Antibacterial non-woven fabric and preparation method thereof

Abstract

The invention relates to a bacteriostatic non-woven fabric. The effective bacteriostatic component of the bacteriostatic non-woven fabric is breast milk oligosaccharide. The antibacterial non-woven fabric provided by the invention is safe and mild, has a good antibacterial effect, and can promote the health balance of skin micro-ecology and reduce skin problems caused by bacterium breeding while inhibiting the growth of harmful microorganisms. In addition, as a natural component, the breast milk oligosaccharide is mild in property, so that the safety and comfort of the product when the product is in contact with skin for a long time are ensured. The antibacterial non-woven fabric produced according to the preparation method is suitable for various disposable hygienic products, such as paper diapers, sanitary towels, panty liners and other personal care products, and can provide higher-level health protection and comfortable experience for consumers.

Description

Technical Field

[0001] The invention relates to the field of sanitary products, and in particular to an antibacterial nonwoven fabric and a preparation method thereof. Background Art

[0002] In the field of sanitary products, non-woven fabrics are widely used due to their good air permeability, softness and strong absorption capacity, especially in disposable sanitary products such as sanitary napkins and diapers that come into direct contact with the skin. However, during the use of disposable sanitary products, long-term contact with a humid and warm environment, especially during women's menstrual period and infant care, can easily breed bacteria, fungi and other microorganisms, leading to health problems such as skin inflammation and reproductive system infection. Therefore, improving the antibacterial effect of non-woven fabrics is of great significance to protecting the health of users.

[0003] Although non-woven fabrics have many advantages, their natural antibacterial effect is limited, and additional antibacterial substances need to be added to enhance their antibacterial properties. Currently, commonly used antibacterial treatment methods mainly rely on inorganic antibacterial agents, such as silver ions, quaternary ammonium salt bactericides, etc. Although they have significant antibacterial effects, they may irritate the human body and have potential safety issues, causing allergies or other adverse reactions. On the other hand, although plant antibacterial agents from natural sources are relatively safe, they have poor stability, and due to their complex ingredients, their antibacterial effects are uncertain.

[0004] Human milk oligosaccharides are the third most active ingredient in breast milk and have been widely studied for their outstanding functional activity. One of its characteristics is that it can act as a prebiotic, selectively promoting the growth of beneficial bacteria in the intestine, such as bifidobacteria, while inhibiting the reproduction of harmful bacteria. This dual regulatory effect makes human milk oligosaccharides perform well in enhancing the body's immunity and preventing pathogen infection, showing its potential as a safe and effective natural antibacterial agent.

[0005] Applying human milk oligosaccharides to antibacterial nonwoven fabrics, especially disposable sanitary products, can not only provide effective antibacterial protection, but also maintain the microecological balance of the skin surface through its prebiotic function, reducing health problems caused by microbial imbalance. In addition, the carbohydrate structure of human milk oligosaccharides gives it a moisturizing function, which can enhance the skin-friendliness of nonwoven fabrics while maintaining skin health. This makes antibacterial nonwoven fabrics containing human milk oligosaccharides have great application potential in the field of personal care products, which can not only protect the health of users, but also improve the comfort and safety of products. Summary of the invention

[0006] Problem that the invention aims to solve

[0007] In view of the above problems existing in the prior art, the object of the present invention is to provide a safe, mild and effective antibacterial nonwoven fabric.

[0008] Solutions for solving problems

[0009] The invention provides an antibacterial nonwoven fabric, which comprises a human milk oligosaccharide antibacterial agent.

[0010] Preferably, the human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides, a surfactant and / or a thickener;

[0011] Preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener;

[0012] More preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener;

[0013] Further preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

[0014] Preferably, the human milk oligosaccharide is selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose;

[0015] Preferably, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose, and the sialyllactose is selected from 3'-sialyllactose and / or 6'-sialyllactose;

[0016] Preferably, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate;

[0017] Preferably, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer.

[0018] Preferably, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 0.5-50 g / m 2 ;

[0019] More preferably, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 1-20 g / m 2 ;

[0020] Further preferably, the loading amount of human milk oligosaccharides in the antibacterial non-woven fabric is 8 g / m 2 .

