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The medical use anti-infection polymeric material and its preparation method

A polymeric material and anti-infection technology, applied in catheters and other directions, can solve problems such as poor effect, environmental pollution, complex process, etc., achieve good thermodynamic properties and physical and mechanical properties, avoid the use of harmful solvents, and have good anti-infection effects Effect

Inactive Publication Date: 2007-04-11
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical measures and existing problems in the treatment of catheter-related infections include: 1. Timely replacement of catheters, but repeated replacement of catheters will increase the patient's pain and chances of infection; Difference; 3. Antibiotics are used, but once a catheter-related infection occurs, it is difficult for antibiotics to pass through the biofilm, and the effect is often not good
[0004] 1. Natural latex: highly irritating to the human body and poor in biocompatibility;
[0005] 2. Polyvinyl chloride: easy to form biofilm, causing catheter-related infection;
[0006] 3. Vacuum silver-plating anti-infection materials: expensive, and silver is toxic to the liver, kidneys, nervous system and mucous membranes
[0010] (2) Sandwich method: put antibacterial drugs into the middle of the material through physical and chemical methods. This method is complicated and difficult to realize industrialization
Professor Zhu Fangming of Sun Yat-Sen University developed a silicone rubber / montmorillonite-loaded antimicrobial drug nanopolymer material through polymer-modified montmorillonite intercalation composite method, which has the effect of controlling drug release ( http: / / 202.116.65.193 / jinpin2005 / zonghe / paper / 4 / 03014.doc Inventor's cooperative project), but there are several problems in this silicone rubber material: (1) the antibacterial performance is unstable, and the release test of antibacterial drugs has only passed 72h, which cannot prove that it can achieve the clinically required anti-infection of more than 20 days Effect; (2) the silicone rubber material used is room temperature vulcanized rubber. In the south, the summer temperature is higher, and the high temperature will cause the molecular structure of room temperature vulcanized rubber to change, thereby reducing the thermodynamic performance of the catheter: (3) the method for preparing this material is solution method, a large amount of organic solvent chloroform will be used, which will bring a series of pollution to the environment

Method used

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  • The medical use anti-infection polymeric material and its preparation method
  • The medical use anti-infection polymeric material and its preparation method
  • The medical use anti-infection polymeric material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] 1. Preparation of Na-montmorillonite: Stir 20 g of raw montmorillonite in 500 mL NaCl saturated deionized aqueous solution to form a stable suspension; stir the suspension at 30°C for 5 hours, filter with suction, and then wash and filter with deionized water object 3 times. The precipitate was vacuum-dried at 60° C. to constant weight, and ball-milled to a particle size of 20-30 μm to obtain Na-montmorillonite.

[0072] 2. Preparation of organic montmorillonite: Stir 20 g of Na-montmorillonite in 400 mL of deionized water dispersion medium to form a stable suspension; then add 18 g of benzethonium chloride to the suspension; The reaction was stirred for 4 hours. Suction filtration, and then wash the filtrate several times with deionized water until the filtrate is free of Cl - Until detected (detection of Cl with silver nitrate aqueous solution - ). The precipitate was vacuum-dried at 60° C. to constant weight, and ball-milled to a particle size of 20-30 μm to obta...

Embodiment 2

[0077] 1. Preparation of Na-montmorillonite: same as in Example 1.

[0078]2. Preparation of organic montmorillonite: add 5g Na-montmorillonite to 100ml deionized water, stir to form a stable suspension; add 1g dodecyltrimethylammonium bromide and 1g hexadecyltrimethylbromide Ammonium chloride was stirred at 85°C for 4 hours. Suction filtration, and then wash the filtrate several times with deionized water until the filtrate is free of Br - Until detection (detection of Br with silver nitrate aqueous solution - ). The precipitate was vacuum-dried at 60° C. to constant weight, and ball-milled to a particle size of 20-30 μm to obtain organic montmorillonite.

[0079] 3. Preparation of loaded econazole montmorillonite: Add 50ml of absolute ethanol to the modified organic montmorillonite obtained above, stir to form a stable suspension, add 2g of econazole, stir at room temperature for 4 hours, suction filter, and then The filtrate was washed 4 times with absolute ethanol. Th...

Embodiment 3

[0082] 1. Preparation of Na-montmorillonite: same as in Example 1.

[0083] 2. Preparation of organic montmorillonite: Stir 30 g of Na-montmorillonite in 600 mL of deionized water dispersion medium to form a stable suspension; then mix 15 g of didecyldimethyl ammonium chloride and 15 g of cetyl tri Methylammonium chloride was added to the suspension; the mixture was stirred and reacted at 85°C for 4 hours. Suction filtration, and then wash the filtrate several times with deionized water until the filtrate is free of Cl - Until detected (detection of Cl with silver nitrate aqueous solution - ). The precipitate was vacuum-dried at 60° C. to constant weight, and ball-milled to a particle size of 20-30 μm to obtain organic montmorillonite.

[0084] 3. Prepare loaded gentamicin montmorillonite: add the organic montmorillonite prepared above into 300ml deionized water, stir to form a stable suspension, add 4 million units (about 40g) of gentamicin, and stir at room temperature fo...

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Abstract

The invention provides an anti-infective medical polymer material, comprising 100 dose of heat curable silicone rubber, 2.5 to 15 dose of Na-montmorillonite, 0.75 to 6.2 dose of quaternary ammonium salt intercalation compounds, 0.3 to 5.6 doses of antibiotics. Preparation method of the materials is: convert the montmorillonite clay to Na-montmorillonite, and then intercalate quaternary ammonium salts to montmorillonite to obtain the organic-montmorillonite with anti-infective drugs attached to it, and compound with heat curable silicone rubber at last. The material has a long anti-infection time, good physical and mechanical properties, and not easy to age. It can be used in the preparation of various medical catheters, such as catheters, deep venous catheters, drainage tubes, trachea intubation and so on.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to an anti-infection medical polymer material. Background technique [0002] Medical catheters are widely used clinically in hospitals, including urinary catheters, drainage tubes, and tracheal intubation tubes. Since these catheters remain in the body for a long period of time, problems with catheter-related infections often arise. The current clinical measures and existing problems in the treatment of catheter-related infections include: 1. Timely replacement of catheters, but repeated replacement of catheters will increase the patient's pain and chances of infection; Difference; 3. Antibiotics are used, but once catheter-related infection occurs, it is difficult for antibiotics to pass through the biofilm, and the effect is often not good. [0003] The polymers currently used to prepare medical catheters are as follows: [0004] 1. Natural latex: highly irritating to the human...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/16
Inventor 韦莉萍邱玉超路新卫李振林谭习有
Owner SOUTHERN MEDICAL UNIVERSITY
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