Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors

A technology of bufasterene and oral mucosa, which is applied in the field of application of bufasterene compounds in the preparation of drugs for the treatment of oral mucosal malignant tumors, can solve the problems of complex components of toad preparations, and achieve anti-oral mucosal malignant tumor tongue squamous cell carcinoma activity Strong, extensive resources, clear effect of active ingredients

Inactive Publication Date: 2012-09-26
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the complex components of current toad preparations, the high incidence of adverse reactions, provide clear components, controllable quality, and use bufa steroids as active components to prepare the application of drugs for the treatment of oral mucosal malignant tumor diseases

Method used

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  • Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors
  • Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors
  • Use of bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors

Examples

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Embodiment

[0027] Example: bufafolin extract, cinobufafalin, bufabufalin, bufabufalin, bufabufalin, bufabufalin, deacetylbufafafalin, hellebore aglycon, lipid Inhibitory effect of bufagenin or cinobufagin on human tongue squamous cell carcinoma cell line Tca-8113.

[0028] According to the MTT experimental method, the bufadene extract and nine monomer compounds cinobufalin, jabubafalin, sabubafalin, bufabufalin, bufabufalin, deacetylbufabafalin, Inhibitory effects of hellebore aglycon, redibufagenin or cinobufafalin on human tongue squamous cell carcinoma cells.

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Abstract

The invention discloses a use of a bufadienolide compound in preparing medicines for treating oral mucosal malignant tumors. Anti-cancer experiments of human tongue squamous cancer cells are carried out in vitro through a bufadienolide extract and monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, cinobufagin, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, and experimental results show that the bufadienolide compound has strong inhibition effect on tongue squamous cancer cells and compared with the bufadienolide extract and eight monomeric compounds, namely gamabufalin, arenobufagin, telocinobufagin, bufotaline, desacetylcinobufotalin, heloniogenin, resibufogenin, and cinobufotalin, cinobufagin has a stronger anti-tumor cell activity. The bufadienolide compound provided by the invention has clear components, controllable quality, strong anti-tumor activity and little adverse reaction and is expected to be developed into a novel anti oral mucosal malignant tumor medicine.

Description

technical field [0001] The present invention relates to a new application of bufastenoid compounds, in particular to the application of bufastenoids compounds in the preparation of drugs for treating oral mucosal malignant tumor diseases. Background technique [0002] Tongue cancer is one of the most common malignant tumors in oral cancer. Oral cancer is a general term for malignant tumors that occur in the oral cavity. It is one of the more common malignant tumors in the head and neck, ranking sixth in the world. Most of them belong to squamous cell carcinoma. Mutations. In recent years, the incidence of tongue cancer has been increasing year by year. Although the diagnosis and treatment of tongue cancer have been greatly improved, the prognosis is poor due to frequent tongue activities and rich lymphatic and blood supply in the tongue tissue. Its survival rate is still low. At present, the treatment schemes routinely adopted by domestic and foreign medical circles in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P35/00A61P1/02
Inventor 马宏跃周婧吴启南段金廒唐于平王剑张军峰詹瑧
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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