51 results about "Cerebral anoxia" patented technology

Methods and apparatus for measuring cerebral O2 saturation and detecting cerebral hypoxia-ischemia using multi-wavelength near infrared spectroscopy (NIRS). Near-infrared light produced by an emitter is directed through brain tissue. The intensity of the light that passes through the brain tissue is measured using photodiode detectors positioned at distinct distances from the emitter. This process is conducted for at least three wavelengths of near-infrared light. One of the wavelengths used is substantially at an isobestic point for oxy-hemoglobin and deoxy-hemoglobin, but the other two may be any wavelengths within the near-infrared spectrum (700 nm to 900 nm), so long as one of the additional wavelengths is greater than the isobestic point and the other is less than the isobestic point. Tissue oxygenation is calculated using an algorithm derived from the Beer-Lambert law. Cerebral hypoxia-ischemia may be diagnosed using the calculated tissue oxygenation value.

The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system. Exemplary SUR1 and / or TRPM4 antagonists that inhibit the NCca-ATP channel may be employed in the combination. The combination therapy also employs one or more of a non-selective cation channel blocker and / or an antagonist of VEFG, NOS, MMP, or thrombin. Exemplary indications for the combination therapy includes the prevention, diminution, and / or treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury, for example. In other embodiments, there are methods and compositions directed to antagonists of TRPM4, including at least for therapeutic treatment of traumatic brain injury, cerebral ischemia, central nervous system (CNS) damage, peripheral nervous system (PNS) damage, cerebral hypoxia, or edema, for example.

The invention belongs to the technical field of medicine, and concretely relates to caffeoyl substituted pentacyclic triterpenoid derivatives as shown in a formula I and a purpose thereof in preparing medicaments or health products for preventing and treating brain injury and / or neurological dysfunction and / or cognitive dysfunction caused by cerebral ischemia, hypoglycemia and cerebral anoxia. Experiments verify that the derivatives is capable of protecting nerve cells under conditions of hypoglycemia and hypoxia, can substantially improve neurological damage induced by cerebral ischemia, and thus is expected to be developed as medicaments for preventing and treating the brain injury caused by the cerebral ischemia, the hypoglycemia and the cerebral anoxia as well as improving corresponding neuroethology functions.

The invention belongs to the technical field of medicines and relates to the use of the chitosan oligosaccharide in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases. Pharmacodynamic experiments prove that chitosan has remarkable effect of resisting cerebral ischemia, cerebral anoxia and the like, is widely available, can be absorbed easily by bodies, has small toxic and side effects and has a bright application prospect.

The invention discloses kudzuvine root and cinnamomvine capsules for cardiovascular and cerebrovascular diseases, and belongs to the field of Chinese medicines. The capsules consist of the following components: incised notopterygium rhizome, astragalus, root of red-rooted salvia, Szechuan lovage rhizome, American ginseng, leech, rosewood heart wood, earthworm, kudzuvine root, Chinese caterpillar fungus, Chinese magnoliavine fruit, oriental waterplantain rhizome, suberect spatholobus stem, bamboo shavings, platycladi seed, cassia twig, Chinese angelica, gambir plant, chrysanthemum, pericarpium trichosanthis, Chinese taxillus twig, centipede, eucommia bark, chaff flower root, white paeony root, cinnamomvine, grassleaf sweelflag rhizome and liquoric root. The kudzuvine root and cinnamomvine capsules improve cerebral anoxia, reduce hypertension, hyperlipaemia and high cholesterol, have the curative effect on cerebral thrombosis, coronary disease, cardiovascular and cerebrovascular sclerosis, insomnia, dreaminess, memory loss, listlessness and aching and limp in lower limbs which are caused by the hypertension, the hyperlipaemia and the high cholesterol, and have the good effect on patients who suffer from the cardiovascular and cerebrovascular diseases and cerebral infarction for half a year. The effective rate is 92 percent, and the cure rate is 85 percent.

