Multi-heavy-component composition with good antibacterial effect and preparation method of multi-heavy-component composition

Abstract

The invention discloses a multi-component composition with a good antibacterial effect, which is prepared from the following raw materials in percentage by weight: 15 to 30 percent of surfactant, 10 to 30 percent of humectant, 1 to 3 percent of skin conditioner, 0.1 to 0.3 percent of antioxidant, 0.1 to 0.3 percent of preservative, 0.1 to 0.3 percent of chelating agent, 0.1 to 0.4 percent of pH regulator, 0.5 to 1.5 percent of emollient, 0.05 to 0.3 percent of plant bacteriostatic agent, 1 to 3 percent of cationic bacteriostatic agent and the balance of deionized water. 0.001-0.02% of a pigment additive, and deionized water is supplemented to 100%. Triple cationic antibacterial components of chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide are matched with triple plant essence antibacterial components of melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil, so that broad-spectrum antibacterial property can be realized, growth of various microorganisms is inhibited, and meanwhile, the antibacterial and anti-bacterial shampoo is comfortable to use, free of toxic and side effects and low in cost. And consumers can easily accept.

Description

Technical Field

[0001] The present invention relates to A61K, and to the field of pharmaceutical preparations, and in particular to a multi-component composition with good antibacterial effect and a preparation method thereof. Background Art

[0002] With the development of society and the improvement of people's living standards, male consumers are paying more and more attention to their health. Due to the living habits and physiological characteristics of male users, the private parts of men are prone to sweating and stickiness, which breeds a variety of microorganisms. If they are not suppressed, it will induce dermatitis, dermatophytes and other skin diseases in the private parts. Most men's cleaning products on the market are soap products, which can easily cause acid-base imbalance after use. In addition, some men's cleaning products have exaggerated shapes, which can easily discourage users from using them. Therefore, it is crucial to change consumers' concepts and develop a private antibacterial product that is similar to conventional cleaning products and has long-term bactericidal stability.

[0003] Chinese invention patent CN201811117189.7 discloses a natural herbal skin and mucous membrane disinfectant for men's private parts. The natural plant essence and biological synergy make the effect of each active ingredient reach the strongest, and will not cause damage to the delicate private skin and mucous membrane; the antibacterial and disinfection effect is significant, and it has a killing and inhibitory effect on bacteria, fungi, and viruses, but the long-term antibacterial stability is not good, and the content of antibacterial ingredients will decrease after long-term storage. Chinese invention patent CN201811606714.1 discloses a natural antibacterial composition, men's antibacterial wash and its preparation method and application. Various natural plant ingredients cooperate with each other to work in a combined and synergistic manner, with obvious bactericidal and anti-inflammatory effects, and it is mild and non-irritating. It can be used in men's wash, but the bactericidal effect is poor. Summary of the invention

[0004] In order to develop a private part antibacterial product with long-term bactericidal stability, the first aspect of the present invention provides a multi-component composition with good antibacterial effect. The preparation raw materials include, by weight percentage: 15-30% surfactant, 10-30% moisturizer, 1-3% skin conditioner, 0.1-0.3% antioxidant, 0.1-0.3% preservative, 0.1-0.3% chelating agent, 0.1-0.3% pH regulator, 0.1-0.4%, emollient 0.5-1.5%, 0.05-0.3% plant antibacterial agent, 1-3% cationic antibacterial agent, 0.001-0.02% pigment additive, and deionized water is supplemented to 100%.

[0005] As a preferred embodiment, the plant antibacterial agent includes at least one of Melaleuca alternifolia leaf oil, Rosemary (ROSMARINUS OFFICINALIS) leaf oil, Menthaceae (MENTHAPIPERITA) oil, Impatiens balsamina extract, Dictamni extract, Sophora flavescens extract, and Phellodendron amurense extract.

