36results about How to "Quality controllable" patented technology

The invention provides a preparation method of cresol trozole trisiloxane, and belongs to the technical field of sun-screening agent preparation. The preparation method of cresol trozole trisiloxane comprises the following steps: carrying out Claisen rearrangement reaction on a concentrated solution of a compound as shown in a formula II to obtain a compound as shown in a formula III; and reacting the compound shown in the formula III with heptamethyltrisiloxane to obtain a compound shown in a formula IV. The concentrated solution of the compound shown in the formula II is subjected to the Claisen rearrangement reaction under the solvent-free condition to prepare the compound shown in the formula III, the reaction time for preparing the compound shown in the formula III is shortened, the reaction efficiency for preparing the compound shown in the formula III is improved, the yield for preparing the compound shown in the formula III is increased, the reaction time for preparing cresol trozole trisiloxane is shortened, and the yield of cresol trozole trisiloxane is increased. The reaction efficiency of cresol trozole trisiloxane preparation is improved, and the yield of cresol trozole trisiloxane preparation is improved.

The invention provides a silibinin mixed micelle injection as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The cholate / lecithin mixed micelle system constructed by adopting specific cholic acid and phospholipid has good stability, can be well compatible with the silibinin so as to well encapsulate the silibinin, can obviously improve the solubility of the silibinin, has higher safety under the condition of ensuring the stability of the silibinin, and can be used for preparing a medicine for treating the silibinin. Therefore, the bioavailability of the silibinin is greatly improved. According to the invention, a shearing dispersion method is adopted to prepare the mixed micelles, and the mixed micelles with high drug loading capacity, clarification and good stability for silibinin are formed by destroying and shearing the raw and auxiliary materials in a molecular level, so that the mixed micelles have better physical and chemical stability, the drug quality is easier to control, the process is more simplified, the clinical medication is safer and the cost is lower; and the accessibility of the medicine is improved.

The utility model discloses a temporary supporting structure for construction of a profiled steel sheet floor. The temporary supporting structure comprises an H-shaped steel beam, a profiled steel sheet, a transverse wood square column, a vertical wood square column and an inclined strut, the two H-shaped steel beams are symmetrically arranged in the height direction of a building floor; the two ends of the profiled steel sheet are bolted to the upper ends of flange plates of the two H-shaped steel beams through studs; the plurality of transverse square wood columns are supported between the two H-shaped steel beams, and the top surfaces of the transverse square wood columns abut against the bottom surface of the profiled steel sheet; the upper end faces of the vertical square wood columns are supported on the bottom faces of the transverse square wood columns in a one-to-one correspondence mode, and the lower end faces of the vertical square wood columns abut against the top face of a lower flange plate of the H-shaped steel beam; the two end faces of the inclined strut are fixed to the side wall, opposite to the web of the H-shaped steel beam, of the vertical wood brace and the bottom face of the transverse wood brace correspondingly. The temporary supporting structure has the advantages of being high in flexibility, economical, efficient, good in bearing capacity and reliable in quality, construction is easy, convenient and fast, and the construction cost is reduced.

The utility model relates to the technical field of construction devices, in particular to a photovoltaic plant grounding material copper-clad steel construction device which comprises a holding mechanism, a first welding die and a second welding die, the first welding die is detachably connected with the holding mechanism, and the second welding die is detachably connected with the holding mechanism. A first flux cavity and a first welding forming cavity are formed in the rear side of the first welding mold, and a second flux cavity and a second welding forming cavity are formed in the front side of the second welding mold. According to the photovoltaic factory grounding material copper-clad steel construction device, copper-clad steel is adopted to replace grounding flat steel to serve as a grounding material, the welding mode is exothermic welding, the material transferring workload is reduced through the construction method, manpower and material resources are saved, and the construction efficiency is improved. The welding method has the advantages of few welding points, short welding time, simple welding method, light weight of materials for welding, no need of an external power supply and the like, solves the problems of difficult welding, undercut, insufficient welding and the like between conductors, improves the working efficiency and shortens the construction period.

