Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof

A technology of transdermal patch and Siwu decoction, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of first-pass effect gastrointestinal tract damage, low bioavailability, etc. The effect of improved bioavailability and less contamination of clothes

Active Publication Date: 2013-02-27
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicines currently used to treat dysmenorrhea are mainly taken orally, and there are problems such as the first pass effect, the destruction of the gastrointestinal tract, and low bioavailability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof
  • Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof
  • Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:

[0030](1) Preparation of the extract parts of Xiangfu Siwu Decoction: Take 450 grams of angelica, 225 grams of Chuanxiong, 225 grams of white peony, 600 grams of Rehmannia glutinosa, 150 grams of woody fragrance, 225 grams of Cyperus cyperi, 225 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 2100 milliliters of the concentrated solution of 1 gram crude drug / ml, then add concentration and be 95% ethanol, make the concentration ...

Embodiment 2

[0034] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:

[0035] (1) Preparation of the extract parts of Xiangfu Siwu Decoction: take 90 grams of angelica, 45 grams of Chuanxiong, 45 grams of white peony, 120 grams of Rehmannia glutinosa, 30 grams of woody fragrance, 45 grams of Cyperus cyperi, 45 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 420 milliliters of the concentrated solution of 1 gram crude drug / ml, then add the ethanol that concentration is 95%, make the concentration o...

Embodiment 3

[0039] A Xiangfu Siwu Tang transdermal patch for treating dysmenorrhea, comprising a heating bag, a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which is as follows:

[0040] (1) Preparation of the extract parts of Xiangfu Siwu Decoction: Take 900 grams of angelica, 450 grams of Chuanxiong, 450 grams of white peony, 1200 grams of Rehmannia glutinosa, 300 grams of woody fragrance, 450 grams of Cyperus cyperi, 450 grams of Corydalis Corydalis, add 10 times the amount of water Soak for 12 hours, pour out the decoction after decocting for 2 hours, continue to add 8 times the amount of water for decoction for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain Concentration is 4200 milliliters of the concentrated solution of 1 gram crude drug / ml, then add concentration and be 95% ethanol, make the concentratio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a rhizoma cyperi four-drug decoction transdermal patch and a preparation method of the rhizoma cyperi four-drug decoction transdermal patch. The patch comprises a heating bag, a back lining layer fixed on the heating bag, a medicine-containing base material layer fixed on the back lining layer and an anti-sticking layer covering the medicine-containing base material layer, wherein the medicine-containing base material layer comprises 30-70 parts of hydrogel base material, 10-50 parts of rhizoma cyperi four-drug decoction extracting part and 10-40 parts of a transdermal accelerant. The transdermal patch disclosed by the invention has scientific and reasonable component proportions and great medicine loading amount; and an organic solvent does not need to be added in a preparation process so that the patch has no skin irritation and sensitization. An experiment result shows that the transdermal patch has the very good effect of treating primary dysmenorrheal; the biological utilization rate is high; the transdermal patch can be continuously released at a constant speed and is good for keeping a stable blood medicine concentration; the pesticide effect time is long; and a preparation process of the patch has strong operability and can realize industrial production.

Description

Technical field: [0001] The invention relates to a patch, in particular to a Xiangfu Siwutang transdermal patch capable of preventing and treating dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to the cramping pain in the lower abdomen that women experience before and after menstruation. In severe cases, it may be accompanied by symptoms such as headache, nausea, vomiting, abdominal distension, backache, and leg pain. At present, it is clinically divided into two types: primary dysmenorrhea and secondary dysmenorrhea. Epidemiological studies have shown that dysmenorrhea is the most common disease in gynecology at present, with an incidence rate between 20% and 90%, and it is a common cause that affects women's normal work and quality of life. [0003] According to traditional Chinese medicine, if any reason causes chongren qi and blood to be blocked, uterine blood stasis, resulting in blocked meridians, or blood not returnin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/70A61K47/36A61K47/38A61P15/00
Inventor 刘培段金廒钱大玮宿树兰唐于平
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap