Anti-radiation traditional Chinese medicine composition
A technology of anti-radiation and composition, which is applied in the field of medicine, can solve the problems of high toxic and side effects, unfavorable preventive medication, and high cost, and achieve the effects of low toxic and side effects, good development and application prospects, and reduced content
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Embodiment 1
[0013] Embodiment 1, preparation of anti-radiation Chinese medicine composition and its extract and preparation
[0014]
[0015] Preparation method: Take 11 medicinal materials such as Astragalus membranaceus according to the prescription, grind them into fine powder, add 8 times the amount of ethanol solution with a volume fraction of 70%, reflux extraction for 2 hours, extract twice in total, combine the extracts, filter, and recover the filtrate solvent to a thick paste, and then dried under reduced pressure into powder to obtain the extract powder of the Chinese medicine composition; the extract powder of the obtained Chinese medicine composition and microcrystalline cellulose are mixed in a weight ratio of 2:1, and the volume fraction The soft material is made of 95% ethanol solution, granulated with No. 2 sieve, dried at 60°C, granulated with No. 2 sieve, filled into empty capsules, and made into 1500 capsules to obtain capsules.
Embodiment 2
[0016] Embodiment 2, pharmacodynamic research of anti-radiation Chinese medicine composition
[0017] Get 8-10 weeks old, Kunming mice with a body weight of 18-20g, and randomly divide them into normal control group, radiation model group, high, medium and low dose groups of anti-radiation Chinese medicine composition and positive drug group (Diyu Shengbai Tablets) group or Yixuesheng capsule group), 10 per group. The normal control group and the radiation model group were intragastrically administered normal saline, the anti-radiation traditional Chinese medicine composition high, medium and low dose groups were intragastrically administered the capsule content solution prepared according to prescription 3 in Example 1, and the positive drug group were intragastrically administered the corresponding drug solution. After 7 days, except for the mice in the normal control group, the mice in the other groups were 60 Coγ irradiation, the dose is 5Gy. After irradiation, each gr...
Embodiment 3
[0057] Example 3, Toxicological Research of Anti-radiation Chinese Medicine Composition
[0058] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicines and Natural Medicines", the acute toxicity study of anti-radiation traditional Chinese medicine compositions was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were gavaged with the maximum dosage of the solution of the contents of the anti-radiation Chinese medicine composition capsules prepared according to the prescription 3 of Example 1, once in the morning and evening; brine. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of the anti-radiation traditional Chinese medicine composition administered to mice twice a day was 293.6g / Kg, equiva...
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