31 results about "Methylene bridge" patented technology

The invention provides a photosensitive resin composition containing an anthracene methyl modified melamine photosensitizer, a photosensitive dry film and application of the photosensitive dry film, the photosensitizer adopts a melamine skeleton to connect three anthracene 9-methyl structures, and through a rigid structure of the melamine skeleton and a methylene bridging (-CH2-An) design of an anthracene group, the photosensitive resin composition has the remarkable advantages that the methylene bridging structure can be used for preparing a photosensitizer, and the photosensitizer can be used as a photosensitizer for photosensitization of the anthracene methyl modified melamine photosensitizer. The breakage of carbon-oxygen bonds on alkoxy caused by p-pi conjugation is avoided, so that the migration of small molecular fragments after initiation is reduced, permeable crystallization to a polyethylene protective film is effectively inhibited, and the risk of short circuit of a line is remarkably reduced; the light quantum yield can be greatly improved by introducing a plurality of light sensing units; the melamine skeleton is used, so that the adhesive force of the initiation system on the metal foil surface can be effectively improved; in addition, the photosensitizer also shows excellent solubility and formula compatibility, and can be widely applied to the photocuring fields of dry films, paints, coatings, printing inks, molding materials and the like.

The invention relates to the technical field of dielectric materials, and discloses polyimide, a polyimide film and a preparation method and application thereof, the polyimide is obtained by a polymerization reaction of a dianhydride monomer and a diamine monomer, the diamine monomer comprises a methylene bridging group and a phenyl group with a substituent group, and the methylene bridging group is a phenyl group with a substituent group. The substituent group at least comprises one methyl group. The molecular twisted conformation lock structure provided by the invention not only can improve the tolerance of polyimide, but also can doubly inhibit intrachain and inter-chain charge migration of the dielectric film, so that the dielectric film still has extremely high energy storage density and energy storage efficiency at a service temperature close to a glass-transition temperature.

The embodiment of the invention provides a preparation method of methylene-bridged substituted phenol substituted by hydroxyl ortho-hydroxymethyl, and the preparation method comprises the following steps: A1, reacting substituted phenol with formaldehyde in the presence of a Lewis acid catalyst to prepare a substituted salicylaldehyde compound (2); a2, carrying out condensation reaction on the substituted salicylaldehyde compound (2) in a system containing formaldehyde and a Bronsted acid catalyst to prepare a methylene-bridged substituted salicylaldehyde compound (3); and A3, reducing the methylene-bridged substituted salicylaldehyde compound (3) to prepare methylene-bridged substituted phenol (4) with hydroxyl ortho-hydroxymethyl substituted. According to the embodiment of the invention, the yield and the chemical purity of the prepared methylene-bridged substituted phenol substituted by hydroxyl ortho-hydroxymethyl can be improved. According to other embodiments of the invention, the invention also provides a preparation method of the polyphenol compound containing multiple phenol units.

The invention relates to a novel modified trinucleotide capped derivative and mRNA introduced with the capped derivative, a methylene bridged heterocyclic compound and a derivative of aryl methyl are respectively introduced at the N7 position of 5 '-terminal guanosine base, and the efficiency is superior to that of a capped substance used in an existing mRNA vaccine; therefore, the present invention can be effectively used in the fields of development of mRNA vaccines and development of various mRNA-based therapeutic agents.

A polycarbonate composition includes particular amounts of a bisphenol A homopolycarbonate, a polycarbonate including repeating units derived from a substituted or unsubstituted cyclohexylidene-bridged bisphenol, and a polyester-carbonate. The composition can exhibit a combination of desirable properties, including low haze and good scratch resistance. Methods for the manufacture of the composition and articles including the composition are also disclosed.