The invention relates to a coating process for parts produced by a whole plate, in particular to a process for arranging a plurality of parts on one plate and coating the surfaces of the parts together. The process is characterized in that a plurality of part patterns are arranged on a plate, chip positioning is arranged in each part pattern, a first part contour groove and a chip positioning pit are machined in the back face of the plate, a second part contour groove is machined in the front face of the plate, and the first part contour groove and the second part contour groove are communicated with each other; the chip is arranged in the chip positioning pit; and after the first part contour grooves, the second part contour grooves and the chip positioning pits are filled with paint and cured, the two surfaces of the plate are coated, and finally, the parts combined on the same plate are segmented out one by one through a numerical control machine tool. The method has the characteristics that the operation is simple and convenient, the production efficiency is high, the quality is easy to control, the material loss is small, the coating cost is low, the environmental pollution is avoided, and the automation of a part coating process can be realized.

The utility model discloses a drainage pipeline rotating device which is used for connecting water pipes and comprises a connecting structure and a lock catch structure, the connecting structure is arranged on the water pipes and used for connecting the pipes, the lock catch structure is arranged on the connecting structure and used for stabilizing connection of the connecting structure, and the connecting structure comprises a shell unit. The shell unit comprises a connecting plug arranged on the water pipe, a containing head arranged on the water pipe and used for being connected with the connecting plug, and a connecting hole formed in the connecting plug and used for assisting in connection of the meshing unit. According to the drainage pipeline rotating device, reinforced concrete pipelines can be conveniently connected, it is ensured that the quality of a connector is easy to control, it is ensured that the problems of deflection, loosening, rolling of a sealing rubber ring and the like are avoided, and serious quality and safety hidden dangers such as surface collapse caused by loosening and water leakage of a pipe opening are avoided.

This utility model discloses a highly stable prefabricated concrete connection node structure, belonging to the field of prefabricated concrete frame structure construction technology. The connection node structure body includes a frame column, and a prefabricated frame beam is fixedly installed on the surface of the frame column. A steel cage is set inside the prefabricated frame beam, and a connecting component is fixedly connected to the surface of the steel cage. This highly stable prefabricated concrete connection node structure adopts normal setting of the upper steel bars of the prefabricated frame beam, and the lower steel bars of the beam are connected by connecting steel bars or beam shoe bolts. No steel bars extend beyond the beam end of the entire prefabricated beam, which solves the problem of steel bar collision between beams and columns in prefabricated frame structures. It is easy to construct, easy to control the quality, has good seismic performance and durability, enhances the safety and stability of the structure, reduces dependence on the construction environment, thereby shortening the construction period and reducing additional costs caused by uncontrollable factors such as weather.

The present invention discloses a tooth block and pull rod combined cable tower anchoring structure of a cable-stayed bridge, comprising a cable tower, a cable anchoring tooth block is arranged on the inner side of the tower wall along the bridge direction of the cable tower, a cable pre-buried pipe is arranged in the front and rear tower walls of the cable tower, an anchor pad for anchoring the cable is arranged at the intersection of the upper end of the pre-buried pipe and the upper tooth surface of the anchor tooth block, and a steel pull rod placed along the bridge direction is arranged in the cable tower, the steel pull rod connects the lower tooth surfaces of the two tooth blocks and is distributed on both sides of the cable pre-buried pipe. Slow-bonding prestressed steel bundles are arranged in the four tower walls of the cable tower. In the present invention, the tooth block is combined with the steel pull rod, and the force is transmitted together with the tower wall and the tooth block through the shear key. The present invention abandons the high-altitude grouting operation with difficult quality control, avoids the cutting of the tower column longitudinal reinforcement by the anchor hole, is convenient for construction, easy to control quality, improves the force performance of the cable tower anchoring, improves the construction quality of the cable tower anchoring structure, and improves the economy of the structure, and has promotion significance.

