Analgesic plaster for knee osteoarthritis

Abstract

The invention discloses a pain-relieving plaster for knee osteoarthritis, and relates to the technical field of preparation of traditional Chinese medicine articles for external use, the pain-relieving plaster comprises a traditional Chinese medicine ointment and a backing layer; the traditional Chinese medicine ointment is prepared from the following raw materials in parts by weight: 320 parts of unprocessed radix aconiti, 64 parts of dragon's blood, 160 parts of cortex phellodendri, 160 parts of rhizoma curcumae longae, 160 parts of rheum officinale, 160 parts of radix angelicae, 64 parts of unprocessed rhizoma arisaematis, 320 parts of radix trichosanthis, 160 parts of flos carthami and 64 parts of borneol. The pain-relieving plaster can effectively relieve pain of knee osteoarthritis patients, improve joint functions and improve life quality of the patients, has a good clinical curative effect on intractable pain of knee osteoarthritis, and is high in safety, low in cost, convenient to treat and high in practicability, and drug resistance is not prone to being generated.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of traditional Chinese medicine external products, and in particular to a pain-relieving plaster for knee osteoarthritis. Background Art

[0002] Knee osteoarthritis is a chronic disease with articular cartilage damage, subchondral bone remodeling and synovial inflammation as the main pathological manifestations. Osteoarthritis (OA) is a whole-joint disease with cartilage damage as the main manifestation, involving structures such as cartilage, synovium and subchondral bone, and leading to the continuous progression of the disease and the occurrence of pain. The ultimate outcome is joint destruction, deformity, reduced or even loss of joint function.

[0003] Due to the multi-structure and dynamic changes of the whole joint pathological characteristics of knee osteoarthritis, there is no drug that can effectively reverse the progression of osteoarthritis. The existing treatments for knee osteoarthritis are all aimed at relieving pain, alleviating symptoms, protecting joint function, etc. Among them, drug treatment is a method generally accepted by people. At present, the most commonly used drugs are non-steroidal anti-inflammatory analgesics such as indomethacin, ibuprofen, diclofenac, meloxicam, etc. or simple analgesics such as acetaminophen, tramadol, etc., but long-term use of Western medicine treatment has many side effects.

[0004] Plaster belongs to one of the traditional Chinese treatment methods. It is one of the five major dosage forms of Chinese medicine pills, powders, pastes, soups, and pills. It is the most common and effective external treatment method. It has been circulated for thousands of years. It is an excellent method for external treatment of internal diseases implemented by general practice. It uses drugs to be directly applied to the patient's external acupuncture points or affected parts, and uses the access of meridians to play the functions of drugs to clear the meridians, remove stagnation and blood stasis, open the mind and penetrate the bones, relax the muscles and activate blood circulation, reduce swelling and remove blood stasis, and dispel wind and cold, so as to achieve the purpose of curing the disease. In addition, plaster belongs to external treatment, thereby avoiding the toxic and side effects of oral drugs, and coupled with a definite therapeutic effect, it has been widely welcomed by patients. Based on this, it is very meaningful to develop a topical plaster for knee osteoarthritis. Summary of the invention

[0005] In view of the above problems, the present invention provides a pain-relieving plaster for knee osteoarthritis.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is as follows: The present invention provides a pain-relieving plaster for knee osteoarthritis, the pain-relieving plaster comprising a traditional Chinese medicine ointment and a backing layer; The Chinese medicine ointment is prepared from the following raw materials in parts by weight: 320 parts of raw Chuanwu, 64 parts of Sanguisorba officinalis, 160 parts of Phellodendron chinense, 160 parts of Curcuma longa, 160 parts of Rhubarb, 160 parts of Angelica dahurica, 64 parts of raw Arisaema, 320 parts of Radix Trichosanthis, 160 parts of Safflower, and 64 parts of Borneol.

[0007] Furthermore, the backing layer is kraft paper or plaster cloth.

