32results about How to "Increased superoxide dismutase activity" patented technology

This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists / partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

The invention relates to the technical field of screening and application of functional microorganisms in particular to screening of Bacillus amyloliquefaciens and application thereof in Apostichopus japonicas culture. The Bacillus amyloliquefaciens is collected on 24th December, 2015 in China Center for Type Culture Collection, abbreviated as CCTCC with the address: Wuchang Luojiashan Wuhan University Collection Center, Wuhan, Hubei, is claimed by Ludong University under CCTCC No. M2015774 and is named as Bacillus amyloliquefaciens ZYTC1-1. The Bacillus amyloliquefaciens is screened from healthy intestines of Apostichopus japonicas, has great ability to produce protease and amylase, can improve the activity of amylase in the testiness of Apostichopus japonicas, promote growth of Apostichopus japonicas and improve immunity and disease resistance of Apostichopus japonicas, and is widely applicable to the field of Apostichopus japonicas culture and aquatic feeds.

The invention discloses an anti-radiation traditional Chinese medicine composition which comprises the following components in parts by weight: 160-200 parts of membranous milkvetch root, 110-130 parts of scurfy pea, 80-100 parts of Chinese angelica, 160-200 parts of epimedium, 135-165 parts of madder root, 110-130 parts of glossy privet fruit, 110-130 parts of white paeony root, 110-130 parts ofradix rehmanniae preparata, 80-100 parts of Szechuan lovage rhizome, 215-265 parts of Chinese yam and 35-45 parts of prepared liquoric root. The traditional Chinese medicine composition can increase thymus index and spleen index of a 60Co gamma-radiated mouse and protect immune organs; improve the activity of superoxide dismutase in blood serum and the liver of the 60Co gamma-radiated mouse, reduce the content of malonaldehyde and improve the anti-oxidation capability of an organism; increase peripheral white blood cells of the 60Co gamma-radiated mouse and improve the hematogenesis function;and reduce the micronuclear rate of marrow cells of the 60Co gamma-radiated mouse and inhibit the action of causing chromosomal aberration of 60Co gamma rays. In addition, the traditional Chinese medicine composition is low in toxicity and side effects, and medicinal materials in the formula are low in price and easy to obtain, thereby having great development and application prospects in the aspects of preventing and treating radiation injuries.

The invention belongs to the field of fruit tree planting, and particularly relates to a method of planting passion fruits. The method comprises the steps of soil preparation, transplanting, trimmingand pruning, field management, and shelf building. In the method, raw materials of soil fertilizer are subjected to fermentation after treatment of irradiation and steaming, the raw materials of pestcontrol liquid are subjected to soaking treatment in alkali liquid, foliar fertilizer is treated under high temperature and pressure, the nutrients needed for the growth of passion fruits are ensured,and through scientific management and fertilization, the yield of the passion fruits is increased by 230-580 kg per mu, the content of soluble sugar is increased by 0.22-1.13 g per 100 g, the contentof chlorogenic acid with anticancer and antibacterial activities is increased by 0.02-0.09 g per 100g. According to the method of planting the passion fruits, the yield is increased, and the qualityis also increased.

The invention discloses a shikimic acid used for the new usage of preparing the medicine for treating ulcerative colitis. By utilizing rat ethanoic acid colitis model, the function of shikimic acid for treating ulcerative colitis is inspected, and the shikimic acid is found to have the function of effectively improving the symptoms such as rat diarrhoea, bloody stool, weight lose and colon histomorphology change; the shikimic acid has scavenging action on neutrophilic granulocyte of colonic structure, can obviously reduce the content of MDA and NO in the rat colonic structure of colonitis and the activity of T-NOS and iNOS, and enhance the level of SOD. Therefore, the shikimic acid can be used for preparing the medicine for treating ulcerative colitis.

A method for increasing the activity of superoxide dismutase comprises steps of: liquid culture, by providing a strain of Bacillus subtilis and a liquid medium to carry out a fed-batch fermentation and to obtain a primary fermentation broth, wherein the liquid medium has 8 wt % to 10 wt % of maltose, 10 wt % to 15 wt % of soya powder and rest of water; and solid culture, by culturing the primary fermentation broth in a solid medium, which has solid substrate and maltose in a ratio of 10:1 to 20:1, to obtain a secondary fermentation broth with SOD in high activity, wherein the solid substrate contains wheat germ and water.

