68 results about "Pelvic organs" patented technology

The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia.

Improved methods and apparatuses for treatment of incontinence or pelvic organ prolapse are provided. A neo ligament for increasing the supportive function of the tissues supporting the urethra, bladder neck, or rectum is disclosed. Methods of using such a neoligament to treat incontinence are disclosed. Additionally, a self tensioning elastic tissue bolster for support of the tissues that support the urethra, rectum, and bladder neck are disclosed. A method of treating incontinence by injecting proliferative agents into supportive structures is disclosed. Methods and apparatus for transvaginal and transperitieai pelvic floor bolster treatment of incontinence and bladder pillar systems are also disclosed.

A system and methodology for the automated localization, extraction, and analysis of MRI-based features with clinical information to improve the diagnosis of pelvic organ prolapse (POP). The system can automatically identify reference points for pelvic floor measurements on MRI rapidly and consistent. It provides a prediction model that analyzes the correlation between current and new MRI-based features with clinical information to differentiate patients with and without POP. This system will enable the high throughput analysis of MR images for their correlation with clinical information to better detect POP. The presented system can also be applied to the automated localization and extraction of MRI features for the diagnosis of other diseases where clinical examination is not adequate.

Improved methods and apparatuses for treatment of pelvic organ prolapse are provided. A specialized sacral colpopexy mesh having a mesh cylinder attached to a first end of a main mesh is disclosed, and a method for use thereof in abdominal sacral colpopexy. A novel connector that is used to attach a mesh to the needle, including gripping features that improve the grip and allowing for easier connection and disconnection is disclosed, as well as a novel method and apparatus for connecting a mesh to a needle.

A compactable vaginal pessary for managing pelvic organ prolapse is provided. The compactable pessary easily expands once inside a patient's vagina, remaining firmly anchored in the vaginal cavity during movement, thereby effectively countering the effects of any prolapsing organ. In a first embodiment, the vaginal pessary employs an expandable and collapsible frame member, while in a second embodiment; the frame member is an open, substantially cone-shaped, collapsible frame member that is biased to an open position. In a third embodiment, the compactable vaginal pessary is a yieldably extensible, self-retracting pessary. The vaginal pessary of the present invention may be easily inserted and removed by a patient on a daily basis, or as needed, thereby facilitating good hygiene and thus reducing or eliminating common pessary related complications.

A prosthesis for addressing pelvic organ prolapse in females comprises a frame fabricated from a shape memory material that supports a thin, flexible mesh sheet in a stretched condition when the frame is unconstrained. The mesh sheet is formed with two finger receiving pockets proximate its posterior periphery to be used by the surgeon in steering the prosthesis to a desired disposition within the pelvic basin. The frame is shaped so as to conform to and be supported by bone structures and muscle tissue in the pelvic basin while providing needed support to pelvic organs to maintain them in a proper position. The use of a shape memory material allows the prosthesis to be rolled or folded into a reduced size for ease of placement through a small incision in the wall of the vagina, but that springs back to its memorized shape following deployment from a delivery sheath.

A prosthesis for addressing pelvic organ prolapse in females comprises a frame fabricated from a shape memory material that supports a thin, flexible mesh sheet in a stretched condition when the frame is unconstrained. The mesh sheet is formed with two finger receiving pockets proximate its posterior periphery to be used by the surgeon in steering the prosthesis to a desired disposition within the pelvic basin. The frame is shaped so as to conform to and be supported by bone structures and muscle tissue in the pelvic basin while providing needed support to pelvic organs to maintain them in a proper position. The use of a shape memory material allows the prosthesis to be rolled or folded into a reduced size for ease of placement through a small incision in the wall of the vagina, but that springs back to its memorized shape following deployment from a delivery sheath.

Systems and related methods for measuring pelvic organ prolapse are disclosed. A plurality of positioning devices, such as RFID tags, ultrasound reflectors or magnetic field sensors, which may be active or passive, and which are preferably disposable, are set at predetermined positions within the patient and their relative positions recorded with one or more corresponding external receiving devices fixed to the patient while the patient is in a relaxed state. The patient is then instructed to perform an action (such as a valsalva maneuver) that causes the positioning devices to move and their movement relative to their initial recorded positions is measured.