The utility model relates to bridge engineering technical field, and disclose a kind of steel box girder and concrete pier column consolidation structure, including steel box girder, concrete pier column, shear nail and the adjusting member for adjusting the elevation of steel box girder installation, concrete pier column top is reserved with shear key, steel box girder bottom is equipped with for with concrete pier column top socket joint connection's notched, concrete pier column top outer circumferential wall is equipped with the slope of being inserted easily, concrete pier column top is inserted in the inside of notched, adjusting member includes jacking corbel and jack, jacking corbel is connected by bolt with the reserved planting bar on the outer wall below concrete pier column, jack is installed in jacking corbel top, jack top and steel box girder bottom are abutted. The present application is simple in structure, high in precision of factory prefabrication, force transmission is direct in socket design, stress concentration is small, and the elevation of section member is accurately adjusted, convenient for construction, applicable to complex environment and large-span bridge.

The utility model relates to the technical field of uniform heating curing barns, in particular to a bidirectional circulating air uniform heating curing barn. The technical problems that in the using process of a curing barn, due to the fact that the flowing direction of unidirectional airflow and wind is fixed, the temperature and humidity of the whole curing barn are not uniform, the temperature and humidity difference between an upper layer and a lower layer is too large, and the requirement stage and the maturing condition of tobacco leaf curing of each layer are not consistent are solved. According to the technical scheme, the uniform heating curing barn with the two-way circulating air comprises a curing barn body and an up-and-down air exhaust assembly. According to the flue-curing barn, the two-way circulating air assembly can achieve conversion in the upper direction and the lower direction through circulating air according to the flue-cured tobacco change condition within the proper time, so that the upper layer and the lower layer of tobacco leaves in the flue-curing barn body are evenly flue-cured; the requirements for dehumidification and sealing in different wind directions can be met by controlling the air inlet and outlet assembly and the up-down exhaust assembly, so that the temperature and humidity of the whole curing barn body are uniform.

The utility model discloses a portal rigid frame supporting system connected with inclined struts through circular tube supporting end connecting nodes. The portal rigid frame supporting system comprises a plurality of parallel portal rigid frames arranged along the same straight line. Each portal rigid frame comprises a beam and a stand column; a plurality of longitudinal supports are arranged between the two beams of at least two adjacent portal rigid frames; the space among the plurality of longitudinal supports is divided into a plurality of rectangular frame structures; two inclined struts are arranged in each rectangular frame structure; each inclined strut is a circular tube, and the end part of each inclined strut is connected with an inner corner in the corresponding rectangular frame structure through a circular tube supporting end connecting node; each circular tube supporting end connecting node comprises a clamping piece located at the end of the corresponding inclined strut and a clamped lug plate fixed to the inner corner of the corresponding rectangular frame structure. And each clamping piece and the corresponding clamped lug plate are fixed by arranging a fastening piece or a limiting piece in the assembly hole. According to the utility model, the structure of the connection node of the circular tube supporting end head in the portal rigid frame supporting system is optimized.

The present invention provides an osthole crystal and a preparation method and application thereof. The osthole crystal is a new II crystal form. During the preparation process, it can be prepared by any one of a solvent-assisted grinding method, a high-temperature volatilization method, a melt quenching method or a solution crystallization method. Compared with osthole on the market, the osthole crystal significantly improves the dissolution rate and solubility, has better bioavailability, greatly improves the fluidity and bulk density of the powder, and provides a better and more optimal choice for the preparation of pharmaceutical preparations and pesticide preparations. In addition, the preparation method is simple in process and low in cost, and can be further developed to be suitable for large-scale production, which is of great significance for the development of drugs and pesticides.