[0008] Furthermore, the preparation method of the analgesic plaster specifically comprises the following steps: S1: Prepare materials: grind raw Chuanwu, Phellodendron, Curcuma longa, Angelica dahurica, raw Arisaema, Safflower, and Rhubarb to obtain coarse powder; grind and sieve Sanguisorba officinalis, Borneolum, and Radix Trichosanthis to obtain fine powder; S2: Extraction of medicinal materials: Put pure, low-boiling-point vegetable oil in a pot, heat it slightly, first add coarse powder of raw Chuanwu, Phellodendron, Curcuma, Angelica dahurica, raw Arisaema, and Rhubarb, then add coarse powder of safflower, heat and stir continuously until the medicinal materials are fried to dark brown on the surface and browned inside, and after frying, use a wire sieve to remove the medicinal residue, and obtain the medicinal oil after removing the residue; S3: Refining: Continue to refine the medicinal oil obtained in step S2, and when the oil temperature rises to 320°C, use medium heat to make the oil oxidatively polymerize and thicken at high temperature until water drops into beads; S4: Add the elixir to make a paste: After the medicinal oil is refined, leave the furnace, and when the oil temperature reaches 300℃, slowly add the dried and sieved yellow elixir powder while stirring continuously, stirring in the same direction, and stir it into a viscous plaster. It is better if the plaster does not stick to the hands and can be drawn into a continuous thread; S5: Remove fire poison: After the plaster is made, put it into cold water, stir it continuously, take it out after cooling, rub it repeatedly, squeeze out the internal water and soak it, change the water once a day, and the plaster will be formed after seven days to obtain a plaster ball; S6: Take the ointment: Place the ointment ball in a container, melt it in a water bath or over a low fire, add the fine powder of Sanguis Dracaena and borneol, stir well, take the ointment with a bamboo stick and apply it on kraft paper or plaster cloth.

[0009] Furthermore, in step S1, the number of sieving is 120 meshes.

[0010] Furthermore, in step S2, the vegetable oil is sesame oil; and the pot is a copper pot.

[0011] Furthermore, in step S4, the mass ratio of the medicinal oil to the yellow lead powder is 2:1; and the sieving number is 100 meshes.

[0012] The analgesic plaster of the present invention is based on nearly 30 years of clinical experience, under the guidance of traditional Chinese medicine theory, combined with the characteristics of clinical various types of arthralgia, with reference to the "Contemporary Chinese Medicine External Treatment Clinical Encyclopedia" Chuanwu, Caowu External Treatment Recipe, composed of: Chuanwu 90 grams, Caowu 90 grams, camphor 90 grams, its main treatment: dispelling wind and dampness, warming the meridians and relieving pain. It is used for wind-cold dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, etc. It is composed of "Xunjing Pills" in "Wonderful Prescriptions" written by Fang Xian in Ming Dynasty: Chuanwu, Angelica, Pheretima each 3 liang, Caowu 1 liang. It is mainly used for pain in men, women, children, virgin menstruation, pain caused by wind, evil, cold current injection, and spasm of meridians, etc. It is modified by two parties and formulated by the author's many years of clinical experience. Raw Chuanwu is used as the main medicine, and raw Tiannanxing is used as the ministerial medicine, which is constantly adjusted. In recent years, the prescription has been adjusted many times to determine the proportion of drug dosage. The properties, flavors, meridians and effects of each herb in this prescription are as follows: Raw Chuanwu tastes bitter and hot in nature. It enters the heart, liver, kidney and spleen meridians and can dispel wind and dampness, warm the meridians and relieve pain. Xuejie, sweet and salty in taste, neutral in nature, enters the liver meridian, can promote blood circulation and relieve pain, resolve blood stasis and stop bleeding, heal sores and promote tissue regeneration; Huangbai: bitter in taste, cold in nature, enters the kidney and bladder meridians, can clear away heat and dampness, purge fire and eliminate steam, detoxify and treat sores; Turmeric: It tastes bitter and warm in nature. It enters the spleen and liver meridians. It can promote blood circulation and relieve pain. Rhubarb: bitter in taste, cold in nature, enters the spleen, stomach, large intestine, liver, and pericardium meridians, can purge and attack stagnation, clear away heat and purge fire, cool blood and detoxify, remove blood stasis and dredge menstruation, and remove dampness and reduce jaundice; Angelica dahurica: spicy, warm in nature, enters the stomach, large intestine, and lung meridians, can relieve cold, dispel wind and relieve pain, open up the nasal passages, dry out dampness and stop leukorrhea, reduce swelling and discharge pus; Raw Arisaema: bitter and pungent in taste, warm in nature, enters the lung, liver, and spleen meridians, can dissipate lumps and reduce swelling, and can be used externally to treat carbuncle; Radix Trichosanthis: sweet, slightly bitter, slightly cold in nature, enters the lung and stomach meridians, can clear away heat and purge fire, promote the production of body fluids and quench thirst, reduce swelling and discharge pus; Safflower: spicy, warm in nature, enters the heart and liver meridians, can promote blood circulation, relieve blood stasis and relieve pain; Borneol: bitter and bitter, slightly cold in nature, enters the heart, spleen, and lung meridians, can open the mind, clear away heat and relieve pain; Huangdan powder: pungent, slightly cold, enters the heart and liver meridians, can remove toxins, promote tissue regeneration, kill insects and relieve itching when used externally; Meaning of the prescription: The prescription makes heavy use of raw Chuanwu, and is combined with Angelica dahurica to dispel wind and dampness, warm the meridians and relieve pain; it is assisted by Xuejie, Safflower, and Curcuma to promote blood circulation, disperse blood stasis and relieve pain, and raw Arisaema to disperse nodules and reduce swelling; in order to prevent the series of warm medicines from accumulating dampness and turning into heat, a large amount of Radix Trichosanthis, Phellodendron, Rhubarb, Borneol and other drugs are added to clear away heat and purge fire, reduce swelling and discharge pus; yellow ochre powder is added to make a pill and also have the effect of removing toxins and promoting tissue regeneration. The combination of these medicines has the effect of dispelling wind and dampness, promoting blood circulation and dispersing blood stasis, reducing swelling and discharge pus, removing toxins, promoting tissue regeneration and relieving pain.

