52 results about "Pelvic organs" patented technology

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

An acellular dermal matrix (ADM) graft product for a pelvic organ prolapse repair procedure includes an ADM graft derived from full-thickness skin, with a pre-formed shape having one or more of a mesh pattern formed in a central portion thereof, suture punch or slit features or radii transitions about the perimeter. The ADM graft is pre-hydrated, placed in a sterilization package and irradiated to provide a two-year shelf-life for the ADM graft product, which is used in the time-saving, efficient, and effective surgical reconstruction of soft tissue defects. One manufacturing method involves providing a portion of full-thickness donor-derived skin, removing an epidermis, basement membrane, and a fat layer form the portion of the skin, decellularizing the skin to form a portion of ADM graft material, pre-shaping and meshing the ADM graft material, verifying a thickness of the ADM graft material, and packaging the pre-shaped, meshed ADM graft material in a sterilizable package and irradiating for a two-year shelf-life to form the ADM graft product. Other embodiments are also disclosed.

A method of preparing a suture fixation device for use in surgery to treat pelvic organ prolapse includes providing a delivery device and a tissue fixation device. The tissue fixation device includes a tab connected to a tissue anchor, with the tissue anchor having a suture eyelet. The method includes instructing a user to hold the tab and insert the tissue anchor into the delivery device and breaking the tab away from the tissue anchor leaving the tissue anchor in the delivery device.

The invention belongs to the technical field of gynecological examination instruments, and provides an automatic pelvic organ prolapse measurement and evaluation system which comprises a scale measuring ruler, a pressure sensor and an automatic evaluation panel. A pressure sensor is embedded in the far end of the measuring scale and fixed in a groove in the far end of the measuring scale, the near end of the sensor is connected with an automatic evaluation panel through a wire, the near end of the measuring scale is embedded in a locking mechanism of the automatic evaluation panel, and different indicator lamps on the automatic evaluation panel feed back data of the pressure sensor qualitatively. The plurality of physical keys control startup, measurement and automatic evaluation calculation, the loudspeaker feeds back evaluation data, and the display screen can visually interact the evaluation data with doctors; the pressure sensor is used for feeding back contact, reading errors can be reduced, various data of POP-Q scores can be conveniently, rapidly and accurately measured, the data are automatically analyzed to evaluate POP-Q staging, work of clinical operators can be greatly facilitated, and evaluation time is shortened.

The invention relates to medical therapeutic and prophylactic low-frequency magnetic pulse devices for providing therapeutic and general stimulation (massage) of tissues by means of electromagnetic induction, specifically for magnetic stimulation of the pelvic floor and pelvic organs. The technical result consists in increasing the reliability of a device for magnetic stimulation of the pelvic floor and pelvic organs. The technical result is achieved by means of a magnetic therapy chair, comprising a body in the form of a chair with a seat, and a magnetic field inductor, wherein the magnetic field inductor is located under the seat and the body of the chair is mounted on a frame, to which an assembly for the movement of the inductor is rigidly attached, said assembly comprising guides along which move carriages that set the magnetic field inductor in motion with the aid of a transmission which converts the motion of the motor into translational motion of the inductor along the guides.

The application discloses a positioning method of uterine cardinal ligament and sacral ligament and a pelvic floor finite element evolution model construction method, and belongs to the field of two-dimensional digital modeling and biomechanics research. According to the pelvic floor anatomy structure, the starting point and the ending point of the cardinal ligament and the sacral ligament in the two-dimensional finite element model are determined, and a distributed nonlinear hyperelastic spring group is proposed to simulate the suspension mechanical properties of the cardinal ligament and the sacral ligament. An organ tissue proportional damage simulation method and a proportional damage expression are proposed, the nonlinear material stress-strain curve of the pelvic floor organ tissue is multiplied by a proportional damage factor to simulate the mechanical properties of the pelvic floor organ damage. A concentrated load application method and a concentrated force-displacement expression of the initial shape feature are proposed to simulate the initial genital cleft and the uterine-vaginal angle. The evolution model can intuitively show the mechanical changes and shape feature change trends of the pelvic floor from the initial injury to the severe prolapse, and provides a basis for the reconstruction surgery design of the pelvic organ prolapse.

