Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof
A technology of transdermal patch and Siwu decoction, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of first-pass effect gastrointestinal tract damage, low bioavailability, etc. The effect of improved bioavailability and less contamination of clothes
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Embodiment 1
[0029] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:
[0030](1) Preparation of the extract parts of Xiangfu Siwu Decoction: Take 450 grams of angelica, 225 grams of Chuanxiong, 225 grams of white peony, 600 grams of Rehmannia glutinosa, 150 grams of woody fragrance, 225 grams of Cyperus cyperi, 225 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 2100 milliliters of the concentrated solution of 1 gram crude drug / ml, then add concentration and be 95% ethanol, make the concentration ...
Embodiment 2
[0034] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:
[0035] (1) Preparation of the extract parts of Xiangfu Siwu Decoction: take 90 grams of angelica, 45 grams of Chuanxiong, 45 grams of white peony, 120 grams of Rehmannia glutinosa, 30 grams of woody fragrance, 45 grams of Cyperus cyperi, 45 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 420 milliliters of the concentrated solution of 1 gram crude drug / ml, then add the ethanol that concentration is 95%, make the concentration o...
Embodiment 3
[0039] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:
[0040] (1) Preparation of the extract parts of Xiangfu Siwu Decoction: Take 900 grams of angelica, 450 grams of Chuanxiong, 450 grams of white peony, 1200 grams of Rehmannia glutinosa, 300 grams of woody fragrance, 450 grams of Cyperus cyperi, 450 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 4200 milliliters of the concentrated solution of 1 gram crude drug / ml, then add concentration and be 95% ethanol, make the concentratio...
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