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New use of spikemoss extract

An extract and new application technology, applied in the new application field of Selaginella extract, can solve problems such as hair loss, immune function decline, and human white blood cell reduction

Active Publication Date: 2008-11-19
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for patients with malignant tumors, high-dose radiation therapy can kill cancer cells, but also lead to serious adverse reactions such as a significant decrease in human white blood cells, decreased immune function, and hair loss. The forced termination of radiotherapy has become a major problem in the clinical treatment of malignant tumors

Method used

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  • New use of spikemoss extract
  • New use of spikemoss extract
  • New use of spikemoss extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: take by weighing fresh Selaginella, put into container after tap water rinses clean, add the water that takes by weighing 10 times of weight of fresh Selaginella in container and decoct after 1.5 hours filter, and filtrate is stand-by, and adds in filter residue Weigh fresh Selaginella 8 times the weight of water and decoct for 1 hour, filter, combine the two filtrates, concentrate at a temperature of 40-50°C and a pressure of 0.09-0.1MPa to obtain the total extract of Selaginella , Finally, the ratio of the total extract of Selaginella is 215-220 g / 1 kg of fresh Selaginella. The prepared Selaginella extract was applied to the biological anti-radiation experiment.

[0022] The effect and experimental situation of the total extract of Selaginella applied in the biological anti-radiation experiment are as follows:

[0023] Forty Kunming (KM) male mice were purchased from the Animal Experiment Center of Henan Province. After 2 days of adaptive feeding, they...

Embodiment 2

[0027] Embodiment 2: Take fresh Selaginella, rinse with tap water, add water decocting for 1.5 hours after weighing 10 times the weight of fresh Selaginella, filter the filtrate for later use, add the weight of fresh Selaginella in the filter residue Decoct with 8 times of water for 1 hour, filter, combine the two filtrates, concentrate at a temperature of 40-50°C and a pressure of 0.09-0.1MPa to obtain an extract. Dissolve the extract with an appropriate amount of water, extract with ether, ethyl acetate and n-butanol in sequence, and dry the remaining part at a temperature of 40-45 ° C and a pressure of 0.1 MPa by using a conventional vacuum drying method. The dry matter of the water part is used for later use. The ratio of finally obtaining the dry matter of the water part of Selaginella is 150 grams / 1 kilogram of fresh Selaginella. The prepared Selaginella extract-water fraction was applied to the study of biological anti-radiation damage.

[0028] Selaginella extract-wa...

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Abstract

The invention provides a novel application of a selaginella extract for resisting the irradiatino-damage, and provides the application of selaginella total-extracts and a selaginella water-fraction for resisting the irradiatino-damage. An experiment shows that the selaginella extract can inhibit the damage on organisms caused by radiation, and prolong the survival time of the organisms; the selaginella water-fraction can obviously inhibit the thymocyte and splenic cell apoptosis of the organisms caused by the radiation. The novel application has the advantages that the inordinate mitotic cycle is regulated, the body immune function is enhanced, and the radioprotection effect on the hemopoietic tissue is realized obviously.

Description

technical field [0001] The invention relates to a new application of the extract of Selaginella chinensis, in particular to the application of the extract of Selaginella selaginella in resisting radiation damage. Background technique [0002] Radiation diagnosis and treatment technology is becoming more and more common in the medical field, and has become an important means of treating tumors. However, for patients with malignant tumors, high-dose radiation therapy can kill cancer cells, but also lead to serious adverse reactions such as a significant decrease in human white blood cells, decreased immune function, and hair loss. The forced termination of radiotherapy has become a major problem in the clinical treatment of malignant tumors. At the same time, with the rapid development of science and technology, more and more ionizing radiation has been integrated into people's daily life, which has brought various damages to the body, such as causing mutations, inducing tumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P17/16A61P35/00
Inventor 郑晓珂冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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