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Medicament composition for treating cognitive dysfunction as well as preparation method and application thereof

A technology for cognitive dysfunction and composition, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc. Ability, blood flow, and immune-boosting effects

Active Publication Date: 2015-04-08
宇特金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned patents have different therapeutic effects on vascular dementia, there are many above-mentioned drugs, and it is difficult to control the impurity content in large-scale industrial production.
In addition, the therapeutic effect of the above-mentioned formula is relatively single, except for vascular dementia, it has no direct therapeutic effect on other diseases.

Method used

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  • Medicament composition for treating cognitive dysfunction as well as preparation method and application thereof
  • Medicament composition for treating cognitive dysfunction as well as preparation method and application thereof
  • Medicament composition for treating cognitive dysfunction as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 10g of Radix Radix Radix Astragali, 8g of Scutellaria Baicalensis, 5g of Rhodiola Rosea, 5g of Shichangpu, and 3g of Earthworm, add 30g of auxiliary materials starch for granulation, 2g of magnesium stearate, 15g of dextrin, and 15g of microcrystalline cellulose, and evenly prepare granules , compressed into tablets to obtain tablets.

Embodiment 2

[0018] Weigh 100g of Radix Radix Radix Astragali, 80g of Scutellaria Baicalensis, 60g of Rhodiola Rosea, 60g of Shichangpu, and 50g of Earthworm, add 350g of auxiliary materials starch for granulation, 30g of magnesium stearate, 150g of dextrin, and 150g of microcrystalline cellulose, and uniformly prepare granules , compressed into tablets to obtain tablets.

Embodiment 3

[0020] Weigh 20g of Radix Radix Astragali, 15g of Scutellaria Baicalensis, 10g of Rhodiola Rosea, 10g of Shichangpu, and 5g of Earthworm, add 60g of auxiliary materials starch for granulation, 5g of magnesium stearate, 30g of dextrin, and 30g of microcrystalline cellulose, and evenly prepare granules , compressed into tablets to obtain tablets.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular provides a medicament composition for treating cognitive dysfunction. The medicament composition is prepared from the following components in parts by weight by virtue of combination: 10-100 parts of manyinflorescaned sweetvetch root, 8-80 parts of baikal skullcap root, 5-60 parts of root of kirilow rhodiola, 5-60 parts of rhizoma acori graminei and 3-50 parts of earth worm. The invention also provides a preparation method and specific application of the medicament composition. Experiments prove that the medicament composition provided by the invention can significantly improve the learning and memorizing abilities of a vascular dementia rat model and reduce activity of MDA and MAO in hippocampus tissues and serums, and can improve mouse pia mater local microcirculation disorders caused by norepinephrine in different degrees to ensure that micro arteries are expanded, and the blood stream is accelerated; and experimental results show that the medicament composition provided by the invention has an obvious treatment effect on vascular dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cognitive dysfunction, in particular to a pharmaceutical composition for treating and alleviating senile dementia or vascular dementia, its preparation method and application, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Dementia refers to chronic acquired progressive mental retardation syndrome, clinically characterized by slow mental decline, accompanied by varying degrees of personality changes, it is a group of clinical syndromes, rather than an independent disease. The onset of dementia is mostly slow and insidious, and its core symptom is mainly memory loss. In the early stage, near memory impairment often occurs, and the ability to learn new things is obviously reduced. With the further development of the disease, the thinking is slow and poor, the understanding and judgment of general things are getting worse and worse, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P25/28A61P9/10A61K35/62
CPCA61K9/2059A61K9/4866A61K35/62A61K36/41A61K36/48A61K36/539A61K36/888A61K2300/00
Inventor 王永炎
Owner 宇特金
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