36 results about "Benzethonium chloride" patented technology

The present invention relates to a use of benzethonium chloride in preparing a drug for improving or treating non-alcoholic fatty liver disease, and relates to the technical field of new uses of products. The present invention discovers for the first time a new use of benzethonium chloride for improving or treating non-alcoholic fatty liver disease. Benzethonium chloride can reduce hepatocyte lipid deposition and regulate hepatocyte lipid metabolism disorder by intervening in a cell lipid deposition model; it can improve liver lipid accumulation in mice caused by lipid metabolism disorder by administering through the digestive tract, and can improve liver coefficient, liver function, hepatic lobular inflammation, and liver fibrosis. The benzethonium chloride of the present invention can be used for the preparation of drugs for improving or treating non-alcoholic fatty liver disease. The benzethonium chloride of the present invention can inhibit the expression of human apolipoprotein C3, thereby reducing the generation of lipids, and is applied to drugs for treating non-alcoholic fatty liver disease, opening up a new use of benzethonium chloride and providing a new drug option for treating non-alcoholic fatty liver disease.

The invention relates to a sterile, ready-to-use, stable aqueous solution of ketamine suitable for direct intravenous infusion to a patient in need thereof, wherein the composition is disposed within a sealed infusion container as a premixture. The invention further relates to aqueous solutions of ketamine that are free of antimicrobials such as benzethonium chloride and are shelf-stable. The pharmaceutical compositions can be used, for example, wherein the subject is in need of anesthesia for a diagnostic or a surgical procedure.

The pressure relief assembly comprises a supporting plate, supporting frames are fixedly installed at the top end of the supporting plate, a pressure relief pipe is arranged between the supporting frames, an input hole and an output hole are formed in the two sides of the pressure relief pipe respectively, the inner wall of the pressure relief pipe is rotationally connected with a rotating shaft, and the inner wall of the rotating shaft is rotationally connected with the pressure relief pipe. The rotating shaft is sleeved with a rotating cylinder, two baffles are fixedly installed at the top end and the bottom end of the rotating cylinder, and the two baffles are slidably connected with the inner wall of the pressure relief pipe. After pressure relief is completed, internal air pressure and external air pressure are balanced, at the moment, under the action of the torsion spring, the rotating shaft is rapidly reset, the baffle is reset to be in a vertical state, and when the internal air pressure is reduced and external air pushes the baffle through the output pipe, under the action of the stop block at the bottom end, the baffle cannot rotate, and the backflow phenomenon cannot occur; and under the elastic action of the torsional spring, the baffle can be reset rapidly, and the backflow phenomenon is avoided.

The application discloses a preparation method of a high-temperature-resistant reverse osmosis membrane and the high-temperature-resistant reverse osmosis membrane. The preparation method comprises the following steps: (1) adding polyarylene ether nitrile into an organic solvent under heating and stirring, stirring for a period of time after the feeding is completed, and obtaining a mixed solution; (2) continuing to add a pore former after the mixed solution is cooled, stirring for a period of time after the feeding is completed, and obtaining a precursor solution; (3) performing vacuum defoaming treatment on the precursor solution, and obtaining a casting solution; (4) loading the casting solution on a carrier, and then performing gel bath treatment, and obtaining a base film; (5) sequentially immersing the base film in a first aqueous solution, a second aqueous solution and an organic phase solution for polyamide treatment, and obtaining the high-temperature-resistant reverse osmosis membrane; wherein the first aqueous solution comprises benzalkonium chloride; the second aqueous solution comprises polyethyleneimine; and the organic phase solution comprises trimesoyl chloride. The application has the advantages of simple process and significantly improved heat resistance of the obtained reverse osmosis membrane.

The utility model discloses an automatic screening device for preparing benzethonium chloride, which comprises a shell, a cover plate is arranged on the upper portion of the shell, a first screening structure and a second screening structure which are distributed up and down are arranged in the shell, the first screening structure comprises a frame, a screening net is arranged on the frame, one end of the frame is hinged to the shell, and the other end of the frame is connected to a reciprocating structure through a connecting line. The second screening structure comprises a second frame, a second screening net is arranged on the second frame, one end of the second frame is hinged to the shell, and the other end of the second frame is connected to the reciprocating structure through a second connecting line. According to the benzethonium chloride production device, large impurities and small impurities are screened by arranging two groups of screening structures, so that the benzethonium chloride preparation and production effects are improved; meanwhile, the reciprocating structure is matched with the spring, vibration of the screening and filtering net is achieved, blocking is prevented, and the screening and filtering efficiency is also guaranteed.

The utility model relates to the technical field of packaging machines, in particular to a special automatic packaging machine suitable for the character of high-purity benzethonium chloride, which comprises a working table, a mounting frame is arranged on the working table, a charging barrel is arranged on the mounting frame, a discharge port is arranged on the charging barrel, a stirring mechanism is arranged in the charging barrel, and the stirring mechanism is arranged on the working table. The workbench is further provided with a vibration mechanism, the vibration mechanism comprises a lifting column fixedly arranged on the mounting frame, a vertical rod is slidably connected into a first sliding groove in the lifting column, the vertical rod is connected with a sleeve through a connecting rod, and the sleeve is slidably connected with the discharging opening; a driving mechanism is further arranged on the lifting column and used for driving the vertical rod to slide in the first sliding groove in a reciprocating mode. By means of the vibration mechanism, attached powder falls off and huddled powder is scattered, the powder on the inner wall is cleaned by moving the sleeve, the structure is simpler, and the cleaning effect is better.

The invention discloses a compound washing preservative as well as a preparation method and application thereof, and the compound washing preservative comprises the following components or consists of the following components: a group: phenoxyethanol; group b: one or more of ethylhexylglycerin, benzethonium chloride, didecyl dimethyl ammonium chloride, benzoic acid, benzyl alcohol and dichlorobenzyl alcohol; and the group c comprises at least one or more of deionized water, ethylene glycol, propylene glycol and butanediol. The preservative composition provided by the invention has the characteristics of mildness, no irritation, moisture retention, no residue and environmental friendliness, the preservative effect is better than that of single use of phenoxyethanol under the condition of lower dosage, and the purposes of composite synergism, additive amount reduction and application cost control are achieved by exerting the respective characteristics of various preservatives.

This invention discloses a microcapsule, its preparation method, and its applications, belonging to the field of bioprotective materials. The microcapsule has a tertiary spherical or near-spherical particle structure, including a core layer, a shell layer covering the core layer, and satellite layers anchored to the outer surface of the shell layer. The core layer includes an active ingredient and a hydrophobic carrier medium. The shell layer is a cross-linked polyurethane-polyurea wall material formed by interfacial polymerization of polyisocyanate and polyols or polyamines containing hydrophilic segments. The satellite layers include active units and bridging and stabilizing units. The active units include benzalkonium chloride or benzyl chloride. The satellite layers exist in the form of nanoparticles or molecular clusters with a size of 10-150 nm. This invention, applied to bioprotective materials, solves the problem of efficient co-loading and intelligent sequential release of multipolar active substances in existing microcapsules. It possesses antiviral, antibacterial, antifungal, and anti-mite functions, a long service life, and features controllable and reproducible processes.

The present invention relates to the field of component detection technology, and in particular to a method for detecting benzethonium chloride in food using ultra-high performance liquid chromatography-tandem mass spectrometry. The method comprises the following steps: extracting a food sample from the food to be tested, and pre-treating the food sample using liquid-liquid extraction and solid-phase extraction methods to obtain a pre-treated liquid sample; concentrating and dissolving the pre-treated liquid sample to obtain a sample mixed solution; performing mass spectrometry analysis on the sample mixed solution using ultra-high performance liquid chromatography-tandem mass spectrometry to obtain state information of characteristic ion signals of benzethonium chloride; obtaining an estimated concentration of benzethonium chloride based on the state information of the characteristic ion signals of benzethonium chloride; and obtaining a final benzethonium chloride concentration by introducing a dynamic ion response model and combining a recursive optimization algorithm. The method solves the technical problem that the traditional method for detecting harmful substances in food has low detection accuracy and poor sensitivity for benzethonium chloride components in food testing.