This information processing system comprises at least one processor. The at least one processor acquires one or more target images indicating one or more target pelvic organs of a subject, and inputs each of the one or more target images to an image analysis model, which is trained so as to identify the pelvic organ and at least one lesion related to the pelvic organ from the input image, to generate one or more analysis result images indicating the result of processing by the image analysis model in a format in which each of the one or more target pelvic organs and a target lesion that is the lesion of the subject are distinguished from each other.

A range of surgical treatment options for pelvic organ prolapse (POP) and urinary incontinence (UI) as well as non-surgical treatments exist for POP and UI. However, the fitting of physical non-surgical devices such as Kegel assist devices and pessaries is by best guess or trial-and-error. The inventors have established methods, processes and devices to provide measurements of user specific anatomy and physiology in a reproducible manner with devices and systems that remove measurement artifacts, errors, bias etc. whilst providing the patient with an improved experience and the medical personnel with ergonomic, efficient, and easy to use systems. Further, new and improved designs, processes and methods for providing user specific physical non-surgical devices based upon such measurements are established that incorporate user specific anatomy and physiology, user lifestyle, and user experiences into the design and implementation of custom vaginal therapeutic devices.

The invention discloses a natural silk patch for treating female pelvic floor dysfunction diseases and a preparation method thereof. The preparation method of the natural silk patch comprises the following steps: carrying out warp knitting on natural silk threads, and then carrying out heat setting to obtain the natural silk patch, and the diameter of the natural silk threads is 20 / 22 / 24D. The natural silk patch prepared by the invention can be used as a pelvic organ prolapse patch. The natural silk patch disclosed by the invention is good in mechanical property, capable of meeting mechanical support required by the pelvic floor, good in biocompatibility and light in foreign matter reaction.

The disclosure relates to a scaffold graft material, or platelet rich plasma (PRP) graft, and method of production thereof, for tissue repair and / or support (e.g. reinforcement). In one particular application, the scaffold material is used for treating pelvic organ prolapse (POP).

In accordance with embodiments of the present disclosure, a flexible and non-absorbent vaginal insert device shaped to be held securely in place in a vagina when inserted, so as to improve symptoms associated with pelvic organ prolapse or urinary incontinence or both, is provided. The device is designed to be relatively easy to insert and remove. An applicator may be used to aid with insertion. The vaginal insert device comprises an upper portion, having a cone-shaped body, having a circular transverse cross-section throughout its length, having a wall with an interior side and an exterior side, an upper open end, a lower end, and a hollow interior, wherein the upper open end of the upper portion is the innermost portion of the device during insertion, and wherein the wall of the upper portion can be squeezed to make the upper portion more compact for easier insertion of the device, and wherein after insertion the wall expands back to its original shape. The device further comprises an exterior rim surrounding and protruding from the exterior side of the wall and being adjacent to the upper open end, and a plurality of ridges surrounding and protruding from the exterior side of the wall, and a removal portion extending from said lower end of said upper portion to assist in removal of the device. The device can also comprise one or more ventilation openings.

The application discloses an artificial fascia which is a composite material with a five-layer structure and is composed of fat stem cell-loaded amniotic membrane, PRP gel and polyurethane film; the five-layer structure material is in sequence of fat stem cell-loaded amniotic membrane, PRP gel, polyurethane film, PRP gel and fat stem cell-loaded amniotic membrane; the fat stem cell-loaded amniotic membrane is acellular amniotic membrane paved with fat stem cells and is prepared by the following method: inoculating fat stem cells on the acellular amniotic membrane and growing for 7-14 days to obtain the fat stem cell-loaded amniotic membrane. The application further discloses a preparation method of the artificial fascia and application of the artificial fascia in preparation of a biological patch for treating hernia or in preparation of a mesh for treating pelvic organ prolapse. The artificial fascia has high tensile strength, good tissue compatibility, good immune function and degradability, is a biological composite material with excellent performance, can be used for treating hernia and pelvic organ prolapse and has great application potential.

The invention provides a pelvic organ prolapse degree assessment method, system, medium and device based on MRI three-dimensional reconstruction pelvis, and the method comprises the following steps: obtaining MRI data of a pelvic organ of a to-be-assessed object, and constructing a pelvic organ complex model with anatomical features based on the MRI data; constructing a three-dimensional reference plane based on the pelvic three-dimensional model of the pelvic organ complex model; marking point positions of prolapse measuring points based on the pelvic organ complex model, constructing a vertical line of the shortest distance from the prolapse measuring points to the three-dimensional reference plane, marking intersection points of the vertical line and the three-dimensional reference plane as foot points, and calculating the distance from the prolapse measuring points to the foot points to obtain a prolapse quantity value; and implementing POP-Q check based on the same object to be evaluated to obtain a POP-Q scoring result, and comparing the POP-Q scoring result with the prolapse quantity value to obtain a prolapse degree evaluation result. By means of the method, POP-Q evaluation deviation caused by different hospitals and doctors can be eliminated, and pelvic floor reconstruction operation approach selection is guided.