The invention discloses a health-care feed additive for improving oxidation resistance of livestock and poultry. The additive is characterized in that: 1 to 3 percent of red-rooted salvia root extract residue is added into livestock and poultry feed, wherein the anti-oxidation active ingredient content of the red-rooted salvia root extract residue is 10 to 20 percent; and the red-rooted salvia root extract residue means decoction dreg and sediment left after the Chinese medicinal red-rooted salvia root is processed and extracted. According to the health-care feed additive of the red-rooted salvia root extract residue, the conventional Chinese medicinal processing wastes treated as garbage are reused, the processing technology is simple, the use is convenient, the oxidation resistance of the livestock and the poultry can be enhanced, the healthy growth of the livestock and the poultry can be promoted, and certain contribution can be made to environmental protection.

The invention disclose a manufacture method for Chinese caterpillar fungus zymogen powder that includes the following steps: making solid culture medium that made up from the solid materials of 82-88wt% rice, 8-12wt% bran, 3-4wt% soybean meal, and 1-2wt% ammonia sulfate, and adding 0.9-1.1 weight ratio water after crushing the solid material taking sterilization and cooling; fermenting under the condition of asepsis and inoculating onto the solid culture medium for 7-10 days in 20-22 degree centigrade, drying the white hypha in 40-50 degree centigrade and crushing, the product would be gained. The invention is low cost and has high yield.

The invention relates to a compound regulator for defending freeze injury of wheat in spring and a method. The compound regulator is a solution containing 0.021g / L-0.11g / L of salicylic acid and 0.5g / L-1.0g / L of a surfactant. The compound regulator is uniformly sprayed to wheat leaves before 1-2 days of the freeze injury of the wheat in the spring. By utilizing a compound regulator solution, the resistance of wheat plants on the freeze injury in the spring can be remarkably enhanced, the freeze injury degree of young ears of wheat can be obviously decreased, and the yield of wheat grains can be increased. The compound regulator has a simple formula and easy for popularization and generalization, the raw materials are easily available, and an application method of the compound regulator is simple.

The invention provides a cultivation method of spirulina platensis in a saline stress environment, and belongs to the field of biotechnology, which comprises the following steps: in the saline stressenvironment, performing salt-tolerant acclimation cultivation on the of spirulina platensis; placing the acclimated and cultivated spirulina in an environment with an elevated oxygen partial pressurefor cell differentiation cultivation; and performing further extended cultivation, and collecting the obtained salt-tolerant and oxygen-tolerant spirulina species. In the above saline stress environment, the initial salt concentration is 0.1-1%, the final concentration is 3.5-5%. The cultivation method provided in the invention may perform stimulant cultivation at an early stage of cells, which improves the algae superoxide dismutase activity, the peroxidase activity and the catalase activity, increases the algal filament thread pitch and the length in order to improve the biomass density andthe filtering and harvesting efficiency, reduces the malondialdehyde production, and promotes increase of algal phycocyanin and polysaccharide contents, facilitating industrial and oriented acquisition of nutrients including phycocyanins and polysaccharides.

The invention discloses a cell beauty preparation. The technical problem to be solved is to treat chloasma, age pigment, splash, acne, alopecia, psoriasis, leucoderma, hyperthyroidism, hypothyroidism as well as gynecologic diseases caused by the weakness of the body and cold-dampness, deficiency of qi and blood, immunocom promise, anencephalohemia, cerebral anoxia, fatigue and climacteric syndrome. The cell beauty preparation is produced from the following raw materials in parts by weight: 1-6000 parts of ants, 1-3500 parts of pearl powder, 1-2000 parts of leonurus, 1-1500 parts of angelica sinensis, 1-2500 parts of bee pollen and 1-3000 parts of wolfberry fruit. Compared with the prior art, the cell beauty preparation provides necessary sufficient living substances for the human tissue cells by reinforcing kidney to replenish essence, reinforcing qi and nourishing blood and dredging the channel, thereby guaranteeing the integrity of the cell structure and normal metabolism, keeping the viability of the tissue cells and delaying the cell aging process; and the problems of wrinkles, pigments, memory deficits and anenergia due to that the cells are disabled in normal vital movements are solved.