The invention belongs to the technical field of biological medicines, and particularly relates to application of benzethonium chloride as an STAT3 inhibitor in preparation of a medicine for treating head and neck tumors. The invention proves that BZN is directly combined with STAT3 protein to reduce tyrosine phosphorylation and nuclear translocation of the STAT3 protein, so that expression of downstream MCL-1 is reduced, and head and neck tumor cells are subjected to apoptosis. According to the application disclosed by the invention, the STAT3 is determined to be a potential target of the BZN, and the BZN is proved to be combined with STAT3 protein in head and neck tumor cells FaDu and CAL-27, so that the CAL-27 and FaDu cells are subjected to apoptosis, and an anti-tumor effect is achieved. BZN is expected to become a new action target of STAT3.

The invention discloses an ultrapure benzethonium chloride raw material crushing and grinding device, relates to the technical field of benzethonium chloride raw material production, comprises a grinding barrel and a crushing port arranged on the upper part of the grinding barrel, and also comprises: a shell body, the shell body is arranged outside the grinding barrel, the interior of the shell body is separated into a sinking cavity and a flow rate cavity by a partition plate, the flow rate cavity and the inner cavity of the grinding barrel are connected by a guide channel; a circulation pipe, the lower end of the circulation pipe is plugged into the shell body, the upper part of the circulation pipe is connected with a conveying pipe, the other end of the conveying pipe extends to the crushing port, and an axial flow fan is arranged inside the conveying pipe; a filter element is arranged at the bottom of the circulation pipe; the invention sucks dust generated during grinding in the grinding barrel through the guide channel, and discharges it to the top of the crushing roller after filtering, so as to generate a downward suction at the crushing port, and finally form a circulating air flow direction, which greatly reduces the escape of dust, improves the crushing continuity, and is more environmentally friendly.

The utility model discloses a high-purity benzethonium chloride bearing mechanism and a full-automatic centrifuge, comprising a bearing rotor, wherein a plurality of mounting holes are provided inside the bearing rotor, a bearing tube is rotatably connected inside the mounting hole, a supporting sheet is slidably provided inside the bearing tube, an adjusting mechanism is provided at the bottom of the bearing tube, and the adjusting mechanism is connected to the supporting sheet through the bearing tube; when the high-purity benzethonium chloride is centrifuged using the bearing rotor, the amount of high-purity benzethonium chloride required for centrifugation is different for different needs, and when a small amount of high-purity benzethonium chloride is centrifuged, the capacity inside the bearing tube is changed by changing the position of the supporting sheet inside the bearing tube, and the device is adapted to centrifuge tubes with a plurality of different capacities, which respectively correspond to different positions of the supporting sheet inside the bearing tube, and the position of the supporting sheet is adjusted by the adjusting mechanism.

The utility model relates to the technical field of chemical preparation, in particular to a mixing device for quaternary ammonium salt benzethonium chloride, which comprises a mixing box, containing grooves are arranged on two sides of the mixing box, rotating shafts are fixedly connected to end corners of the containing grooves, a rotating lifting frame is sleeved on the outer side of each rotating shaft, a clamping groove is arranged in each rotating lifting frame, and a measuring and adding device is sleeved in each clamping groove. A plurality of stirring rods are connected to the front and rear end surfaces inside the mixing box through rotating shafts; the mixing device for the quaternary ammonium salt benzethonium chloride has the beneficial effects that the metering and adding device is arranged, so that when reaction solutions are metered and mixed, a piston can be directly opened after the reaction solutions are metered to enable the solutions to enter the mixing box, the pouring step is reduced, and when the reaction solutions need to be metered and added for multiple times, the metering and adding time is shortened. More steps can be saved, and the operation efficiency is improved.

