the essence in the traditional chinese medicine components is extracted, and the absorption of the humanbody is promoted., the use comfort is improved, the manufacturing process is simple, the required cost is low, and the requirements of patients can be met.