[0013] Clinical observations have shown that the analgesic plaster of the present invention has the therapeutic effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. The ointment acts directly on the affected part and uses the meridians to transfer the medicinal power to the affected part, thereby achieving the purpose of curing the disease.

[0014] Compared with the prior art, the present invention has the following beneficial effects: In the present invention, according to the treatment of arthralgia due to syndrome differentiation, unified medication, external treatment of internal diseases, combined with modern pharmacological research of drugs, selected Chinese medicines, rigorous compatibility, and this prescription is composed, which has the effects of dredging collaterals to relieve pain, and removing stagnation and removing blood stasis. The pain-relieving plaster of the present invention can effectively relieve the pain of patients with knee osteoarthritis, improve joint function, and improve the quality of life of patients, and has good clinical efficacy for treating intractable pain of knee osteoarthritis, and it has high safety, is not easy to produce drug resistance, has low cost, is convenient to treat, has strong practicality, is easy to use, and is easily accepted by patients, and is worthy of clinical promotion and application. DETAILED DESCRIPTION

[0015] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0016] The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are all conventional instruments, reagents, materials, etc. in the prior art and can be obtained through regular commercial channels. The experimental methods, detection methods, etc. involved in the following examples, unless otherwise specified, are all conventional experimental methods, detection methods, etc. in the prior art.

[0017] Example 1 The present embodiment provides a pain-relieving plaster for knee osteoarthritis, which comprises a Chinese medicine ointment and a backing layer; the backing layer is kraft paper or a plaster cloth; the Chinese medicine ointment is prepared from the following raw materials in parts by weight: 320 parts of raw Chuanwu, 64 parts of Sanguisorba officinalis, 160 parts of Phellodendron chinense, 160 parts of Curcuma longa, 160 parts of Rhubarb, 160 parts of Angelica dahurica, 64 parts of raw Arisaema, 320 parts of Radix Trichosanthis, 160 parts of Safflower, and 64 parts of Borneol.