The high-purity benzethonium chloride stirring mechanism comprises a supporting frame and a motor fixedly installed at the top end of the supporting frame, the output end of the motor is in transmission connection with a rotating shaft, a first fluted disc is fixedly installed on the rotating shaft, two connecting plates are arranged on one side of the supporting frame, and a second fluted disc is arranged on the other side of the supporting frame. The side walls of the two connecting plates are rotationally connected with a first rotating shaft and a second rotating shaft correspondingly, a second fluted disc and a first gear are fixedly installed on the first rotating shaft, a second gear and a rotating disc are fixedly installed on the second rotating shaft, the second gear is meshed with the first gear, the first fluted disc is meshed with the second fluted disc, and the rotating disc is fixedly installed on the rotating shaft. A transmission shaft is rotationally connected to the side wall of the rotating disc, a rotating ring is fixedly installed at one end of the transmission shaft, and a piston is rotationally connected to the rotating ring. According to the utility model, redundant expansion gas generated in the dissolving, stirring and heating process is smoothly pumped out and then discharged.

The utility model discloses a filtering device for a benzethonium chloride production line, and relates to the technical field of filtering devices. The device comprises a filtering tank, a dismounting mechanism and a configuration mechanism, the dismounting mechanism and the configuration mechanism are arranged on the filtering tank, a base is fixedly connected to the inner wall of the filtering tank, a circular groove is formed in the top of the base, a sliding groove is formed in the top of the filtering tank, and a circular filter screen is slidably connected to the interior of the circular groove; the top of the circular filter screen extends out of the sliding groove and is in sliding connection with the sliding groove. Through the arrangement of the dismounting mechanism, when the circular filter screen needs to be replaced, the strip-shaped rod can be pulled outwards, the strip-shaped rod drives the limiting rod to slide upwards on the outer wall of the sliding rod, and meanwhile, the spring on the outer wall of the sliding rod is compressed, so that the limiting rod can release the limiting of the circular filter screen; the circular filter screen can be conveniently and quickly replaced, so that the filtering effect of the filter screen is remarkably improved, and the service life of the filter screen is remarkably prolonged.

The present invention relates to the pharmaceutical industry and introduces innovative methods for producing highly active pharmaceutical heparin products using conventional crude bovine heparin (HBI) as the starting material. The methods include the production of (1) crude bovine heparin (crude SBH), (2) Active Pharmaceutical Ingredients (API) of unfractionated bovine heparin (SBH- UFH API), and (3) API of bovine low-molecular-weight heparin (B-LMWH), for preparing pharmaceutical compositions comprising them. By utilizing cetylpyridinium chloride (CPC) for selective precipitation, these methods achieve enhanced control over purity and anticoagulant potency, yielding products comparable to porcine-derived heparins. Additionally, the use of benzethonium chloride (CBZ) for producing B-LMWH demonstrates the expanded applicability of quaternary ammonium compounds and the flexibility of this invention. This practical, cost-effective process is suitable for large-scale manufacturing and addresses the need for diversified heparin sources, reducing dependency on porcine products and mitigating supply chain risks. It is particularly significant for markets requiring non-porcine medical products, such as those adhering to Halal laws, thus meeting a critical demand in the global pharmaceutical industry.

The present invention relates to a composition for removing post-etch residues from a substrate comprising a surface of a molybdenum layer, the composition comprising: (a) 10% to 60% by weight of a water-miscible organic solvent; (b) from 4% to 15% by weight of a C1-C12 amine; (c) 0.1% to 4% by weight of a C4 to C16 quaternary ammonium hydroxide; (d) 0.5% to 5% by weight of a C2 to C10 polyol; (e) from 0.01% to 1% by weight of a polyalkoxylated polyethyleneimine; (f) from 0.001% to 0.17% by weight of benzethonium chloride or benzalkonium chloride; and (g) water.

