2704 results about "Methylene radical" patented technology

Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer(s) as the first stereoisomer of LNA modified oligonucleotides. Modelling clearly indicated the xylo-LNA monomers to be locked in an N-type furanose conformation. Whereas the parent 2′-deoxy-β-D-xylofuranosyl nucleosides were shown to adopt mainly an N-type furanose conformation, the furanose ring of the 2′-deoxy-β-D-xylofuranosyl monomers present in xylo-DNA were shown by conformational analysis and computer modelling to prefer an S-type conformation thereby minimising steric repulsion between the nucleobase and the 3′-O-phopshate group (Seela, F.; Wömer, Rosemeyer, H. Helv. Chem. Acta 1994, 77, 883). As no report on the hybridisation properties and binding mode of xylo-configurated oligonucleotides in an RNA context was believed to exist, it was the aim to synthesise 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer and to study the thermal stability of oligonucleotides comprising this monomer. The results showed that fully modified or almost fully modified Xylo-LNA is useful for high-affinity targeting of complementary nucleic acids. When taking into consideration the inverted stereochemistry at C-3′ this is a surprising fact. It is likely that Xylo-LNA monomers, in a sequence context of Xylo-DNA monomers, should have an affinity-increasing effect.

The present invention relates to a composition comprising a polyester, a copolyester ether and an oxidation catalyst, wherein the copolyester ether comprises a polyether segment comprising poly(tetramethylene-co-alkylene ether). The composition has oxygen scavenging properties and produces articles having low haze. Other embodiments of the present invention disclosed herein are articles made from the composition and methods to make such articles.

The present invention provides a compound of the formula:wherein Ar represents an aromatic group which may be substituted;X represents methylene, S, SO, SO2 or CO;Y represents a spacer having a main chain of 2 to 5 atoms;n represents an integer of 1 to 5;i) R1 and R2 each represents a hydrogen atom or a lower alkyl which may be substituted,ii) R1 and R2 form, taken together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring which may be substituted, oriii) R1 or R2 together with -(CH2)n-N= form, bonded to a component atom of Ring B, a spiro-ring which may be substituted;Ring A represents an aromatic ring which may be substituted;Ring B represents a 4- to 7-membered nitrogen-containing non-aromatic ring which may be further substituted by alkyl or acyl,with a proviso that X represents S, SO, SO2 or CO when Ring A has as a substituent a group represented by the formula:where R11 represents alkyl, alkoxyalkyl, alkylthioalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or a group represented by the formula:where R12 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, or a salt thereof; which has an excellent somatostatin receptor binding inhibition action.

The invention discloses polyhexamethylene guanidine propionic acid and preparing method thereof. The preparing method employs stepwise synthesis, which includes steps of: sufficiently mixing dicyandiamide and alanine under high temperature to synthesize aminoguanidine propionic acid, mixing the aminoguanidine propionic acid, triethylidenepropyldiamine and initiator under high temperature to synthesize the polyhexamethylene guanidine propionic acid. Advantages of the invention are: sterilization effect is excellent, toxity is actually nontoxic level, effect of sterilization is better than existent technique, due to overcoming strong hygroscopicity in existence, the polyhexamethylene guanidine propionic acid can be produced to stable powder, thereby being widely used in fields such as weave, plastic, daily chemicals and water treatment.

Saturated and unsaturated compounds having sweet, salt or umami taste enhancement qualities. The compounds have the structure:

where R¹═H or methyl;

• R² is selected from the group consisting of H, C1-C4 alkyl, alkenyl and methylene;
• R³ is selected from the group consisting of H, C1-C8 straight or branched chain alkyl, alkenyl, dienalkyl or phenyl;
• or if R¹═H, R² and R³ taken together can represent

cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, or cyclohexenyl;

R⁴ is selected from the group consisting of H, methyl and ethyl;

R⁵ is selected from the group consisting of H, methyl and ethyl;

R⁶ is selected from the group consisting of H, C1-C9 straight or branched chain alkyl, alkenyl, alkyldienyl, acyclic or containing no more than one ring;

with the proviso that in structure 1 when R⁴ is H or Me; and

R⁵═H or methyl, R⁶ may be selected from the group described above or phenyl.

