The invention provides an anti-infective medical polymer material, comprising 100 dose of heat curable silicone rubber, 2.5 to 15 dose of Na-montmorillonite, 0.75 to 6.2 dose of quaternary ammonium salt intercalation compounds, 0.3 to 5.6 doses of antibiotics. Preparation method of the materials is: convert the montmorillonite clay to Na-montmorillonite, and then intercalate quaternary ammonium salts to montmorillonite to obtain the organic-montmorillonite with anti-infective drugs attached to it, and compound with heat curable silicone rubber at last. The material has a long anti-infection time, good physical and mechanical properties, and not easy to age. It can be used in the preparation of various medical catheters, such as catheters, deep venous catheters, drainage tubes, trachea intubation and so on.