15 results about "Methylene bridge" patented technology

The invention relates to a novel modified trinucleotide capped derivative and mRNA introduced with the capped derivative, a methylene bridged heterocyclic compound and a derivative of aryl methyl are respectively introduced at the N7 position of 5 '-terminal guanosine base, and the efficiency is superior to that of a capped substance used in an existing mRNA vaccine; therefore, the present invention can be effectively used in the fields of development of mRNA vaccines and development of various mRNA-based therapeutic agents.

A polycarbonate composition includes particular amounts of a bisphenol A homopolycarbonate, a polycarbonate including repeating units derived from a substituted or unsubstituted cyclohexylidene-bridged bisphenol, and a polyester-carbonate. The composition can exhibit a combination of desirable properties, including low haze and good scratch resistance. Methods for the manufacture of the composition and articles including the composition are also disclosed.

The patent application discloses a kind of polyquinoline acridinedione macrocyclic derivatives and its preparation method and application.The application is by methylene bridging, multiple single-molecule fragments of quinoline acridinedione is gathered into macrocycle, the difference between the electron-withdrawing and electron-donating properties of carbonyl and nitrogen atom is synthesized into a variety of quinoline acridinedione macrocyclic derivatives containing the relative distribution structure of carbonyl and nitrogen atom, the interaction of carbonyl and nitrogen atom heterocycle is conducive to realize high color purity molecular luminescence.Because the free rotation of benzene ring and intramolecular vibration caused by single fragment molecule itself is not fixed, energy is attenuated in the form of non-radiative transition, and the benzene ring after being polymerized into ring can efficiently emit light due to the limited rotation, and improve the color purity of luminescence.

This invention relates to a method for preparing a steel slag-supported catalyst for simultaneous colorimetric detection and photocatalysis, and to the steel slag-supported catalyst itself. The preparation method comprises the following steps: dissolving steel slag powder in water to obtain a dispersion solution; placing a magnet on the outer wall of a glass container and mechanically stirring; after settling, obtaining a mixed solution of non-magnetic steel slag powder not attracted by the magnet; centrifuging and washing to obtain non-magnetic steel slag powder; adding the obtained non-magnetic steel slag powder to water to obtain dispersion A; dissolving an organic photosensitizer with a macromolecular heterocyclic structure formed by four pyrrole subunits of α-carbon atoms interconnected by methylene bridges (=CH-) in an organic solvent to obtain solution B; mixing dispersion A and solution B uniformly and reacting them in a sealed container to obtain the steel slag-supported catalyst. The steel slag-supported catalyst prepared by this invention has advantages such as simple process, easy operation, mild reaction conditions, low cost, good stability, high sensitivity, low detection limit, and good photocatalytic performance.

The application relates to the technical field of dielectric materials, and discloses a polyimide, a polyimide film and a preparation method and application thereof, wherein the polyimide is obtained through polymerization reaction of a dianhydride monomer and a diamine monomer; the diamine monomer comprises a methylene bridging group and a phenyl group with a substituent group; and the substituent group comprises at least one methyl group. The molecular twisted conformation lock structure can not only improve the resistance performance of the polyimide, but also can doublely inhibit the intrachain and interchain charge migration of the dielectric film, so that the dielectric film still has extremely high energy storage density and energy storage efficiency at a service temperature close to a glass transition temperature.