[0021] The present invention also provides a method for preparing the antibacterial non-woven fabric, the method comprising the following steps:

[0022] (1) preparing human milk oligosaccharide antibacterial agent;

[0023] (2) loading the human milk oligosaccharide antibacterial agent prepared in step (1) onto a non-woven fabric;

[0024] (3) Drying.

[0025] Preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener;

[0026] More preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener;

[0027] Further preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

[0028] Preferably, the step (1) comprises adding the human milk oligosaccharide, surfactant and / or thickener to purified water and stirring evenly;

[0029] Preferably, the human milk oligosaccharide is selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose. More preferably, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose, and the sialylated lactose is selected from 3'-sialylated lactose and / or 6'-sialylated lactose.

[0030] Preferably, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate;

[0031] Preferably, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer.

[0032] Preferably, the purified water is warm purified water, and more preferably, the purified water is 40-50°C purified water.

[0033] Preferably, the loading in step (2) is to evenly coat the human milk oligosaccharide antibacterial agent onto the non-woven fabric by immersion or spraying, and then perform a roller pressing process;

[0034] Preferably, the soaking is for 5-15 minutes;

[0035] Preferably, the spraying amount is 0.5-50g human milk oligosaccharide / m 2 More preferably, the spraying amount is 1-20g human milk oligosaccharide / m 2Preferably, the spraying amount is 8 g human milk oligosaccharide / m 2 .

[0036] Preferably, the drying in step (3) is high-temperature drying until the surface of the non-woven fabric is completely dry;

[0037] Preferably, the high temperature is 80-120°C, more preferably, the high temperature is 100°C.

[0038] The present invention also provides an application of the antibacterial non-woven fabric in disposable sanitary products.

[0039] Effects of the Invention

[0040] The antibacterial nonwoven fabric of the present invention is safe, mild, has good antibacterial effect, and while inhibiting the growth of harmful microorganisms, can promote the healthy balance of skin microecology and reduce skin problems caused by bacterial growth. In addition, human milk oligosaccharides, as natural ingredients, are mild in nature, ensuring the safety and comfort of the product when in long-term contact with the skin. The antibacterial nonwoven fabric produced according to the preparation method of the present invention is suitable for various disposable sanitary products, such as diapers, sanitary napkins, panty liners and other personal care products, and can provide consumers with a higher level of health protection and comfort experience. DETAILED DESCRIPTION

[0041] In order to make the technical solutions and beneficial effects of the present invention more clearly understood, the following is a detailed description by listing specific embodiments. Unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application belongs.

[0042] The invention provides an antibacterial nonwoven fabric, which comprises a human milk oligosaccharide antibacterial agent.

[0043] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides, a surfactant and / or a thickener.

[0044] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides and a surfactant.

[0045] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides and a thickener.

[0046] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides, a surfactant and a thickener.

[0047] In certain embodiments, the human milk oligosaccharide antibacterial agent further comprises water.

[0048] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of human milk oligosaccharides, a surfactant and water.

[0049] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of human milk oligosaccharides, a thickener and water.

[0050] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of human milk oligosaccharides, a surfactant, a thickener and water.

[0051] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener.

[0052] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener, and the balance is water.

[0053] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener.

[0054] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, 0.1-1% thickener, and the balance is water.

[0055] In certain embodiments, the human milk oligosaccharide antibacterial agent includes, by weight: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

[0056] In certain embodiments, the human milk oligosaccharide antibacterial agent includes, by weight: 20% human milk oligosaccharide, 0.5% surfactant, 0.5% thickener, and the balance is water.

[0057] In certain embodiments, the human milk oligosaccharides are selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose.

[0058] In certain embodiments, the human milk oligosaccharides are fucosyllactose and lacto-N-neotetraose.

[0059] In certain embodiments, the human milk oligosaccharides are fucosyllactose and sialyllactose.

[0060] In certain embodiments, the human milk oligosaccharides are lactose-N-neotetraose and sialylated lactose.

[0061] In certain embodiments, the human milk oligosaccharide is fucosyllactose.

[0062] In certain embodiments, the human milk oligosaccharide is lactose-N-neotetraose.

