184 results about "Methylene radical" patented technology

The present application relates to a kind of equipment and method for preparing hexamethylene diisocyanate by hexamethylene diaminoformate intermediate pyrolysis, the present application uses continuous pyrolysis reaction device, HDI can be prepared in high-boiling solvent, can completely replace the existing phosgene and phosgene derivative method for preparing HDI, solve the safety and pollution problem of phosgene method;Compared with low-boiling solvent process, the present application can greatly reduce energy consumption in product separation stage, and the energy consumption required for separating solvent in high-boiling solvent method is 1 / 10 of low-boiling solvent process, it is a green environmental protection energy-saving process;The present application uses non-toxic high-boiling solvent, compared with low-boiling solvent method, production safety is guaranteed;Compared with ordinary high-boiling solvent, the present application can avoid multiple contact between isocyanate and alcohol, and the yield of HDI can be further improved;The process flow of the present application is simple, and the operating condition is mild, it is a process that can be rapidly industrialized.

The present application provides a photosensitive resin composition, dry film resist, photosensitive dry film and application thereof. The photosensitive resin composition comprises 45-60 parts of alkali-soluble resin, 35-50 parts of photopolymerization monomer, 2.5-5 parts of photoinitiator and 0.1-0.8 parts of sensitizer; the sensitizer is a compound shown in the general formula, R1 represents methylene or carbonyl, n represents 0 or 1; R2 represents phenyl, and any hydrogen atom on R2 is optionally substituted by methoxy, C1-C 10 alkyl, phenyl, benzyl or phenoxy. The sensitizer of the present application can make the product have better photosensitivity and resolution. Moreover, based on the above specific weight parts of alkali-soluble resin, photopolymerization monomer, photoinitiator and sensitizer, the comprehensive performance of the product of the present application is better.

This invention discloses an amplification-free electrochemical biosensor and method based on CRISPR-Cas13a. The sensor includes an electrochemical biosensor substrate, a dual-channel RNA reporter molecule, a CRISPR-Cas13a reaction system, and a dual-channel differential signal processing module. The working electrode surface is immobilized with a stem-loop structured first reporter molecule and a linear second reporter molecule loaded with gold nanoparticles, labeled with methylene blue and ferrocene signal molecules respectively, and immobilized with a ferrocene-specific capture probe. When target RNA is present, Cas13a is activated and non-specifically cleaves the reporter molecule, reducing the methylene blue signal and enriching and enhancing the ferrocene signal. Background self-calibration is achieved through dual-channel differential ratio calculation. This invention integrates signal attenuation and signal enhancement modes, offering advantages such as nucleic acid amplification-free operation, fast detection speed, high sensitivity, and strong anti-interference capability.

This compound is represented by general formula (A), where: R1 is a hydrogen atom, a halogen atom, a hydroxy group, or an optionally substituted C1-10 hydrocarbon group; R2 is a hydrogen atom, a halogen atom, a hydroxy group, or an optionally substituted C1-10 hydrocarbon group; X is a nitrogen atom or a hydrogen-bonded carbon atom; Y is a carbonyl group or an optionally substituted methylene group; and n is an integer of 1-3.

The invention relates to a porous metal-organic network (MOF) comprising metal ions coordinated to an organic ligand, wherein at least 66% of the metal ions are iron(III) ions and the organic ligand is 5,5'-methylenediisophthalic acid, its preparation process, and its use for releasing a substance in a controlled manner. The present invention also relates to pharmaceutical compositions comprising such a metal-organic network.

This invention relates to a method for preparing hexamethylenediamine by hydrogenation of adiponitrile in the presence of a Raney nickel catalyst, wherein a Raney nickel catalyst modified by treatment with carbon monoxide or carbon dioxide in a liquid medium is used.