The invention discloses a medicament for treating composite water in a hot water boiler. The medicament comprises the following components by mass percent: 0.1-3% of inorganic phosphate, 0.1-2% of organic phosphoric acid and/or organic phosphate, 0.1-4% of component A, 0.1-3% of component B, 0.6-1.0% of organic amine deoxidizer, 0.1-2% of tannin and/or chitosan and the balance of water, wherein the mass percent of the components is 100%, the component A is one or more of an organic antisludging agent, an organic dispersant and an organic dispersible antisludging agent, and the component B is one or more of an organic carboxylic acid corrosion inhibitor, an organic carboxylate corrosion inhibitor and sodium methylene dinaphthalenesulfonate. The invention further discloses a preparation method and a use method of the medicament, the preparation process is clean, and the medicament is low in toxicity for body health and environment in the using process. The medicament is excellent in corrosion resistance and scale inhibition effects and simple and convenient to store and transport, and the corrosion and scale inhibition effects cannot be reduced after the medicament is stored and transported for a long term.

The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1, and other genes with relative susceptibility for various pregnancy-related and other complications.

The invention discloses application and a preparation method of biomass-based nitrogen-doped porous carbon. The method includes: taking cheap cellulose carbamate as a raw material and urea as a nitrogen source, well mixing with sodium hydroxide solution, drying to form sol, and performing high-temperature calcination to obtain the porous-structure biomass-based nitrogen-doped porous carbon high in specific surface area and pore volume. According to electron microscopy images, the prepared material is in a three-dimensional inner-crosslinked porous structure; according to XPS and elemental analysis, nitrogen is successfully doped into a carbon substrate, the nitrogen content is 7.7-15.5%, and the specific surface area is 700-3700m<2>/g; according to supercapacitor experiments, the biomass-based nitrogen-doped porous carbon is great in electrochemical performance; according to pollutant adsorption experimental data, the material is high in adsorption rate and adsorption capacity in adsorption of dye pollutant methylene blue, and the adsorption capacity reaches 1520mg/g. The method is simple in preparation, the raw materials are renewable, and low cost is realized. In addition, sodium carbonate which is a by-product is obtained by washing of calcined samples, so that cost can be effectively reduced, and economic benefits are increased.

Compounds of Formula (I) are effective in the treatment of a microbial infection.

The invention discloses a visible and reversible fluorescent probe which comprises a cyanine fluorescent group and a benzothiazole group, and the general formula of the probe is shown in the description. The preparation method of the reversible fluorescent probe comprises the following steps: (1) dropwise adding phosphorus oxychloride into salicylaldehyde and paraformaldehyde for reaction, so as to obtain a product 1; (2) enabling the product 1 and hexamethylene-tetramine to react, so as to obtain a product 2; (3) enabling the product 2 and 2-aminobenzenethiol to react at the room temperature, so as to obtain a product 3; (4) enabling the product 3 and a compound 4 to react, so as to obtain the visible and reversible fluorescent probe. According to the ratiometric fluorescent probe provided by the invention, obvious color variation can be found out under natural light or an ultra-violet lamp, and the qualitative detection of sulfur dioxide gas can be implemented under natural light or a hand-held ultra-violet lamp, so that the operation is simple, high convenience and quickness are achieved, and the effect is remarkable; the fluorescent probe can effectively prevent interference from other impurities in samples, and is excellent in selectivity; in addition, the cumbersome pre-processing process of samples is avoided, so that the detection efficiency is high.

There is provided a CRF receptor antagonist comprising a compound of the formula (I):

A-W—Ar  (I)

wherein, A is a group represented by the formula (A1) or (A2):

• (wherein, ring Aa is a 5- or 6-membered ring which may be further substituted; ring Ab is a 5- or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R¹ is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, —O—, —S—, etc.; Y¹, Y² and Q are independently optionally substituted carbon or nitrogen; is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, —O—, —S—, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.

