66results about How to "Increase spleen index" patented technology

The invention discloses a use of butenolide I for preparing drugs for controlling immunological liver injury. With the present invention, the butenolide I can reduce levels of TNF-alpha and NO, wherein the TNF-alpha and the NO play important roles in a pathogenic process of the immunological liver injury; the butenolide I can reduce elevated levels of the NO and the iNOS in liver homogenates of immunological liver injury mice so as to decrease the liver injury induced by the NO; the butenolide I can inhibit a overexpression of the TNF-alpha so as to decrease the direct liver injury or the indirect liver injury induced by the TNF-alpha. In addition, the use of the butenolide I as the drug for controlling the immunological liver injury has advantages of convenient preparation, extensive sources, low price and high safety, and has good development and application prospect.

The invention relates to traditional Chinese medicine compound polysaccharide with a function of synergistically enhancing humoral and cellular immunity. The traditional Chinese medicine compound polysaccharide comprises the following components in parts by mass: 25 parts of lentinan, 50 parts of astragalus polysaccharide and 125 parts of odonopsis pilosula polysaccharide. The optimal dosage of the traditional Chinese medicine compound polysaccharide for oral administration of a mouse is 1 g per kilogram of body weight per day, and the mouse is continuously dosed for 7-10 days; the optimal dosage of the traditional Chinese medicine compound polysaccharide of a pig is 0.111 g per kilogram of body weight per day, and the pig is continuously dosed for 14-21 days. The three polysaccharides are scientifically and reasonably matched and combined to generate complementary and synergetic enhancement functions, the formed polysaccharide composition can comprehensively recover and enhance the immunity of organism, thereby having an obvious immunity enhancement effect, and the components of the traditional Chinese medicine compound polysaccharide are common raw medicinal materials, thereby being good in safety and free of toxic side effect.

The invention discloses an environmentally-friendly compound Chinese herbal medicinal feed additive for enhancing the immunities of broilers, and an application thereof, and belongs to the technical field of animal feed additives. The bulk drugs of the additive comprise Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos, hyacinth bean, medicated leaven, hawthorn fruit and malt. The additive is prepared through drying the bulk drugs at 50-60DEG C, crushing, sieving, and mixing 29-31g of Radix Astragali, 29-31g of Radix Codonopsis, 29-31g of Rhizoma Atractylodis Macrocephalae, 29-31g of Poria cocos, 29-31g of hyacinth bean, 14-16g of medicated leaven, 14-16g of hawthorn fruit and 14-16g of malt The prepared additive is added to a mixed broiler feed according to a mass percentage of 0.5-1.5% to obtain a mixture for use in order to substantially reduce the feed conversion ratio and increase the spleen index, the thymus index and the index of bursa of Fabricius.

The invention belongs to the technical field of feed compositions and relates to growing-period feed capable of promoting the development of digestive organs of laying hens and a preparation method. The growing-period feed is mainly prepared from the following raw materials in parts by weight: 45 to 60 parts of cereal, 8 to 15 parts of soybean meal, 1 to 8 parts of miscellaneous meal, 6 to 15 parts of bran, 3 to 8 parts of pomace, 2 parts of evening primrose meal, 0.8 to 1.5 parts of mountain flour, 0.8 to 1.5 parts of calcium hydrogen phosphate, 0.35 to 0.43 part of amino acid, 0.5 to 15 parts of vegetable oil, 1 part of compound premix, 0.05 to 0.2 part of prebiotics, 0.01 to 0.05 part of zinc methionine, 0.05 to 0.2 part of hydrolyzed tannic acid, 0.05 to 0.08 part of a compound enzyme preparation, 0.02 to 0.1 part of a mycotoxin adsorbent, 0.04 to 0.2 part of a mycotoxin degradation enzyme, 0.1 to 0.5 part of yeast hydrolysate and 1 to 5 parts of dietary fiber. By adopting the growing-period feed, indexes of all the digestive organs at a growing period of the laying hens are improved to different degrees.

The present invention discloses a fermented feed containing humic acid chelated trace elements. Bacterium strains are inoculated into a fermentation medium containing the humic acid chelated trace elements and the mixture is fermented to obtain the fermented feed containing the humic acid chelated trace elements. The fermentation medium is composed of fermentation materials and water. The raw materials of the fermentation materials consist of 10-20 parts of soybean meal, 20-45 parts of bran, 5-10 parts of humic acids, 40-50 parts of stone powder, 5-10 parts of chloranthus fortunei, 5-10 parts of chloranthus japonicus, 4-8 parts of apocynum venetum leaves, 4-8 parts of conyza blinii, 4-8 parts of folium microcotis and 0.7-1.4 parts of the humic acid chelated trace elements. The present invention also discloses a preparation method of the fermented feed. The fermented feed is prepared by the chelation of the humic acids and trace elements, helps alleviate the problems of resource wastes and environmental pollutions caused by the additions of the inorganic trace elements, and solves the problems that the amino acid trace element chelate is high in production costs and not conducive to wide uses.