[0018] The preparation method of the analgesic plaster specifically comprises the following steps: S1: Prepare materials: grind raw Chuanwu, Phellodendron, Curcuma longa, Angelica dahurica, raw Arisaema, Safflower, and Rhubarb to obtain coarse powder; grind Sanguisorba officinalis, Borneolum, and Radix Trichosanthis to obtain fine powder; S2: Extraction of medicinal materials (boil until dry and remove residue): Put pure sesame oil with low boiling point into a copper pot, and after slightly heating, add medicinal materials in batches according to different textures. First, add coarse powder of raw Chuanwu, Huangbai, turmeric, angelica, raw Tiannanxing, and rhubarb, and then add loose safflower coarse powder. Heat and stir continuously until the medicinal materials are fried to dark brown on the surface and browned inside. At this time, the temperature can reach 220℃. After frying, use a wire sieve to remove the medicinal residue, and get the medicinal oil after removing the residue; S3: Oil refining: continue to refine the medicinal oil obtained in step S2, and when the oil temperature rises to 320℃, use medium heat to make the oil oxidatively polymerize at high temperature, thicken, and refine until water drops into beads; the temperature of oil refining: first, check the thermometer to see if it reaches the specified temperature; second, check the oil smoke, which is light green, gradually turns black and thick, and then turns into white smoke, with white smoke being the top when there is no wind; third, check the oil droplets: when boiling begins, the oil droplets are mostly near the periphery of the pot wall, and when the oil droplets gather towards the center of the pot, it is the degree; fourth, check if water drops into beads: take a small amount of oil and drop it into cold water, the medicinal oil will aggregate into beads, which will not disperse when blown or will disperse and gather again.

[0019] S4: Make ointment: After the medicinal oil is refined, remove the fire from the furnace and add the yellow ochre powder (the mass ratio of medicinal oil to yellow ochre powder is 2:1) after drying through a 100-mesh sieve when the oil temperature is 300°C. Add a small amount while stirring in the same direction until it becomes a viscous ointment. The ointment should not be sticky and can be drawn into threads. If it is too hard, it is old, and if it is too sticky, it is tender. S5: Remove fire poison: After the plaster is made, put it into cold water, stir it continuously, take it out after cooling, rub it repeatedly, squeeze out the internal water and soak it, change the water once a day, and the plaster will be ready after seven days; S6: Take the ointment: Place the ointment ball in a container, melt it in a water bath or over a low fire, add the fine powder of Sanguis Dracaena and borneol, stir well, take the ointment with a bamboo stick and apply it on kraft paper or plaster cloth.

[0020] Experimental Example 1 1. Information 1.1 General Information 500 patients were randomly selected from our hospital from May 2019 to May 2022, 50 of them were excluded, and the remaining 450 were divided into two groups using the random number table method. There were 225 cases in the treatment group, including 110 males and 115 females; the age ranged from 19 to 58 years old, with an average age of (36.21±13.25) years old. There were 225 cases in the control group, including 113 males and 112 females; the age ranged from 20 to 59 years old, with an average age of (35.91±14.59) years old. There was no statistical difference in gender, age and symptoms between the two groups (P>0.05), and they were comparable.

[0021] Treatment group: The rehabilitation department received routine basic treatment plus the analgesic plaster prepared in Example 1, which was applied to the painful area to cover the entire lesion area as much as possible, and the dressing was changed once every 12 to 24 hours for one course of treatment (2 weeks). During the treatment, other drugs related to the disease were discontinued to avoid drug conflicts.

[0022] Control group: Routine basic treatment of the rehabilitation department, namely ordinary acupuncture, cupping and Chinese medicine fumigation treatment.

[0023] 1.2 Diagnostic criteria Refer to the "Guidelines for the Diagnosis and Treatment of Osteoarthritis" (2007 edition) issued by the Chinese Medical Association Orthopedics Branch. Table 1 Diagnostic criteria for knee OA

[0024] Note: Comprehensive clinical, laboratory and X-ray examinations can diagnose knee OA if 1+2, 1+3+5+6 or 1+4+5+6 are met. 1.3 X-ray grading of knee osteoarthritis (according to the Kellgren and Lawrence radiological diagnostic criteria).

[0025] (1) Grade 0: normal. (2) Grade I: suspected narrowing of the joint space, possible osteophytes; (3) Grade II: suspected narrowing of the joint space, obvious osteophytes; (4) Grade III: clear narrowing of the joint space, moderate osteophytes; (5) Grade IV: obvious narrowing of the joint space, large osteophytes, sclerosis and deformity.