[0006] As a preferred embodiment, the plant antibacterial agent includes a combination of Melaleuca alternifolia leaf oil, rosemary leaf oil, and peppermint oil, and the weight ratio of the Melaleuca alternifolia leaf oil, rosemary leaf oil, and peppermint oil is (0.05-0.2): (0.01-0.03): (0.005-0.02).

[0007] As a preferred embodiment, the cationic antibacterial agent includes at least one of chlorhexidine digluconate, benzethonium chloride, and polyaminopropyl biguanide.

[0008] As a preferred embodiment, the cationic antibacterial agent includes a combination of chlorhexidine digluconate, benzethonium chloride, and polyaminopropyl biguanide, and the weight ratio of the chlorhexidine digluconate, benzethonium chloride, and polyaminopropyl biguanide is (1-2): (0.005-0.02): (0.005-0.02).

[0009] The applicant found in the experiment that the use of chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide triple cationic antibacterial ingredients with Melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil triple plant extract antibacterial ingredients can achieve broad-spectrum antibacterial properties, inhibit the growth of multiple microorganisms, and feel comfortable to use, which is easy for consumers to accept. It is speculated that the possible reason is that the existing products use a single cationic antibacterial ingredient, which will have a certain irritation to the skin while achieving a bactericidal effect, and the stability of the single cationic antibacterial ingredient is not good, and the content of the antibacterial ingredient will decrease after storage, resulting in a decrease in the antibacterial effect. In order to reduce the bactericidal irritation, although the comfort of use of botanical antibacterial agents is better, the bactericidal effect is not comprehensive, and only some pathogens have an inhibitory effect. In this application, the triple cationic antibacterial ingredient is matched with the plant extract antibacterial ingredient, which can not only maintain the long-term preservation of the bactericide, but also have a comprehensive inhibitory effect on a variety of pathogens, and provide comprehensive protection for the male private parts, and is comfortable to use and easily accepted by consumers.

[0010] As a preferred embodiment, the surfactant includes at least one of sodium lauroamphoacetate, cocamidopropyl hydroxysulfobetaine, polyglyceryl laurate, capryl / capryl glucoside and cocoyl glucoside.

[0011] As a preferred embodiment, the moisturizing agent is a polyol, and the polyol includes at least one of butylene glycol, glycerol, propylene glycol, hexylene glycol, caprylyl glycol, pentylene glycol, maltitol, sorbitol, polyethylene glycol, polypropylene glycol, panthenol, and ethylhexylglycerin.

[0012] As a preferred embodiment, the average molecular weight of the polyethylene glycol is 100-600 Da.

[0013] As a preferred embodiment, the average molecular weight of the polyethylene glycol is 150 Da.

[0014] As a preferred embodiment, the glycerol polymerization number of the polyglycerol laurate is 2-10.

[0015] As a preferred embodiment, the glycerol polymerization number of the polyglycerol laurate is 10.

[0016] As a preferred embodiment, the surfactant includes a combination of sodium lauroamphoacetate, cocamidopropyl hydroxysulfobetaine, polyglyceryl-10 laurate, capryl / capryl glucoside, and cocoyl glucoside.

[0017] As a preferred embodiment, the weight ratio of sodium lauroamphoacetate, cocamidopropyl hydroxysulfobetaine, polyglyceryl-10 laurate, capryl / capryl glucoside and cocoyl glucoside is (9-12):(4-7):(0.8-1.5):(0.5-1):(3-5).

[0018] As a preferred embodiment, the weight ratio of sodium lauroamphoacetate, cocamidopropyl hydroxysulfobetaine, polyglyceryl-10 laurate, capryl / capryl glucoside and cocoyl glucoside is 11.5:6:1:0.8:4.

[0019] As a preferred embodiment, the moisturizing agent includes a combination of butylene glycol, glycerol, maltitol, polyethylene glycol-150, panthenol, and ethylhexylglycerin.

[0020] As a preferred embodiment, the weight ratio of butylene glycol, glycerol, maltitol, polyethylene glycol-150, panthenol and ethylhexylglycerin is (6-9): (4-7): (3-5): (1.5-2.5): (0.8-1.5): (0.03-0.1).