[0063] In certain embodiments, the human milk oligosaccharide is sialylated lactose.

[0064] In certain embodiments, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose.

[0065] In certain embodiments, the fucosyllactose is 2'-fucosyllactose and 3'-fucosyllactose.

[0066] In certain embodiments, the fucosyllactose is 2'-fucosyllactose.

[0067] In certain embodiments, the fucosyllactose is 3'-fucosyllactose.

[0068] In certain embodiments, the sialyllactose is selected from 3'-sialyllactose and / or 6'-sialyllactose.

[0069] In certain embodiments, the sialyllactose is 3'-sialyllactose and 6'-sialyllactose.

[0070] In certain embodiments, the sialyllactose is 3'-sialyllactose.

[0071] In certain embodiments, the sialyllactose is 6'-sialyllactose.

[0072] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose, 3'-fucosyllactose and lactose-N-neotetraose.

[0073] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose and lacto-N-neotetraose.

[0074] In certain embodiments, the human milk oligosaccharides consist of 3'-fucosyllactose and lacto-N-neotetraose.

[0075] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose, 3'-fucosyllactose, 3'-sialyllactose and 6'-sialyllactose.

[0076] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose, 3'-fucosyllactose and 3'-sialyllactose.

[0077] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose, 3'-fucosyllactose and 6'-sialyllactose.

[0078] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose, 3'-sialyllactose, and 6'-sialyllactose.

[0079] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose and 3'-sialyllactose.

[0080] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose and 6'-sialyllactose.

[0081] In certain embodiments, the human milk oligosaccharides consist of 3'-fucosyllactose, 3'-sialyllactose and 6'-sialyllactose.

[0082] In certain embodiments, the human milk oligosaccharides consist of 3'-fucosyllactose and 3'-sialyllactose.

[0083] In certain embodiments, the human milk oligosaccharides consist of 3'-fucosyllactose and 6'-sialyllactose.

[0084] In certain embodiments, the human milk oligosaccharide consists of lactose-N-neotetraose, 3'-sialyllactose and 6'-sialyllactose.

[0085] In certain embodiments, the human milk oligosaccharides consist of lactose-N-neotetraose and 3'-sialylated lactose.

[0086] In certain embodiments, the human milk oligosaccharides consist of lactose-N-neotetraose and 6'-sialylated lactose.

[0087] In certain embodiments, the human milk oligosaccharides consist of 2'-fucosyllactose and 3'-fucosyllactose.

[0088] In certain embodiments, the human milk oligosaccharide is 2'-fucosyllactose.

[0089] In certain embodiments, the human milk oligosaccharide is 3'-fucosyllactose.

[0090] In certain embodiments, the human milk oligosaccharides consist of 3'-sialyllactose and 6'-sialyllactose.

[0091] In certain embodiments, the human milk oligosaccharide is 3'-sialyllactose.

[0092] In certain embodiments, the human milk oligosaccharide is 6'-sialyllactose.

[0093] In certain embodiments, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate.

[0094] In certain embodiments, the surfactant is Tween-80, cocamidopropyl betaine, lauryl glucoside and glyceryl stearate.

[0095] In certain embodiments, the surfactant is Tween-80, cocamidopropyl betaine, and lauryl glucoside.

[0096] In certain embodiments, the surfactant is Tween-80, cocamidopropyl betaine and glyceryl stearate.

[0097] In certain embodiments, the surfactant is Tween-80, lauryl glucoside, and glyceryl stearate.

[0098] In certain embodiments, the surfactant is cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate.

[0099] In certain embodiments, the surfactant is Tween-80 and cocamidopropyl betaine.

[0100] In certain embodiments, the surfactants are Tween-80 and lauryl glucoside.

[0101] In certain embodiments, the surfactant is Tween-80 and glyceryl stearate.

[0102] In certain embodiments, the surfactants are cocamidopropyl betaine and lauryl glucoside.

[0103] In certain embodiments, the surfactants are cocamidopropyl betaine and glyceryl stearate.

[0104] In certain embodiments, the surfactants are lauryl glucoside and glyceryl stearate.

[0105] In certain embodiments, the surfactant is Tween-80.