The medicine for treating cardiac and cerebral vascular diseases is prepared with astragalus root and notoginseng as material, and is Chinese medicine injection, including injection liquid, transfusion liquid and freeze dried powder for injection, prepared through extraction, purification and addition of proper amount of medicinal supplementary material. The medicine has high stability and long effective period, and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic test shows that the medicine can protect brain against oxygen lack and cardiac muscle damage, raise anaerobic resistance, lower serum LDH and CK activity and reduce myocardial infarction range. The medicine is used in treating cardiac and cerebral vascular diseases and has fast acting, determined curative effect and no toxic side effect.

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-90 wt% and medicinal supplementary material the rest. The medicine is prepared into tablet, coated tablet, oral controlled release preparation, capsule, etc. and is used in treating hyperlipemia, atherosclerosis, coronary heart disease and other cardiac and cerebral vascular diseases.

This invention relates to synthetic craft, preparation and new medicine function of a new water-solubility ramification of tanshinone iia: tanshinone iia sulfonic acid kalium ( potassium tanshinone iia sulfonate, PTS). The invention concretely relates to the pharmic application of tanshinone iia sulfonic acid kalium in prevention and treatment of myocardial ischemia and anoxia, cerebral ischemia and anoxia, microcirculation ameliorating, memory enhancing and corelated disease(cerebralthrombosis, acute cerebral ischemia, coronary heart disease, angina pectoris, myocardial infarction0.

An application of the quercetol-3-0-beta-D-glucoside in preparing the medicines for treating cerebral anoxia and ischemia, and thrombosis is disclosed. Said quercetol-3- 0-beta-D-glucoside is prepared from rutine by semi-synthesis method with high output.

An extrant of cimicifuga rhizome, its preparing process, the medicine containint it, and its medical application in treating cerebrovascular disease, especially the cerebral ischemia and cerebral anoxia are disclosed.

A ventilatory laryngoscope with disposable laryngoscope lens including: a laryngoscope handle and a laryngoscope lens that is connected with an extension arm of the handle; transparent lens protecting cover on the end of the lens cavity; oxygen injecting through-hole on the cover; oxygen supply pipe in seal plug connection with the through-hole, the other end connected with an oxygen source pipe; scrubbing nozzle on the cover, and a drug delivery pipe. The laryngoscope has advantages: during the trachea intubation, ventilation and oxygen supply may be achieved in the body to effectively prevent cerebral anoxia and prolong the safe time limit of the intubation, improve the success rate of cardio-pulmonary resuscitation, and provide a safe and reliable guarantee; improve intubation safety and reduce professional risk; the secreta may be removed from the cover to achieve timely rescue of critically ill patients by collecting clear glottis image and smoothly completing the intubation.

The invention belongs to the technical field of medicament, particularly relates to an application of liquiritin in preparing medicament for treating cardiovascular and cerebrovascular diseases, more specifically relates to an application of liquiritin in preparing medicine for treating cerebrovascular diseases. Pharmacological experiments reveal that liquiritin has distinct effects in resisting thrombosis, resisting cerebral ischemia, resisting cerebral anoxia and improving memory. The medicine with liquiritin as active ingredient has low medication dose and high safety, and has wide application prospect.

The invention belongs to the technical field of medicine, and provides application of dracocephalum moldavica L. general flavone in preparing a medicament for preventing and treating cerebrovascular disease. Proven by pharmacological experiments, the dracocephalum moldavica L. general flavone has the effects on resisting cerebralthrombosis, resisting cerebral ischemia, resisting cerebral anoxia, resisting vascular dementia and the like. The dracocephalum moldavica L. general flavone has notable effects on preventing and treating cerebrovascular disease and is hopeful to become a medicament for preventing and treating cerebrovascular disease.

The invention discloses a preparation method of saponin extracts in xanthoceras sorbifolia shells. The preparation method comprises the following steps: crushing the xanthoceras sorbifolia shells, performing reflux extraction for 2 to 4 times by using 70 to 80 percent ethanol solution, wherein the extraction time is 1 to 2 hours for each time, the extraction temperature is 65 to 75 DEG C, mergingthe extract liquid, concentrating until no alcohol smell exists, and obtaining ethanol extract concentrated liquid; diluting the obtained ethanol extract concentrated liquid by using water, extractingsuccessively by using petroleum ether, vinyl acetate and water saturated n-butyl alcohol, decompression concentrating, and separately obtaining petroleum ether extract, vinyl acetate extract, and n-butyl alcohol extract; and enriching active ingredients from the vinyl acetate extract by using macroporous resin, washing 8 column volumes by using 10 percent ethanol to remove large polarity components, then eluting 12 column volumes by using 80 percent ethanol, collecting 80 percent eluent, and performing decompression concentrating, thus obtaining the saponin extracts. By adopting the preparation method, the saponin components in the xanthoceras sorbifolia shell can be obtained and have the effect for improving the memory disorder and resisting the cerebral anoxia injury.