The method for high-efficiency catalysis of Knoevenagel condensation reaction by a porphyrin and quaternary ammonium salt synergistic catalytic system belongs to the technical field of catalyzing Knoevenagel condensation reaction. The synergistic catalytic system comprises a porphyrin ligand and a quaternary ammonium salt compound. The method for high-efficiency catalysis of Knoevenagel condensation reaction of aldehyde ketone and active methylene to generate methylene malononitrile compounds is to use the porphyrin ligand and the quaternary ammonium salt as a synergistic catalytic system to catalyze the condensation of aldehyde ketone and active methylene to generate methylene malononitrile compounds. The porphyrin ligand and quaternary ammonium salt synergistic catalytic system avoids the disadvantages of environmental pollution and difficult recycling of traditional basic homogeneous catalysts, so that the porphyrin ligand and quaternary ammonium salt synergistic catalytic system is easy to operate and recycle, has universal practicability, can be used by ordinary experimental operators, and provides an easy-to-operate, inexpensive and efficient route for the synthesis of methylene malononitrile compounds, which has a popular prospect.

The present invention relates to use of a pharmaceutical composition for multiple myeloma containing 5-fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azabicyclo[2.2.2]octane-3-carbonyl]-2,7-diazaspiro[3.5]nonan-2-yl}pyrimidine-5-yl)oxy]-N,N-di(propan-2-yl)benzamide.

This invention proposes a method for preparing and applying an indium sulfide photocatalytic material with specific vacancies. The method involves forming a first solution with ethanol and deionized water; dissolving InCl3·4H2O and thioacetamide, or InCl3·4H2O, thioacetamide, and hexamethylenetetramine, in the first solution by stirring; obtaining a clear solution; reacting the clear solution at a constant temperature; cooling after the reaction; and collecting the product by centrifugation; washing the product; and drying it at a constant temperature; finally, obtaining the photocatalytic material with specific vacancies. This invention introduces vacancies into In2S3, thereby regulating the surface active sites, enhancing its light utilization efficiency and the separation and transfer ability of photogenerated carriers, and improving the photocatalytic activity of N2 to NH3 reduction.

Symmetric Star Poly(Substituted Glycolide) Homopolymers and Their Surface Properties The invention include the synthesis, thin film formation, surface properties, and comprehensive analysis of star-shaped well-defined symmetric poly(substituted glycolide) (s-PSG) homopolymers, which are alternatives to polylactides and polyglycolides. Four-armed symmetric poly(L-diisopropyl glycolide) (4s-PLDIPG) and poly(L-diisobutyl glycolide) (4s-PLDIBG) prepared by ring opening polymerization (ROP) under melt conditions with tin (II) 2- ethylhexanoate catalyst and pentaerythritol initiator exhibited high conversions (92-98%) and desirable PDI values (1.23-1.49). The NMR data of all s-PSGs showed that the methylene peaks of pentaerythritol were shifted, proving that polymerization took place in all arms. The molecular weights (Mn NMR, Mw GPC, Mn GPC) of s-PSGs determined by NMR and GPC data were consistent with the theoretical values. By increasing the side chain length of s-PSG homopolymers, there was a consistent increase in the water contact angles and surface roughness values of the thin films, whereas the surface free energy diminished.

The present invention provides a polyimide film comprising, as polymeric units, dianhydride monomers comprising pyromellitic dianhydride (PMDA), and diamine monomers comprising 4,4'-methylenedianiline (MDA), meta-phenylenediamine (MPD), 4,4'-diaminodiphenyl ether (ODA), and para-phenylenediamine (PPD), the tensile strength and percent elongation of the polyimide film being 180 MPa or greater and 90% or greater, respectively.

This invention relates to a process for preparing compounds having formula (I): R 1 ‑C(=O)‑O‑CH2‑O‑C(=O)‑R 2 (I), where R 1 and R 2 Each of the terms represents an alkyl, cycloalkyl, or aryl group independently, wherein the alkyl, cycloalkyl, or aryl group is optionally substituted; the process includes step i) reacting the following substances: compound A selected from: trioxane, polyoxymethylene without a hydroxyl terminal group; compound (II): R 1 -C(=O)-O-C(=O)-R 2 (II); and perfluorosulfonic acid; wherein step i) is carried out at a temperature T1 of at least 50°C, wherein the molar ratio of compound (II) to compound A is 1:1 to 1.2:1.