An insertion needle that is turnably mounted on a handle, which holds the insertion needle, wherein the insertion needle includes a turn arm that turns so as to face the tip of the insertion needle, and a target site that guides the insertion needle provided on the tip of the turn arm, and is further provided with: through-holes in two locations that are provided separated in the longitudinal direction of the tip of the insertion needle; an indentation formed between these through-holes; and a groove in the direction from the tip of the insertion needle toward the base of the insertion needle. Furthermore, the insertion needle is suitably used in urinary incontinence surgery, pelvic organ prolapse surgery or the like.

A prosthesis for addressing pelvic organ prolapse in females comprises a frame comprising first and second segments or halves fabricated from a shape memory material that together support a thin, flexible sheet in a stretched condition when the frame is unconstrained. The frame is shaped so as to conform to and be supported by bone structures and muscle tissue in the pelvic basin while providing needed support to pelvic organs to maintain them in a proper position. The use of a shape memory material allows the prosthesis to be rolled or folded into a reduced size for ease of placement through a small incision in the wall of the vagina, but that springs back to its memorized shape following deployment from a. delivery sheath. By providing a two-piece segmented frame, removal of the frame structure post implantation of the prosthesis is facilitated.

A device sized and shaped for alleviating organ prolapse when inserted into a vagina, comprising: (a) an adjustably flexible, substantially planar ring; (b) a telescoping locking mechanism extending in a central axis, but within the plane of the ring, from a first side of the ring to a second side of the ring, comprising, (i) a first element extending from a side of the ring including an elastic diamond shaped snap, and, (ii) a second element extending from a second side of the ring, opposite the first element, including at least one window configured as a counterpart to the snap, wherein the device is configured to be in an expanded, treatment rendering state when the snap is released into the window and a reduced profile state when the snap is not in the window.

Compounds represented by the general formula (I):wherein each symbol is as defined in the description [with the proviso that 9-chloro-7-(1,1-dimethylethyl)-2,3,4,5-tetrahydro-1,4-benz-oxazepine and N-[[(5S)-2-oxo-3-(2,3,4,5-tetrahydro-1,4-benz-oxazepin-7-yl)-5-oxazolidinyl]methyl]acetamide are excluded], salts of the same, and prodrugs thereof have selective activation effect on serotonin 5-HT2C receptor and are useful as preventive and therapeutic agents for lower urinary tract diseases, obesity, and / or pelvic organ prolapse.

The present disclosure, in certain embodiments, relates to a flexible and non-absorbent vaginal insert device that is easier to insert and remove and is for use in improving and preventing symptoms associated with pelvic organ prolapse and urinary and / or fecal incontinence when the device is inserted. In certain embodiments, the device has an optionally cone-shaped upper portion that provides pelvic organ support and a removal portion or stem that facilitates insertion and removal of the device.

The invention discloses a preparation method of a pelvic floor patch composite biological material. The preparation method comprises the specific step of treating accellular matrix gel and a polypropylene material at pressure of at least 100MPa for at least 5 minutes. The preparation method is simple, enables the accellular matrix gel and the polypropylene material to be combined firmly, does not utilize chemical crosslinking agent in a crosslinking process, and is free from chemical residuals. The invention also discloses the pelvic floor patch composite biological material prepared by the method, and application of the material. Animal experiments prove that the material has the advantages of being good in tissue compatibility and being free from inflammatory response and can be used for treating pelvic organ prolapse.

A prosthesis for addressing pelvic organ prolapse in females comprises a frame fabricated from a shape memory material that supports a thin, flexible sheet in a stretched condition when the frame is unconstrained. The frame is shaped so as to conform to and be supported by bone structures and muscle tissue in the pelvic basin while providing needed support to pelvic organs to maintain them in a proper position. The use of a shape memory material allows the prosthesis to be rolled or folded into a reduced size for ease of placement through a small incision in the wall of the vagina, but that springs back to its memorized shape following deployment from a delivery sheath.