This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists / partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be utilized to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.

The present disclosure provides variant superoxide dismutase polypeptides, compositions comprising the polypeptides, and nucleic acids comprising nucleotide sequences encoding the polypeptides. The present disclosure provides methods of reducing oxidative damage in a cell, tissue, or organ. The present disclosure provides methods of identifying agents that increase superoxide dismutase activity.

The present application relates to the field of medicine. The present application relates to an isolated Saposhnikovia divaricata polysaccharide and use thereof in the manufacture of a medicament for treating diabetes mellitus or hyperlipoidemia. In particular, the present application relates to an isolated Saposhnikovia divaricata polysaccharide comprising L-arabinose, D-galacturonic acid, D-mannose, D-glucose and D-galactose, wherein the molar ratio of the L-arabinose: D-galacturonic acid: D-mannose: D-glucose: D-galactose is 1-15:1-10:1-10:10-40:1-15, preferably 1-5:5-10:1-5:20-25:1-5.

The invention discloses a method for preparing a complete pellet feed for pregnant ewes by taking gardenia jasminoides ellis meal as a feed raw material. The method is characterized in that every 100gof the complete pellet feed contains 1g of gardenia jasminoides ellis meal, 20g-30g of corn, 5g-10g of soybean meal, 15g-25g of peanut vines, 25g-35g of barley hulls, and 1g-5g of a premix. The production process comprises the following steps: extracting gardenia jasminoides ellis meal by an extraction method, carrying out superfine grinding on the extracted gardenia jasminoides ellis meal, grinding peanut vines and barley hulls until the particle size is 5-10.0 mm, sieving other composition materials until the particle size is 0.5-5 mm, performing mixing in a mixer according to the formula,and uniformly performing stirring; ventilating, cooling and airing the granules discharged from a granulator, and bagging and storing the processed granules when the water content is reduced to 8-11%.The feed can be used for increasing the conception rate of ewes, the postpartum estrus phenomenon is obvious, the nonpregnant rate is obviously reduced, the lamb survival rate is increased, and the comprehensive economic benefits are remarkable.

The invention discloses an anti-radiation traditional Chinese medicine composition which comprises the following components in parts by weight: 160-200 parts of membranous milkvetch root, 110-130 parts of scurfy pea, 80-100 parts of Chinese angelica, 160-200 parts of epimedium, 135-165 parts of madder root, 110-130 parts of glossy privet fruit, 110-130 parts of white paeony root, 110-130 parts of radix rehmanniae preparata, 80-100 parts of Szechuan lovage rhizome, 215-265 parts of Chinese yam and 35-45 parts of prepared liquoric root. The traditional Chinese medicine composition can increase thymus index and spleen index of a 60Co gamma-radiated mouse and protect immune organs; improve the activity of superoxide dismutase in blood serum and the liver of the 60Co gamma-radiated mouse, reduce the content of malonaldehyde and improve the anti-oxidation capability of an organism; increase peripheral white blood cells of the 60Co gamma-radiated mouse and improve the hematogenesis function; and reduce the micronuclear rate of marrow cells of the 60Co gamma-radiated mouse and inhibit the action of causing chromosomal aberration of 60Co gamma rays. In addition, the traditional Chinese medicine composition is low in toxicity and side effects, and medicinal materials in the formula are low in price and easy to obtain, thereby having great development and application prospects in the aspects of preventing and treating radiation injuries.

The invention discloses face cream with an anti-aging function and a preparation method of the face cream. The face cream disclosed by the invention contains hydrolyzed cod fish skin collagen, carboxymethyl chitosan, a tremella extract, oat-beta glucan and a composite plant anti-aging agent. The face cream with the anti-aging function disclosed by the invention is mild in property, natural and free of irritation and has a relatively good function of scavenging free radicals. By comprehensively applying various anti-aging policies, the face cream not only can be used as a skin care article for delaying senescence after aging, but also can be used as a daily skin care product for preventing aging. The face cream is obvious in anti-aging effect.