The invention discloses an iron maltol-oxalic acid eutectic crystal which is formed by taking iron maltol as a medicinal active component and oxalic acid as a eutectic crystal ligand and adopting a suspension stirring method. In an X-ray powder diffraction pattern obtained through Cu-K alpha radiation measurement, the iron maltol-oxalic acid eutectic crystal has characteristic diffraction peaks at the diffraction angles 2 theta of about 14.7 + / -0.2 degrees, 17.0 + / -0.2 degrees, 17.6 + / -0.2 degrees, 24.8 + / -0.2 degrees, 26.6 + / -0.2 degrees and 26.9 + / -0.2 degrees. The iron maltol-oxalic acid eutectic crystal is good in stability, and does not generate crystal transformation in at least 60 days under an accelerated condition. Compared with iron maltol, the iron maltol-oxalic acid eutectic has the advantages that the solubility of the iron maltol-oxalic acid eutectic in water is relatively low, the dissolution rate of the eutectic with low solubility is generally low, the drug concentration peak value in a short time can be avoided, the toxic and side effects of the iron maltol are reduced, and the medication compliance is improved.

The invention discloses a method for preparing a wind turbine blade recycled fiber reinforced polyolefin masterbatch. A method for preparing a wind turbine blade recycled fiber reinforced polyolefin masterbatch comprises the following steps: S1: low temperature plasma treatment of wind turbine blade recycled fiber; S2: preparation of silane coupling agent solution; S3: soaking and aging; S4: drying; S5: low temperature plasma treatment; S6: DCP dissolution; S7: spraying and stirring; S8: dissolving DCP and MAH; S9: spraying DCP and MAH solution in polyolefin; S10: granulation to obtain wind turbine blade recycled fiber reinforced polyolefin masterbatch. The invention is conducive to overcoming the defects of the prior art that the wind turbine blade recycled fiber cannot be well utilized and the performance is insufficient when preparing composite materials.

The invention discloses a horizontal full-diameter bidirectional eccentric hemispherical valve, comprising a valve body, an eccentric hemispherical valve arranged in a valve cavity of the valve body, an inlet end and an outlet end arranged at the left and right ends of the valve body, a floating valve seat arranged at the outlet end, a main sealing ring and a ball crown arranged on the eccentric hemispherical valve, a sealing pair formed by the floating valve seat and the main sealing ring, a first pressure chamber arranged between the inner side of the main sealing ring and the eccentric hemispherical valve, and a second pressure chamber arranged between the end face of the floating valve seat and the valve body. The front and rear ends of the eccentric hemispherical valve are respectively connected with a front valve stem and a rear valve stem, the eccentric hemispherical valve, the front valve stem and the rear valve stem form a valve shaft, the valve shaft is in a horizontal direction, a valve cover is arranged on the upper part of the valve body, an arc bottom matching the inner circle of the diameter is arranged at the lower end of the valve body, and the eccentric hemispherical valve forms a full-circle flow channel with the arc bottom after opening. The invention adopts a horizontal structure, has a small height, is easy to maintain by opening the cover, and realizes the online maintenance function; the flow channel is unobstructed, the water loss is small, and there is no impurity accumulation; the forward and reverse seals are suitable for circulating water and various special working conditions.

The invention relates to a construction structure and a construction method for pouring a strong and weak electricity box in advance in two layers, and belongs to the technical field of building construction.The construction structure for pouring the strong and weak electricity box in advance in two layers comprises a wall body, an upper-layer beam or plate is arranged above the wall body, and a lower-layer beam or plate is arranged below the wall body; the thickness of the wall body is 200mm, the front side of the wall body is provided with a vertically-through mounting groove, the thickness of the mounting groove is 100mm, the thickness of the wall body on the rear side of the mounting groove is 100mm, and a mounting back wall is formed; a strong and weak electricity box and an internal pipeline are installed in the installation groove, the four corners of the strong and weak electricity box are fixed to the installation back wall through screws, and the internal pipeline is connected into the threading pipe in a penetrating mode. The problems that grooving is labor-consuming and time-consuming when multiple pipelines are arranged at the installation position of the strong and weak electricity box, a wall body is prone to hollowing under the condition that the pipelines are dense, forming is difficult during plastering, and the construction quality is not easy to guarantee are solved.