[0106] In certain embodiments, the surfactant is cocamidopropyl betaine.

[0107] In certain embodiments, the surfactant is lauryl glucoside.

[0108] In certain embodiments, the surfactant is glyceryl stearate.

[0109] In certain embodiments, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer.

[0110] In certain embodiments, the thickener is xanthan gum, sodium carboxymethylcellulose, guar gum, and acrylate copolymer.

[0111] In certain embodiments, the thickener is xanthan gum, sodium hydroxymethylcellulose and guar gum.

[0112] In certain embodiments, the thickener is xanthan gum, sodium hydroxymethylcellulose and acrylate copolymer.

[0113] In certain embodiments, the thickener is xanthan gum, guar gum, and acrylate copolymer.

[0114] In certain embodiments, the thickener is sodium carboxymethylcellulose, guar gum, and an acrylate copolymer.

[0115] In certain embodiments, the thickening agents are xanthan gum and sodium hydroxymethylcellulose.

[0116] In certain embodiments, the thickeners are xanthan gum and guar gum.

[0117] In certain embodiments, the thickener is a copolymer of xanthan gum and acrylates.

[0118] In certain embodiments, the thickener is sodium hydroxymethylcellulose and guar gum.

[0119] In certain embodiments, the thickener is sodium carboxymethylcellulose and acrylate copolymer.

[0120] In certain embodiments, the thickener is a copolymer of guar gum and acrylates.

[0121] In certain embodiments, the thickening agent is xanthan gum.

[0122] In certain embodiments, the thickening agent is sodium hydroxymethylcellulose.

[0123] In certain embodiments, the thickener is guar gum.

[0124] In certain embodiments, the thickener is an acrylate copolymer.

[0125] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of human milk oligosaccharides, Tween-80, xanthan gum and water.

[0126] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, Tween-80, xanthan gum and water.

[0127] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10-30% 2'-fucosyllactose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0128] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 20% 2'-fucosyllactose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0129] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, lactose-N-neotetraose, Tween-80, xanthan gum and water.

[0130] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10-20% 2'-fucosyllactose, 1-10% lactose-N-neotetraose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0131] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 15% 2'-fucosyllactose, 5% lactose-N-neotetraose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0132] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, lactose-N-neotetraose, 3'-sialyllactose, Tween-80, xanthan gum and water.

[0133] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 5-15% 2'-fucosyllactose, 1-10% lactose-N-neotetraose, 1-10% 3'-sialylated lactose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0134] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10% 2'-fucosyllactose, 5% lactose-N-neotetraose, 5% 3'-sialylated lactose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0135] In certain embodiments, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 0.5-50 g / m 2 .

[0136] In certain embodiments, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 0.5 g / m 2 , or 0.6g / m 2 , or 0.7g / m 2 , or 0.8g / m 2 , or 0.9g / m 2 , or 1g / m 2 , or 2g / m 2 , or 3g / m 2 , or 4g / m 2 , or 5g / m 2 , or 6g / m 2 , or 7g / m 2 , or 8g / m 2 , or 9g / m 2 , or 10g / m 2 , or 11g / m 2 , or 12g / m 2 , or 13g / m 2 , or 14g / m 2 , or 15g / m 2 , or 16g / m 2 , or 17g / m 2 , or 18g / m 2 , or 19g / m 2 , or 20g / m 2 , or 21g / m 2 , or 22g / m 2 , or 23g / m 2 , or 24g / m 2 , or 25g / m 2 , or 26g / m 2 , or 27g / m 2 , or 28g / m 2 , or 29g / m 2 , or 30g / m 2 , or 31g / m 2 , or 32g / m 2 , or 33g / m 2 , or 34g / m 2 , or 35g / m 2 , or 36g / m 2 , or 37g / m 2 , or 38g / m 2 , or 39g / m 2 , or 40g / m 2 , or 41g / m 2 , or 42g / m 2 , or 43g / m 2 , or 44g / m 2, or 45g / m 2 , or 46g / m 2 , or 47g / m 2 , or 48g / m 2 , or 49g / m 2 , or 50g / m 2 .

[0137] In certain embodiments, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 1-20 g / m 2 .

[0138] In certain embodiments, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 8 g / m 2 .

