Anti-cancer analgetic preparation

The technology of a kind of preparation, aconitine, is applied in the field of anti-cancer analgesic preparations, which can solve the problems of no anti-tumor drug resistance effect, achieve the effects of difficult recovery of blood supply, reduce economic burden, and overcome the number of medications

Inactive Publication Date: 2005-10-19
刘宝虎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have no obvious anti-tumor drug resistance effect in clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Weigh the raw materials according to the following proportioning relationship:

[0055] Aconitine 6.0mg Aldehyde Vinblastine 0.33mg 40% Lipiodol 2.0ml

[0056] Polyvinylpyrrolidone (Povidone) 2.0g appropriate amount of water for injection (total amount is 5ml).

[0057] Preparation method: take povidone, add water, heat to dissolve, set up a high-speed milk homogenizer to homogenize, add iodized oil one by one and continue to stir evenly, add aconitine and aldehyde vinblastine step by step, stir evenly, and fill and sterilize. Can.

Embodiment 2

[0059] Weigh the raw materials according to the following proportioning relationship:

[0060] Aconitine 6.0mg Aldehyde Vinblastine 0.33mg 40% Lipiodol 4.6ml

[0061] Appropriate amount of water for injection (total amount made 5ml).

[0062] Preparation method: take aconitine and vinblastine, dissolve in water, put them in a high-speed milk homogenizer, add iodized oil one by one, stir evenly, filter, and sterilize by filling.

Embodiment 3

[0064] Weigh the raw materials according to the following proportioning relationship:

[0065] Aconitine 6.0mg Aldehyde Vinblastine 0.33mg 40% Lipiodol 2.5ml

[0066] Polyethylene glycol-600 2.0ml appropriate amount of water for injection (total amount is 5ml).

[0067] Preparation method: take aconitine and aldehyde vinblastine, dissolve in water, add polyethylene glycol-600 to heat, stir evenly, add iodized oil one by one, stir well, filter, fill and sterilize while hot; .

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PUM

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Abstract

The anticancer analgetic preparation has lappaconitine and vincristine as main active anticancer components. Lappaconitine has the effect of increasing the sensitivity of vincristine in killing cancer cell, so that the preparation of the present invention can reverse the drug resistance of tumor. The present invention has obvious functions of resisting liver cancer, lung cancer, cancer of uterus and breast cancer, stopping pain, etc. and has the feature of less recovery of the blood supply to embolized tumor artery. Compared with similar medicines, the present invention has the advantages of less side effect, high tumor cell killing effect, high stability, low cost, etc.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to an anticancer analgesic preparation. Background technique [0002] Multidrug resistance (MDR) of tumor cells refers to the cross-resistance of tumor cells to drugs with different structures and functions at the same time as tumor cells are resistant to one anti-tumor drug. In recent years, literature reports have confirmed that a variety of traditional Chinese medicine ingredients have the tumor-reversing activity of MDR, and the screening is based on the fact that malignant tumors are always closely related to phlegm and blood stasis in the process of occurrence and progression. However, these drugs have no obvious anti-tumor drug resistance in clinical application. Therefore, it is of great significance to screen out suitable tumor multidrug resistance reversal agents. SUMMARY OF THE INVENTION [0003] The purpose of the present invention is to study the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/475A61P25/04A61P29/00A61P35/00
Inventor 江立富
Owner 刘宝虎
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