248 results about "Computer modelling" patented technology

Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer(s) as the first stereoisomer of LNA modified oligonucleotides. Modelling clearly indicated the xylo-LNA monomers to be locked in an N-type furanose conformation. Whereas the parent 2′-deoxy-β-D-xylofuranosyl nucleosides were shown to adopt mainly an N-type furanose conformation, the furanose ring of the 2′-deoxy-β-D-xylofuranosyl monomers present in xylo-DNA were shown by conformational analysis and computer modelling to prefer an S-type conformation thereby minimising steric repulsion between the nucleobase and the 3′-O-phopshate group (Seela, F.; Wömer, Rosemeyer, H. Helv. Chem. Acta 1994, 77, 883). As no report on the hybridisation properties and binding mode of xylo-configurated oligonucleotides in an RNA context was believed to exist, it was the aim to synthesise 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer and to study the thermal stability of oligonucleotides comprising this monomer. The results showed that fully modified or almost fully modified Xylo-LNA is useful for high-affinity targeting of complementary nucleic acids. When taking into consideration the inverted stereochemistry at C-3′ this is a surprising fact. It is likely that Xylo-LNA monomers, in a sequence context of Xylo-DNA monomers, should have an affinity-increasing effect.

A method and apparatus for automatically generating a three-dimensional computer model from a “point cloud” of a scene produced by a laser radar (LIDAR) system. Given a point cloud of an indoor or outdoor scene, the method extracts certain structures from the imaged scene, i.e., ceiling, floor, furniture, rooftops, ground, and the like, and models these structures with planes and/or prismatic structures to achieve a three-dimensional computer model of the scene. The method may then add photographic and/or synthetic texturing to the model to achieve a realistic model.

A method for estimating the CCS for a rock in the depth of cut zone of a subterranean formation which is to be drilled using a drilling fluid is disclosed. An UCS is determined for a rock in the depth of cut zone. A change in the strength of the rock due to applied stresses imposed on the rock during drilling is calculated which includes estimating the ΔPP. The CCS for the rock in the depth of cut zone is calculated by adding the estimated change in strength to the UCS. The present invention calculates the ΔPP in accordance with Skempton theory where impermeable rock or soil has a change in pore volume due to applied loads or stresses while fluid flow into and out of the rock or soil is substantially non-existent. CCS may be calculated for deviated wellbores and to account for factors such as wellbore profile, stress raisers, bore diameter, and mud weight utilizing correction factors derived using computer modeling and using a baseline formula for determining an uncorrected value for CCS.

Method for evaluating cement integrity in a cased well environment using a logging tool that has a neutron source and one or more neutron or gamma ray detectors. Neutron porosity logs are obtained from the well before (42) and after (41) casing. This log data along with well dimensions and material composition parameters are the input quantities to a multi-parameter database (43) that is constructed by computer modeling or laboratory experiments to relate volume fraction for fluid filled channels in the cement sheath to the input quantities. The channel volume fraction (45) corresponding to the input quantities is identified or interpolated (44) from the multi-parameter database.

A high-technology method for creating, reproducing, and or precisely fitting custom appendages to topographically complex structures. The method comprises a combination of novel measurement techniques in conjunction with computerized modeling and machining processes applied to achieve a virtually perfect tailored fit with mating structures. The method does not require the physical presence of the mating structure so the modeling and machining operations may be conducted at a separate location based solely on parametric dimensional and/or graphical data inputs and a customized data form Said data may be transmitted conventionally or electronically as by fax or the internet. The invention includes a printed virtual protractor tool (16) for accurately measuring angles. A means for direct digitization of the required topological data input is also provided. The novel aspects of this invention can be combined with conventional fitting equipment and processes. The scope of this invention is exceedingly broad with a variety of potential applications cited. Two examples are presented to illustrate utility in the context of complex operations routinely encounter by gunsmiths in fitting recoil pads (9) to gunstocks (23) and fitting sighting ribs (37) to gun barrels (42).

The present invention provides a performance management system and method for generating a plurality of forecasts for one or more electronic devices. The forecasts are generated from stored performance data and analyzed to determine which devices are likely to experience performance degradation within a predetermined period of time. A single forecast is extracted for further analysis such that computer modeling may be performed upon the performance data to enable the user to predict when device performance will begin to degrade. In one embodiment, graphical displays are created for those devices forecasted to perform at an undesirable level such that suspect devices may be subjected to further analysis.

