6 results about "Benzethonium chloride" patented technology

The utility model discloses an automatic screening device for preparing benzethonium chloride, which comprises a shell, a cover plate is arranged on the upper portion of the shell, a first screening structure and a second screening structure which are distributed up and down are arranged in the shell, the first screening structure comprises a frame, a screening net is arranged on the frame, one end of the frame is hinged to the shell, and the other end of the frame is connected to a reciprocating structure through a connecting line. The second screening structure comprises a second frame, a second screening net is arranged on the second frame, one end of the second frame is hinged to the shell, and the other end of the second frame is connected to the reciprocating structure through a second connecting line. According to the benzethonium chloride production device, large impurities and small impurities are screened by arranging two groups of screening structures, so that the benzethonium chloride preparation and production effects are improved; meanwhile, the reciprocating structure is matched with the spring, vibration of the screening and filtering net is achieved, blocking is prevented, and the screening and filtering efficiency is also guaranteed.

This invention discloses a microcapsule, its preparation method, and its applications, belonging to the field of bioprotective materials. The microcapsule has a tertiary spherical or near-spherical particle structure, including a core layer, a shell layer covering the core layer, and satellite layers anchored to the outer surface of the shell layer. The core layer includes an active ingredient and a hydrophobic carrier medium. The shell layer is a cross-linked polyurethane-polyurea wall material formed by interfacial polymerization of polyisocyanate and polyols or polyamines containing hydrophilic segments. The satellite layers include active units and bridging and stabilizing units. The active units include benzalkonium chloride or benzyl chloride. The satellite layers exist in the form of nanoparticles or molecular clusters with a size of 10-150 nm. This invention, applied to bioprotective materials, solves the problem of efficient co-loading and intelligent sequential release of multipolar active substances in existing microcapsules. It possesses antiviral, antibacterial, antifungal, and anti-mite functions, a long service life, and features controllable and reproducible processes.

The present invention relates to the pharmaceutical industry and introduces innovative methods for producing highly active pharmaceutical heparin products using conventional crude bovine heparin (HBI) as the starting material. The methods include the production of (1) crude bovine heparin (crude SBH), (2) Active Pharmaceutical Ingredients (API) of unfractionated bovine heparin (SBH- UFH API), and (3) API of bovine low-molecular-weight heparin (B-LMWH), for preparing pharmaceutical compositions comprising them. By utilizing cetylpyridinium chloride (CPC) for selective precipitation, these methods achieve enhanced control over purity and anticoagulant potency, yielding products comparable to porcine-derived heparins. Additionally, the use of benzethonium chloride (CBZ) for producing B-LMWH demonstrates the expanded applicability of quaternary ammonium compounds and the flexibility of this invention. This practical, cost-effective process is suitable for large-scale manufacturing and addresses the need for diversified heparin sources, reducing dependency on porcine products and mitigating supply chain risks. It is particularly significant for markets requiring non-porcine medical products, such as those adhering to Halal laws, thus meeting a critical demand in the global pharmaceutical industry.

The invention relates to the technical field of moisture detection, in particular to a dynamic moisture content monitoring device for benzethonium chloride reduced pressure crystallization, which comprises a mounting flange, a mounting block and an infrared detection probe for moisture content monitoring, the mounting block is coaxially and fixedly connected in the mounting flange, and the mounting block completely seals an inner hole of the mounting flange; a mounting hole is formed in the mounting block, and the infrared detection probe is fixedly mounted in the mounting hole; the scraping plate is arranged at the front end of the mounting block, the front-back projection of the detection end of the infrared detection probe is always within the rotation track coverage range of the scraping plate, the outer edge of the rear side continuously sweeps the surface of the detection window when the scraping plate rotates, crystal nucleuses just formed on the edge of the scraping plate are removed in real time in a mechanical mode, and crystal film layers are prevented from being formed; therefore, the problem of monitoring failure caused by crystal attachment of the infrared detection probe in the benzethonium chloride crystallization working condition is solved, and the accuracy and continuity of moisture content monitoring are ensured.

The invention discloses wet toilet paper capable of relieving haemorrhoids pain and a preparation method thereof, and belongs to the field of wet toilet paper, the wet toilet paper comprises spunlace non-woven fabric and production liquid, the production liquid comprises sodium benzoate, polyaminopropyl biguanide, benzethonium chloride, glycerin, Kava pepper extract, turmeric extract, purslane extract, inulin, lactic acid and deionized water, through the mutual synergistic effect of plant compositions composed of the pepper kava extract, the turmeric extract, the purslane extract and the inulin, the effects of better relieving haemorrhoids pain and the like are achieved from the aspects of inflammation inhibition, pain relief, tissue repair, inducement control and the like; the single product can achieve the effects of quickly relieving pain in a short time, efficiently inhibiting inflammation and repairing tissues in a middle stage, improving local environment for a long time and reducing relapse, is convenient for patients to continuously use, has better and more lasting analgesic effect, can repair haemorrhoids parts in time, avoids the conditions that various products are replaced and used and the effect is difficult to last, reduces the use cost, and is worthy of popularization and application. No stimulation is caused.

The invention belongs to the technical field of organic synthesis, and particularly relates to a solvent-recycled benzethonium chloride environment-friendly production method which comprises the following steps: (1) addition reaction: mixing p-tert-octylphenol, ethylene oxide and epichlorohydrin according to a molar ratio of 1: (1.2-1.5): (1.05-1.35), adding the mixture into a composite solvent A, and carrying out addition reaction under the action of a catalyst, reaction liquid containing chloride intermediates is obtained; the composite solvent A is formed by mixing ethanol and ethyl acetate according to a volume ratio of (3-5): 1, and the mass of the composite solvent A is 1.2-2.0 times of the total mass of p-tert-octylphenol, ethylene oxide and epichlorohydrin; (2) quaternization reaction; (3) purifying a crude product; (4) solvent recovery; and (5) treating residues. According to the method, a composite solvent system is adopted, a multi-tower rectification recovery process is optimized, the solvent recovery rate can reach 95% or above, and closed-loop cyclic utilization of the solvent is achieved.