[0021] As a preferred embodiment, the weight ratio of butylene glycol, glycerol, maltitol, polyethylene glycol-150, panthenol and ethylhexylglycerin is 8:6:4:2:1:0.05.

[0022] As a preferred embodiment, the skin conditioning agent includes at least one of polyquaternium-39, menthol lactate, and allantoin.

[0023] As a preferred embodiment, the weight ratio of polyquaternium-39, menthol lactate, and allantoin is (1-2): (0.03-0.1): (0.05-0.2).

[0024] As a preferred embodiment, the weight ratio of polyquaternium-39, menthol lactate, and allantoin is 1.5:0.05:0.1.

[0025] As a preferred embodiment, the antioxidant is raspberry ketone, and the preservative is phenoxyethanol.

[0026] As a preferred embodiment, the chelating agent is disodium EDTA.

[0027] As a preferred embodiment, the pH adjuster is a combination of citric acid and sodium citrate, and the weight ratio of the citric acid to sodium citrate is (0.1-0.3): (0.01-0.03).

[0028] As a preferred embodiment, the weight ratio of citric acid to sodium citrate is 0.2:0.02.

[0029] As a preferred embodiment, the emollient is PEG-7 glyceryl cocoate.

[0030] As a preferred embodiment, the pigment additive is caramel color, and the components of the caramel color are selected from at least one of low molecular weight acidic products, cyclic structure compounds, polysaccharide derivatives, and heterocyclic compounds.

[0031] As a preferred embodiment, the low molecular weight acidic product includes at least one of furfural, 5-hydroxymethylfurfural, acetic acid, and lactic acid; the cyclic structure compound includes at least one of pyrazine compounds; the polysaccharide derivative includes at least one of sugar oligomers and melanin polymers; the heterocyclic compound includes at least one of pyrrole compounds and furanone compounds.

[0032] The second aspect of the present invention provides a method for preparing a multi-component composition with good antibacterial effect, comprising the following steps:

[0033] S1 Weigh each component according to the formula, heat the moisturizer, antioxidant, chelating agent and deionized water to 80-85℃, stir and dissolve, and mix evenly;

[0034] S2 adds surfactant and emollient and stirs evenly;

[0035] S3 cools down to 50-60°C and adds preservatives, cools down to 40-50°C and adds skin conditioners, cationic antibacterial agents, plant antibacterial agents, pigment additives, and pH regulators, and stirs and mixes evenly to obtain a multi-component composition with good antibacterial effect.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] (1) The multi-component composition with good antibacterial effect of the present invention adopts chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide triple cationic antibacterial components to cooperate with each other, and can achieve good antibacterial effect at low concentration.

[0038] (2) The multi-component composition with good antibacterial effect described in the present invention, which is a combination of triple cationic antibacterial ingredients of chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide and triple plant extract antibacterial ingredients of Melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil, can achieve broad-spectrum antibacterial properties and inhibit the growth of multiple microorganisms. At the same time, it is comfortable to use and easy for consumers to accept.

[0039] (3) The multi-component composition with good antibacterial effect of the present invention, the cationic antibacterial agent and the plant antibacterial agent work together to improve the stability of the antibacterial components in the antibacterial composition and prolong the storage time of the antibacterial composition.

[0040] (4) The multi-component composition with good antibacterial effect of the present invention can be used for cleaning male private parts, and has excellent acid-base balance, is non-irritating to the skin and private parts, and is comfortable to use.

[0041] (5) The multi-component composition with good antibacterial effect described in the present invention can further improve the stability of the composition by introducing the caramel color substance of the polysaccharide derivative. At the same time, the hydroxyl groups contained in the composition have a certain hydrophilic effect on the skin, which has a certain auxiliary effect on the slip of the foam and the moist feeling after cleaning. DETAILED DESCRIPTION

[0042] Example

[0043] A multi-component composition with good antibacterial effect, the raw materials for preparation are shown in the following Table 1 in terms of weight percentage:

[0044] Table 1

[0045]

[0046]

[0047] The polyglyceryl-10 laurate was purchased from Guangzhou KLD PGLA-W.