[0139] The present invention also provides a method for preparing the antibacterial non-woven fabric, the method comprising the following steps:

[0140] (1) preparing human milk oligosaccharide antibacterial agent;

[0141] (2) loading the human milk oligosaccharide antibacterial agent obtained in step (1) onto a non-woven fabric;

[0142] (3) Drying.

[0143] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener.

[0144] In certain embodiments, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener.

[0145] In certain embodiments, the human milk oligosaccharide antibacterial agent includes, by weight: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

[0146] In certain embodiments, step (1) comprises adding the human milk oligosaccharide, surfactant and / or thickener to purified water and stirring evenly.

[0147] In certain embodiments, the human milk oligosaccharides are selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose.

[0148] In certain embodiments, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose.

[0149] In certain embodiments, the sialyllactose is selected from 3'-sialyllactose and / or 6'-sialyllactose.

[0150] In certain embodiments, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate.

[0151] In certain embodiments, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer.

[0152] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, Tween-80, xanthan gum and water.

[0153] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10-30% 2'-fucosyllactose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0154] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 20% 2'-fucosyllactose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0155] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, lactose-N-neotetraose, Tween-80, xanthan gum and water.

[0156] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10-20% 2'-fucosyllactose, 1-10% lactose-N-neotetraose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0157] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 15% 2'-fucosyllactose, 5% lactose-N-neotetraose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0158] In certain embodiments, the human milk oligosaccharide antibacterial agent consists of 2'-fucosyllactose, lactose-N-neotetraose, 3'-sialyllactose, Tween-80, xanthan gum and water.

[0159] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 5-15% 2'-fucosyllactose, 1-10% lactose-N-neotetraose, 1-10% 3'-sialylated lactose, 0.1-1% Tween-80, 0.1-1% xanthan gum, and the remainder is water.

[0160] In certain embodiments, the human milk oligosaccharide antibacterial agent contains, by weight, 10% 2'-fucosyllactose, 5% lactose-N-neotetraose, 5% 3'-sialylated lactose, 0.5% Tween-80, 0.5% xanthan gum, and the remainder is water.

[0161] In certain embodiments, the purified water is warm purified water.

[0162] In some embodiments, the purified water is purified water at 40-50°C.

[0163] In certain embodiments, the purified water is purified water at 40°C, or 41°C, or 42°C, or 43°C, or 44°C, or 45°C, or 46°C, or 47°C, or 48°C, or 49°C, or 50°C.

[0164] In certain embodiments, the purified water is purified water at 45°C.

[0165] In certain embodiments, the loading in step (2) is performed by evenly coating the human milk oligosaccharide antibacterial agent on the non-woven fabric by immersion or spraying, and then performing a roller pressing process.

[0166] In certain embodiments, the soaking is for 5-15 minutes.

[0167] In certain embodiments, the soaking is for 5 min, or 6 min, or 7 min, or 8 min, or 9 min, or 10 min, or 11 min, or 12 min, or 13 min, or 14 min, or 15 min.

[0168] In certain embodiments, the spraying amount is 0.5-50 g human milk oligosaccharide / m 2 .

[0169] In certain embodiments, the spraying amount of the spray is 0.5g, or 0.6g, or 0.7g, or 0.8g, or 0.9g, or 1g, or 2g, or 3g, or 4g, or 5g, or 6g, or 7g, or 8g, or 9g, or 10g, or 11g, or 12g, or 13g, or 14g, or 15g, or 16g, or 17g, or 18g, or 19g, or 20g, or 21g, or 22g, or 23g, or 24g, or 25g, or 26g, or 27g, or 28g, or 29g, or 30g, or 31g, or 32g, or 33g, or 34g, or 35g, or 36g, or 37g, or 38g, or 39g, or 40g, or 41g, or 42g, or 43g, or 44g, or 45g, or 46g, or 47g, or 48g, or 49g, or 50g human milk oligosaccharides.

[0170] In certain embodiments, the spraying amount is 1-20 g human milk oligosaccharide / m 2 .

[0171] In certain embodiments, the spraying amount is 8 g human milk oligosaccharide / m 2 .