The invention discloses an online monitoring method and device for a polymer type anionic scale inhibitor. Based on a multipoint chelation reaction principle, after circulating cooling water is sampled, a sodium citrate solution is firstly added for pretreatment to eliminate metal ion interference, then a benzethonium chloride solution is added, a quaternary ammonium group of the benzethonium chloride solution and a plurality of anion groups on a molecular chain of the polymer type anion scale inhibitor are subjected to a multipoint chelation reaction, and the polymer type anion scale inhibitor is obtained. A cross-linked macromolecular network structure is formed, a stable turbidity signal is generated, the intensity of the optical signal is detected through a scattered light detector, and the concentration of the scale inhibitor is calculated in combination with a multi-curve automatic identification technology. The device adopts a modular design, takes an intelligent control system as a core, and integrates six functional modules of sampling, reagent adding, reaction, detection, discharge and communication. The method is suitable for online monitoring of polymer type organic phosphonic acid, carboxylic acid and sulfonate scale inhibitors, realizes unattended real-time monitoring, and provides an effective technical means for accurate control of addition of the scale inhibitors in a circulating cooling water system.

The invention discloses a bacteriostatic temperature-sensitive no-wash hand washing gel containing hydrophilic ozone oil emulsion and a preparation method thereof, and the bacteriostatic temperature-sensitive no-wash hand washing gel comprises the following components: 30-55 wt% of hydrophilic ozonized oil emulsion, 5-10 wt% of glycerol, 8-15 wt% of propylene glycol, 5-8 wt% of carbomer 940, 1-2 wt% of vitamin E, 0.1-1 wt% of triethanolamine, 0.3-2 wt% of benzethonium chloride, 0.3-0.5 wt% of phenoxyethanol, 0.5-2 wt% of 1, 2-hexanediol, 1-3 wt% of plant essential oil, and the balance of deionized water. The content of ozonized oil in the hydrophilic ozonized oil emulsion is 0.5-5 wt%; the prepared bacteriostatic temperature-sensitive no-wash hand-washing gel containing the hydrophilic ozone oil emulsion has a relatively strong bacteriostatic effect on pathogenic bacteria, and can inhibit rapid breeding of residual and newly added bacteria on hands, so that the hands are kept clean for a long time, frequent use of hand sanitizers is avoided, and the gel is milder, is very suitable for dry skin and being used in winter, and has a good application prospect. A certain skin nourishing effect is achieved.

The invention belongs to the technical field of benzethonium chloride production methods, and particularly relates to a method for continuously producing benzethonium chloride, which comprises the following steps: S1, dissolving p-tert-octylphenol in dichlorodiethyl ether at room temperature to prepare a p-tert-octylphenol-dichlorodiethyl ether mixed solution; pumping the p-tert-octylphenol-dichlorodiethyl ether mixed solution and a potassium hydroxide solution with the concentration of 10-80% into a reaction kettle by a continuous flow method for etherification reaction, adding water for extraction and layering, separating out a lower water layer, and washing an organic phase at the lower layer twice; and S2, after washing, desolventizing under reduced pressure to recover dichlorodiethyl ether, so as to obtain p-tert-octyl phenoxy ethyoxyl ethyl chloride. According to the invention, the yield and purity of the product and the utilization rate of the raw materials can be improved at a relatively low temperature within a relatively short reaction time, and the production efficiency is ensured.

The invention relates to a sterile, ready-to-use, stable aqueous solution of ketamine suitable for direct intravenous infusion to a patient in need thereof, wherein the composition is disposed within a sealed infusion container as a premixture. The invention further relates to aqueous solutions of ketamine that are free of antimicrobials such as benzethonium chloride and are shelf-stable. The pharmaceutical compositions can be used, for example, wherein the subject is in need of anesthesia for a diagnostic or a surgical procedure.