The invention belongs to the field of preparation of methylene bridge polypeptides, and particularly relates to a preparation method of methylene bridge polypeptides, which comprises the following steps: synthesizing a naked peptide, taking dichloro resin as a solid phase carrier, cutting resin peptide by adopting TFA cutting liquid after synthesis is completed, and carrying out diethyl ether sedimentation centrifugation and freeze-drying treatment to obtain the naked peptide with the molecular weight of 833.4 + / -0.5. Therefore, through a-S-CH-S-methylene bridge structure constructed by taking diiodomethane as a methylene bridge forming reagent, the effects of remarkably improving the chemical stability, reduction resistance and enzymolysis resistance of the polypeptide are achieved, and the problems that a disulfide bond formed by traditional sulfydryl crosslinking is easy to break in an in-vivo reduction environment, and the potential safety hazard is caused are solved. The core problems of insufficient polypeptide stability and difficulty in long-acting maintenance of biological activity caused by the fact that the polypeptide is not stable in the prior art are solved, and the effects of guaranteeing high purity and structural integrity of the naked peptide and specificity and controllability of methylene bridge formation reaction are achieved, so that the problems that in traditional polypeptide synthesis, sequences are prone to error, many impurity residues exist, modification reaction selectivity is poor, and by-products are prone to being generated are solved.

A solid phloroglucinolic resin comprises reacting a phloroglucinolic compound and a ketone in the presence of an acid catalyst. The solid phloroglucinolic resin formed includes multiple phloroglucinolic units defined by formula (I)wherein at least one of R1, R2, and R3 combines with a second phloroglucinolic unit to form a di-substituted methylene bridge, wherein the second one of R1, R2, and R3 is a hydrogen atom or combines with a third phloroglucinolic unit to form another di-substituted methylene bridge, and wherein the third one of R1, R2 and R3 is a hydrogen atom.

The invention discloses supramolecular macrocyclic aromatic hydrocarbon constructed on the basis of naphthalene rings and benzophenone as well as a synthesis method and application of the supramolecular macrocyclic aromatic hydrocarbon, and belongs to the technical field of supramolecular chemistry. The supramolecular macrocyclic aromatic hydrocarbon takes a naphthalene ring and benzophenone as construction units, forms a central symmetry structure through methylene bridge connection, and has the characteristics of a hexagonal electron-deficient cavity and a non-covalent bond molecular pipeline; the synthesis method comprises two steps of Friedel-Crafts acylation synthesis of an intermediate and cyclization condensation synthesis of a target product, the reaction condition is mild, the operation is simple, and the cyclization yield is high. The invention further discloses a reddish charge transfer composite material formed by the macrocyclic aromatic hydrocarbon and 1, 2, 4, 5-tetracyanobenzene, the composite material has specific gasochromic response to benzene vapor, the color of the composite material is changed from reddish to orange brown after the composite material adsorbs the benzene vapor, and the composite material has no obvious response to other benzene series pollutants such as methylbenzene and dimethylbenzene. The method can be used for rapid and visual detection of benzene steam. The method has an important application value in the fields of supramolecular sensing and environmental monitoring.

A solvent free method for producing chimeric hemicucurbit[n]urils. The method comprises a first step of contacting, under mechanical agitation, at least two different cyclic urea derivatives and a compound that can form methylene bridges in the presence of an acid and templating anions and a second step of aging the products for at least about 30 minutes. The method has a very low process mass intensity (PMI) of 4, making it very attractive from a green chemistry perspective. New chimeric hemicucurbit[n]urils incorporating D-biotin are also described.

The application relates to a method for regulating the microstructure of wood tar resin derived hard carbon by a compound crosslinking agent, a material and an application, and belongs to the technical field of biomass-based hard carbon material preparation. The method comprises the following steps: step one: mixing wood tar, a compound crosslinking agent and a catalyst, and carrying out hydrothermal reaction at 120-240 DEG C for 6-48 hours to obtain a compound crosslinking wood tar resin; and step two: carbonizing the compound crosslinking wood tar resin in an inert atmosphere, and obtaining a wood tar resin derived hard carbon material after cooling. The compound ratio is regulated, the proportion of methylene bridge and methylene bridge is balanced, the crosslinking density and carbon layer regularity are considered, the hard carbon interlayer spacing and microcrystalline size are directionally optimized, the defects of single crosslinking agent such as "insufficient interlayer spacing" or "excessive disorder" are avoided, the obtained hard carbon interlayer spacing is suitable for rapid deintercalation of sodium ions, the microcrystalline size considers the capacity and cycle stability, the interface side reaction is greatly reduced, and the comprehensive performance of the battery material is improved.