This invention discloses an automatic identification method for pelvic organ prolapse based on deep learning and the PCL line, comprising: S1: acquiring and preprocessing medical images of the pelvic floor region, and simultaneously annotating the bladder, uterus, rectum, and bony anatomical structures to construct a training dataset; S2: constructing and training a multi-objective deep learning segmentation model based on the training data to achieve automatic segmentation of the bladder, uterus, rectum, pubic symphysis, and the two vertebrae from the coccyx; S3: extracting the lowest edge point of the segmented pubic symphysis region and the highest edge point of the two vertebrae from the coccyx region to construct a set of bony key points; S4: connecting the bony key points to automatically generate the pelvic floor reference line (PCL line); S5: analyzing the spatial positional relationship of the bladder, uterus, and rectum relative to the PCL line to obtain the downward displacement feature information of the pelvic organs; S6: automatically determining the degree of pelvic organ prolapse based on the spatial positional relationship. This invention achieves automated identification of the degree of pelvic organ prolapse, reduces subjective errors caused by manual measurement, and improves the consistency, accuracy, and efficiency of the assessment.

Devices and methods for performing image-guided vaginal fixation, such as sacrospinous ligament vaginal fixation, to treat pelvic organ prolapse are disclosed. The device is configured for transvaginal or subcutaneous approach methods, including a rotatable and translatable vaginal device with image-guided indicia, an anchoring device, an anchor, and a pulley and pusher. A path is established between the vaginal wall and the pelvic ligament by precise placement of the vaginal device and the anchoring device and is used for insertion of a retention assembly that is capable of juxtaposing and securing the vaginal wall to the pelvic ligament for vaginal fixation.

A transvaginal lift device that includes a speculum having an upper vane and a lower vane. The upper and lower vanes are each elongate with a front end and a rear end. Further, the upper and lower vanes are attached at the rear end such that the two vanes move between a closed position and an open position. Specifically, the upper vane has an opening / window configured to allow prolapsed tissue to protrude through the opening / window into an interior portion of the speculum. A suturing instrument includes a needle cannula and a suture. The suturing instrument is attached to the speculum. Furthermore, the suturing instrument is configured to place the suture in the prolapsed tissue protruding through the opening / window.

The present application relates to a urethral mesh for female urinary incontinence and moderate pelvic organ prolapse, which comprises a middle support sheet, a first wing sheet and a second wing sheet; a first preset mesh fixing line and a second preset mesh fixing line are arranged on the front side of the middle support sheet; a third preset mesh fixing line and a fourth preset mesh fixing line are arranged on the back side of the middle support sheet; a fifth middle mark traction line is arranged between the first preset mesh fixing line and the second preset mesh fixing line; and a sixth middle mark traction line is arranged between the third preset mesh fixing line and the fourth preset mesh fixing line. The advantages are that the urethral tip can be provided with support strength to prevent the anterior pelvic organ from bulging; meanwhile, the bladder neck and the posterior urethral segment are reconstructed, and the middle urethral support is strengthened, which is particularly suitable for patients with larger urethral activity, wider vaginal split, recurrent cases and shorter anterior vaginal wall, so as to reduce the operation difficulty and the incidence of complications, and can become a new type of medical instrument with wide application prospect.

In accordance with embodiments of the present disclosure, a flexible and non-absorbent vaginal insert device shaped to be held securely in place in a vagina when inserted, so as to improve symptoms associated with pelvic organ prolapse or urinary incontinence or both, is provided. The device is designed to be relatively easy to insert and remove. An applicator may be used to aid with insertion. The vaginal insert device comprises an upper portion, having a cone-shaped body, having a circular transverse cross-section throughout its length, having a wall with an interior side and an exterior side, an upper open end, a lower end, and a hollow interior, wherein the upper open end of the upper portion is the innermost portion of the device during insertion, and wherein the wall of the upper portion can be squeezed to make the upper portion more compact for easier insertion of the device, and wherein after insertion the wall expands back to its original shape. The device further comprises an exterior rim surrounding and protruding from the exterior side of the wall and being adjacent to the upper open end, and a plurality of ridges surrounding and protruding from the exterior side of the wall, and a removal portion extending from said lower end of said upper portion to assist in removal of the device. The device can also comprise one or more ventilation openings.

