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Use of shikimic acid in preparing medicament for treating ulcerative colitis

A technology for ulcerative colitis and shikimic acid, applied in the field of medicine, can solve the problems of uncertain effect, expensive clinical application, and large side effects

Inactive Publication Date: 2010-09-15
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biological therapy, such as the application of tumor necrosis factor TNF-α antibody, interferon, cell adhesion molecule inhibitors, etc. However, long-term use may have large side effects, or the effect is uncertain, or the price is expensive, which limits its clinical application

Method used

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  • Use of shikimic acid in preparing medicament for treating ulcerative colitis
  • Use of shikimic acid in preparing medicament for treating ulcerative colitis
  • Use of shikimic acid in preparing medicament for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The therapeutic effect of embodiment 1 shikimic acid on rat acetic acid colitis

[0011] Experimental Materials

[0012] (1) Animal SD rats, clean grade, male, weighing 220-240 g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: scxk (Beijing) 2002-0003.

[0013] (2) Drugs and reagents Positive control drugs: Sulfasalazine Tablets (SASP), produced by Shanghai Sanwei Pharmaceutical Co., Ltd.; Glacial acetic acid is a product of Beijing Chemical Factory; Myeloperoxidase (MPO) test kit, fecal occult blood (OB) Test boxes were provided by Nanjing Jiancheng Institute of Bioengineering.

[0014] (3) Instruments High-speed tissue homogenizer, D-37520 high-speed low-temperature centrifuge, 722 spectrophotometer, OHAUS analytical balance, etc.

[0015] experimental method

[0016] (1) Preparation of rat acetic colitis model

[0017] Rats were fed routinely in the laboratory, fasted for 24 hours before modeling, and given 10% MgS...

Embodiment 2

[0032] Example 2 Effect of shikimic acid on oxidative damage of intestinal mucosa in rats with acetic acid colitis

[0033] Experimental Materials

[0034] (1) Animal SD rats, clean grade, male, weighing 220-240 g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: scxk (Beijing) 2002-0003.

[0035] (2) Positive control drugs for drugs and reagents: sulfasalazine tablets (SASP), produced by Shanghai Sanwei Pharmaceutical Co., Ltd.; glacial acetic acid is a product of Beijing Chemical Plant; ) test kit, nitric oxide test kit (nitrate reductase method), nitric oxide synthase (NOS) test kit, protein assay (Coomassie Brilliant Blue method) kit, the above test kits are provided by Nanjing Jiancheng Bioengineering Research Institute .

[0036] (3) Instruments High-speed tissue homogenizer, D-37520 high-speed low-temperature centrifuge, 722 spectrophotometer, OHAUS analytical balance, etc.

[0037] experimental method

[0038] (1) Prep...

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Abstract

The invention discloses a shikimic acid used for the new usage of preparing the medicine for treating ulcerative colitis. By utilizing rat ethanoic acid colitis model, the function of shikimic acid for treating ulcerative colitis is inspected, and the shikimic acid is found to have the function of effectively improving the symptoms such as rat diarrhoea, bloody stool, weight lose and colon histomorphology change; the shikimic acid has scavenging action on neutrophilic granulocyte of colonic structure, can obviously reduce the content of MDA and NO in the rat colonic structure of colonitis andthe activity of T-NOS and iNOS, and enhance the level of SOD. Therefore, the shikimic acid can be used for preparing the medicine for treating ulcerative colitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the new application of shikimic acid in preparing medicine for treating ulcerative colitis. Background technique [0002] Shikimic acid is an active ingredient contained in the fruits of various plants of the genus Star Anise in the Chinese herbal medicine Magnoliaceae. Its molecular formula is C 7 h 10 o 5 , the relative molecular mass is 174.15, and the chemical name is 3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid. Shikimic acid has anti-inflammatory and analgesic effects; shikimic acid can exert an antithrombotic effect by affecting the metabolism of arachidonic acid, inhibiting platelet aggregation, and inhibiting the coagulation system. In addition, shikimic acid is widely used as an intermediate of antiviral and antitumor drugs. But so far, there is no report about the effect of shikimic acid on preventing and treating ulcerative colitis. [0003] Ulcerative coli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P1/04
Inventor 邢建峰孙建宁董亚琳屈清慧袁志瞾胡萨萨石锐才
Owner XI AN JIAOTONG UNIV
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