[0048] The polyethylene glycol-150 was purchased from Miwon with the brand name MONOPOL PEG6000;

[0049] The polyquaternium salt-39 is purchased from Lubrizol with the brand name MERQUAT TM 3330PR;

[0050] The PEG-7 glyceryl cocoate was purchased from Croda with the brand name SP GLYCEROX HE;

[0051] The Melaleuca alternifolia leaf oil was purchased from Phoenix Aromas and Essential Oils, LLC, with the brand name Tea Tree Oil (Australia);

[0052] The rosemary leaf oil was purchased from Robertet, with the brand name ROSEMARY OIL 00003903;

[0053] The peppermint oil was purchased from Hexin, Jiangmen City, with the brand name BT404612;

[0054] The polyaminopropyl biguanide was purchased from Thor with the brand name Microcare MBG (C);

[0055] The caramel color was purchased from Sensient, with the brand name being CR BROWN 6DLWS.

[0056] A method for preparing a multi-component composition with good antibacterial effect comprises the following steps:

[0057] S1 weighs each component according to the formula, heats the moisturizer, antioxidant, chelating agent and deionized water to 85°C, stirs and dissolves, and mixes evenly;

[0058] S2 adds surfactant and emollient and stirs evenly;

[0059] S3 cools down to 55°C and adds preservatives, cools down to 45°C and adds skin conditioners, cationic antibacterial agents, plant antibacterial agents, pigment additives, and pH regulators, and stirs and mixes evenly to obtain a multi-component composition with good antibacterial effect.

[0060] Comparative Example 1

[0061] A multi-component composition with good antibacterial effect, the specific implementation method is the same as Example 2, but the difference is that it does not contain a pigment additive.

[0062] Comparative Example 2

[0063] A multi-component composition with good antibacterial effect, the specific implementation method is the same as that of Example 2, except that it does not contain a plant antibacterial agent.

[0064] Performance Testing

[0065] 1. pH: The pH value of the embodiment was tested using a pH meter. The test results are shown in Table 2.

[0066] Table 2

[0067] Example 1 Example 2 Example 3 pH 7.72 7.75 7.74

[0068] The pH value of the sample is 7.74, which is in line with Q / JNHZP 3-2024 TM Men's private parts antibacterial liquid" requirements.

[0069] 2. Stability test of bactericidal substance content: Refer to Method 1 in Appendix A of GB / T 26367-2020 Standard Hygiene Requirements for Guanidine Disinfectants, use 3.1260Ifinity Agilent HPLC to test the content of bactericidal substances, and then place it in an environment of 37°C for 3 months to test the content of chlorhexidine gluconate. The test results are shown in Table 3.

[0070] Table 3

[0071]

[0072] Decline rate = (before storage - after 3 months) / before storage × 100%

[0073] After the sample was placed in an environment with a temperature of 37°C for three months, the decrease rate of chlorhexidine gluconate content was 8.4%, and the storage validity period was 2 years.

[0074] 3. Test for the content of bactericidal substances: The multi-component compositions with good antibacterial effects prepared in Example 2, Comparative Example 1, and Comparative Example 2 were tested for the content of benzethonium chloride, chlorhexidine gluconate, and polyaminopropyl biguanide. Benzethonium chloride was tested for the content of benzethonium chloride using the NBC-SW-QC220 method, chlorhexidine gluconate was tested for the content of chlorhexidine gluconate using the method 1 method of Appendix A of GB / T26367-2020 standard guanidine disinfectant sanitation requirements, and polyaminopropyl biguanide was tested for the content of polyaminopropyl biguanide using the method 2 method of Appendix B of GB / T26367-2020 guanidine disinfectant sanitation requirements. The test results are shown in Table 4.