Embodiments of the present application provide a method for preparing a hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol, the method comprising the following steps: A1, reacting a substituted phenol with formaldehyde in the presence of a Lewis acid catalyst to prepare a substituted salicylaldehyde compound (2); A2, condensing the substituted salicylaldehyde compound (2) in a system containing formaldehyde and a Brønsted acid catalyst to prepare a methylene-bridged substituted salicylaldehyde compound (3); A3, reducing the methylene-bridged substituted salicylaldehyde compound (3) to prepare a hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol (4). Embodiments of the present application can improve the yield and chemical purity of the prepared hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol. According to other embodiments of the present application, a method for preparing a polyphenol compound containing multiple phenol units is also provided.

The patent application discloses a kind of polyquinoline acridinedione macrocyclic derivatives and its preparation method and application.The application is by methylene bridging, multiple single-molecule fragments of quinoline acridinedione is gathered into macrocycle, the difference between the electron-withdrawing and electron-donating properties of carbonyl and nitrogen atom is synthesized into a variety of quinoline acridinedione macrocyclic derivatives containing the relative distribution structure of carbonyl and nitrogen atom, the interaction of carbonyl and nitrogen atom heterocycle is conducive to realize high color purity molecular luminescence.Because the free rotation of benzene ring and intramolecular vibration caused by single fragment molecule itself is not fixed, energy is attenuated in the form of non-radiative transition, and the benzene ring after being polymerized into ring can efficiently emit light due to the limited rotation, and improve the color purity of luminescence.

The invention belongs to the technical field of luminescent materials, and discloses a luminous stable cation free radical compound based on methylene bridging pyrrole dimer and preparation and application thereof. The structure of a cation free radical of the luminescence-stable cation free radical compound is shown in a formula II, and the cation free radical is stabilized by anions or a stabilizer. The preparation method comprises the following steps: oxidizing a compound shown as a formula I in a solvent through an oxidizing agent or under the action of lewis acid or protonic acid in a solid state, or oxidizing through ultraviolet irradiation in an oxygen atmosphere, thereby obtaining the cation free radical compound with stable luminescence. The cation free radical compound with stable luminescence has the advantages of high generation efficiency, good stability, high luminescence efficiency and the like, is used for cell fluorescence imaging and / or blood vessel fluorescence imaging, and has a good imaging effect.

This invention relates to a method for preparing a steel slag-supported catalyst for simultaneous colorimetric detection and photocatalysis, and to the steel slag-supported catalyst itself. The preparation method comprises the following steps: dissolving steel slag powder in water to obtain a dispersion solution; placing a magnet on the outer wall of a glass container and mechanically stirring; after settling, obtaining a mixed solution of non-magnetic steel slag powder not attracted by the magnet; centrifuging and washing to obtain non-magnetic steel slag powder; adding the obtained non-magnetic steel slag powder to water to obtain dispersion A; dissolving an organic photosensitizer with a macromolecular heterocyclic structure formed by four pyrrole subunits of α-carbon atoms interconnected by methylene bridges (=CH-) in an organic solvent to obtain solution B; mixing dispersion A and solution B uniformly and reacting them in a sealed container to obtain the steel slag-supported catalyst. The steel slag-supported catalyst prepared by this invention has advantages such as simple process, easy operation, mild reaction conditions, low cost, good stability, high sensitivity, low detection limit, and good photocatalytic performance.

The invention provides a well wall stabilizer for drilling fluid as well as a preparation method and application thereof. The invention provides a well wall stabilizer for drilling fluid. The raw materials of the stabilizer comprise cucurbituril and cyclodextrin, the cucurbituril is an annular cage compound formed by connecting 2n methylene bridges with n glycolurils, and n is selected from 5-20. Wherein cucurbituril is called Q [n] for short. The invention provides a preparation method of a stabilizer. The preparation method of the stabilizer comprises the step of mixing water, cucurbituril, an alkali supply agent, cyclodextrin, a surfactant, organic silanol and a salt bridging agent to obtain the stabilizer. The invention provides the drilling fluid well wall stabilizer prepared from cucurbituril and cyclodextrin, the prepared drilling fluid well wall stabilizer is used in drilling fluid, the rolling dispersion recovery rate of the drilling fluid can reach 65% or above, and the membrane efficiency of the drilling fluid can reach 17% or above.