A method for producing a 3D print fastening piece of a three-layer structure from inside to outside comprises the specific steps that computer modeling and layer-by-layer cutting are carried out; graphs are converted to light beams carrying graph information, a photosensitive drum is charged to obtain electric potential, and an electrostatic latent image is formed through light beam scanning; the electrostatic latent image passes through a magnetic brush and attracts powder to from an internal component, the surface of the internal component is processed, the steps are executed repeatedly to print the intermediate layer and the outer layer, and the surfaces of the intermediate layer and the outer layer are processed. The 3D print fastening piece made through the method has the advantages of being high in manufacturing precision, long in service life, and good in performance.

The invention discloses a method for producing high-strength fasteners in batch by using a 3D (three dimensional) printing technology. The method specifically comprises the following steps: carrying out computer modeling, segmenting layer by layer, converting a graph into a light beam loaded with graph information; charging a photosensitive drum to obtain a potential, scanning by the light beam to form an electro-static latent image; enabling the electro-static latent image to pass through a magnetic brush, absorbing powder to form an internal member; forming the internal member; and carrying out punching cutting and surface treatment. According to the method for producing the fasteners in batch, the production efficiency is high, the accuracy is high, and the obtained fasteners in batch are excellent in performance.

A 3D printing production method of a coated fastener particularly includes the steps that computer modeling and layer-by-layer segmentation are conducted; graphs are converted into light beams with graphic information; photosensitive drums are charged to acquire electric potential, and static latent images are formed through light beam scanning; the static latent images adsorb powder to form internal components through a magnetic brush; the surfaces of the internal components are processed; coating is conducted; a coated layer is processed. The fastener produced through the 3D printing production method has the advantages of being high in production accuracy and excellent in anti-corrosion performance.

Subsurface reservoir properties are predicted despite limited availability of well log and multiple seismic attribute data. The prediction is achieved by computer modeling with least square regression based on a support vector machine methodology. The computer modeling includes supervised computerized data training, cross-validation and kernel selection and parameter optimization of the support vector machine. An attributes selection technique based on cross-correlation is adopted to select most appropriate attributes used for the computerized training and prediction in the support vector machine

The invention discloses a method for monitoring mountain landslide and debris flow in mountainous areas based on an unmanned aerial vehicle. The method is characterized in that photographing is carried out through directional cruising of the unmanned aerial vehicle and an imaging device and a positioning device which are carried by the unmanned aerial vehicle, and collected data is analyzed through computer software so as to work out an accurate rescue mode and a path method in allusion to mountain landslide and debris flow in the mountainous areas. The method disclosed by the invention can accurately judge the damage area of a region in which mountain landslide or debris flow occurs through applying unmanned aerial vehicle remote sensing technologies to the field of mountainous area sudden accident rescue, and seamless searching is carried out by means of the unmanned aerial vehicle through computer modeling and planning, thereby monitoring damage conditions of the affected region quickly and comprehensively, transmitting information to a rescue command center timely, being convenient for rescue workers to plan an accurate rescue path timely, and greatly improving the rescue efficiency; and the method is applicable to detection work for affected mountainous areas under various complex conditions.

The invention relates to a preparation method of a mask for accurate repair and care, and belongs to the technical field of beauty cosmetics. The method comprises the following steps that 1, a facial skin image is obtained through a facial imaging device, a three-dimensional (3D) facial shape image is constructed, and meanwhile analysis and data collection are conducted on the facial skin type and state, target positions, unusual conditions and the like, and a 3D facial skin state data packet is constructed; 2, computer modeling is conducted according to the facial morphology and state data, a mold is printed through a 3D printing technology, and a mask substrate is prepared through the mold; 3, ingredients with corresponding repair and care effectiveness are precisely sprayed on corresponding positions of the mask substrate according to the skin state data packet, rapid vacuum drying is conducted, and a dry mask which has the effectiveness and is precisely distributed is obtained; 4, a wetting penetrating fluid is prepared and packed separately and matched with the dry mask to be applied to a user. The mask prepared through the method has the shape capable of being well attached to the face, and meanwhile the mask has the advantages of achieving personalized accurate care and fixed-point facial drug administration.

