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Effervescent tablets and preparing method and application thereof

A technology for effervescent tablets and extracts, applied in the field of effervescent tablets and their preparation, can solve the problems of difficult treatment effect, reducing the probability of malignant lesions and the like

Active Publication Date: 2019-08-23
广东海亿健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a common disease and easy to relapse. Due to the complex factors that induce ulcers, Helicobacter pylori infection is one of the main factors. Secondly, drugs, diet and immunity can all induce ulcers. It is difficult to achieve a stable therapeutic effect if combined with traditional Chinese medicine, but the treatment of the above chronic diseases with traditional Chinese medicine can achieve good therapeutic effect and is not easy to relapse
In addition, Helicobacter pylori infection may induce gastric cancer, so taking advantage of the function of traditional Chinese medicine compound to treat ulcers and reduce the chance of malignant lesions is something that cannot be achieved by Western medicine at this stage

Method used

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  • Effervescent tablets and preparing method and application thereof
  • Effervescent tablets and preparing method and application thereof
  • Effervescent tablets and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] (1) Active substance extraction:

[0096] Extract 1 extraction: use water as the extractant, add 1% vitamin C, crush 35 parts of kiwi fruit, 35 parts of okra, and 30 parts of yam, the solid-liquid ratio (volume ratio) is 1:6, and the pH is 5.5. Add 1% cellulase (enzyme activity: 50000U / g) and 2% hemicellulase (enzyme activity: 3000U / g) per 100g of solid to treat for 2h, inactivate at 100°C for 1min; Flash extractor, extraction time 150s, extraction voltage 180-220v, extraction temperature: 20°C to obtain extract, centrifuge at 4000r / min for 15min, spray dry to obtain extract 1 for later use.

[0097] Extract 2 Extraction: 30 parts of mulberry, 40 parts of black currant, 30 parts of blueberry. With 10% ethanol-water as solvent, the solid-liquid ratio is 1:10, and the flash extraction method is used to extract 100s, and the pectinase (enzyme activity is 40000U / g) with a mass percentage concentration of 2% is added per 100g of solid, and the mass The percentage concentra...

Embodiment 2

[0105] (1) Active substance extraction:

[0106] Extract 1 extraction: use water as the extractant, add 1% vitamin C, crush 30 parts of kiwi fruit, 40 parts of okra, and 30 parts of yam, the solid-liquid ratio (volume ratio) is 1:5, and the pH is 6, According to the addition of 1% cellulase (enzyme activity: 50,000 U / g) and 2% hemicellulase (enzyme activity: 3,000 U / g) per 100 g of solids, treat for 2 hours at 100°C Inactivate for 1 min; transfer to a flash extractor, extraction time 100s, extraction voltage 180-220v, extraction temperature: 20°C to obtain extract, centrifuge at 4000r / min for 10min, spray dry to obtain extract 1 for later use.

[0107] Extract 2 Extraction: 40 parts of mulberry, 30 parts of black currant, 30 parts of blueberry. With 20% ethanol-water as solvent, the solid-liquid ratio is 1:10, and the flash extraction method is used to extract 100s, and the pectinase (enzyme activity is 40000U / g) with a mass percentage concentration of 1% is added per 100g of...

Embodiment 3

[0115] 1. Acute toxicity test

[0116] ① Acute toxicity test: 30 rats were randomly divided into a blank group, a control group and an experimental group with 10 rats in each group. Water and food were fasted for 6 hours before the experiment. The experimental group was given the effervescent agent (crushed to 100-200 mesh before tableting, sterilized distilled water, and processed by a high-speed homogenizer to obtain the suspension) for intragastric administration in 3 times within 1 day, each time at 0.25 g / mL, The maximum gastric capacity was 4m L / 100g, and the interval between two gavages was 6h. After the gavage, food and water were not allowed for 4h; with the experimental group. After gavage, the rats in the three groups were observed for 14 days in a row for changes in hair, breathing, eating, feces, oral and nasal secretions, mental state and body weight, once a day in the morning and afternoon, and recorded the time of symptom appearance, recovery and death. Body ...

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Abstract

The invention discloses effervescent tablets and a preparing method and application thereof. The effervescent tablets comprise active components and auxiliary materials, wherein the active componentscomprise, by mass, 5-30 parts of an extract 1, 10-30 parts of an extract 2, 10-20 parts of an extract 3, 5-20 parts of an extract 4 and 15 parts of an extract 5. The extract 1 is prepared from 30 or 35 parts of fruits of actinidia arguta, 20-40 parts of abelmoschus esculentus and 10-40 parts of Chinese yam; the extract 2 is prepared from 30 or 40 parts of mulberry fruits, 20-50 parts of black currants and 10-40 parts of blueberries; the extract 3 is prepared from 5 parts of radix codcnopsitis pilosulas, 5-10 parts of rhizome chuanxiong, 20-30 parts of herba taraxaci, 20-30 parts of roasted malt, 5-10 parts of fructus evodiae and 10-30 parts of fructus ziziphi jujubae. The extract 4 is prepared from black rice bran; the extract 5 is prepared from honey. The effervescent tablets are appliedto preparing products with the function of alleviating and restoring gastric ulcers, at least one activity function of resisting oxidation, resisting fatigue, resisting tumors and reducing blood sugarand the effect of protecting the liver.

Description

technical field [0001] The invention relates to an effervescent tablet, a preparation method and application thereof, and belongs to the field of health food processing and application. Background technique [0002] Gastric ulcer refers to ulcers that occur in the gastric angle, gastric antrum, cardia, and hiatal hernia, and is a type of peptic ulcer. Peptic ulcer is a common digestive tract disease that can occur in the esophagus, stomach or duodenum. Because gastric ulcer and duodenal ulcer are the most common, the so-called peptic ulcer generally refers to gastric ulcer and duodenal ulcer. duodenal ulcer. It is a common disease and easy to relapse. Due to the complex factors that induce ulcers, Helicobacter pylori infection is one of the main factors. Secondly, drugs, diet and immunity can all induce ulcers. It is difficult to achieve a stable therapeutic effect if combined with traditional Chinese medicine, but using Chinese medicine to treat the above chronic diseases...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/395A23L33/105A23L33/10A61K36/8998A61K9/20A61P1/04A61P35/00A61P39/06A61P3/10A61P1/16A61K35/644
CPCA23L2/395A23L33/105A23L33/10A61K36/185A61K36/8945A61K36/605A61K36/45A61K36/344A61K36/236A61K36/288A61K36/8998A61K36/754A61K36/725A61K36/899A61K35/644A61K9/0007A61K9/205A61P1/04A61P35/00A61P39/06A61P3/10A61P1/16A23V2002/00A61K2236/19A61K2236/333A61K2236/55A61K2236/51A23V2200/32A23V2200/30A23V2200/308A23V2200/328A23V2250/21A23V2250/20A23V2300/14A23V2300/02A23V2300/48A23V2300/10A23V2300/24A61K2300/00
Inventor 柴军红何婷婷杨爽景云荣金志民钟读波柴雅菡
Owner 广东海亿健康科技有限公司
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