The application relates to the technical field of dielectric materials, and discloses a polyimide, a polyimide film and a preparation method and application thereof, wherein the polyimide is obtained through polymerization reaction of a dianhydride monomer and a diamine monomer; the diamine monomer comprises a methylene bridging group and a phenyl group with a substituent group; and the substituent group comprises at least one methyl group. The molecular twisted conformation lock structure can not only improve the resistance performance of the polyimide, but also can doublely inhibit the intrachain and interchain charge migration of the dielectric film, so that the dielectric film still has extremely high energy storage density and energy storage efficiency at a service temperature close to a glass transition temperature.

The invention discloses a biomass halogen-free phosphorus-free flame retardant, a durable flame-retardant modified silk fabric and a preparation method of the durable flame-retardant modified silk fabric, and belongs to the field of functional textiles. The preparation method of the flame retardant comprises the following steps: enabling tannic acid and terephthalaldehyde to react under a proper pH condition to form a prepolymer with a three-dimensional network structure, and arranging the prepolymer on the silk fabric. The core of the invention is to realize lasting immobilization of the flame retardant through a step-by-step covalent cross-linking strategy: firstly, an aldehyde group of terephthalaldehyde and a phenolic hydroxyl group of tannic acid are subjected to electrophilic substitution to form a methylene bridge, and a three-dimensional network is constructed; afterwards, in high-temperature finishing, surplus aldehyde groups in the network and amino groups on the surface of the silk fabric form C = N covalent bonds through Schiff base reaction. The flame retardant and the fibers are stably combined in a dual covalent cross-linking'structure anchoring 'mode, so that the flame-retardant efficiency and durability of the modified silk fabric are remarkably improved, and the defect that the traditional flame retardant is easy to dissolve and lose is overcome.

The present invention provides a catalyst for the synthesis of a polyolefin elastomer, a polyolefin elastomer, and a preparation method, and specifically relates to the technical field of polyolefin elastomers. The present invention uses a metallocene catalyst (phenyl, indenyl)-methylene-bridged (indenyl, fluorenyl) zirconium dichloride as a main catalyst and triisobutylaluminum as a co-catalyst, and adopts a continuous polymerization process to polymerize ethylene and α-olefin comonomers at high temperature to prepare a polyolefin elastomer. The polyolefin elastomer prepared by the present invention has a high molecular weight and a narrow molecular weight distribution, a low glass transition temperature, simplifies the polymerization process, and greatly saves costs.

The invention belongs to the field of preparation of methylene bridge polypeptides, and particularly relates to a preparation method of methylene bridge polypeptides, which comprises the following steps: synthesizing a naked peptide, taking dichloro resin as a solid phase carrier, cutting resin peptide by adopting TFA cutting liquid after synthesis is completed, and carrying out diethyl ether sedimentation centrifugation and freeze-drying treatment to obtain the naked peptide with the molecular weight of 833.4 + / -0.5. Therefore, through a-S-CH-S-methylene bridge structure constructed by taking diiodomethane as a methylene bridge forming reagent, the effects of remarkably improving the chemical stability, reduction resistance and enzymolysis resistance of the polypeptide are achieved, and the problems that a disulfide bond formed by traditional sulfydryl crosslinking is easy to break in an in-vivo reduction environment, and the potential safety hazard is caused are solved. The core problems of insufficient polypeptide stability and difficulty in long-acting maintenance of biological activity caused by the fact that the polypeptide is not stable in the prior art are solved, and the effects of guaranteeing high purity and structural integrity of the naked peptide and specificity and controllability of methylene bridge formation reaction are achieved, so that the problems that in traditional polypeptide synthesis, sequences are prone to error, many impurity residues exist, modification reaction selectivity is poor, and by-products are prone to being generated are solved.