The invention relates to a sterile, ready-to-use, stable aqueous solution of ketamine suitable for direct intravenous infusion to a patient in need thereof, wherein the composition is disposed within a sealed infusion container as a premixture. The invention further relates to aqueous solutions of ketamine that are free of antimicrobials such as benzethonium chloride and are shelf-stable. The pharmaceutical compositions can be used, for example, wherein the subject is in need of anesthesia for a diagnostic or a surgical procedure.

The invention relates to the technical field of moisture detection, in particular to a dynamic moisture content monitoring device for benzethonium chloride reduced pressure crystallization, which comprises a mounting flange, a mounting block and an infrared detection probe for moisture content monitoring, the mounting block is coaxially and fixedly connected in the mounting flange, and the mounting block completely seals an inner hole of the mounting flange; a mounting hole is formed in the mounting block, and the infrared detection probe is fixedly mounted in the mounting hole; the scraping plate is arranged at the front end of the mounting block, the front-back projection of the detection end of the infrared detection probe is always within the rotation track coverage range of the scraping plate, the outer edge of the rear side continuously sweeps the surface of the detection window when the scraping plate rotates, crystal nucleuses just formed on the edge of the scraping plate are removed in real time in a mechanical mode, and crystal film layers are prevented from being formed; therefore, the problem of monitoring failure caused by crystal attachment of the infrared detection probe in the benzethonium chloride crystallization working condition is solved, and the accuracy and continuity of moisture content monitoring are ensured.

The invention relates to the technical field of component detection, in particular to a method for detecting benzethonium chloride in food by using ultra-high performance liquid chromatography-tandem mass spectrometry. The method comprises the following steps: extracting a food sample from to-be-detected food, and pretreating the food sample by adopting liquid-liquid extraction and solid-phase extraction methods to obtain a pretreated liquid sample; concentrating and dissolving the pretreated liquid sample to obtain a sample mixed solution; carrying out mass spectrometry on the sample mixed solution by using ultra-high performance liquid chromatography-tandem mass spectrometry to obtain state information of characteristic ion signals of benzethonium chloride; based on the state information of the characteristic ion signal of the benzethonium chloride, obtaining a concentration estimation value of the benzethonium chloride; the final concentration of benzethonium chloride is obtained by introducing a dynamic ion response model and combining a recursive optimization algorithm. The technical problems that in food detection, a traditional method for detecting harmful substances in food is low in detection accuracy and poor in sensitivity when being used for detecting benzethonium chloride components are solved.

The present disclosure provides an aerogel-type antibacterial and mildew-proof agent and its preparation method and application, which belongs to the technical field of antibacterial and mildew-proof agents. The aerogel-type antibacterial and mildew-proof agent disclosed herein includes the following components in parts by weight: 15-30 parts of zirconium dioxide aerogel, 10-20 parts of antibacterial and mildew-proof agent, and 0.1-0.5 parts of coating agent; wherein the antibacterial and mildew-proof agent is at least three of polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorphenesin, cetylpyridinium chloride, cetrimide bromide, benzethonium chloride, chlorhexidine glucose, and dimethyl ammonium chloride; the coating agent is hydrophilic wax powder. The antibacterial and mildew-proof plastic prepared by the aerogel-type antibacterial and mildew-proof agent disclosed herein has the advantages of good killing effect on bacteria and fungi, high light transmittance, and low yellowing.

The invention discloses application of benzethonium chloride as a c-KIT inhibitor, and belongs to the technical field of medicines. The invention proves that benzethonium chloride can obviously lower the c-KIT protein level in tumor cells, further inhibits the activation level of the downstream Mnk1 / 2-eIF4E axis, expands the new mechanism of benzethonium chloride for inhibiting the occurrence and development of tumors, reveals the potential of benzethonium chloride serving as a c-KIT inhibitor for new anti-tumor application, and has very important significance.