Provided is an implantable sling for supporting a body organ. The sling may be used, for example, as a urethral sling, a puborectal sling or a surgical mesh for pelvic organ prolapsed repair. The sling of the invention has a first sling element, having a first sling body and two or more slender first projections extending from the first sling body. The sling may further include a second sling element having a second sling body and two or more slender second projections extending from the second sling body, and one or more detachable connections connecting the first sling element and the second sling element. In some embodiments, the connections are configured to tear when the first and second sling elements are pulled apart.

The invention discloses a pelvic organ automatic segmentation method for CT examination. The method comprises the steps of based on the model establishment process of a training database, establishing a deformable model for the segmentation process and hierarchical clustering models, wherein the hierarchical clustering models are formed in such a manner that organs in the training database are segmented into five regions for the amplitude-stated prostate CT examination and each region is in the form of an outline-based hierarchical clustering model established according to the segmentation of the amplitude-stated prostate CT examination; during the local segmentation process, adopting the deformable model as a deformation guidance, finding out an optimal segmentation outline for each region according to the hierarchical clustering model of the region, and recombining the optimal segmentation outlines of the five regions as an initial outline of the global segmentation process; during the global segmentation process, segmenting and regulating the initial outline of the global segmentation process in the same way with that of the local segmentation process to obtain final segmented images.

The invention discloses an absorbable uterine fundus patch composite material and a preparation method thereof. The composite material is composed of a biofilm matrix and a coating, and the coating is evenly distributed on the surface of the biofilm matrix; the biofilm matrix is ​​composed of The natural biofilm is formed after degreasing and decellularization; the coating is composed of a biodegradable high molecular polymer; and the biofilm matrix is ​​also subjected to cross-linking treatment. The invention adopts the biofilm matrix as the matrix material, and the biofilm matrix is ​​cross-linked, and the coating adopts biodegradable high molecular polymers, and the obtained palace fundus patch composite material not only has good mechanical properties, but also has It has good biocompatibility and can be absorbed and degraded by organisms, providing a new composite material for pelvic organ prolapse surgery.

The invention relates to an application of a STAC2 gene and a STAC2 gene coding protein in inhibition of pelvic organ prolapsed. On the basis of high-throughput sequencing results, the candidate STAC2 gene in down-regulated expression is screened out. Further, according to experiments of cell biology, the STAC2 gene affects growth and proliferation activity of uterosacral ligament fibroblasts, is applicable to preparation of preparations for auxiliary diagnosis and treatment of pelvic organ prolapse and has significant clinical application values.

A finger-splinting sheath device is provided for use as a self-treatment aid in assisting a bowel in a patient suffering from complications of pelvic organ prolapse, namely rectocele. The finger-splinting sheath device generally includes a monolithic molded body including a flange-element, and a sheath-element having a proximal end and a distal end, wherein the sheath-element is coupled to the flange-element at the proximal end and is closed at the distal end. The sheath-element generally includes an elliptical cross-section configured to receive two-fingers therein, wherein the sheath-element functions to splint the two fingers during use. A method for using the device includes inserting the device with two fingers within the sheath-element into the vagina and applying pressure to the vaginal walls to assist a bowel movement.

A device sized and shaped for alleviating organ prolapse when inserted into a vagina, comprising: (a) an adjustably flexible, substantially planar ring provided with at least one opposing snapping element; (b) a central rod extending at least partially through the ring transverse to the snapping elements, where the central rod is provided with counterpart slots configured for insertion of the snapping elements therein; and, (c) a connection block, co-axial with the central rod and slidable thereover to transition the device from an expanded state to a collapsed state, configured with slots which align with the counterpart slots of the central rod for passage of at least one snapping element therethrough when the device is in the collapsed state.

The invention relates to a manufacturing method of a male pelvic organ group entity model. The method comprises the steps of three-dimensional reconstruction of a medical image of a male pelvic organ group, designing and manufacturing of a single organ casting mold; selection and preparation of a single organ material and casting of a single organ; assembly of the single organ; internal environment simulation of a human pelvic cavity; and completing of manufacturing of the pelvic organ group entity model and experimental verification of the mechanical property of the pelvic organ group entity model. The male pelvic organ group entity model is highly consistent with the human actual condition in the aspects of pelvic organ structure and mechanical property, and can be applied to research of the total puncture force of the pelvic cavity and the deformation theory and simulated operation training; the problems that a living tissue is constrained by ethics and law are solved; the blank of a pelvic organ group entity model development technique is filled; and the manufacturing method has very wide application prospect in clinical medicine and experiment research.