Computer modeling of interactions between and among cortico and subcortical areas of the human brain, for example in a normal and a pathological state resembling schizophrenia which pathological state has inputs representing the effects of a drug(s), for the purpose of using the outputs to predict the effect of drugs in psychiatric and cognitive diseases. A method is provided for developing a computer model of interactions between and among cortico and subcortical areas of the human brain which comprises the steps of identifying data relating to a biological state of a generic synapse model, the striatum, Locus Coeruleus, Dorsal raphe, hippocampus, amygdala and cortex; identifying biological processes related to the data, these identified biological processes defining at least one portion of the biological state of the generic synapse model, the striatum, Locus Coeruleus, Dorsal raphe, hippocampus, amygdala, and cortex; and combining the biological processes to form a simulation of the biological state of interactions between and among cortico and subcortical areas of the human brain. Diseases that can be modeled include psychiatric disorders, such as schizophrenia, bipolar disorder, major depression, ADHD, autism, obsessive-compulsive disorder, substance abuse and cognitive deficits therein and neurological disorders such as Alzheimer's disease, Mild Cognitive impairment, Parkinson's disease, stroke, vascular dementia, Huntington's disease, epilepsy and Down syndrome. A resulting computer model is of the biological state of interactions between and among cortico and subcortical areas of the human brain, comprising code to define the biological processes related to the biological state of the generic synapse model, the striatum, Locus Coeruleus, Dorsal raphe, hippocampus, amygdala and cortex, and code to define the mathematical relationships related to interactions among biological variables associated with the biological processes. At least two of the biological processes are associated with the mathematical relationships. A combination of the code to define the biological processes and the code to define the mathematical relationships define a simulation of the biological state of the interactions between and among cortico and subcortical areas of the human brain. Computer executable software code is provided comprised of code to define biological processes related to a biological state of interactions between and among cortico and subcortical areas of the human brain including code to define mathematical relations associated with the biological processes. A computer model of interactions between and among cortico and subcortical areas of the human brain is provided, comprising a computer-readable memory storing codes and a processor coupled to the computer-readable memory, the processor configured to execute the codes. The memory comprises code to define biological processes related to the biological state of interactions between and among cortico and subcortical areas of the human brain, and code to define mathematical relationships related to interactions among biological variables associated with the biological processes.

Methods and systems for interfacing computer modeled design and manufacture data from an Manufacturing Process Planning (MPP) system to peripheral computer systems, via an integration server interface, that resolves data transfer format conflicts between the MPP system and the peripheral systems and facilitates the use of predetermined data standards of a business entity to be universally used despite incongruous computer systems.

The present invention concerns a method for determining optimised parameters for mechanical ventilation, MV, of a subject, comprising: a) obtaining data concerning a three-dimensional image of the subject's respiratory system; b) calculating a specific three-dimensional structural model of the subject's lung structure from the image data obtained in step a); c) calculating a specific three-dimensional structural model of the subject's airway structure from the image data obtained in step a); d) calculating a patient-specific three-dimensional structural model of the subject's lobar structure from the lung model obtained in step b); e) modeling by a computer, the air flow through the airway, using the models of the airway and lobar structure of the subject obtained in steps c) and d) at defined MV parameters; f) modeling by a computer, the structural behavior of the airway and the interaction with the flow, using the models of the airway and lobar structure of the subject obtained in steps b) and c) at defined MV parameters; g) determining the MV parameters which lead to a decrease in airway resistance and hence an increase in lobar mass flow for the same driving pressures according to the model of step d), thereby obtaining optimized MV parameters. It also relates to a method for assessing the efficacy of a treatment for a respiratory condition.

The invention relates to a construction method for manufacturing a multi-pipe intersecting steel pipe component and belongs to the technical field of steel structure manufacturing. The construction method is characterized in that: 1) intersecting lines are drawn by adopting three-dimensional AutoCAD modeling and circumference bisecting tessellation line methods, thereby filling the blank that most intersecting line software in markets cannot solve the problems of complicated intersecting line forms that the axes of multi-pipe intersecting and intersecting steel pipes are not intersected on one point, the steep pipe is intersected with a steel plate and the like; 2) a sample figure is printed in a ratio of 1 to 1 instead of a conventional manual lofting method ; 3) relative space relations among cross lines of a main pipe and branch pipes are found out by a computer, a method combining projection, space angles and characteristic points and lines is used as a method for positioning manufacturing spaces, so that a great amount of investment in high-precision measurement instruments is saved, and the method is the low-cost, high-efficiency and high-precision method for measuring and positioning the spaces; and 4) a welding method is adopted for welding lines of large-diameter and small-angle intersecting lines by combining internal and external groove welding and internal and external welding, so the problem that the welding lines of the roots of the intersecting lines cannot be fully welded is solved.

Described is a dynamic emergency exit sign comprising one or more pictograms and at least one light source for accentuating one or more of the one or more pictograms either singly or in combination, wherein at least one light source is controlled by signals from evacuation computer modelling software to assist occupants egress in emergency or other critical situations.