A mixture of methylene diphenylamine isomers and polymethylene polyaniline is prepared with a controllable ratio of methylene diphenylamine isomers. Aniline and formaldehyde are reacted to produce N,N'-diphenylmethylenediamine (acetalamine), which is then partially rearranged in the presence of a heterogeneous catalyst to a mixture of aminobenzylaniline and methylene diphenylamine isomers. Further rearrangement is performed in the presence of a homogeneous catalyst to convert the remaining aminobenzylaniline isomers to methylene diphenylamine and polymethylene polyaniline.

This invention is entitled "A Method for Preparing an Intermediate of Aericoxib," belonging to the field of pharmaceutical preparation technology. The technical problem to be solved is to provide a method for preparing an intermediate of Aericoxib that is simple to operate, uses readily available raw materials, and has simple post-processing. The key points of the technical solution are that the preparation method includes the following steps: (1) 2-bromo-1-(4-methanesulfonyl)acetophenone, hexamethylenetetramine and solvent are reacted, filtered, hydrochloric acid and methanol are added, and the reaction is continued to obtain 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride; (2) 2-amino-1-(4-methanesulfonyl)acetophenone hydrochloride, p-methylphenylacetic acid, base 1 and solvent are mixed, reacted, cooled to -5℃-15℃, base 2 and 1-bromopropane are added, and the reaction is continued to obtain the intermediate.

This invention discloses a layer-by-layer deposition modified ultrafiltration membrane with both antifouling and antibacterial properties, its preparation method, and its applications. Through layer-by-layer assembly technology, a tannic acid (TA) anion layer and a polyhexamethylene biguanide (PHMB) cation layer are alternately deposited on the surface of an ultrafiltration membrane. Under weakly alkaline conditions, electrostatic interactions, hydrogen bonding, Schiff base reactions, and Michael addition reactions are simultaneously utilized to achieve both non-covalent and covalent bonding, constructing a stable and dense integrated antibacterial-antifouling composite coating. This coating has a contact-type antibacterial structure, which can effectively kill bacteria in water and inhibit biofilm formation at the source. Simultaneously, it significantly improves the hydrophilicity of the membrane surface, reduces pollutant adsorption and deposition, and achieves synergistic enhancement of antibacterial and antifouling properties. The preparation process of this invention is mild, simple, low-cost, and environmentally friendly. The modified membrane exhibits high flux retention, excellent separation performance, and excellent operational stability, and can be widely applied in water treatment scenarios such as municipal wastewater treatment.

This invention belongs to the field of SERS detection technology, specifically relating to an Ag-Cu 0.5 Zn 0.5 Application of Fe2O4 composite SERS substrate in the detection of methylene blue in wastewater. First, Cu was prepared using a calcination method. 0.5 Zn 0.5 Fe2O4 nanomaterials, and then Ag NPs are grown on Cu 0.5 Zn 0.5 Ag-Cu was prepared on Fe2O4 support surface. 0.5 Zn 0.5 Fe2O4 composite SERS substrate was loaded onto a glass slide. This substrate integrates the LSPR effect of Ag NPs and Cu. 0.5 Zn 0.5 The cation rearrangement and lattice distortion effects introduced by Fe2O4 optimize the separation and migration behavior of photogenerated charges. The abundant defect states and tunable electronic structure brought about by Cu / Zn synergistic regulation are conducive to constructing efficient interfacial charge transfer channels, thereby enhancing the Raman signal and enabling the detection of trace amounts of methylene blue in wastewater.

The application discloses a new method for synthesizing 3-acyl imidazo[1,5-a]pyridine compounds. The method comprises the following steps: adding 2-pyridyl-p-methanequinone (2-Py-p-QMs), terminal alkyne and p-toluenesulfonyl azide (TsN3), catalyst CuI, organic solvent and alkali into a reaction container under the condition of RT and O2 atmosphere, stirring the reaction for 4 hours, and then separating and purifying 3-acyl imidazo[1,5-a]pyridine compounds after the reaction is completed. The method expands the structure range of 3-acyl imidazo[1,5-a]pyridine products, and more compounds with rich structures can be obtained. Compared with the previous method for synthesizing the target product, the method is efficient, the reaction reagent is non-corrosive, the method design is novel, the raw material is cheap, the operation method is simple, and the product can be directly obtained under mild conditions.