[0026] 1.4 Disease staging (1) Early stage: Symptoms and signs include knee pain, mostly on the inner side, which is more severe when going up and down stairs or standing up, no obvious deformity, tenderness in the joint space and around the joint, patellar grinding test (+), and good joint movement. X-ray manifestations: 0, I (2) Mid-stage: Severe pain, with possible swelling, varus deformity, knee flexion deformity and limited mobility, tenderness, patellar grinding test (+), and joint instability. X-ray manifestations: Grade II, III (3) Late stage: severe pain, needing a brace to walk or unable to walk, obvious varus and knee flexion deformity, tenderness, patellar grinding test (+), significantly reduced range of motion, severe instability. X-ray manifestations: Grade IV.

[0027] 1.5 Inclusion criteria: (1) Meet the diagnostic criteria. (2) Age 45 ≤ ≤ 75 years old. (3) Joint function is at level I-II. (4) Patients taking nonsteroidal anti-inflammatory drugs have stopped taking them for more than 7 days. (6) Sign the informed consent form.

[0028] 1.6 Exclusion criteria (1)Those who do not meet the inclusion criteria. (2)Patients with severe joint deformities, joint function at grade III or IV, and X-ray staging at stage III or IV. (3)Those with overlapping other rheumatic diseases. (4)Patients with severe cardiovascular, cerebrovascular, hematological and other diseases. (5)Pregnant or lactating women. (6)Patients with allergic constitution. (7)Those who participate in other clinical trials. (8)Those who have fertility requirements recently. (9)Those who use biological agents.

[0029] 1.7 Observation indicators Pain index: The VAS pain scoring standard is adopted: 0 points indicates no pain; 0 - 3 points indicates slightly painful and tolerable; 4 - 6 points indicates that the patient's pain can be barely tolerated, but it has affected sleep; 7 - 10 points indicates that the patient has severe pain, is difficult to tolerate, and affects sleep and appetite.

[0030] Degree of swelling classification: Grade 0 indicates no swelling; Grade 1 indicates swelling compared with normal skin, but skin lines still exist; Grade 2 indicates swelling compared with normal skin, but skin lines disappear; Grade 3 indicates the appearance of tension blisters.

[0031] Mobility score: 0 points indicates unrestricted movement; 1 point indicates slight limitation of movement and basically free movement; 2 points indicates moderate limitation of movement and requires the company of others for activities; 3 points indicates severe limitation of movement and complete care by others.

[0032] Ecchymosis degree score: 0 points indicates intact skin; 1 point indicates slightly bruised locally, mainly purple (area < 1cm × 1cm); 2 points indicates obvious local bruising, mainly blue (area 1cm × 1cm - 4cm × 4cm); 3 points indicates large local bruising area, mainly blue (area > 4cm × 4cm).

[0033] 1.8 Treatment effect Count the number of cases of cure, improvement, invalidation, and total effective rate in the two groups of patients after 1 treatment course (2 weeks). The total effective rate = (cured + improved) / total number of patients × 100%.

[0034] 1.9 Safety and adverse reactions Observe the liver and kidney functions, blood and urine routine, electrocardiogram examination and skin adverse reactions of the two groups of patients.

[0035] 1.10 Statistical method Statistical analysis is performed using SPSS 20.0 software. The data are expressed as mean ± standard deviation (s), and the t-test is used. P < 0.05 indicates that the difference is statistically significant.

[0036] 2. Results 2.1 Index observation in the two groups after 1 treatment course Table 2 Comparison of symptom and sign score values in the two groups of patients before and after treatment

[0037] Table 3 Comparison of symptom and sign scores between the two groups before and after treatment

[0038] The results showed that the treatment group had better therapeutic effects than the control group in terms of pain, swelling, joint mobility, ecchymosis and other indicators, indicating that the analgesic patch has a better comprehensive therapeutic effect.

[0039] 2.2 Observation of efficacy of the two groups after one course of treatment Table 4 Comparison of efficacy between the two groups after one course of treatment (cases (%))

[0040] As can be seen from Table 4, the cure rate (92.9%) and total effective rate (100%) of the treatment group were significantly higher than those of the control group, and the difference was statistically significant (P<0.05). The treatment group had a significant effect compared with the control group. The drug in the analgesic plaster acts directly on the affected area, which increases the efficacy several times and is not easy to produce drug resistance.

[0041] 2.3 Safety indicators and adverse reactions in the two groups Both the treatment group and the control group experienced skin redness, swelling, itching, rash, and blisters in the local medication area, and the adverse reactions were subsequently cured. There were no abnormalities in the laboratory indicators of the two groups, and the difference was not statistically significant (P>0.05).