[0172] In certain embodiments, the spraying amount is 20-80 ml human milk oligosaccharide antibacterial agent / m 2 .

[0173] In certain embodiments, the spraying amount is 20ml, or 25ml, or 30ml, or 35ml, or 40ml, or 45ml, or 50ml, or 55ml, or 60ml, or 65ml, or 70ml, or 75ml, or 80ml of human milk oligosaccharide antibacterial agent per square meter.

[0174] In certain embodiments, the spraying amount is 30-50 ml human milk oligosaccharide antibacterial agent / m 2 .

[0175] In certain embodiments, the spraying amount is 40 ml human milk oligosaccharide antibacterial agent / m 2 .

[0176] In certain embodiments, the drying in step (3) is high-temperature drying until the surface of the non-woven fabric is completely dry.

[0177] In certain embodiments, the elevated temperature is 80-120°C.

[0178] In certain embodiments, the elevated temperature is 80°C, or 81°C, or 82°C, or 83°C, or 84°C, or 85°C, or 86°C, or 87°C, or 88°C, or 89°C, or 90°C, or 91°C, or 92°C, or 93°C, or 94°C, or 95°C, or 96°C, or 97°C, or 98°C, or 99°C, or 100°C, or 101°C, or 102°C, or 103°C, or 104°C, or 105°C, or 106°C, or 107°C, or 108°C, or 109°C, or 110°C, or 111°C, or 112°C, or 113°C, or 114°C, or 115°C, or 116°C, or 117°C, or 118°C, or 119°C, or 120°C.

[0179] In certain embodiments, the elevated temperature is 100°C.

[0180] The present invention also provides an application of the antibacterial non-woven fabric in disposable sanitary products.

[0181] In certain embodiments, the disposable hygiene product is a disposable hygiene product that directly contacts the skin.

[0182] In certain embodiments, the disposable sanitary products include diapers, sanitary napkins, panty liners and other personal care products.

[0183] Example 1: Preparation of antibacterial nonwoven fabric 1

[0184] 1. Preparation of human milk oligosaccharide antibacterial agent: Heat purified water to 45°C, add 20% human milk oligosaccharide (2'-fucosyllactose), 0.5% Tween-80, and 0.5% xanthan gum in order by weight percentage, and stir until completely dissolved and evenly distributed.

[0185] 2. Load the human milk oligosaccharide antibacterial agent onto the non-woven fabric: Use the spraying method to load 8g human milk oligosaccharide / m 2 The prepared human milk oligosaccharide antibacterial agent is evenly sprayed on the surface of the non-woven fabric (i.e., 100 g / m2). 2 Spray 40 ml of human milk oligosaccharide antibacterial agent) and then perform roller pressing to ensure that the antibacterial agent human milk oligosaccharide is evenly distributed between the fibers of the non-woven fabric to prevent liquid accumulation.

[0186] 3. Drying: Dry the treated non-woven fabric at a temperature of 100° C. until the surface of the non-woven fabric is completely dry to obtain the antibacterial non-woven fabric 1.

[0187] Example 2: Preparation of antibacterial nonwoven fabric 2

[0188] 1. Preparation of human milk oligosaccharide antibacterial agent: Heat purified water to 45°C, add 20% human milk oligosaccharide (15% 2'-fucosyllactose, 5% lactose-N-neotetraose), 0.5% Tween-80, and 0.5% xanthan gum in order by weight percentage, and stir until completely dissolved and evenly distributed.

[0189] 2. Load the human milk oligosaccharide antibacterial agent onto the non-woven fabric: Use the spraying method to load 8g human milk oligosaccharide / m 2 The prepared human milk oligosaccharide antibacterial agent is evenly sprayed on the surface of the non-woven fabric (i.e., 100 g / m2). 2 Spray 40 ml of human milk oligosaccharide antibacterial agent) and then perform roller pressing to ensure that the antibacterial agent human milk oligosaccharide is evenly distributed between the fibers of the non-woven fabric to prevent liquid accumulation.

[0190] 3. Drying: Dry the treated non-woven fabric at a temperature of 100° C. until the surface of the non-woven fabric is completely dry to obtain the antibacterial non-woven fabric 2.