The preparation method comprises the following steps: preparing a deodorization core, preparing wrapping slurry, wrapping the deodorization core with the wrapping slurry to form a shell, and preparing the cat litter antibacterial and deodorant particles. According to the preparation method of the bacteriostatic and deodorant cat litter particles, the bacteriostatic and deodorant cat litter particles are prepared into a deodorant core prepared by mixing fluff pulp, baking soda, benzethonium chloride, cetylpyridinium chloride and benzalkonium chloride, and a shell prepared by mixing glue, a curing agent and benzethonium chloride; the benzethonium chloride is dissolved in water, so that the shell forms an adsorption capillary hole for communicating the inner cavity with the external connection, the shell can physically isolate the deodorization core, the deodorization core can adsorb urine for deodorization, and as the main components of the shell are glue and a curing agent, health hazards cannot be caused when pets contact the shell.

The invention discloses a multi-component composition with a good antibacterial effect, which is prepared from the following raw materials in percentage by weight: 15 to 30 percent of surfactant, 10 to 30 percent of humectant, 1 to 3 percent of skin conditioner, 0.1 to 0.3 percent of antioxidant, 0.1 to 0.3 percent of preservative, 0.1 to 0.3 percent of chelating agent, 0.1 to 0.4 percent of pH regulator, 0.5 to 1.5 percent of emollient, 0.05 to 0.3 percent of plant bacteriostatic agent, 1 to 3 percent of cationic bacteriostatic agent and the balance of deionized water. 0.001-0.02% of a pigment additive, and deionized water is supplemented to 100%. Triple cationic antibacterial components of chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide are matched with triple plant essence antibacterial components of melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil, so that broad-spectrum antibacterial property can be realized, growth of various microorganisms is inhibited, and meanwhile, the antibacterial and anti-bacterial shampoo is comfortable to use, free of toxic and side effects and low in cost. And consumers can easily accept.

The integrated synthesis kettle comprises a cylinder body, the inner side wall of the cylinder body is provided with a curved surface with convex surfaces and concave surfaces arranged alternately, a stirring shaft is rotatably arranged in the cylinder body, stirring blades and axial flow stirrers are alternately arranged on the stirring shaft, and the axial flow stirrers are arranged in the cylinder body. A sliding block is arranged in the two ends of the stirring blade in a sliding mode, one end of the sliding block extends into the stirring blade and then is connected with the inner wall of the stirring blade through a spring, the other end of the sliding block is fixedly connected with a scraping plate, and the scraping plate abuts against the inner wall of the barrel. According to the reaction kettle disclosed by the utility model, the telescopic stirrer is fixedly sleeved on the stirring shaft and is matched with the convex surface and the concave surface, so that automatic stretching of the telescopic stirrer is realized, the aim of improving the mixing efficiency at the edge of the inner wall of the reaction kettle is fulfilled, the reaction rate of chemical reaction is further improved, and a solution adhered to the inner wall of the barrel body is scraped by the scraper; the raw material mixing efficiency is further improved, and the chemical reaction progress is accelerated.

The invention relates to the technical field of chemical synthesis, and particularly provides a preparation method of benzethonium chloride, which comprises the following steps: under the protection of nitrogen, mixing p-tert-octylphenol, dimethylaminoethoxyethanol methanesulfonate, a solvent toluene and a catalyst, heating for etherification reaction, standing for layering after the reaction is completed, removing the solvent from an organic layer, and rectifying and purifying by a short column to obtain benzethonium chloride. The p-tert-octylphenoxy ethyoxyl ethyl dimethylamine is obtained after the reaction is completed; the method comprises the following steps: under the protection of nitrogen, mixing p-tert-octyl phenoxy ethyoxyl ethyl dimethylamine with ethyl acetate, adding benzyl chloride to carry out quaternization reaction, filtering reaction liquid, pulping and washing solid with acetone, and drying to obtain benzethonium chloride. The method solves the problems of high-temperature and high-pressure potential safety hazards and insufficient purity of the traditional process, and has the advantages of high efficiency, safety and environmental protection.