[0042] This clinical validation result shows that the analgesic plaster of the present embodiment has the effects of dispelling wind and dampness, promoting blood circulation and relieving pain. It can be used for osteoarthritis of the knee joint caused by wind-cold-damp arthralgia and blood stasis blocking the meridians. It has better curative effect on the syndrome of cold-dampness blocking the collaterals and the syndrome of blood stasis blocking the collaterals of traditional Chinese medicine arthralgia, especially better curative effect on the cold pain in the limb joints, heavy pain, coldness of the joints, swelling, and severe pain in the muscle joints caused by cold-dampness blocking the collaterals and blood stasis blocking the collaterals. Although very few adverse reactions occur in the treatment process, they are all very slight, do not affect treatment, and do not need to do special treatment. This clinical validation design is rigorous and reasonable, and it has been verified objectively and truly that this medicine is indeed an effective and safe external Chinese medicine preparation.

[0043] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A pain-relieving plaster for knee osteoarthritis, characterized in that: The pain-relieving plaster comprises a Chinese medicine ointment and a backing layer; The Chinese medicine ointment is prepared from the following raw materials in parts by weight: 320 parts of raw Chuanwu, 64 parts of Sanguisorba officinalis, 160 parts of Phellodendron chinense, 160 parts of Curcuma longa, 160 parts of Rhubarb, 160 parts of Angelica dahurica, 64 parts of raw Arisaema, 320 parts of Radix Trichosanthis, 160 parts of Safflower, and 64 parts of Borneol.

2. The analgesic plaster for knee osteoarthritis according to claim 1, characterized in that: The backing layer is kraft paper or plaster cloth.

3. A pain-relieving plaster for knee osteoarthritis according to claim 1 or 2, characterized in that: The preparation method of the analgesic plaster specifically comprises the following steps: S1: Prepare materials: grind raw Chuanwu, Phellodendron, Curcuma longa, Angelica dahurica, raw Arisaema, Safflower, and Rhubarb to obtain coarse powder; grind and sieve Sanguisorba officinalis, Borneolum, and Radix Trichosanthis to obtain fine powder; S2: Extraction of medicinal materials: Put pure, low-boiling-point vegetable oil in a pot, heat it slightly, first add coarse powder of raw Chuanwu, Phellodendron, Curcuma, Angelica dahurica, raw Arisaema, and Rhubarb, then add coarse powder of safflower, heat and stir continuously until the medicinal materials are fried to dark brown on the surface and browned inside, and after frying, use a wire sieve to remove the medicinal residue, and obtain the medicinal oil after removing the residue; S3: Refining: Continue to refine the medicinal oil obtained in step S2, and when the oil temperature rises to 320°C, use medium heat to make the oil oxidatively polymerize and thicken at high temperature until water drops into beads; S4: Add the elixir to make a paste: After the medicinal oil is refined, leave the furnace, and when the oil temperature reaches 300℃, slowly add the dried and sieved yellow elixir powder while stirring continuously, stirring in the same direction, and stir it into a viscous plaster. It is better if the plaster does not stick to the hands and can be drawn into a continuous thread; S5: Remove fire poison: After the plaster is made, put it into cold water, stir it continuously, take it out after cooling, rub it repeatedly, squeeze out the internal water and soak it, change the water once a day, and the plaster will be formed after seven days to obtain a plaster ball; S6: Take the ointment: Place the ointment ball in a container, melt it in a water bath or over a low fire, add the fine powder of Sanguisorba officinalis, borneol and Radix Trichosanthis, stir well, take the ointment with a bamboo stick and apply it on kraft paper or plaster cloth.

4. The analgesic plaster for knee osteoarthritis according to claim 3, characterized in that: In the step S1, the number of sieving is 120 meshes.

5. The analgesic plaster for knee osteoarthritis according to claim 3, characterized in that: In step S2, the vegetable oil is sesame oil; and the pot is a copper pot.

6. The analgesic plaster for knee osteoarthritis according to claim 3, characterized in that: In the step S4, the mass ratio of the medicinal oil to the yellow lead powder is 2:1; and the sieving number is 100 meshes.

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