The invention discloses an anti-yellowing additive, a preparation method of the anti-yellowing additive, a coating and a preparation method of the coating, and relates to the technical field of anti-yellowing additives. 1 to 5 parts of 3-chloro-2 hydroxy propionitrile; 0.8 to 1.2 parts of formaldehyde; 0.1 to 0.3 part of a catalyst; 0.5 to 2 parts of 4, 4 '-diaminodiphenylmethane; and 0.3 to 0.6 part of silver oxide. According to the preparation method disclosed by the invention, a multi-functional-group framework with amino groups, hydroxyl groups, ether bonds and methylene bridges is constructed by gradually reacting and combining a regulating solution with 3-chloro-2-hydroxypropionitrile and formaldehyde; an aromatic ring structure of 4, 4 '-diaminodiphenylmethane and a conjugated system catalyzed by silver oxide are further introduced, and a triple protection mechanism of free radical capture, ultraviolet shielding and energy dissipation is formed.

The invention discloses a high-temperature-resistant well completion fluid viscosity-shear improving agent based on covalent bond-secondary bond double bond cooperation and a preparation method of the high-temperature-resistant well completion fluid viscosity-shear improving agent, and belongs to the technical field of oil and gas resource exploration. On one hand, the viscosity and shear improving agent can form a new methylene bridge covalent bond crosslinking point, and on the other hand, the viscosity and shear improving agent can form a supramolecular association system through intermolecular hydrogen-bond interaction, and a structural system of an effective suspension stable high-density solid phase weighting agent can be formed without ultra-high molecular weight. The improvement of the crosslinking degree can effectively counteract the thermal degradation effect of high temperature on the polymer, and the high-pressure environment of the deep well can obviously enhance the stability of hydrogen bonds, so that the polymer body and a supramolecular association system formed by the polymer body are not easily damaged by the high-temperature effect, and the viscosity and cutting improving performance of the polymer in the completion fluid is further ensured.

The present invention provides a photosensitive resin composition containing an anthracene methyl-modified melamine photosensitizer, a photosensitive dry film, and applications thereof. The photosensitizer uses a melamine skeleton to connect three anthracene 9-methyl structures. Through the rigid structure of the melamine skeleton and the methylene bridge (-CH2-An) design of the anthracene group, it has significant advantages: the methylene bridge structure avoids the breakage of the carbon-oxygen bond on the alkoxy group due to p-π conjugation, thereby reducing the migration of small molecule fragments after initiation, effectively inhibiting penetration and crystallization into the polyethylene protective film, and significantly reducing the risk of circuit short circuits; the introduction of multiple photosensitive units can greatly improve the photon yield; the use of the melamine skeleton can effectively improve the adhesion of the initiation system to the metal foil surface; and the photosensitizer also exhibits excellent solubility and formulation compatibility, and can be widely used in photocuring fields such as dry films, paints, coatings, inks, and molding materials.

The present invention provides a benzene-cucurbit ring compound, which belongs to the technical field of macrocyclic compounds. The benzene-cucurbit ring compound is a cage-shaped compound formed by two benzene ring monomers and four glycoside urea monomers connected by 12 methylene-CH2-bridges, and the general chemical formula is C 40 H 36 N 16 O8, with a molecular weight of 868.83200, is a white solid soluble in the organic solvents formic acid, acetic acid, and trifluoroacetic acid. The product composition was accurately confirmed by mass spectrometry, nuclear magnetic resonance, and single crystal structure. The present invention also provides a preparation method and application of a benzene-containing cucurbitacin compound.

A solid phloroglucinolic resin comprises reacting a phloroglucinolic compound and a ketone in the presence of an acid catalyst. The solid phloroglucinolic resin formed includes multiple phloroglucinolic units defined by formula (I)wherein at least one of R1, R2, and R3 combines with a second phloroglucinolic unit to form a di-substituted methylene bridge, wherein the second one of R1, R2, and R3 is a hydrogen atom or combines with a third phloroglucinolic unit to form another di-substituted methylene bridge, and wherein the third one of R1, R2 and R3 is a hydrogen atom.