The invention discloses a traditional Chinese medical composition for prevention and control of avian influenza and a preparation method thereof. The traditional Chinese medical composition is prepared with astragali, couch grass roots and licorice according to a ratio, and can be applied to improve the immunity. Moreover, the traditional Chinese medical composition has significant effects on prevention and control of the avian influenza and can be widely applied in animals.

The invention discloses an active polypeptide with an antagonistic chemotactic factor receptor CCR5, which has an amino acid sequence in SEQ ID NO:1 or an amino acid sequence obtained by carrying out deletion, addition, insertion and substitution of one or more amino acid residues on the amino acid sequence in SEQ ID NO:1. The invention also discloses a preparation method of the polypeptide, which comprises the following steps of: searching related protein sequences in a database; carrying out multiple alignment comparative analysis to screen out a highly conservative region for combination of a vMIP-II receptor; eliminating interference of unrelated residues through analysis simulation means; determining a target peptide sequence; synthetizing the active polypeptide by a solid-phase synthesis method; and finally testing the bioactivity of the polypeptide. The polypeptide can be used as a CCR5 receptor antagonist for the development of an anti-inflammatory drug, can be used as a lead drug for treating AIDS (Acquired Immune Deficiency Syndrome) and can also be used as a medicament with the immune regulation effect or a medicament for improving the functions of an immune system of an organism.

The invention belongs to the technical field of food, and discloses a black garlic extract and application thereof in preventing and curing breast cancer. It is proved by the cell test that the black garlic extract inhibits growth of breast cancer MD231 cells and T47D cells in a concentration-dependent and time-dependent manner, so that the adhesiveness among cancer cells is enhanced, and the vigor of the cancer cells is reduced; besides, it is proved by the animal test that the black garlic extract can inhibit growth of nude mouse MCF-7 transplanted tumor remarkably, the gross tumor volume is reduced, the thymus index and the spleen index are increased, tumor immunosuppression is avoided, and the black garlic extract has the immunological enhancement effect. Therefore, the black garlic extract can be used for preventing and curing breast cancer, is rich in source and pure-natural, and has important development and application prospects.

The invention provides a medicated diet composition for enhancing immunity. The medicated diet composition comprises, by weight, 60-75 parts of selenium-rich grifola frondosa, 35-45 parts of selenium-rich agaricus blazei murill, 30-40 parts of selenium-rich radix astragali, 2-10 parts of gypenoside and 2-10 parts of glutathione, wherein the selenium contents of the selenium-rich grifola frondosa,the selenium-rich agaricus blazei murill and the selenium-rich radix astragali are greater than 400 ppm. The invention further provides a preparation method of the medicated diet composition. The method is based on water extraction and repeated low-temperature extraction. The medicated diet composition has the advantages that components are reasonably compounded, the formulation is ingenious, andthe composition has the effect of regulating the balance of qi, blood, yin and yang of the human body and enhancing the body immunity. The preparation method has the advantages that through repeated low-temperature extraction, active ingredients can be extracted as many as possible on the premise of ensuring the activity of the active ingredients.

The invention discloses a Zhuang medicine composition assisted in resisting lung cancer. The Zhuang medicine composition is characterized by being prepared from the following Zhuang medicinal materials: Nyarinngoux (Chinese name: baihuasheshecao), Gaeubwnhgauh (Chinese name: baiying), Byaekloekhauj (Chinese name: longkui), Buenqcilienz (Chinese name: banzhilian), Ginghgun (Chinese name: guangxi eshu), Fouxndoengz (Chinese name: shishangbai), Swnjgyaeujhenj (Chinese name: huanghuadaoshuilian), Raggongox (Chinese name: lugen), GO gyauhgujlanz (Chinese name: jiaogulan) and Lozhangoj (Chinese name: luohanguo). The Zhuang medicine composition is combined with chemical drugs for curing lung cancer, can reduce the toxic and side effects of inappetence caused by the chemical drugs, reduce the damage of the chemical drugs to immune organs, increase white blood cell count, blood platelet count, red blood cell count and hemoglobin count to reduce the inhibiting effect on myelosuppression, reduce the content of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase to alleviate the damage to liver functions and increase the tumor suppression function of the chemical drugs. Namely, the Zhuang medicine composition is combined with the chemical drugs for curing the lung cancer and has the effects of toxicity reducing and efficacy enhancing.