The utility model discloses a thread rolling device for bolt machining, and belongs to the technical field of bolt machining. The thread rolling device is characterized in that a feeding assembly comprises a left feeding plate and a right feeding plate which are arranged in parallel, a feeding channel is formed between the left feeding plate and the right feeding plate, and parts are arranged in the feeding channel; the thread rolling assembly comprises a thread plate fixed plate and a thread plate movable plate which are arranged in parallel, a thread rolling channel is formed between the thread plate fixed plate and the thread plate movable plate, the thread rolling channel is parallel to the feeding channel, and thread rolling is conducted on the part through the thread rolling channel; and the pushing assembly is arranged between the feeding assembly and the thread rolling assembly and can push the parts in the feeding channel into the thread rolling channel to be machined into products. The debugging method of the thread rolling device is simple and easy to operate, the service life of the debugged thread plate is stable, the quality is easy to control, the rejection rate is low, the machining efficiency is improved, and the cost is low. The utility model belongs to a thread rolling technology after heat treatment.

This utility model discloses a waterproof structure for an embedded skylight on a wooden tile roof, relating to the field of building waterproofing technology. Its specific structure includes: a skylight frame, embedded and assembled into the wooden tile roof; timber beams fixed to the wooden tile roof to support the skylight frame; a drainage board disposed around the skylight frame; a waterproof membrane laid on the wooden tile roof, with the waterproof membrane located inside the drainage board and overlapping it; a sealant layer filling the space between the skylight frame and the wooden tile roof; a window sash that fits into the skylight frame; and glass installed inside the window sash. This utility model solves the technical problem of easy leakage in traditional skylights in the prior art.

The present invention provides a glycopyrronium bromide intermediate and its preparation method and application, and relates to the technical field of chemical synthesis. The preparation method of glycopyrronium bromide intermediate comprises the following steps: using α-cyclopentylmandelic acid methyl ester as raw material, and 1,4-dibromo-2-butanol undergoes ester exchange reaction under the action of a first base catalyst to obtain a glycopyrronium bromide intermediate, i.e., compound 2. The preparation method of glycopyrronium bromide comprises the following steps: compound 2 undergoes quaternization reaction with dimethylamine under the action of a second base catalyst to obtain glycopyrronium bromide. The raw materials of the present invention are cheap and easy to obtain, and the use of toxic gas methyl bromide commonly used in the prior art is avoided, the environmental pollution is small, the green environmental protection, the reaction conditions are mild, the reaction process is easy to control, the use of metallic sodium is avoided, the operation is safe, the safety factor is high, and the reaction steps are greatly reduced, the production cost is saved, the product yield obtained is high, the purity is high, and a process route for industrial production of higher quality products is provided.

The invention provides an assembly type stainless steel-FRP (fiber reinforced plastic) steel tube concrete composite column connecting node, which relates to the technical field of assembly type steel tube composite column connecting structures, and is characterized by comprising a connecting assembly, annular end plates fixed at two ends of the connecting assembly, and an energy consumption assembly fixed on a condensation assembly, the connecting assembly comprises transverse webs, longitudinal webs and a butt joint sleeve, the transverse webs and the longitudinal webs are perpendicularly arranged between the annular end plates, a plurality of steel bar holes are formed in the transverse webs and the longitudinal webs, the butt joint sleeve is arranged in the center of the connecting assembly, and the transverse webs and the longitudinal webs are fixed to the peripheral side of the butt joint sleeve. The energy dissipation assembly comprises reset plates and self-reset vibration isolation springs, reset keys are arranged between the transverse webs, the reset plates are perpendicularly fixed between the longitudinal webs, and the self-reset vibration isolation springs are arranged between the reset plates. And in addition, the construction technology is simple, the quality is easy to control, and low carbon and environmental protection are achieved.

