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Compound traditional Chinese medicine extract, as well as preparation method and application thereof

An extract and compound technology, applied in the field of traditional Chinese medicine compound extracts, can solve the problems of not considering the extraction of active ingredients, poor taste, waste of medicinal resources, etc.

Active Publication Date: 2014-12-03
BEIJING HANDIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above method is only a simple preparation method of traditional Chinese medicine decoction, and does not consider how to fully extract the active ingredients in the medicine, which causes a serious waste of medicinal material resources, but the medicinal effect is not significant; at the same time, the water decoction brings a large dosage and poor taste , inconvenient to carry, not suitable for long-term storage

Method used

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  • Compound traditional Chinese medicine extract, as well as preparation method and application thereof
  • Compound traditional Chinese medicine extract, as well as preparation method and application thereof
  • Compound traditional Chinese medicine extract, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1 A preparation method of Chinese medicine compound extract and the prepared Chinese medicine compound extract

[0078] API prescription:

[0079] Astragalus 6kg, Ligustrum lucidum 3kg, Motherwort 3kg, Black plum 1.8kg, Coptis 1.2kg, Cinnamon 0.2kg, Budisma 1.2kg

[0080] The concrete steps of described preparation method are as follows:

[0081] (1) Prepare various medicinal materials according to the prescription.

[0082] (2) Add water 10 times the weight of medicinal materials to cinnamon, extract the volatile oil by steam distillation, collect the distilled aqueous solution in another device, and use the dregs for later use; add 2 times the volume of absolute ethanol to dissolve the volatile oil; take 10 times the volume of the volatile oil β-cyclodextrin, an aqueous solution of β-cyclodextrin made by adding water 25 times the weight of β-cyclodextrin; at a speed of 150 rpm, slowly add volatile oil ethanol to the aqueous solution of β-cyclodextrin, Af...

Embodiment 2

[0088] Example 2 A preparation method of Chinese medicine compound extract and the prepared Chinese medicine compound extract

[0089] API prescription:

[0090] Astragalus 6kg, Ligustrum lucidum 3kg, Motherwort 3kg, Black plum 1.8kg, Coptis 1.2kg, Cinnamon 0.2kg, Budisma 1.2kg

[0091] The concrete steps of described preparation method are as follows:

[0092] (1) Prepare various medicinal materials according to the prescription.

[0093] (2) Add water 8 times the weight of the medicinal material to cinnamon, extract the volatile oil by steam distillation, collect the distilled aqueous solution in another device, and use the dregs for later use; add 1 times the volume of absolute ethanol to dissolve the volatile oil, and take 6 times the volume of β of the volatile oil -Cyclodextrin, add β-cyclodextrin aqueous solution made by adding 15 times the weight of β-cyclodextrin water; at a speed of 150 rpm, slowly add volatile oil ethanol solution to the β-cyclodextrin aqueous ...

Embodiment 3

[0099] Example 3 A preparation method of Chinese medicine compound extract and the prepared Chinese medicine compound extract

[0100] API prescription:

[0101] Astragalus 6kg, Ligustrum lucidum 3kg, Motherwort 3kg, Black plum 1.8kg, Coptis 1.2kg, Cinnamon 0.2kg, Budisma 1.2kg

[0102] The concrete steps of described preparation method are as follows:

[0103] (1) Prepare various medicinal materials according to the prescription.

[0104] (2) Add cinnamon with 12 times the weight of the medicinal material, extract the volatile oil by steam distillation, collect the distilled aqueous solution in another device, and use the dregs for later use; add 3 times the volume of absolute ethanol to dissolve the volatile oil, and take 20 times the volume of β of the volatile oil -cyclodextrin, add β-cyclodextrin aqueous solution made of water 40 times the weight of β-cyclodextrin; at a speed of 150 rpm, slowly add volatile oil ethanol solution to the β-cyclodextrin aqueous solution,...

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Abstract

The invention provides a traditional Chinese medicine extract and a preparation method thereof. The compound traditional Chinese medicine extract is prepared from the following raw medicinal materials in parts by weight: 30-60 parts of astragalus membranaceus, 9-15 parts of glossy privet fruit, 9-30 parts of herba leonuri, 3-10 parts of fructus mume, 2-9 parts of coptis chinensis, 1-5 parts of cinnamon and 3-9 parts of butterflybush flower. The preparation method comprises the following steps: extracting volatile oil from cinnamon, and including the volatile oil by beta-cyclodextrin; extracting the cinnamon residue, astragalus membranaceus, glossy privet fruit, butterflybush flower and fructus mume by an ethanol solution I, and refining by means of macroporous adsorption resin to prepare dried extract powder 1; extracting the coptis chinensis and herba leonuri by an ethanol solution III, and refining by ion-exchange resin to prepare dried extract powder 2; and uniformly mixing the dried extract powder 1, the dried extract powder 2 and the volatile oil inclusion compound to obtain the compound traditional Chinese medicine extract. The preparation method is capable of remarkably improving the bioactive substance content and the pharmacologic action of the compound traditional Chinese medicine extract.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of a Chinese medicine compound extract for diabetic retinopathy, and the prepared Chinese medicine compound extract and its application. Background technique [0002] Diabetic Retinopathy (DR) is one of the serious and common eye complications of diabetes. With the prolongation of the duration of diabetes, the incidence of DR also increased. The incidence of diabetic retinopathy is about 50% in those with a course of more than 8 years. The early symptoms of the disease are not obvious and are easy to be ignored. In the late stage, there is no effective control method, and the disease is lingering and intractable. If the disease is not treated, the consequences are serious, and it is the main cause of adult blindness, with a blinding rate of 8-12%, which has a serious adverse effect on the quality of life of the affected population. ...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K47/48A61P3/10A61P9/10
Inventor 林德良
Owner BEIJING HANDIAN PHARMA CO LTD
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