The invention discloses a preparation method for TAT-NEP1-40 fusion protein and application in treating the injuries of a central nervous system, CNS. The TAT-NEP1-40 fusion protein is characterized in that the TAT-NEP1-40 fusion protein comprises the protein transduction domain (PTD) of a transactivating transduction protein TAT of the human immunodeficiency virus (HIV) and Nogo extracellular peptide residues 1-40, NEP1-40. The fusion protein retains the selective antagonistic activity of the NEP1-40 to a Nogo receptor, NgR, and has the advantages of high transduction efficiency and easy penetration of BBB and BCSB, thereby overcoming the limitation of the NEP1-40, avoiding the extra injuries on nervous tissues caused by the mode of injecting the NEP1-40 through microinjection or miniature pump implantation, and overcoming the problem that the NEP1-40 can hardly pass BBB and BCSB to reach corresponding biological concentration. The fusion protein can be prepared in a large quantity, has a low cost and high activity, and can be used for treating a plurality of CNS injuries including cerebral ischemia, cerebral anoxia, cerebral hemorrhage, cerebral trauma, spinal core injury, and the like, and promoting the regeneration and functional rehabilitation of nervous tissues.

The invention discloses a cell beauty preparation. The technical problem to be solved is to treat chloasma, age pigment, splash, acne, alopecia, psoriasis, leucoderma, hyperthyroidism, hypothyroidism as well as gynecologic diseases caused by the weakness of the body and cold-dampness, deficiency of qi and blood, immunocom promise, anencephalohemia, cerebral anoxia, fatigue and climacteric syndrome. The cell beauty preparation is produced from the following raw materials in parts by weight: 1-6000 parts of ants, 1-3500 parts of pearl powder, 1-2000 parts of leonurus, 1-1500 parts of angelica sinensis, 1-2500 parts of bee pollen and 1-3000 parts of wolfberry fruit. Compared with the prior art, the cell beauty preparation provides necessary sufficient living substances for the human tissue cells by reinforcing kidney to replenish essence, reinforcing qi and nourishing blood and dredging the channel, thereby guaranteeing the integrity of the cell structure and normal metabolism, keeping the viability of the tissue cells and delaying the cell aging process; and the problems of wrinkles, pigments, memory deficits and anenergia due to that the cells are disabled in normal vital movements are solved.

The invention provides a beverage with cerebral anoxia resisting effect, which comprises the following components (per 1,000 mL): (1) sucrose, glucose or fructose 10-150 g; (2) Chrysanthemum morifolium flower 1-20 g, Lycium barbarum fruit 10-100 g and Lophatherum gracile 2-60 g; and (3) water in balance. The inventive beverage has the effects of regulating yin yang, qi and blood, regulating functions of heart, liver, spleen, lung and kidney, resisting anoxia, resisting fatigue, and enhancing immunity; is suitable for long-term consumption by brain workers and people in poor health; and has wide market prospect.

The invention discloses a refreshing, inflammation eliminating and pain relieving ointment prepared from raw materials of, by weight: 3 to 20g of emu oil, 1 to 15g of a nano-grade anion solution, 1 to 18g of menthene, 0.5 to 5g of grape seed oil, 1 to 10g of vitamin B, 1 to 10g of azone, 1 to 10g of propylene glycol, 10 to 25g of dehydrated alcohol, and 30 to 50g of deionized water. The ointment provided by the invention provides functions of mind refreshing, cerebral anoxia correcting, pain relieving, inflammation eliminating, and cerebral nervous reflex activity activating. With the ointment, fatigue and sleepiness caused by long-term cerebral activities, and disasthesia caused by car-sickness or sea sickness can be relieved. Also, the ointment is convenient to use.