The application provides a nine-membered macrocyclic compound, belongs to the technical field of macrocyclic compounds, and is named as a cucurbit[3,6] containing benzene, which is a gourd-shaped compound formed by connecting 3 benzene monomers and 6 urea monomers through 18 methylene-CH2-bridges. 60 H 54 N 24 O 12 The chemical composition general formula of the cucurbit[3,6] containing benzene is C 60 H 54 N 24 O 12 1303.24800, the cucurbit[3,6] containing benzene is white solid, and is dissolved in at least one of organic solvents dimethyl sulfoxide, formic acid, acetic acid and trifluoroacetic acid. The application further provides a preparation method and application of the nine-membered macrocyclic compound.

The invention discloses supramolecular macrocyclic aromatic hydrocarbon constructed on the basis of naphthalene rings and benzophenone as well as a synthesis method and application of the supramolecular macrocyclic aromatic hydrocarbon, and belongs to the technical field of supramolecular chemistry. The supramolecular macrocyclic aromatic hydrocarbon takes a naphthalene ring and benzophenone as construction units, forms a central symmetry structure through methylene bridge connection, and has the characteristics of a hexagonal electron-deficient cavity and a non-covalent bond molecular pipeline; the synthesis method comprises two steps of Friedel-Crafts acylation synthesis of an intermediate and cyclization condensation synthesis of a target product, the reaction condition is mild, the operation is simple, and the cyclization yield is high. The invention further discloses a reddish charge transfer composite material formed by the macrocyclic aromatic hydrocarbon and 1, 2, 4, 5-tetracyanobenzene, the composite material has specific gasochromic response to benzene vapor, the color of the composite material is changed from reddish to orange brown after the composite material adsorbs the benzene vapor, and the composite material has no obvious response to other benzene series pollutants such as methylbenzene and dimethylbenzene. The method can be used for rapid and visual detection of benzene steam. The method has an important application value in the fields of supramolecular sensing and environmental monitoring.

A solvent free method for producing chimeric hemicucurbit[n]urils. The method comprises a first step of contacting, under mechanical agitation, at least two different cyclic urea derivatives and a compound that can form methylene bridges in the presence of an acid and templating anions and a second step of aging the products for at least about 30 minutes. The method has a very low process mass intensity (PMI) of 4, making it very attractive from a green chemistry perspective. New chimeric hemicucurbit[n]urils incorporating D-biotin are also described.

The application relates to a method for regulating the microstructure of wood tar resin derived hard carbon by a compound crosslinking agent, a material and an application, and belongs to the technical field of biomass-based hard carbon material preparation. The method comprises the following steps: step one: mixing wood tar, a compound crosslinking agent and a catalyst, and carrying out hydrothermal reaction at 120-240 DEG C for 6-48 hours to obtain a compound crosslinking wood tar resin; and step two: carbonizing the compound crosslinking wood tar resin in an inert atmosphere, and obtaining a wood tar resin derived hard carbon material after cooling. The compound ratio is regulated, the proportion of methylene bridge and methylene bridge is balanced, the crosslinking density and carbon layer regularity are considered, the hard carbon interlayer spacing and microcrystalline size are directionally optimized, the defects of single crosslinking agent such as "insufficient interlayer spacing" or "excessive disorder" are avoided, the obtained hard carbon interlayer spacing is suitable for rapid deintercalation of sodium ions, the microcrystalline size considers the capacity and cycle stability, the interface side reaction is greatly reduced, and the comprehensive performance of the battery material is improved.

The invention discloses a chemical depolymerization-repolymerization method for recycling melamine waste, and relates to the technical field of recycling and recycling of resin solid waste. The method comprises the following steps: crushing the melamine waste, performing pretreatment and surface modification, and then attacking methylene bridges in the melamine waste by using OH <-> as a nucleophilic reagent under an alkaline condition to initiate C-N bond breakage in the melamine waste, so that the melamine waste is gradually degraded to generate melamine; adding the obtained melamine into a formaldehyde solution, and reacting again to obtain new melamine resin.

