Chinese medicinal composition for treating dysmenorrhea and preparation method thereof

A technology of composition and pharmaceutical preparation, which is applied in the field of traditional Chinese medicine composition for treating dysmenorrhea and its preparation, can solve the problems of unprofessional effect, insignificant curative effect, unsatisfactory effect, etc., achieve clear active ingredients, enhance clinical safety, and condition mild effect

Active Publication Date: 2009-03-04
SHANDONG BUCHANG SHENZHOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicines involved in these patents are either single medicines with low potency and insignificant curative effect; or they are composed of multi-taste medicines, which not only have many medicine flavors and large doses, but also generalize syndrome types, which cannot meet the guidance and protection of health economics. Principles of Traditional Chinese Medicine Resources

Method used

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  • Chinese medicinal composition for treating dysmenorrhea and preparation method thereof
  • Chinese medicinal composition for treating dysmenorrhea and preparation method thereof
  • Chinese medicinal composition for treating dysmenorrhea and preparation method thereof

Examples

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preparation example Construction

[0040] A preparation method of a traditional Chinese medicine composition for treating dysmenorrhea, the method comprising the following steps:

[0041] 1) Crush the xiangfu and chuanxiong into 10 mesh sieve, and set aside;

[0042] 2) Mix the crushed xiangfu and chuanxiong, using supercritical CO 2 Volatile oil extracted by extraction method; supercritical CO 2 The extraction conditions of the extraction method are: extraction pressure is 25~30Mpa; extraction temperature is 45~55℃; desorption pressure is 10Mpa; desorption temperature is 50~55℃; CO 2 The flow rate is 25-30kg / h; the extraction time is 2-3h.

[0043] 3) The volatile oil was dissolved in ethyl acetate, extracted with sulfuric acid solution, the ethyl acetate layer was separated, dried over anhydrous sodium sulfate, filtered off the desiccant, and the ethyl acetate was recovered under reduced pressure at low temperature to obtain ligustilides and incense The active ingredient of ketone compounds. The weight ratio of e...

Embodiment 1

[0054] Example 1: Preparation of soft capsules containing Xiangfu and Chuanxiong

[0055] 1. Prescription:

[0056]

[0057] 2. Extraction of volatile oil of Cyperus rotundus and Ligusticum chuanxiong:

[0058] (1) Crush the Xiangfu and Chuanxiong into 10 mesh sieves, and set aside.

[0059] (2). Mix the crushed xiangfu and Ligusticum chuanxiong according to the prescription ratio, and use the supercritical extraction method with appropriate supercritical CO. 2 The extraction is carried out in the extractor, the extraction pressure is 25Mpa, the extraction temperature is 45℃, the desorption pressure is 10Mpa, the desorption temperature is 55℃, and CO 2 The flow rate is 25kg / h, the extraction time is 2h, and the extract is collected at room temperature to obtain the volatile oil.

[0060] (3) Dissolve the volatile oil in 2000ml of ethyl acetate, extract twice with 400ml of 2mol / L sulfuric acid solution, separate the ethyl acetate layer, dry with anhydrous sodium sulfate, filter o...

Embodiment 2

[0077] Example 2: The volatile oil extracted according to this process and the chemical composition analysis according to CN1352980A

[0078] 1) Medicinal materials: Xiangfu and Ligusticum chuanxiong were purchased from the Chinese herbal medicine wholesale market on Wanshou Road, Xi'an.

[0079] 2) Instrument: Supercritical CO 2 Extraction device (1L), made by the Laboratory of Chemical Engineering Principles of Northwestern University.

[0080] GC-MS gas-mass spectrometer HP5973, chromatographic column is DB-1, 30m×0.32mm×0.25μm. Column temperature: programmed temperature, 80℃ for 5min, 10℃ / min to 150℃, keep for 2min, then Raise 2°C / min to 240°C and hold for 15 minutes. The temperature of the inlet is 250°C.

[0081] Mass spectrometry conditions: EI ion source, ion source temperature 240°C, electron energy 100ev.

[0082] 3) Test method:

[0083] A. Preparation of volatile oil extracted according to this process: Fragrant xiangfu and Ligusticum chuanxiong were pulverized into 10...

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Abstract

The invention relates to a Chinese medicinal composition for treating dysmenorrhea and a preparation method thereof, and the Chinese medicinal composition is prepared from Cyperus rotundus and Ligusticum chuanxiong. The invention has the advantages of easily accessible raw materials, good therapeutic effect, definite active ingredients, stable quality, simple process, low time and labor consumption and high extraction yield.

Description

Technical field [0001] The present invention relates to the technical field of biomedicine, in particular to a traditional Chinese medicine composition for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to the menstrual cycle accompanied by cramping abdominal pain, accompanied by symptoms of general discomfort. There are two types: primary and secondary. Those who fail to find obvious abnormalities in pelvic organs after detailed clinical examination of gynecology are called primary dysmenorrhea, or functional dysmenorrhea, which is more common in unmarried women aged 20-25. It refers to women's pain in the lower abdomen or waist, and even pain in the lumbosacrum during and after menstruation. Every time it occurs with the menstrual cycle, severe cases may be accompanied by nausea, vomiting, cold sweat, cold hands and feet, and even fainting, which seriously affects the work and life of the patient. [0003] For the treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P15/00
Inventor 张登科
Owner SHANDONG BUCHANG SHENZHOU PHARMA
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