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Weight-losing capsule based on biodegradable stent material

A technology of scaffold materials and degradable materials, which is applied in the field of weight-loss capsules based on degradable scaffold materials, can solve the problems of complex use, continuous burden on the stomach, and long residence time, and achieve low difficulty, reduce food intake, and good degradability effect

Inactive Publication Date: 2018-07-06
SHANGHAI TENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the device is complicated to use and stays in the stomach for a long time, which will cause a long-term and continuous burden on the stomach

Method used

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  • Weight-losing capsule based on biodegradable stent material
  • Weight-losing capsule based on biodegradable stent material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Dissolve PCL in a mixed solvent of dichloromethane / N,N-dimethylformamide (ratio 40:60) at a concentration of 6 wt%, and electrospin to form a PCL film. The electrostatic high voltage is 10-15kV, the diameter of the receiving roller is 25cm, the length is 30cm, the receiving distance is 25cm, the flow rate is 3.0mL / h, and the rotational speed of the receiving roller is 100rpm.

[0037] (2) The PCL film obtained in the step (1) was soaked in liquid nitrogen to be brittle, ground 10 times, filtered, and the above steps were repeated 10 times to obtain PCL nanowires. Among them, the brittle fracture temperature of liquid nitrogen was -196°C, the soaking time was 10s, the grinding method was manual grinding in a mortar, and the frequency was 10-20 times, and the filtration was gauze filtration, and the filtering frequency was 2-5 times.

[0038] (3) Disperse the PCL nanowires prepared in step (2) in ethanol / water / gelatin mixed solution, wherein the concentration of gelat...

Embodiment 2

[0041] (1) PCL was dissolved in a mixed solvent of dichloromethane / N,N-dimethylformamide (ratio 50:50) at a concentration of 8 wt%, and electrospun into a PCL film. The electrostatic high voltage is 10-15kV, the diameter of the receiving roller is 25cm, the length is 30cm, the receiving distance is 25cm, the flow rate is 3.0mL / h, and the rotational speed of the receiving roller is 100rpm.

[0042] (2) The PCL film obtained in the step (1) was soaked in liquid nitrogen to be brittle, ground 10 times, filtered, and the above steps were repeated 10 times to obtain PCL nanowires. Among them, the brittle fracture temperature of liquid nitrogen was -196°C, the soaking time was 10s, the grinding method was manual grinding in a mortar, and the frequency was 10-20 times, and the filtration was gauze filtration, and the filtering frequency was 2-5 times.

[0043](3) Disperse the PCL nanowires prepared in step (2) in ethanol / water / gelatin mixed solution, wherein the concentration of gela...

Embodiment 3

[0046] (1) Dissolve PCL in a mixed solvent of dichloromethane / N,N-dimethylformamide (ratio 60:40) at a concentration of 9 wt%, and electrospin to form a PCL film. The electrostatic high voltage is 10-15kV, the diameter of the receiving roller is 25cm, the length is 30cm, the receiving distance is 25cm, the flow rate is 3.0mL / h, and the rotational speed of the receiving roller is 100rpm.

[0047] (2) The PCL film obtained in the step (1) was soaked in liquid nitrogen to be brittle, ground 10 times, filtered, and the above steps were repeated 10 times to obtain PCL nanowires. Among them, the brittle fracture temperature of liquid nitrogen was -196°C, the soaking time was 10s, the grinding method was manual grinding in a mortar, and the frequency was 10-20 times, and the filtration was gauze filtration, and the filtering frequency was 2-5 times.

[0048] (3) Disperse the PCL nanowires prepared in step (2) in ethanol / water / gelatin mixed solution, wherein the gelatin aqueous soluti...

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Abstract

The invention relates to a weight-losing capsule based on a biodegradable stent material. The weight-losing capsule is prepared by coating the biodegradable stent material in a capsule housing. The invention further provides a preparation method and application of the weight-losing capsule. The advantage of the weight-losing capsule is expressed as follows: spinning a biodegradable material by using the electrostatic spinning, performing brittle failure by liquid nitrogen, grinding to be a thread, dispersing, forming by thermal induction, and improving the thermal induction forming ability thereof by using gelatin; exchanging solvents, and preparing the biodegradable stent material after freeze-drying; and extruding the material to be a minimum volume, and coating in the capsule housing toprepare the weight-losing capsule. After the weight-losing capsule is administered, the capsule housing is corroded and broken in the stomach, the internal biodegradable stent material is rapidly expanded after absorbing water, and a partial space in the stomach is occupied, thereby the food acceptable daily intake is reduced, and the effect of dieting and losing weight is achieved.

Description

technical field [0001] The invention relates to the technical field of weight-loss capsules, in particular to a weight-loss capsule based on a degradable scaffold material. Background technique [0002] "Obesity" is a world-wide disease that endangers health, and is known as the three major killers of human health together with smoking and AIDS. With the improvement of people's living standards, the acceleration of the pace of life and the change of diet structure, obesity is a serious epidemic situation in the world. It has been identified as an important disease by WHO and listed as an important public health problem worldwide. [0003] Weight loss needs to follow the principle of "eat less and move more", that is, reduce intake and increase energy consumption. While ensuring the normal intake of nutrients needed by the human body and reasonable exercise, the patient's bad eating habits must be corrected. Nowadays, there are a variety of weight-loss drugs on the market. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/34A61K47/42A61P3/04A61L31/14A61L31/04A61L31/06D04H1/435D01D5/00A23L33/00A23P10/30
CPCA23V2002/00A61K9/4866A61L31/045A61L31/06A61L31/146A61L31/148A23L33/00A23P10/30D01D5/003D01D5/0061D01D5/0076D01D5/0092D04H1/435C08L67/04A23V2200/332
Inventor 隋晓锋曲伸成欢肖咏梅尤慧张超卜乐
Owner SHANGHAI TENTH PEOPLES HOSPITAL
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