The utility model relates to a uterine prolapse teaching model, which comprises a pelvic organ model, the pelvic organ model comprises a vagina anterior wall, a vagina posterior wall and a uterus, the pelvic organ model is equally divided into a first model and a second model along the vertical direction, and the first model and the second model can rotate relatively. The vagina front wall and the vagina rear wall are located on the sides, close to each other, of the first model and the second model respectively, the first model and the second model are arranged in a closed mode in the initial state, and the uterus is located in a channel formed by the vagina front wall and the vagina rear wall and can move along the channel. The vagina front wall and the vagina rear wall are both provided with scale marks used for displaying uterine prolapse scale division. The uterine prolapse teaching mold not only can clearly demonstrate different prolapse graduations of the uterus and ensure the teaching quality, but also is convenient to store when not in use.

The invention relates to the technical field of cell therapy, and particularly discloses a repairable fibroblast preparation for treating pelvic organ prolapse. The active ingredients of the preparation are fibroblasts which highly express HAS1, POLR3G and DDR2 at the same time and do not express alpha-smooth muscle actin, and the preparation is compatible with pharmaceutic adjuvants such as normal saline, human serum albumin and dimethyl sulfoxide. The dosage form of the composition comprises an injection and a gel containing a hyaluronic acid matrix. The preparation method comprises the following steps: performing enzymolysis treatment to obtain primary cells, promoting repair phenotypic differentiation through estrogen induction, purifying target cells by adopting a fluorescence labeling flow sorting technology, and performing amplification in a serum-free culture medium to prepare a final preparation. According to the preparation, through the synergistic effect of fibroblasts and pericytes and the perivascular positioning characteristic, targeted repair of pelvic floor supporting tissue can be achieved; according to the preparation method, the cell phenotype stability and the preparation reproducibility are ensured by optimizing process parameters and quality control standards.

A device and method for use in transvaginal procedures involving the suturing in place of a permanent suture anchored to the obturator membranes at the posterior vaginal wall. An introducer assembly includes a hollow sheath and an introducer having a screw tip. The hollow sheath includes a knob with an anchor compartment. The introducer is selectively secured, axially and radially, relative to the sheath. A suture line is threaded along a channel of the introducer and through anchor holes of an anchor stored in the anchor compartment. After removal of the introducer from the sheath, a latch covering the anchor compartment is opened and the suture is pulled to draw the anchor out of the compartment, and through the sheath. The anchor may then be secured to an obturator membrane.

A pelvic organ prolapse pressure measuring device and an application thereof are provided. The pelvic organ prolapse pressure measuring device includes a pelvic organ prolapse pressure sensing system and a data acquisition system, the prolapse pressure sensing system includes a support body and pressure sensors which are distributed outside the support body. The pelvic organ prolapse pressure measuring device is applied to the pressure detection around the cavity. The above-mentioned pelvic organ prolapse pressure measuring device is adopted, which can objectively and accurately judge the abnormal stress relationship inside the prolapsed organ, and accurately evaluate the weak area of the pelvic floor muscle fascia. Its operation method is simple, and its cost is low.

The invention belongs to the technical field of biological detection, and particularly relates to application of a biomarker in preparation of a pelvic organ prolapse early diagnosis product. And the biomarker is one or more of 25 proteins such as ELN (Extreme Leukemia Nucleic Acid), COL6A2 (Colorful Leukemia 6A2), ENTPD1 (Enhanced Nitrate Transcriptase Dehydrogenase 1), AOC3 ( ROC analysis results show that the five proteins can be used as a biomarker group, the prediction accuracy is as high as 97.8%, and technical reference is provided for diagnosis of POP.

The invention discloses an in-vitro experimental model for simulating pelvic organ prolapse and a modeling method thereof. According to the method, a CELL-TANK cell stretching system is used for copying a dynamic environment in a human body, mechanical stress is applied to primary mouse uterus uterus sacral ligament fibroblasts cultured in vitro, and after stimulation of the mechanical stress, changes and reactions of cultured cells which cannot be obtained in conventional static cell culture can be observed, so that the method is suitable for clinical application. And further constructing an in-vitro model of pelvic organ prolapse. The pelvic organ prolapse in-vitro experiment model is beneficial to development of pelvic organ prolapse in-vitro experiments, and provides an ideal modeling mode for in-vitro research of pelvic organ prolapse diseases.