[0075] Table 4

[0076]

[0077]

[0078] 4. Metal ion content test: refer to the "Technical Specification for Safety of Cosmetics" (2015 edition) to test the content of lead, arsenic and mercury in Example 2. The ambient temperature is 24.8°C and the relative humidity is 66%. The test results are shown in Table 5.

[0079] Table 5

[0080] Test results lead Not detected (<0.09mg / kg) arsenic Not detected (<0.09mg / kg) mercury Not detected (<0.09mg / kg)

[0081] The lead content of the sample was undetectable (<0.09mg / kg), the arsenic content was undetectable (<0.0033mg / kg), and the mercury content was undetectable (<0.0033mg / kg).

[0082] 5. Microbial content test: Refer to Appendix B of GB 15979-2002 "Hygiene Standard for Disposable Hygiene Products" to test the microbial content in Example 2. The ambient temperature is 20.8°C and the relative humidity is 53%. The test results are shown in Table 6.

[0083] Table 6

[0084] Test results Total bacterial colony count (CFU / g) ＜4 Coliform bacteria Not detected Pseudomonas aeruginosa Not detected Staphylococcus aureus Not detected Hemolytic Streptococcus Not detected Total fungal colony count (CFU / g) ＜4

[0085] The microbiological indicators of the sample all meet the requirements of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products".

[0086] 6. Antibacterial effect test: Refer to Appendix B of GB 15979-2002 "Hygiene Standards for Disposable Hygiene Products" to test the antibacterial effect of Example 2. The antibacterial rates of the product of Example 2 against Escherichia coli, Staphylococcus aureus, and Candida albicans after 2 minutes, 5 minutes, 10 minutes, and 20 minutes of use were tested. The test results are shown in Table 7.

[0087] Table 7

[0088]

[0089] The sample has antibacterial effects on Escherichia coli, Staphylococcus aureus and Candida albicans, and meets the requirements of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products".

[0090] 7. Skin irritation test: refer to the "Technical Specifications for Disinfection" (2002 edition) 2.3.3.3.3 multiple complete skin irritation test method.

[0091] 24 hours before the test, remove the hair on both sides of the spine of the guinea pig's back without damaging the skin. The hair removal range is about 3cm×3cm on the left and right sides. During the test, apply 0.5mL of the test sample solution on the hairless skin on the left side, and the hairless skin on the right side is used as a control. 4 hours after application, wash with warm water to remove the residue. Apply once a day for 14 consecutive days.

[0092] 4 hours after each application of the test substance, the residual test substance was cleaned with water or a non-irritating solvent, and the erythema and edema of the animal skin were observed 24 hours after the application of the test substance, and the score was given according to the scoring standard for skin irritation reaction. The test results are shown in Table 8.

[0093] Table 8

[0094]

[0095]

[0096] The sample's multiple intact skin irritation intensity on guinea pigs was non-irritating, meeting the requirements of Technical Specifications for Disinfection (2002 edition).

[0097] 8. Acute eye irritation test: refer to the acute eye irritation test method in 2.3.4 of the Technical Specifications for Disinfection (2002 edition).

[0098] According to the acute eye irritation test method in 2.3.4 of the "Technical Specifications for Disinfection" (2002 Edition): Check both eyes of the experimental rabbits 24 hours before the test, and eliminate those with abnormalities. During the test, draw 0.1mL of the test substance stock solution and drip it into the conjunctival sac of one eye of the rabbit. The other eye is treated with normal saline as a normal control. After dripping the test substance, the eye is passively closed for 4s, and rinsed with normal saline after 30s.

[0099] Observe the damage and recovery of the conjunctiva, iris and cornea of ​​the rabbits with naked eyes at 1h, 24h, 48h, 72h, 7d, 14d and 2d after eye drops and record them. If no irritation reaction occurs within 72h, or the eye irritation reaction is completely recovered on the 7th or 14th day, the test can be terminated early.