The invention discloses a strain of a bacterium of Zobellella sp. and application thereof for improving plant stress resistance. The strain of the bacterium of the Zobellella sp. is specifically Zobellella sp. DQSA1, which is preserved at China Center for Type Culture Collection under the preservation number CCTCCNO: M 2018587. Tests have proven that, being applied to roots of corn or mung beans,the Zobellella sp. DQSA1 CCTCCNO: M 2018587 is capable of promoting growth of the corn or the mung beans as well as enhancing salt-alkali stress resistance; more specifically, the Zobellella sp. DQSA1CCTCCNO: M 2018587 is capable of increasing plant height, fresh weight, dry weight, chlorophyll content, soluble sugar content, soluble protein content and superoxide dismutase activity of the corn or the mung beans. The strain of the bacterium of the Zobellella sp. and the application thereof are of great application values.

The present invention belongs to the technical field of feed compositions, and relates to a broiler feed for prolonging the shelf life of fresh-processed chicken and a preparation method of the feed.The broiler feed comprises the following main raw materials: 50 to 55 parts of corn, 4 to 6 parts of fermented soybean meal, 2 to 3 parts of corn DDGS, 2 to 3 parts of nucleotide slag, 4 to 8 parts ofpuffed flax seeds, 0.5 to 0.9 part of stone powder, 5 to 8 parts of a bio-fermented feed, 0.03 to 0.05 part of Nutri.P, 0.03 to 0.04 part of yeast selenium, 1 to 2 parts of pine needle powder, 2 to 3parts of winkled gianthyssop herb powder, 3 to 5 parts of seabuckthorn leaf powder, 1-2 parts of Chinese mosla leaf powder, 3-5 parts of mixed oil and 1-3 parts of grape seed meal. The bio-fermentedfeed is prepared by the mixed fermentation of bacillus coagulans, lactobacillus plantarum, pediococcus lactis and saccharomyces cerevisiae. The broiler feed is used for broiler breeding, and can prolong the shelf life of commonly-packaged slaughtered fresh-processed broiler for at least one day at 2+ / -2 DEG C.

The invention discloses a strong aphrodisiac maca agent. The strong aphrodisiac maca agent comprises, by weight, 13.3-36.4 parts of maca, 13.3-36.4 parts of oat, 6.7-27.3 parts of yohimbine and 26.7-54.5 parts of L-arginine-alpha-ketoglutarate. The strong aphrodisiac maca agent has the advantages that cell autophagy signal pathways in muscle tissues can be activated, the serum urea nitrogen contents can be reduced, the activity of superoxide dismutase of bodies can be improved, the antioxidant stress reaction of the bodies can be enhanced, accordingly, the sports ability can be obviously improved, and obvious fatigue relieving and fatigue elimination accelerating effects can be realized.

The invention discloses a cell beauty preparation, and the technical problem to be solved is to treat gynecological diseases and qi and blood caused by chloasma, senile plaque, pigmentation, acne, alopecia, psoriasis, vitiligo, hyperthyroidism, hypothyroidism, frailty, cold and dampness Deficiency, low immune function, cerebral anemia, cerebral hypoxia, fatigue and menopausal syndrome. This product is made of the following raw materials in mass ratio: ants 1-6000, pearl powder 1-3500, motherwort 1-2000, angelica 1-1500, bee pollen 1-2500, medlar 1-3000. Compared with the prior art, the present invention provides necessary and sufficient life substances to human tissue cells by nourishing the kidneys and essence, replenishing qi and nourishing blood, clearing the meridians, ensuring the integrity of the cell structure and the normal progress of metabolism, and making the tissue cells full of youth. Vitality, delaying the aging process of cells, and solving wrinkles, pigmentation, memory loss, and lack of energy caused by the inability of cells to carry out normal life activities.