The invention discloses a Chinese medicine composite capable of improving immunity. The composite comprises the following components: 30-60% of barbary wolfberry fruit, 10-50% of white atractylodes rhizome, 10-50% of Chinese yam, 10-40% of liquorice and 10-40% of medicated leaven. The composite can be prepared into medicines in the forms of powder, liquid, paste, particles or capsules or a pharmaceutically acceptable physical form. According to the Chinese medicine composite disclosed by the invention, the survive rate can reach 70%, the immunity is effectively improved, and specific to the immune organ indexes, the spleen index is improved by 23.2 percent, the thymus index is improved by 32.4%, and the index of bursa of Fabricius is improved by 41.2%; and especially, in terms of the contents of serum globulins, the content of IgA (immunoglobulin A) is improved by 20.7%, and the content of IgY (immunoglobulin Y) is improved by 23.4%, so that the composite disclosed by the invention can obviously promote specific immunity.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating a porcine reproductive and respiratory syndrome andan application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises saffron crocus, fructus amomi, folium perillae, radix rehmanniae recen, gastrodia elata, ganoderma lucidum polysaccharide, folium artemisiae argyi, a glossy privet fruit, acanthopanax and dandelion. According to the composition, different traditional Chinese medicine ingredientsare matched for use; the traditional Chinese medicine composition is based on enhancement and repairing of a porcine immune system, and has functions of enhancing phagocytosis of mononuclear macrophages, activating lymphocytes, promoting immune response of a body, and enhancing and regulating humoral immunity; based on a combined effect of traditional Chinese medicine active ingredients, the composition directly eliminates reproductive and respiratory syndrome viruses, controls development of viremia, can effectively rise an antibody level of the porcine reproductive at the same time, and respiratory syndrome and enhances porcine immunologic functions and disease resistance.

The invention discloses an application of codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder in preparing medicament for improving immunity of rabbits. According to the application, the codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder accounting for 1-5 percent of the weight of basic ration is added into the basic ration, the basic ration is fed to rabbits, and the rabbit sacculus rotundus index, thymus index, spleen index or dendritic index of a rabbit can be increased, the immunity of the rabbit can be improved, the expression quantity of an antifungal protein gene can be increased, and theoretical direction is provided to the codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder in improving rabbit immunity.

The invention belongs to the technical field of traditional Chinese medicines, and in particular provides a medicament composition for treating cognitive dysfunction. The medicament composition is prepared from the following components in parts by weight by virtue of combination: 10-100 parts of manyinflorescaned sweetvetch root, 8-80 parts of baikal skullcap root, 5-60 parts of root of kirilow rhodiola, 5-60 parts of rhizoma acori graminei and 3-50 parts of earth worm. The invention also provides a preparation method and specific application of the medicament composition. Experiments prove that the medicament composition provided by the invention can significantly improve the learning and memorizing abilities of a vascular dementia rat model and reduce activity of MDA and MAO in hippocampus tissues and serums, and can improve mouse pia mater local microcirculation disorders caused by norepinephrine in different degrees to ensure that micro arteries are expanded, and the blood stream is accelerated; and experimental results show that the medicament composition provided by the invention has an obvious treatment effect on vascular dementia.

The invention relates to a traditional Chinese medicine composition with qi-tonifying and blood-nourishing effects and a preparation method thereof. The traditional Chinese medicine composition is prepared by processing radix codonopsis, radix rehmanniae preparata, radix angelicae sinensis, poria cocos, radix paeoniae alba, rhizoma atractylodis macrocephalae stir-fried with bran, rhizoma chuanxiong and licorice roots. The traditional Chinese medicine composition has the effects of tonifying qi and nourishing the blood and is used for qi-blood deficiency, sallow complexion, inappetence, limb weakness, menometrorrhagia and the like. The traditional Chinese medicine composition does not contain ethyl alcohol and is small in irritation to gastrointestinal tracts and suitable for females not good at drinking, patients who have gastrointestinal ulcers and the like and need to be prohibited from drinking wine and people who have allergy to alcohol for drinking.

The invention provides a composition with an immunity enhancement effect and belongs to the technical field of immunoregulation drugs. The composition comprises garlic lectin, alliin and garlic polysaccharide in a mass ratio being (0.4-0.6):(0.8-1.2):(17-25). The composition can increase a spleen index and a thymus index of immunosuppression mice, increase total white blood cells, a clearance index K and a phagocytic index alpha and ensure content levels of IL-2, TNF-alpha and IFN-gamma in serum to approach to normal levels and has the significant immunity enhancement effect.

The invention provides a novel application of a selaginella extract for resisting the irradiatino-damage, and provides the application of selaginella total-extracts and a selaginella water-fraction for resisting the irradiatino-damage. An experiment shows that the selaginella extract can inhibit the damage on organisms caused by radiation, and prolong the survival time of the organisms; the selaginella water-fraction can obviously inhibit the thymocyte and splenic cell apoptosis of the organisms caused by the radiation. The novel application has the advantages that the inordinate mitotic cycle is regulated, the body immune function is enhanced, and the radioprotection effect on the hemopoietic tissue is realized obviously.