The invention relates to a medical care instrument of the ears and the brain, which comprises a magnetic bar, a casing and medicinal powder. The medical care instrument of the ears and the brain has the effects of dredging the channel, activating the collaterals, regulating the encephalic blood circulation and the encephalic nervous disorder, promoting blood circulation, lowering pressure, relieving convulsion, alleviating pain, diminishing inflammation, killing bacteria and the like. The invention can be used for preventing and treating the diseases of tinnitus, deafness, tympanitis, auditory vertigo, neural headache, migraine, various kinds of headache, neurosis, insomnia, cerebral insufficiency of blood supply, cerebral anoxia, cerebrovascular spasm, hypertension and the like.

The invention relates to a treatment liquid for treating cerebral arterial thrombosis and a preparation method and application thereof. The treatment liquid is prepared by mixing an up-conversion nanoparticle resuspension solution and a synechococcus elongatus resuspension solution in a volume ratio of 1:(1-10). The invention further discloses a preparation method of the treatment liquid for cerebral arterial thrombosis. The method comprises the following specific steps: S1, culturing synechococcus elongatus to obtain a synechococcus elongatus resuspension solution; S2, carrying out modification treatment on up-conversion nanoparticles to obtain the up-conversion nanoparticle resuspension solution; and S3, mixing the synechococcus elongatus resuspension solution in the S1 with the up-conversion nanoparticle resuspension solution in the S2 in a proportion to obtain the treatment liquid. The treatment liquid has the beneficial effects that: the treatment liquid can effectively provide required oxygen for the brain of a human body, can improve the cell metabolic capability of hypoxic brain tissues to a certain extent, not only improves dysfunction caused by cerebral anoxia, but also can avoid injuries and risks caused by surgical craniotomy.

The invention discloses a fag detecting and refreshing massager. The massager of a head-mounted claw type structure comprises a motor, a control structure and a massage structure. The massage structure comprises a support, a protection cover, a torque spring and the like. Through the oriented finger massage proved to be effective on refreshing acupuncture points, the aims of improving brain bloodsupply, relieving cerebral anoxia and brainfag and avoiding cerebral lesion are achieved. Massage heads on the left temple and the right temple are electric signal testing electrodes; by means of thewet electrode structure, interference and misjudgment are reduced; tested electric signals are converted into original data of brain waves, effective data is separated out through a treatment and denoising algorithm on data obtained through an action sensor, whether fag exists or not is judged by comparing real-time data with data in a waking state, the acupuncture point refreshing massage actionsare automatically started, and the massager is light in structure and can be conveniently used by a user for a long time.

The invention provides a cervical vertebra protective bedding which can be adjusted and particularly used for protecting cervical vertebra. The cervical vertebra protective bedding is composed of three independent portions which are a main bedding, a controllable bedding portion and a pillow bedding portion. When the main bedding and the pillow bedding portion are connected through hook & loop fasteners, a recess portion without beddings can be formed between the main bedding and the pillow bedding portion, the controllable bedding portion can be transversally put in the recess portion, a plurality of types of recess portions can be achieved through freely moving and arranging the controllable bedding portions in the recess portion, so people can comfortably put his shoulder and arm in this recess portion when he sleeps on one side. His shoulder will distinctly not be pressed because his shoulder is lower than the surface of the main bedding, his upper half body is supported on the main bedding by his chest portion under the oxter, his head can lean against the pillow in parallel because his head is closer to the pillow, his cervical vertebra will not bend and be pressed, his channels, collaterals and blood flow will be unblocked, chronic diseases such as morning stiffness, stiff neck, shoulder and back pain, cerebral anoxia, hand anaesthesia and cervical vertebra discomfort and the like will not easily occur.

The invention belongs to the technical field of medicine, and specifically relates to an oxiracetam compound and a preparation method thereof. The provided oxiracetam compound contains a half of crystal water, and has the advantages of high purity, good stability, and excellent technology repeatability. The invention also relates to an application of oxiracetam in preparation of drugs for treating brain damages caused by physical and chemical factors, various cerebral anoxia, and chronic cerebral insufficiency.