The invention relates to the technical field of functional microorganism screening and application, in particular to the screening of a strain of Bacillus amyloliquefaciens and its application in sea cucumber cultivation. A strain of Bacillus amyloliquefaciens of the present invention was deposited in the China Center for Type Culture Collection, abbreviated as CCTCC, on December 24, 2015, and its address is: Wuhan University Collection Center, Luojia Mountain, Wuchang, Wuhan City, Hubei Province; requesting depositor : Ludong University; the preservation number is CCTCC NO: M2015774, and the bacterium is named Bacillus amyloliquefaciens Bacillus amyloliquefaciens ZYTC1‑1. The bacillus amyloliquefaciens of the present invention is screened from the intestinal tract of healthy sea cucumbers. The bacterial strain has strong protease and amylase production capabilities, can improve the activity of amylase in the intestinal tract of sea cucumbers, promote the growth of sea cucumbers, and improve the immunity and immunity of sea cucumbers. Disease resistance, can be widely used in sea cucumber cultivation and aquatic feed fields.

The invention provides a vitamin B 2 Modified iron-based nanozymes, specifically vitamin B 2 Modified nano-scale ferric oxide particles, also provides vitamin B 2 A preparation method of a modified iron-based nanozyme and a composition for promoting the healing of oral ulcers. Vitamin B provided by the present invention 2 Modified iron-based nanozyme, which has higher catalase activity and superoxide dismutase activity than iron-based nanozyme, and compared with vitamin B used alone 2 and iron-based nanozymes, vitamin B provided by the invention 2 The modified iron-based nanozyme showed a better protective effect on BALB / 3T3 cells and HOK cells in hydrogen peroxide environment, ROS scavenging ability at the cellular level, and the ability to reduce IFN-γ and IL-6 in ulcers. It has better therapeutic effect and can be used to prepare a medicine for promoting the healing of oral ulcer with high efficiency.

The invention provides a method for planting malus micromalus for saline-alkali land natural soil planting by use of a rooting agent containing a radix notoginseng extract. The method comprises a step of spraying the rooting agent, wherein the rooting agent comprises the following components: alpha-naphthylacetic acid, indoleacetic acid, H3BO3, a soil activator, a slow-release agent, tobacco leaf residue, a radix notoginseng extract, antophyllite tailing powder, rubber powder, inositol, instant sodium silicate, machine oil, shrimp shell powder, betaine, an anti-caking agent and ramie leaves. Through the natural soil planting method provided by the invention, the superoxide dismutase activity of new roots is greatly increased by 5.2-6.1% in comparison with the control group.

The invention relates to a healthcare product or medicine and a preparation method thereof. In particular, the healthcare product or medicine is prepared by taking active elements with the function of suppressing the formation of end-stage glycosylation final products in four natural plants including plantain, root of kudzuvine, cornel and turmeric as main raw materials and adding conventional auxiliary materials. The invention can efficiently prevent and suppress diabetes complication and senium caused by the end-stage glycosylation final products and has no toxic and side effects.

The invention discloses a bacterium of the genus Zorbella and its application in improving the stress resistance of plants. The bacterium of the genus Zobellella is specifically Zobellella sp. DQSA1, and its preservation number in the China Center for Type Culture Collection is CCTCC NO: M 2018587. Experiments have shown that applying Zobellella sp. DQSA1 CCTCCNO: M 2018587 to the root system of corn or mung bean can promote growth and improve resistance to saline-alkali stress, specifically expressed as plant height, fresh weight, dry weight, chlorophyll , soluble sugar content, soluble protein content and the increase of superoxide dismutase activity. The invention has important application value.

Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic / Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.

The present invention provides an Actinidia chinensis Planch ferment and the use thereof in a composition for increasing the antioxidant activity, increasing the anti-glycation activity, increasing the activity of proteolytic enzymes, improving the gastrointestinal dyspepsia, and increasing the gastrointestinal flora diversity. The Actinidia chinensis Planch ferment can increase the normal function of the gastrointestinal tract, maintain the normal function of the immune system, delay the progression of chronic diseases and aging, and increase the gastrointestinal digestive function to achieve the maintaining of the normal function of the intestinal tract. The Actinidia chinensis Planch ferment is prepared by fermenting the Actinidia chinensis Planch extracts to yeast, lactic acid bacteria and acetic acid bacteria for the three-staged fermentation.