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Antineoplastic usage of sinomenine and its preparation

A technology of sinomenine and drugs, applied in the anti-tumor effect of sinomenine and the preparation of anti-tumor drugs, can solve the problem that there is no anti-tumor drug of sinomenine, and the anti-tumor effect of sinomenine has not been reported. question

Inactive Publication Date: 2007-06-20
MOLECULAR BIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the anti-tumor effect of sinomenine has not been reported so far, and there is no anti-tumor drug with sinomenine as the main active ingredient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] The preparation of pharmaceutical composition A

[0086] In this embodiment, a kind of pharmaceutical composition (composition A) is provided, wherein, the proportioning of three kinds of Chinese medicines is:

[0087] Qingfengteng 82 parts by weight (820 grams)

[0088] Radix Paeoniae Alba 12 parts by weight (120 grams)

[0089] Angelica 6 parts by weight (60 grams)

[0090] The three kinds of traditional Chinese medicines used in this example are all tested by HPLC, and the quality meets the requirements.

[0091] First select the sinomenine coarse powder with higher sinomenine content to extract the aqueous solution containing sinomenine in the percolation tank after soaking in 0.4% sulfuric acid solution, then adjust pH=12 with milk of lime to obtain precipitation, and then use Reflux extraction with 95% ethanol, and then concentrate under reduced pressure to obtain sinomenine coarse powder. Add hydrochloric acid to the coarse powder to obtain sinomenine hydroch...

Embodiment 2

[0095] Preparation of Pharmaceutical Composition B

[0096] According to the extraction method described in Example 1, sinomenine was prepared respectively, and Radix Paeoniae Alba and Angelica sinensis were made into concentrated extracts. After the content determination of each extract, the formula in the following table A is weighed and fully mixed with the auxiliary materials (microcrystalline fiber and magnesium stearate), and granulated by dry method and filled with capsules to make a total of 1000 capsules. Each capsule The content of 300mg or 250mg.

[0097] Table A: Quantities of each ingredient per capsule

[0098] content

Embodiment 3

[0100] Conversion of sinomenine hydrochloride to sinomenine

[0101] At present, the sinomenine produced industrially in my country is the hydrochloride of sinomenine, but internationally, its monomer is more acceptable. Therefore, in this example, sinomenine hydrochloride was converted into sinomenine. Methods as below:

[0102] Dissolve the purchased sinomenine hydrochloride in 65% boiling ethanol, add ammonia water to adjust the pH to 9-10, place and filter, and vacuum-dry the filtrate at 40°C, and the obtained white crystalline powder is sinomenine monomer.

[0103] As determined by HPLC, the content of sinomenine is above 98%.

[0104] Because infrared spectroscopy is highly characteristic, it can be used for the identification of drugs and the determination of chemical structures. Measure the infrared spectrum of the sinomenine monomer prepared above with a Bruker VECTORZZ transform infrared spectrophotometer, and compare with the sinomenine standard substance (batch ...

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PUM

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Abstract

An antineoplastic action of coculine and the composite medicine containing said coculine and the application of coculine in preparing antineoplastic medicines are disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for antitumor, its preparation method and application. More specifically, the present invention relates to the antitumor effect of sinomenine and a compound pharmaceutical composition containing sinomenine, and their use in the preparation of antitumor drugs. Background technique [0002] Tumor is a disease that seriously threatens people's health. In order to effectively treat tumors, people are looking for various substances that can inhibit or kill tumors. [0003] Sinomenime is an alkaloid extracted from the traditional Chinese medicine Sinomenium acutum Rehd.et.wils. Its chemical name is 7,8-didehydro-4-hydroxy-3.7-dimethylhydrogen-17-methyl-9a, 13a, 14a-morphinan-6-one, and its molecular formula is C 19 h 23 NO 4 , the molecular weight is 329.38. Sinomenine has anti-inflammatory, analgesic, hypotensive, anti-arrhythmic and other pharmacological effects, and its preparations have been used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/7048A61P35/00
Inventor 陆德如
Owner MOLECULAR BIOLOGY
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