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Preparation method of medicine capable of moistening dryness and relieving itching

A medicine and dryness-moistening technology, which is applied in the field of preparation of dryness-moistening and antipruritic compositions, can solve the problems of low quality standards, large doses, and ineffective control of product quality, and achieve the effects of increasing compliance and reducing oral doses

Inactive Publication Date: 2019-12-20
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although Runzao Zhiyang Capsules are widely used clinically and have achieved good therapeutic effects, the product has primitive extraction methods of some medicinal materials, undetailed process parameters, large dosage, low quality standards, and poor product quality. Disadvantages such as effective control

Method used

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  • Preparation method of medicine capable of moistening dryness and relieving itching
  • Preparation method of medicine capable of moistening dryness and relieving itching
  • Preparation method of medicine capable of moistening dryness and relieving itching

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0404] Take Radix Polygoni Multiflori, Radix Polygoni Multiflori, add 3 times the amount of water and ß-CD equivalent to 5% of the extracted medicinal materials, dissolve in the soaking solution, soak for 3 hours, then add 3 times the amount of water to reflux for 1.5 hours, the second and third times Add 6 times the amount of water and 5% ß-CD to each extraction, each time for 1.5h, the extract is concentrated to a thick paste with a relative density of 1.10 (60°C), and the feed rate is 10-15ml / min, the inlet air temperature Spray-dry under the condition of 185℃~195℃, and set aside.

[0405] Add 10 times the amount of water to soak the other four medicinal materials such as raw land and mulberry leaves for 3 hours, decoct for 1.5 hours, and filter; add 10 times the amount of water for the second and third extractions, decoct for 1.5 hours, filter, and extract Concentrate to a clear paste with a relative density of 1.10 (60°C), spray-dry, feed at a rate of 10ml / min, and enter ...

Embodiment 2

[0407] Take Radix Polygoni Multiflori, Polygonum Polygoni Multiflori, add 3 times the amount of water and ß-CD equivalent to 5% of the amount of extracted medicinal materials and dissolve it in the soaking solution. After soaking for 3 hours, add 7 times the amount of water to reflux and extract for 1.5 hours. The second and third times Add 10 times the amount of water and 5% ß-CD to each extraction, each time for 1.5h, the extract is concentrated to a thick paste with a relative density of 1.15 (60°C), spray-dried, and the feed rate during spray-drying is 10-15ml / min, the inlet air temperature is 185℃~195℃, and it is reserved.

[0408] Add 10 times the amount of water to soak the other four medicinal materials such as raw land and mulberry leaves for 3 hours, decoct for 1.5 hours, and filter; add 10 times the amount of water for the second and third extractions, decoct for 1.5 hours, filter, and extract Concentrate to a clear paste with a relative density of 1.15 (60°C), and...

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Abstract

The invention discloses a preparation method of a medicine capable of moistening dryness and relieving itching. The raw materials of the medicine consist of traditional Chinese medicine materials of 50-300 parts of prepared polygonum multiflorum root tubers, 80-350 parts of polygonum multiflorum root tubers, 300-500 parts of unprepared rehmannia glutinosa root tubers, 80-350 parts of sophora flavescens roots, 80-350 parts of morus alba leaves and 50-200 parts of laportea bulbifera herbs. The preparation method comprises the steps of (1) taking the polygonum multiflorum root tubers, the prepared polygonum multiflorum root tubers and beta-CD, enabling the polygonum multiflorum root tubers, the prepared polygonum multiflorum root tubers and the beta-CD to dissolve in water, performing soaking, performing reflux extraction, performing concentrating to obtain an extracting solution, and performing spray drying to obtain spray dried powder 1 for standby application; and (2) adding water to the remaining four medicinal materials of the unprepared rehmannia glutinosa root tubers, the morus alba leaves and the like, performing soaking, performing decoction, performing filtration, performingconcentrating to obtain an extracting solution, performing spray drying to obtain spray dried powder 2, uniformly mixing the spray dried powder 2 with the spray dried powder 1 obtained through extraction and concentration of the polygonum multiflorum root tubers and the prepared polygonum multiflorum root tubers, and performing loading into capsules so as to obtain the medicine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine manufacture, and in particular relates to a preparation method of a composition for moistening dryness and relieving itching. Background technique [0002] Senile pruritus is a common and frequently-occurring disease in dermatology. It is more common in the elderly, especially in winter. It brings great trouble to the elderly, seriously affects the physical and mental health of the elderly, and reduces the quality of life. The curative effect of western medicine on the above diseases is average, and it is easy to relapse after stopping the medicine, which has a serious impact on the patient's physiology and psychology. [1] . [0003] Runzao Zhiyang Capsules are developed on the basis of the Miao nationality's proven prescriptions for skin itching, combined with traditional Chinese medicine theory, and are composed of Polygonum multiflorum, Polygonum multiflorum, Rehmannia glutinosa, m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/48A61P17/04A61P17/16
CPCA61K9/4808A61K36/185A61K36/489A61K36/605A61K36/704A61K36/804A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P17/04A61P17/16A61K2300/00
Inventor 孙宜春李慧馨漆正方庞媛媛夏欢张建锋谢隼邹良梅
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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