An insertion needle that is turnably mounted on a handle, which holds the insertion needle, wherein the insertion needle includes a turn arm that turns so as to face the tip of the insertion needle, and a target site that guides the insertion needle provided on the tip of the turn arm, and is further provided with: through-holes in two locations that are provided separated in the longitudinal direction of the tip of the insertion needle; an indentation formed between these through-holes; and a groove in the direction from the tip of the insertion needle toward the base of the insertion needle. Furthermore, the insertion needle is suitably used in urinary incontinence surgery, pelvic organ prolapse surgery or the like.

A system and methodology for the automated localization, extraction, and analysis of MRI-based features with clinical information to improve the diagnosis of pelvic organ prolapse (POP). The system can automatically identify reference points for pelvic floor measurements on MRI rapidly and consistent. It provides a prediction model that analyzes the correlation between current and new MRI-based features with clinical information to differentiate patients with and without POP. This system will enable the high throughput analysis of MR images for their correlation with clinical information to better detect POP. The presented system can also be applied to the automated localization and extraction of MRI features for the diagnosis of other diseases where clinical examination is not adequate.

The invention provides a measuring instrument for pelvic organ prolapsed. The instrument includes a graduated scale body, a pull rod and a vernier; the graduated scale body is axially provided with alimiting groove or a limiting hole, the pull rod is inserted into the limiting groove or the limiting hole, and the vernier is fixedly arranged on the front end of the pull rod; and when the pull rodis stressed, the pull rod drives the vernier to move axially. The instrument has the following advantages: the instrument provided by the invention can facilitate the work of clinical operators and reduce reading errors.

Provided are methods for diagnosing an increased risk of failure in a female pelvic organ prolapse surgery. Also provided are devices and kits for detection of a SNP associated with increased risk of failure in a female pelvic organ prolapse surgery.

The invention discloses a Pelvic Organ Prolapse Quantification (POP-Q) tool and the instructions thereof. The tool comprises a measuring rod and a quantification mechanism, wherein an electric resistance ITO film is arranged on the outer surface of the measuring rod. The quantification mechanism comprises a button, a memory, a CPU and a display. When the measuring rod extends into each detection position of the vagina in turn, the corresponding button is pressed accordingly. The point on the electric resistance ITO film corresponding to the position of the hymen edge of the measuring rod is pressed at the same time, and the measured value of the voltage change of the pressing point on the electric resistance ITO film is stored in the corresponding memory in response to the button. The CPUconverts the measurement value into a physical position value and compares the physical position value with the specified comparison value. Therefore, the quantification result is produced on the display by the CPU. The POP-Q tool has the advantages that the tool runs without the endoscope, the reading and recording of the data are not processed by itself, the POP-Q work is convenient, fast and accurate. The POP-Q can significantly save the medical resources and ease the pain of patient.

The invention relates to a urethra mesh for female urinary incontinence and moderate pelvic organ prolapse. The urethra mesh comprises a middle supporting piece, a first wing piece and a second wing piece; a first preset mesh fixing line and a second preset mesh fixing line are arranged on the front side of the middle supporting piece; a third preset mesh fixing line and a fourth preset mesh fixing line are arranged on the rear side of the middle supporting piece; a fifth middle mark traction line is arranged between the first preset mesh fixing line and the second preset mesh fixing line; and a sixth middle mark traction line is arranged between the third preset mesh fixing line and the fourth preset mesh fixing line. The urethral mesh has the advantages that supporting force can be provided for the top end of a urethra, and anterior pelvic organs are prevented from bulging; the urethral mesh can be used for simultaneously completing the reconstruction of a bladder neck and a posterior urethra section and strengthening the support of a middle urethra section, and is particularly suitable for patients with relatively large urethra activity, broadened vaginal fissure, relapse and relatively short anterior vaginal wall, so that the operation difficulty is reduced, the complication occurrence rate is reduced, and the urethral mesh can become a novel medical instrument and has a wide application prospect.