The invention relates to a novel method of producing 4,4'-methylene diphenyl diisocyanate (MDI). A phosgene-free method of producing 4,4'-methylene diphenyl diisocyanate is characterized in that diphenylurea is produced from urea and aniline in an aromatic hydrocarbon medium, and the resulting diphenylurea is reacted with an excess of methanol to produce O-methyl-N-phenyl carbamate; molten O-methyl-N-phenyl carbamate is reacted with anhydrous derivatives of formaldehyde in the presence of acidic catalysts to produce 4,4'-methylene diphenyl dicarbamate; 4,4'-methylene diphenyl dicarbamate in the form of a melt, or of a suspension in an inert carrier liquid, or of a powder is subjected to continuous thermal decomposition in a stream of inert gas, and 4,4'-methylene diphenyl diisocyanate is isolated by fractionation. The invention provides a novel phosgene-free method of synthesizing 4,4'-MDI, which is suitable for industrial-scale implementation.

The invention relates to organic synthesis techniques, and more particularly to a method of thermally decomposing 4,4'-methylene diphenyl dicarbamate (4,4'-MDC) to 4,4'-methylene diphenyl diisocyanate (4,4'-MDI), which is characterized in that 4,4'-MDC, in the form of a melt, or of a suspension in an inert carrier liquid, or of a powder, and an inert gas are fed into a column for conducting continuous thermal decomposition, the mixture is heated to 200-400°C inside the column for the gas-phase decomposition of 4,4'-MDC in the stream of inert gas at atmospheric pressure, then the mixture is separated in a fractionation column to isolate high-purity 4,4'-MDI. The technical result of the proposed invention is an improved method resulting in a high yield of high-purity 4,4'-MDI.

The application belongs to the technical field of rare earth molecule-based magnetic refrigeration material preparation, and discloses a rare earth molecule-based magnetic refrigeration material, a preparation method and application thereof. The preparation method provided by the application is as follows: Schiff base ligand H2mpcd ((E)-N-[(2-hydroxy-3-methoxyphenyl)methylene]pyrazine-2-formylhydrazine), Gd(OTF)3 and Li2CO3 are mixed and dissolved in a mixed solvent of CH3OH and C2H5OH in a certain proportion, stirring, filtering, standing and volatilizing to obtain orange-yellow block crystals. The rare earth molecule-based magnetic refrigeration material is a five-core ladder-shaped metal skeleton structure, and can be applied to the preparation of molecular magnetic materials and molecular magnetic refrigeration materials.

This invention relates to the field of ceramic materials, specifically disclosing a high water-resistant magnesium phosphate cement-based foam ceramic and its preparation method. The foam ceramic comprises the following components: 100-150 parts magnesium phosphate cement, 1-5 parts retarder, 5-20 parts foaming agent, 1-5 parts foam stabilizer, 5-15 parts lutetium ion source, 1-8 parts methylene phosphonic acid component, and 30-60 parts water. The method includes: (1) mixing the lutetium ion source, methylene phosphonic acid component, and water to obtain a complex solution. (2) mixing the magnesium phosphate cement and foam stabilizer, then adding the complex solution to the mixture and mixing to obtain a slurry. (3) adding the foaming agent to the slurry and allowing it to stand for foaming, followed by curing to obtain the foam ceramic. This invention not only effectively reduces the solubility of magnesium phosphate cement hydration products, but also combines CO2 foaming to generate a low-solubility magnesium carbonate shell, significantly improving the long-term stability of the foam ceramic in an aquatic environment while maintaining high porosity.

This invention relates to elastomer compositions, elastomer compounds for tires, and vehicle wheel tires comprising said elastomer compounds, said elastomer compositions comprising a novel secondary crosslinking system comprising at least one methylene donor reagent having general formula (I) and at least one phenolic resin as a methylene acceptor reagent, wherein R1 is ethyl. The novel secondary crosslinking system of this invention allows for the imparting of optimal stiffness, thermal stability, tensile strength, and adhesion to reinforcing elements to materials, thereby improving the crosslinking kinetics and processability of the compound, while reducing or maintaining hysteresis. These materials comprising such crosslinking systems are less harmful than conventional crosslinking systems because they do not contain resorcinol, formaldehyde, and similar substances, and are therefore advantageously suited for tire components requiring a certain stiffness and tensile strength and / or high adhesion to fabric or metal reinforcing elements and low rolling resistance. (I)