To provide a vaginal insert device that facilitates insertion and removal, and ameliorates and prevents prescribed symptoms when being inserted.SOLUTION: A vaginal insert device for ameliorating, managing, treating, preventing, and / or eliminating symptoms associated with pelvic organ prolapse, urinary incontinence, fecal incontinence, or combinations thereof includes: a cone-shaped body configured to apply pressure onto an organ wall; and a stem configured to adjust the pressure applied to the organ wall.SELECTED DRAWING: Figure 35A

The present invention relates to a device for treating pelvic organ prolapse, including a mesh, a uterine prolapse surgical tool, and a vault prolapse surgical tool; the mesh is in a "cross" shape; the uterine prolapse surgical tool consists of a uterine prolapse surgical tool tray and a uterine prolapse surgical tool handle; the vault prolapse surgical tool consists of a vault prolapse surgical tool cone and a vault prolapse surgical tool handle. Its advantages are as follows: compared with the current "gold standard" transabdominal sacral colpopexy, the curative effect is the same, and it can more effectively solve anterior vaginal wall bulging. The anatomical difficulty is reduced, it is easy to master, there are no serious complications, and it is easy to promote.

The present disclosure relates to a devices and methods for use in surgery. In particular, the present disclosure is directed to devices and methods for the treatment of pelvic organ prolapse conditions, and in particular for the treatment of uterine prolapse.

A pelvic organ group module for CT-guidable puncture injection via a posterior fornix of a vagina and a manufacturing method therefor, and a female pelvis model. The pelvic organ group module is a module made of silicone gel and comprising a pelvic organ cavity. The pelvic organ cavity contains a bladder (a) and a urinary tract connected to the bladder (a), a uterus (b) and a vagina connected to the uterus (b), and a rectal segment (c) in a female pelvis. The pelvic organ group module further comprises a separable puncture replacement block. The puncture replacement block is a replacement block composed of a lower half cavity wall of the vagina from a vaginal orifice to a posterior fornix of the vagina and an upper half cavity wall of a rectal wall adjacent to a lower half cavity of the vagina. An injection cavity for hydrogel is further reserved in the puncture replacement block, and the position of the injection cavity for hydrogel is a position between the posterior fornix of the vagina and the rectal wall. The reliability and safety of a CT-guided puncture procedure for injection of medical hydrogel via the posterior fornix of the vagina can be improved.

The invention provides a pelvic organ model construction method and system based on an MRI three-dimensional reconstruction technology, and a medium. The method comprises the following steps: obtaining MRI data used for constructing a pelvic organ model; pelvic organ tissue segmentation is carried out based on the MRI data to obtain pelvic organ tissue three-dimensional point cloud data; performing three-dimensional modeling based on the pelvic organ tissue three-dimensional point cloud data to obtain a pelvic organ tissue entity model; constructing a bladder cavity model, a muscle uterus cavity model, a vagina cavity model and a rectum cavity model based on the pelvic organ tissue entity model; and carrying out original point assembly on the bladder cavity model, the muscular uterus cavity model, the vagina cavity model and the rectum cavity model to obtain the pelvic organ model. The pelvic organ model constructed by the method not only can be seamlessly connected with finite element analysis software to realize biomechanical behavior simulation, but also can be used for carrying out anatomical form dynamic evolution analysis such as pelvic organ prolapse displacement simulation and the like.

The present invention discloses a comprehensive experimental model for simulating pelvic organ prolapse pressure and a method for using the same, which belongs to the field of obstetrics and gynecology and surgical technology. The comprehensive experimental model includes an in vitro pressure measuring device, and the in vitro pressure measuring device includes a base, on which a three-way connection and a pressure gauge are arranged. The present invention adopts the above-mentioned comprehensive experimental model for simulating pelvic organ prolapse pressure and a method for using the same, performs three-dimensional spatial pressure simulation of pelvic organ prolapse from five directions, realizes three-dimensional spatial pressure measurement, overcomes the limitation of detecting pelvic floor pressure in a single direction, and improves the accuracy and precision of pelvic organ prolapse pressure measurement.