[0100] The acute irritation reaction of the cornea, iris and conjunctiva of the rabbits was scored, and the "average score" of corneal damage, iris damage, conjunctival congestion and conjunctival edema was calculated for each animal at three different observation times (24h, 48h, 72h) (i.e. the sum of the scores of each animal at 24h, 48h and 72h divided by the number of observations * 3). The average scores and recovery time of the corneal, iris and conjunctival congestion and edema of the animals were used to determine the irritation intensity of the test substance to the eyes according to the eye irritation reaction grading standard. The test results are shown in Table 9.

[0101] Table 9

[0102]

[0103]

[0104] The acute eye irritation intensity of the sample to New Zealand rabbits is non-irritating and meets the requirements of the "Technical Specifications for Disinfection" (2002 edition).

Claims

1. A multi-component composition with good antibacterial effect, characterized in that: The raw materials for preparation include, by weight percentage, 15-30% of a surfactant, 10-30% of a moisturizing agent, 1-3% of a skin conditioning agent, 0.1-0.3% of an antioxidant, 0.1-0.3% of a preservative, 0.1-0.3% of a chelating agent, 0.1-0.3% of a pH regulator, 0.5-1.5% of an emollient, 0.05-0.3% of a plant antibacterial agent, 1-3% of a cationic antibacterial agent, 0.001-0.02% of a pigment additive, and deionized water is added to 100%.

2. The multi-component composition with good antibacterial effect according to claim 1, characterized in that: The plant antibacterial agent comprises at least one of Melaleuca alternifolia leaf oil, Rosemary leaf oil, Mentha piperita oil, Impatiens balsamina extract, Dictamni extract, Sophora flavescens extract and Phellodendron amurense extract.

3. The multi-component composition with good antibacterial effect according to claim 2, characterized in that: The plant antibacterial agent comprises a combination of Melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil, wherein the weight ratio of the Melaleuca alternifolia leaf oil, rosemary leaf oil and peppermint oil is (0.05-0.2): (0.01-0.03): (0.005-0.02).

4. The multi-component composition with good antibacterial effect according to claim 1, characterized in that: The cationic antibacterial agent includes at least one of chlorhexidine digluconate, benzethonium chloride, and polyaminopropyl biguanide.

5. The multi-component composition with good antibacterial effect according to claim 4, characterized in that: The cationic antibacterial agent comprises a combination of chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide, wherein the weight ratio of the chlorhexidine digluconate, benzethonium chloride and polyaminopropyl biguanide is (1-2): (0.005-0.02): (0.005-0.02).

6. The multi-component composition with good antibacterial effect according to claim 1, characterized in that: The surfactant includes at least one of sodium lauroamphoacetate, cocamidopropyl hydroxysulfobetaine, polyglyceryl laurate, capryl / capryl glucoside and cocoyl glucoside.

7. The multi-component composition with good antibacterial effect according to claim 1, characterized in that: The moisturizing agent is a polyol, and the polyol includes at least one of butylene glycol, glycerol, propylene glycol, hexylene glycol, octanediol, pentylene glycol, maltitol, sorbitol, polyethylene glycol, polypropylene glycol, panthenol, and ethylhexylglycerin.

8. The multi-component composition with good antibacterial effect according to claim 7, characterized in that: The average molecular weight of the polyethylene glycol is 100-600 Da.

9. The multi-component composition with good antibacterial effect according to claim 6, characterized in that: The glycerol polymerization number of the polyglycerol laurate is 2-10.

10. A method for preparing a multi-component composition with good antibacterial effect according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1 Weigh each component according to the formula, heat the moisturizer, antioxidant, chelating agent and deionized water to 80-85℃, stir and dissolve, and mix evenly; S2 adds surfactant and emollient and stirs evenly; S3 cools down to 50-60°C and adds preservatives, cools down to 40-50°C and adds skin conditioners, cationic antibacterial agents, plant antibacterial agents, pigment additives, and pH regulators, and stirs and mixes evenly to obtain a multi-component composition with good antibacterial effect.

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