A method for manufacturing a composite bacterial plant growth regulator belongs to the technical field of microbial fertilizers. With components such as Laxogenin, Laxogenin C and Laxogenin derivatives, glucose, starch, EDTA-iron, EDTA-zinc, DA series, organosilicon, lithium oxide, etc., after fusion dispersion under ultrapure water liquid phase, it is warmed to 30-85°C, slowly added with hydrogen peroxide for hydroxylation reaction, and after keeping the temperature for 30-120min, it is cooled to room temperature, and then a bacterial agent is added, such as: yeast water agent, and the composite bacterial plant growth regulator is fully stirred and dispersed to obtain the composite bacterial plant growth regulator. The composite bacterial plant growth regulator produced by the present invention can be used for foliar spraying, drip irrigation or hydroponics, can effectively improve the plant growth state, can also improve the soil environment, while improving plant resistance, improving crop traits and up-regulating various metabolic functions, efficiently promoting root and leaf to promote chlorophyll synthesis, effectively improving tillering number and disease and insect resistance, therefore, compared with other chemical regulation and regulation substances, it also has pleiotropic function and wide-spectrum applicability.

The invention discloses a preparation method of isoliquiritin and artificially synthesized liquiritin, which is characterized by comprising the following steps: carrying out aldol condensation reaction on 2, 4-dihydroxyacetophenone of which hydroxyl is protected by acyl and 4-hydroxybenzaldehyde to obtain acyl-protected isoliquiritigenin as a precursor; the preparation method comprises the following steps: carrying out glycosylation reaction on a precursor and an acyl-protected glucosyl donor in the presence of an accelerant to obtain acyl-protected isoliquiritin, then carrying out deprotection to obtain isoliquiritin and artificially synthesized liquiritin at the same time, and further carrying out alkali catalysis ring closing on the isoliquiritin to obtain the artificially synthesized liquiritin. Compared with a method for directly extracting liquiritin and isoliquiritin from licorice roots in the prior art, the method has very obvious technical and industrial advantages, raw materials are cheap and easy to obtain, reaction conditions are mild, product purity is high, the defects that an existing isoliquiritin synthesis method is low in yield, large in workload and the like are overcome, artificially synthesized liquiritin can be further obtained, and the method is suitable for industrial production. The method has a very good industrialization prospect and a great prospect of modernization of traditional Chinese medicines through chemical modification and transformation.

This invention relates to a method for horizontally assembling and vertically rotating a tower assembly. A hinge is installed on the tower foundation, and a slide rail is installed on the tower assembly platform. A sliding shoe is mounted on the slide rail. The tower is assembled horizontally on the assembly platform, and the lower end of the tower is hinged to the hinge. A chain rod is then installed between the sliding shoe and the tower frame. A tension jack is used to pull the sliding shoe along the slide rail, and the chain rod transmits force to rotate the tower vertically around the hinge into position. Finally, the hinge is locked, and a column is installed between the lower end of the tower and the tower foundation to complete the tower installation. This invention allows for the segmental assembly of the tower on the ground, eliminating the need for large hoisting equipment and significantly reducing high-altitude work and construction risks.

The utility model provides a safe and environment-friendly waste plastic degradation system which is characterized in that a reaction device is arranged on an integrated stirring and heating device, a temperature measuring device is arranged in the reaction device, a first inlet of the reaction device is communicated with an outlet of a nitrogen device, and a second inlet of the reaction device is connected with a condensing device; a third inlet of the reaction device is used for introducing reaction raw materials, an outlet of the reaction device is communicated with an inlet of the suction filtration device, and an outlet of the suction filtration device is communicated with an inlet of the degradation product collecting device. According to the reaction device, the problems of difficulty in temperature control and low stirring efficiency of the existing reaction system are solved, the whole degradation reaction is complete in one-time reaction in the reaction device, the product quality is controllable, ethylene glycol in reaction byproducts is recovered, and the problem that the byproducts are difficult to recover in the traditional reaction device is solved.