The application belongs to the technical field of battery materials, and specifically discloses a preparation method of battery-grade trimanganese tetraoxide. The application first mixes a complexing agent, a pH regulator and an ethanol aqueous solution to obtain a mixed solution; then the mixed solution is mixed with a manganese source to perform a complexing dissolution reaction; after the reaction is completed, oxygen is introduced into the mixed solution to sequentially perform an oxidation reaction, an induced hydrolysis assembly and aging, so as to obtain the battery-grade trimanganese tetraoxide; the complexing agent comprises one or more of glycine, sodium glutamate, ammonium acetate, triammonium citrate and aminotri (methylene) phosphonic acid. The preparation method provided by the application has the advantages of few steps, short path and low energy consumption; and the trimanganese tetraoxide obtained finally has the advantages of stable properties, high quality, high sphericity and high manganese content.

This invention discloses a method and application for preparing metal-doped composite catalysts based on ZIF-67, relating to the field of wastewater treatment technology. This invention constructs a multi-component synergistic system through the coordination of functional groups on the surface of biochar with ZIF-67 and the electronic coupling effect between rare earth metals and Co. Compared with traditional pure chemical support synthesis methods, this reduces costs and improves environmental compatibility. The metal-doped composite catalyst prepared by this invention is a novel heterogeneous catalyst. Through the electrostatic interaction between the biochar support and Co ions, and the metal-metal bonds formed between La / Ce and Co, it significantly enhances the stability of Co ions, effectively avoiding secondary pollution. The metal-doped composite catalyst prepared by this invention can efficiently activate persulfate to generate reactive oxygen species and synergistically remove multiple pollutants from complex water bodies containing sulfamethoxazole, tetracycline, levofloxacin, and other antibiotics such as methylene blue.

Provided is the following as a PVA-based film excellent in transparency, particularly yellowing resistance.　A polyvinyl alcohol-based film containing a polyvinyl alcohol-based resin, wherein the integral ratio of the polyvinyl alcohol-based film as determined by formula (1) below from an 1H-NMR spectrum of the polyvinyl alcohol-based film is 7.0 x 10-3 or less.　(1): Integral ratio = (B / 3) / (b / 3 + a / 2 + B / 3) In formula (1), B is the integral value of methyl groups observed at 2.19 to 2.18 ppm, a is the integral value of methylene groups observed at 2.30 to 2.19 ppm and 2.18 to 1.47 ppm, and b is the integral value of methyl groups observed at 2.49 to 2.30 ppm.

An ophthalmic composition according to the present invention contains (A) 0.01-0.5 w / w% of a copolymer having constituent units represented by formula (1a) to formula (1c), where the molar ratio of each constituent unit is a:b:c=100:10-400:2-50 and the weight average molecular weight is 5,000-2,000,000, (B) 0.000001-0.0001 w / w% of polyhexamethylene biguanide represented by formula (2) or a salt thereof, and (C) 0.02-5.0 w / w% of polyoxyethylene hydrogenated castor oil and / or (D) 0.02-5.0 w / w% of polyoxyethylene glycol monostearate.　According to the present invention, it is possible to provide an ophthalmic composition that exhibits sufficient preservation efficacy and has high lubricity.

The application discloses a Schiff base catalyst, a preparation method thereof and a preparation method of allyl glycidyl ether. The Schiff base catalyst comprises a Schiff base ligand and a central metal ion, wherein the Schiff base ligand is a condensate of ethylenediamine, one molecule of 3,5-di-tert-butyl salicylaldehyde and one molecule of 5-tert-butyl salicylaldehyde, and the central metal ion is selected from any one of Sn, Al and Fe. The Schiff base catalyst can efficiently catalyze the ring opening of allyl alcohol and epichlorohydrin, and the reaction period can be compressed to 3 hours. Meanwhile, the asymmetric structure of the Schiff base complex can effectively control the ring opening position of epichlorohydrin, improve the ring opening selectivity, and the methylene ring opening selectivity can be up to 99%.