The invention discloses a preparation method of methylene methanedisulfonate, which comprises the following steps: taking methanedisulfonic acid and paraformaldehyde as raw materials, carrying out condensation reaction in an aprotic organic solvent in the presence of a catalyst, and after the reaction is finished, carrying out post-treatment to obtain the methylene methanedisulfonate, continuously removing the generated water in the reaction process; the catalyst is selected from Lewis acid, Bronsted acid or a compound thereof. Through the synergistic effect of the specific catalyst and efficient dehydration, methylene bridged bond formation is efficiently promoted, forward reaction is promoted, meanwhile, side reactions such as decomposition of raw materials and products are effectively inhibited, and the method has the advantages of being mild in reaction condition, few in by-products, high in yield, good in product purity and few in three wastes, and is suitable for industrial production.

The invention relates to a process for preparing a key intermediate of Formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of Formula (II) with a thionating reagent to create an S-substituted thioisoxazole of Formula (III); and combining the S-substituted thioisoxazole of Formula (III) with a pyrazole of the Formula (IV) by introducing a methylene bridge, to obtain a compound of Formula (I). The invention also relates to novel S-substituted thioisoxazole of Formula (III) and processes of preparation thereof, wherein L is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable thionating reagent: dimethyl thioformamide, thiosulfate salts, dithiooxamide, alkyl xanthate salts, thiobenzamide, V-substituted thiourea and thioacetate salts.

Indol[3,2-b]carbazole dimer derivative and preparation method and application thereof, belong to medical technology field, the structural general formula of indol[3,2-b]carbazole dimer derivative is one of following structures, the present application provides a kind of method for improving the oxidation or the method of derivative after oxidation to indol[3,2-b]carbazole dimer, obtain the synthesis method of methylene bridge modified indol[3,2-b]carbazole dimer derivative.Indol[3,2-b]carbazole dimer derivative has fixed cavity and rich π electron system, not only can be loaded with the drug of larger molecular size, improve the lipophilic partition coefficient of drug, and it has good ultraviolet absorption and fluorescence color performance, form strong fluorescence and rigid fixed dimer compound, widely potential use, such as drug diagnostic reagent, ion fluorescence sensing, drug molecule carrier and biological macromolecule recognition etc.

The present invention relates to a process for the preparation of a key intermediate of formula (I) in the synthesis of pyroxasulfone. The process comprises reacting an isoxazole of formula (II) with a sulfurizing reagent to produce an S-substituted thioisoxazole of formula (III); and coupling the S-substituted thioisoxazole of formula (III) with a pyrazole of formula (IV) by introduction of a methylene bridge to obtain a compound of formula (I). The present invention also relates to novel S-substituted thioisoxazoles of formula (III) wherein L1 is halogen or an anionic residue derived from an acid; R is an organic residue derived from a suitable sulfurizing reagent selected from dimethylthiocarbamide, thiosulfate, dithiooxamide, alkyl xanthate, thiobenzamide, N-substituted thiourea and thioacetate, and processes for their preparation.

The invention provides a mono-titanocene complex as well as a preparation method and application thereof. According to the mono-titanocene complex, methylene bridged diarylboronic acid is adopted as an auxiliary ligand, the electrophilicity of titanium metal is improved through the strong electron withdrawing effect of boron oxygen, coordination insertion of styrene monomers is facilitated, and then the chain growth rate is increased. Meanwhile, through the steric effect of an auxiliary ligand of methylene bridged diarylboronic acid, a catalytic active center can be stabilized and a chain transfer reaction can be inhibited, so that high-molecular-weight syndiotactic polystyrene can be prepared with high activity and can catalyze syndiotactic polymerization of styrene with high activity. Tests show that the mono-titanocene complex provided by the invention is used as a catalyst, the activity is high, and the ash content of a product is as low as 18 ppm.