According to the specific implementation mode, a grouting sleeve is arranged at the upper end of a vertical column rib, the upper end of the grouting sleeve is open, the lower end of the vertical column rib of an upper layer prefabricated frame module unit is inserted into the grouting sleeve to achieve connection, and a top plate is of a structure with the fully-prefabricated center and the periphery laminated layer. Post-pouring holes are formed in the side faces of the beams, and shear-resistant steel bars are inserted to form connecting structures on the lower portions of the adjacent beams. Through optimization of a column vertical rib connection form, innovation of a top plate structure and improvement of a beam connection structure, the defects that in the prior art, pressure grouting operation is complex, connection construction conflicts with indoor decoration, and the connection strength between modules is poor are overcome, the connection strength of prefabricated frame module units is improved, the construction difficulty of a construction site is reduced, and the construction efficiency is improved. And the control difficulty of the connection construction quality is reduced.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The invention relates to the technical field of biological medicine, in particular to a phosphatidyl polymer, a preparation method, an mRNA phosphatidyl polymer delivery system and application. The phosphatidyl polymer has a structure as shown in a formula I. The phosphatidyl polymer can be self-assembled with mRNA and modified amphiphilic molecules to form an mRNA delivery system. According to the invention, the organ targeting characteristic of the compound in vivo can be changed by regulating and controlling the mass ratio of the phosphatidyl polymer to the mRNA during preparation of the compound. Along with the increase of the proportion of the phosphatidyl polymer in the mass ratio formula, the target organ of the compound changes from spleen to liver to lung. Compared with a traditional mRNA delivery system, the organ targeting characteristics of the delivery system can be regulated and controlled only by changing the mass ratio formula, efficient in-vivo and in-vitro mRNA delivery efficiency is achieved, the large-scale production difficulty and cost of raw materials are reduced, and a new platform is provided for efficient, accurate and universal delivery of mRNA.

The invention provides a traditional Chinese medicine composition for treating diabetic erectile dysfunction, a preparation method, a preparation and application, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials: salvia miltiorrhiza and ligusticum wallichii, wherein the mass ratio of the salvia miltiorrhiza to the ligusticum wallichii is (0.1-10): 1. The raw materials of the traditional Chinese medicine composition are only composed of the salvia miltiorrhiza and the ligusticum wallichii, the composition is simple, the quality is easy to control, the raw materials are easy to obtain and low in price, the traditional Chinese medicine composition has a remarkable treatment effect on the diabetic erectile dysfunction, and the action effect is superior to that of each pair of medicines; according to the traditional Chinese medicine composition, the combined use of the two medicines has a better positive regulation effect than the single medicine effect, and the medicine synergistic effect is achieved.

This invention discloses a coupling method for aerodynamics and vehicle dynamics applicable to high-speed trains, relating to the interdisciplinary field of aerodynamics and vehicle dynamics. The method includes: establishing separate aerodynamic and vehicle dynamic models for the high-speed train; exchanging data between the two models using a dual-time-step time-progression method, improving computational time accuracy, step size, and stability. While comprehensively considering the interaction between the high-speed train and its surrounding flow field, the influence of track irregularities, and tunnel effects, a multi-region mesh generation method is adopted, improving the quality and efficiency of mesh generation. Furthermore, the overlapping mesh method avoids mesh reconstruction problems. Simultaneously, the use of six-degree-of-freedom motion velocity to reflect the attitude changes of the high-speed train simplifies the coupling steps. The entire process saves time on mesh generation, calculating the displacement of mesh nodes around the train, mesh reconstruction, and computational iterations, enabling the coupling method to be implemented quickly and on a large scale.

The utility model provides a drainage type pavement water seepage treatment structure for an operation tunnel, which comprises a permeable cover plate, a first drainage blind ditch arranged in a pavement water seepage area and a second drainage blind ditch communicated with the first drainage blind ditch and a tunnel side ditch, and the permeable cover plate is laid at the top of the first drainage blind ditch. The first drainage blind ditch comprises a first water permeable pipe, a first isolation filter layer wrapping the periphery of the first water permeable pipe and a first water passing filling layer filled between the first water permeable pipe and the first isolation filter layer; the second drainage blind ditch comprises a second water permeable pipe, a second isolation filter layer wrapping the periphery of the second water permeable pipe and a second water passing filling layer filled between the second water permeable pipe and the second isolation filter layer. By arranging the drainage type blind ditch, the drainage path is clear, water seepage of the tunnel pavement structure can be effectively eliminated, the water pressure is reduced, and the new water seepage phenomenon can be effectively prevented.