The invention discloses a therapeutic apparatus, and belongs to the technical field of medical equipment. A therapeutic apparatus is characterized in that a gas supply pipeline of the therapeutic apparatus is provided with a gas supply unit, and a pressure adjusting unit for processing output gas of the gas supply unit is arranged between the gas supply unit and a user inhalation device in the therapeutic apparatus. The pressure regulating unit comprises a gas storage part for receiving gas at the output end of the gas supply unit and realizing temporary storage; the air pump is used as a transmission device to transmit air, so that the pressure and the flow of the output air are average and stable, the breathing difficulty of an inhaler caused by unstable output air pressure is avoided, the heart rate of the inhaler is prevented from being increased, the cerebral anoxia condition of the inhaler is avoided, and the breathing quality of the inhaler is improved. Further, symptoms such as dizziness, headache, nausea, vomiting and weakness of an inhaler are avoided, and conditions such as pulmonary edema and coma are avoided.

The invention provides a method for establishing an acute high altitude anoxia and anxiety stress response animal model. The method comprises the following steps of (1) raising mice at conventional elevation environment, and performing cold water forced swimming adaptability training; (2) and then enabling the mice obtained in the step (1) to be exposed to high-elevation environmental conditions for raising, and performing high-elevation environment composite cold water forced swimming so as to obtain the acute high altitude anoxia and anxiety stress response animal model. The acute high altitude anoxia and anxiety stress response animal model obtained by the method disclosed by the invention has cerebral anoxia pathology characteristics that an aerobic metabolism way of sugar in brain tissues is blocked, so that the supply of ATP energy sources is obviously reduced, and lactic acid is accumulated, and behavioral expression of anorexia and enhanced anxiety behavior, and the induced stimulating factors and clinical pathology behavioral expression of the model both approach the actual situations of acute altitude stress response.

The invention belongs to the technical field of medicines, and provides application of chorispora bungeana or an extract thereof in the preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases. The extract of the chorispora bungeana comprises a water extract and an alcohol extract of the chorispora bungean. Studies indicate that the chorispora bungeana orthe extract thereof has the obvious effects of resisting cerebral ischemia, cerebral anoxia, cerebral thrombosis and vascular dementia in human bodies, has small side effect and can be taken for a long term.

An application of the quercetol-3-0-beta-D-glucoside in preparing the medicines for treating cerebral anoxia and ischemia, and thrombosis is disclosed. Said quercetol-3- 0-beta-D-glucoside is prepared from rutine by semi-synthesis method with high output.

The invention provides a head chopping device used for an acute cerebral anoxia pharmacology experiment. The head chopping device comprises a cuboid (1) with a groove, a hollow pipeline section (2) and a chopper cutter. According to the assembling connection mode, the hollow pipe is transversely arranged at one end of the cuboid groove and closely fits the groove, and the fractured end edge of thehollow pipe and the fractured end edge of the groove coincide and closely fit the cut of the fixed edge of the chopper cutter. The specification of the cuboid is that the length is 4-1000 centimeters, the width is 10-15 centimeters, and the height is 8-15 centimeters; the diameter of the hollow pipe is 3-10 centimeters, and the length of the hollow pipe is 5-10 centimeters; the chopper cutter isprovided with a base, the fixed edge and the movable edge of the chopper cutter are provided with cutter edges, the cutter edges of the upper and lower edges are opened to form a hole shape, the diameter of the hole shape is 4-10 centimeters, and the height of the fixed edge is 6-12 centimeters. The device can solve the problem that in the head chopping process, an animal is nervous and strugglesor bites an experimenter, blood oxygen loss of the experiment animal before head chopping is reduced to the largest extent, it is avoided that the experiment error is caused due to different-degree struggling of the experiment animal, the experiment operation is standard, and experiment data is credible and reliable. The operation is convenient, cost of manufacturing materials is low, and the device is suitable for application and popularization.

An extrant of cimicifuga rhizome, its preparing process, the medicine containint it, and its medical application in treating cerebrovascular disease, especially the cerebral ischemia and cerebral anoxia are disclosed.

A Chinese medicine in the form of oral liquid for treating cerebral anoxia, ametropia, myopia, amblyopia, insomnia, etc is prepared from 6 Chinese-medicinal materials including ash bark, green tangerine peel, chaenomeles fruit, mulberry fruit, etc through pulverizing or slicing or crushing, proportional mixing, decocting, filtering and concentrating.