The invention discloses a modified petroleum coke granule composite profile control water blocking agent and a multi-round bidirectional blocking control technology. The water blocking agent comprises agents A, B and C, the agent A comprises the ingredients: polyacrylamide solution with the concentration of 0.1-0.3% (by weight), sodium silicate, aluminum potassium sulfate, hydrochloric acid with the concentration of 30% ( by weight), and calcium chloride, the agent B comprises polyacrylamide solution with the concentration of 0.1-0.3% (by weight), modified petroleum coke granules of 20-800mum and surfactant, and the agent C comprises the ingredients: polyacrylamide solution with the concentration of 0.3-0.7% (by weight), N-N' methylene bisacrylamide, organic chromium crosslinking agent, and thiocarbamide; and the multi-round bidirectional blocking control technology is of a multi-round bidirectional blocking control measure developed according to geologic features, state and oil producing conditions of different regions of oil fields; and the water blocking agent is matched with the blocking control technology, so that the problems that the conventional profile control water blocking agent is low in strength, and bad in anti-erosion property and shearing resistance property can be solved, further digging of remaining petroleum is conducted, the water content ratio of an oil well can be reduced, the effect of displacement in flooding can be improved, and the production demand of the oil field can be met.

The invention discloses a preparation method and an application of a core-shell TiO2/ZnIn2S4 composite photocatalyst. The preparation method comprises the following steps: performing ultrasonic dispersion on TiO2 in an ethanol solvent; adding zinc chloride and indium nitrate into the ethanol solvent, and stirring to dissolve; mixing the two systems, and adding thioacetamide; transferring the mixed system into a high pressure kettle to react; performing vacuum filtration, washing, drying and grinding on a product after the reaction is finished to obtain the core-shell TiO2/ZnIn2S4 composite photocatalyst. According to the method, the core-shell TiO2/ZnIn2S4 composite photocatalyst is prepared in one step by adopting a solvothermal synthesis method, the catalyst is wide in visible light response range and high in photocatalysis activity, is applicable to organic dye wastewater degradation, and can be used for degrading methylene blue-containing wastewater in the field of solar energy transformation and utilization and environment management.

A process for treating the methylene blue dye sewage features that the nano-class oxide of Mn is used as catalyst to catalyze the oxidizing of H2O2 to decompose the methylene blue dye.

The invention belongs to strong-fluorescence boron dipyrromethene dyes containing a carbazole structure in the technical field of organic chemical industry and fine chemical industry. Because a method for preparing the strong-fluorescence boron dipyrromethene dye containing the carbazole structure and derivatives thereof adopts boron dipyrromethene and carbazole aldehyde with substituent as raw materials, the molar ratio of the boron dipyrromethene to the carbazole aldehyde is 1:2-5, piperidine is a catalyst, a 4-angstrom molecular sieve is a dehydrating agent, and the molar ratio of the borondipyrromethene to the catalyst is 1:0.01-0.20; in an organic solvent, at the temperature of between 100 and 150 DEG C and under the protection of argon or nitrogen, the mixture reacts for 8 to 50 hours by stirring, the carbazole aldehyde and the active methylene of the boron dipyrromethene are dehydrated to generate the boron dipyrromethene derivatives; and after the carbazole structure with different substituents is introduced into the boron dipyrromethene, the optical property of the boron dipyrromethene compound is changed, the red shift of the absorption spectrum thereof is 80 nanometers, the red shift of the emission spectrum is 90 nanometers, higher fluorescence quantum yield is kept at 0.67, the laser efficiency reaches more than 30 percent, and the strong-fluorescence boron dipyrromethene derivatives containing the carbazole structure are obtained.

The invention discloses a preparation method and application of a cadmium sulfide/graphite like carbon nitride (CdS/g-C3N4) composite visible light catalyst. The preparation method of the catalyst is a chemical precipitation method which is performed in an alkaline environment, wherein g-C3N4 is taken as a matrix, and CdCl2 and Na2S are taken as raw materials. The weight ratio of CdS to g-C3N4 in CdS/g-C3N4 is (1:2)-(5:1), and when the composite visible light catalyst is used for visible light catalysis treatment of methylene blue and methyl violet solutions, a better degradation effect can be obtained; and furthermore, the catalyst can still keep higher catalytic activity after being reused for five times. The composite visible light catalyst disclosed by the invention has important significance for development of the visible light catalyst, and also has good application prospects in treatment of dye wastewater.

The invention provides a method for preparing 1, 3-methyl-5-(2, 6, 6-trimethyl-1- cyclohexene-1-yl)-2, 4-pentadiene methyl phosphonate. In the method, a benzophenone compound preventing transposition is added in the process of generating the 1, 3-methyl-5-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4-pentadiene methyl phosphonate by the reaction of methylene diphosphate four alkyl and C14 aldehyde in a mixed solvent of methylbenzene and tetrahydrofuran, thereby inhibiting the generation of a target product isomer in order that the content of the target product in a final product reaches up to 97 percent.

