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Preparation for anti-tumor compound medicine active ingredients

A drug activity and anti-tumor technology, which is applied in the direction of anti-tumor drugs, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of stability and uniformity, and difficult quality of compound ingredients, so as to achieve controllable quality, clear active ingredients, stable effect

Inactive Publication Date: 2014-05-07
CHIFCON DRUG DISCOVERY SUZHOU
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Problems solved by technology

[0002] In today's society, tumor has become one of the most serious diseases that threaten human survival. Its morbidity and mortality rate rank first among all kinds of diseases, and it has become the number one enemy of human beings. Therefore, the treatment of tumors is also a hot spot in current medical research. In view of the current Western medicines have many toxic and side effects. Traditional Chinese medicine, especially compound medicine, has attracted more and more attention from researchers because of its mild curative effect and mild side effects. Therefore, compound prescriptions are often used in traditional Chinese medicine prescriptions, and a variety of Chinese herbal medicines are used in combination. Various Chinese herbal medicines perform their duties and work together to play a role towards one goal. However, under various quality standard control environments, complex compound ingredients are very difficult. It is difficult to make the quality stable and uniform

Method used

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  • Preparation for anti-tumor compound medicine active ingredients
  • Preparation for anti-tumor compound medicine active ingredients
  • Preparation for anti-tumor compound medicine active ingredients

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Embodiment

[0017] The preparation of the active component of a kind of anti-tumor compound medicine of the present embodiment, its one dosage compound prescription comprises following medicine:

[0018]

[0019] The preparation of its compound drug active component comprises the following steps:

[0020] Step 1, crushing all medicinal materials in the compound prescription, washing and drying with clean water;

[0021] Step 2, using medicinal ethanol with a purity of 95% for 3 times, the first time using 3 times the volume of medicinal ethanol for 4 hours to 6 hours, and using 2 times the volume of medicinal ethanol for the second time Extract with ethanol for 3 hours to 5 hours, use medicinal ethanol 1.5 times the volume of medicinal materials for the third time for 2 hours to 4 hours, filter and combine the extracts, recover ethanol, and obtain a dry extract;

[0022] Step 3: ultrasonically dissolve the obtained dry extract with water more than 5 times the volume of the dry extract...

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Abstract

The invention provides preparation for anti-tumor compound medicine active ingredients. The compound comprises the following medicines: sculellaria barbata, Chinese lobelia, oldenlandia diffusa and windpipe trachea. The preparation for compound medicine active ingredients comprises the following steps: first, all the medicinal materials of the compound are crushed; second, extraction is carried out with medicinal ethanol for 3 times, filtration is carried out and the extraction solutions are mixed, ethanol is recycled and a dry extract is obtained; third, the dry exact is subjected to ultrasonic dissolution with water, a suspension is obtained, extraction is carried out for 3-5 times by utilization of isopyknic ethyl acetate, the extraction solutions are mixed, heating decolouring is carried out with active carbon, ethyl acetate is recycled and a solid is obtained; fourth, the solid is dissolved through squeezing with petroleum ether, filtration is carried out, insoluble substances are obtained, namely the active ingredients are obtained. The anti-tumor effects are stable, the active components are clear, the quality is controllable, the technology is simple, the preparation method is suitable for industrial production and the officinal prospect is wide.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to the preparation of active components of antitumor compound medicines. Background technique [0002] In today's society, tumor has become one of the most serious diseases that threaten human survival. Its morbidity and mortality rate rank first among all kinds of diseases, and it has become the number one enemy of human beings. Therefore, the treatment of tumors is also a hot spot in current medical research. In view of the current Western medicines have many toxic and side effects. Traditional Chinese medicine, especially compound medicine, has attracted more and more attention from researchers because of its mild curative effect and mild side effects. Therefore, compound prescriptions are often used in traditional Chinese medicine prescriptions, and a variety of Chinese herbal medicines are used in combination. Various Chinese herbal medicines p...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/748A61P35/00
Inventor 沈金辉
Owner CHIFCON DRUG DISCOVERY SUZHOU
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