The invention discloses a preparation method of methylene methanedisulfonate, which comprises the following steps: taking methanedisulfonic acid and paraformaldehyde as raw materials, carrying out condensation reaction in an aprotic organic solvent in the presence of a catalyst, and after the reaction is finished, carrying out post-treatment to obtain the methylene methanedisulfonate, continuously removing the generated water in the reaction process; the catalyst is selected from Lewis acid, Bronsted acid or a compound thereof. Through the synergistic effect of the specific catalyst and efficient dehydration, methylene bridged bond formation is efficiently promoted, forward reaction is promoted, meanwhile, side reactions such as decomposition of raw materials and products are effectively inhibited, and the method has the advantages of being mild in reaction condition, few in by-products, high in yield, good in product purity and few in three wastes, and is suitable for industrial production.

The invention belongs to the technical field of medicines, and discloses quinoid chalcones with an A ring having an isopentenyl group and an anti-diabetes application thereof. The compound provided by the invention has a structure shown in a general formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method comprises the following steps: (1) synthesizing 3, 5-dihydroxy-2-acetyl-6, 6-diisopentenyl cyclohexane-2, 4-dienone, (2) synthesizing a quinone chalcone compound with an A ring having an isopentenyl group, and (3) synthesizing a quinoid chalcone compound with an A ring having an isopentenyl group. And (3) synthesizing a dimer compound with an A ring having isopentenyl and quinoid chalcone bridged by methylene. The compound provided by the invention is simple in preparation method and has a remarkable anti-diabetic effect. # imgabs0 #

The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene bridge, to obtain a compound of Formula (I). The invention also relates to novel S-substituted thioisoxazole of Formula (III) and processes of preparation thereof, wherein L is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable thionating reagent: dimethyl thioformamide, thiosulfate salts, dithiooxamide, alkyl xanthate salts, thiobenzamide, V-substituted thiourea and thioacetate salts.

Indol[3,2-b]carbazole dimer derivative and preparation method and application thereof, belong to medical technology field, the structural general formula of indol[3,2-b]carbazole dimer derivative is one of following structures, the present application provides a kind of method for improving the oxidation or the method of derivative after oxidation to indol[3,2-b]carbazole dimer, obtain the synthesis method of methylene bridge modified indol[3,2-b]carbazole dimer derivative.Indol[3,2-b]carbazole dimer derivative has fixed cavity and rich π electron system, not only can be loaded with the drug of larger molecular size, improve the lipophilic partition coefficient of drug, and it has good ultraviolet absorption and fluorescence color performance, form strong fluorescence and rigid fixed dimer compound, widely potential use, such as drug diagnostic reagent, ion fluorescence sensing, drug molecule carrier and biological macromolecule recognition etc.

The present invention relates to a process for the preparation of a key intermediate of formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of formula (II) with a sulfurizing reagent to produce an S-substituted thioisoxazole of formula (III); and coupling the S-substituted thioisoxazole of formula (III) with a pyrazole of formula (IV) by introduction of a methylene bridge to obtain a compound of formula (I). The present invention also relates to novel S-substituted thioisoxazoles of formula (III) wherein L1 is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable sulfurizing reagent selected from dimethylthiocarbamide, thiosulfate, dithiooxamide, alkyl xanthate, thiobenzamide, N-substituted thiourea and thioacetate, and processes for their preparation.

The invention provides a mono-titanocene complex as well as a preparation method and application thereof. According to the mono-titanocene complex, methylene bridged diarylboronic acid is adopted as an auxiliary ligand, the electrophilicity of titanium metal is improved through the strong electron withdrawing effect of boron oxygen, coordination insertion of styrene monomers is facilitated, and then the chain growth rate is increased. Meanwhile, through the steric effect of an auxiliary ligand of methylene bridged diarylboronic acid, a catalytic active center can be stabilized and a chain transfer reaction can be inhibited, so that high-molecular-weight syndiotactic polystyrene can be prepared with high activity and can catalyze syndiotactic polymerization of styrene with high activity. Tests show that the mono-titanocene complex provided by the invention is used as a catalyst, the activity is high, and the ash content of a product is as low as 18 ppm.