The present invention relates to polyurethane ionomers based on polytrimethylene ether glycol (“PO3G”), aqueous dispersions of such polyurethanes, and their manufacture and use.

The invention discloses preparation of a Ni<2+> doped geopolymer catalyst and application of the catalyst in organic matter degradation. The preparation method utilizes industrial solid waste fly ash or mineral slag or steel slag as the raw material, which, excited by a chemical exciting agent sodium silicate, can generate a fly ash or mineral slag or steel slag based geopolymer respectively. Then through NH4<+> and Ni<2+> ion exchange reactions in order, a Ni<2+> doped geopolymer catalyst can be generated. The catalyst can be used for degradation reaction of methylene blue in industrial wastewater and has a degradation rate up to 77.29%. The preparation and organic matter degradation processes have the advantages of simplicity and practicability, no need for heating, energy saving and environmental protection, thus being able to realize large scale preparation and application.

The invention relates to a pyrazole oxime ester derivatives and the use, the derivatives are compounds having a structural formula of (II), wherein R1, R2 are C1-C6 alkyl, X is O or S, Y is substituted aryl, Z is methano, Ar is substituted pyridinyl, T is N, R10 is C1-C6 alkyl or substituted alkyl, halogen, OR4 or COOR4, R11 is identical to R10. The derivatives can be used as agricultural insecticide.

The invention relates to a body anti-corrosive preservation solution. The raw materials in percentage by weight of the preservation solution are: 10 to 40 percent of glycerol, 10 to 70 percent of ethanol, 1 to 20 percent of metacetonic acid, 0.1 to 20 percent of hexamethylene tetramine, 0.2 to 10 percent of 5-chloro-2-methyl-4-isothiazoline-3-ketone, 0.1 to 1 percent of peppermint oil and the balance being water. The application mode of the preservation solution comprises the following steps: the anti-corrosive preservation solution is injected into the digestive system of a body from the oral cavity or the nose and the throat of the body; the anti-corrosive preservation solution is injected through an aortic arch, a brachial artery or a femoral artery; and the anti-corrosive preservation solution can also be used to wipe the surface of a body by a tampon dipped in the preservation solution. The body anti-corrosive preservation solution is nontoxic and harmless to an operator and is easy to operate; moreover, the preservation solution has no influence on the environment and excellent anti-corrosive effects, and can ensure that a body maintains a natural state and softness in a natural state (at room temperature) for 5 to 12 days. In addition, the preservation solution can be used repeatedly and has a simple preparing method, easily obtained raw materials and strong maneuverability; moreover, the preservation solution has convenient practical application and is propitious to popularize and use.

The invention relates to a polyurethane patching material used for settlement repairing of a ballastless structure for a high-speed railway. The polyurethane patching material is formed by hybrid reaction of an A component material and a B component material by a high-pressure impact. The volume ratio of the A component and the B component is 1:1-1:1.8. The A component is a mixture formed by polyhydric alcohol modified diphenylmethane diisocyanate and multi-methylene multi-phenyl isocyanate. The viscosity of the A component ranges from 100 mPa.s to 200 mPa.s at the 25 DEG C temperature. The B component is a mixture formed by polyhydric alcohol, a coupling agent, a hydrolytic stabilizing agent, a cross-linking agent, a foam stabilizing agent, a catalyst agent and a foaming agent. The viscosity of the B component ranges from 150 mPa.s to 300 mPa.s at the 25 DEG C temperature. The B component is characterized in that at least a part of end amido polyolefin polyhydric alcohol with 8 functionalities is in the polyhydric alcohol, and the content of the end amido ranges from 60%-80%. According to the polyurethane repairing material, the chemical reaction speed is high, the expansibility is high, the mechanical strength is high, the binding power is high, the size stability is high, the anti-hydrolysising property is good, and the deformation of accumulated residues is low. The polyurethane repairing material can be used for the settlement repairing of the ballastless structure for the high-speed railway, and can also be used for the pavement structure repairing of an expressway and the settlement repairing of an industrial building terrace.