[0191] Example 3: Preparation of antibacterial nonwoven fabric 3

[0192] 1. Preparation of human milk oligosaccharide antibacterial agent: Heat purified water to 45°C, add 20% human milk oligosaccharides (10% 2'-fucosyllactose, 5% lactose-N-neotetraose, 5% 3'-sialylated lactose), 0.5% Tween-80, and 0.5% xanthan gum in order by weight percentage, and stir until completely dissolved and evenly distributed.

[0193] 2. Load the human milk oligosaccharide antibacterial agent onto the non-woven fabric: Use the spraying method to load 8g human milk oligosaccharide / m 2 The prepared human milk oligosaccharide antibacterial agent is evenly sprayed on the surface of the non-woven fabric (i.e., 100 g / m2). 2 Spray 40 ml of human milk oligosaccharide antibacterial agent) and then perform roller pressing to ensure that the antibacterial agent human milk oligosaccharide is evenly distributed between the fibers of the non-woven fabric to prevent liquid accumulation.

[0194] 3. Drying: Dry the treated non-woven fabric at a temperature of 100° C. until the surface of the non-woven fabric is completely dry to obtain an antibacterial non-woven fabric 3.

[0195] Comparative Example 1: Preparation of antibacterial nonwoven fabric 4

[0196] 1. Preparation of human milk oligosaccharide antibacterial agent: Heat purified water to 45° C., add 1% human milk oligosaccharide (2'-fucosyllactose), 0.5% Tween-80, and 0.5% xanthan gum in order by weight percentage, and stir until completely dissolved and evenly distributed.

[0197] 2. Load the human milk oligosaccharide antibacterial agent onto the non-woven fabric: Use the spraying method at a rate of 0.4g human milk oligosaccharide / m 2 The prepared human milk oligosaccharide antibacterial agent is evenly sprayed on the surface of the non-woven fabric (i.e., 100 g / m2). 2 Spray 40 ml of human milk oligosaccharide antibacterial agent) and then perform roller pressing to ensure that the antibacterial agent human milk oligosaccharide is evenly distributed between the fibers of the non-woven fabric to prevent liquid accumulation.

[0198] 3. Drying: Dry the treated non-woven fabric at a temperature of 100° C. until the surface of the non-woven fabric is completely dry to obtain an antibacterial non-woven fabric 4.

[0199] Example 4: Antibacterial test of nonwoven fabric

[0200] The nonwoven fabrics prepared in Examples 1 to 3 and Comparative Example 1 were tested for antibacterial performance according to the method in GB 15979-2002 "Hygiene Standard for Disposable Hygiene Products", and the tested bacteria species were: Escherichia coli, Staphylococcus aureus and Candida albicans.

[0201] Test method: The 24-hour slant culture of the test bacteria was washed with PBS and made into (1-9)×10 4CFU / mL of bacterial suspension, take 2.0cm*3.0cm test pieces (Examples 1 to 3, Comparative Example 1) and control pieces (untreated non-woven fabric), respectively add 100μL of bacterial suspension on them, evenly spread them, act for 10min, then put them into 5mL of PBS solution, mix them thoroughly, make appropriate dilution, take 0.5mL and put it in a plate containing nutrient agar medium (bacteria) or Sabouraud agar medium (yeast), rotate the plate to make the solution evenly spread on the plate, culture at 37℃ for 48h, and calculate the number of viable colonies.

[0202] The test was repeated 3 times, and the inhibition rate was calculated according to the following formula:

[0203] X=(AB) / A×100%

[0204] Wherein, X is the inhibition rate, A and B are the average colony counts of the control sample and the test sample, respectively. The test results are shown in Table 1.

[0205] Table 1: Antibacterial rate of non-woven fabrics

[0206] Group Escherichia coli Staphylococcus aureus Candida albicans Example 1 98.75％ 98.87％ 94.11％ Example 2 99.04％ 99.33％ 95.24％ Example 3 99.41％ 99.86％ 95.75％ Comparative Example 1 85.62％ 71.83％ 69.54％

[0207] The results show that the nonwoven fabrics prepared in Examples 1-3 and Comparative Example 1 have a certain antibacterial effect; compared with Comparative Example 1, the nonwoven fabrics prepared in Examples 1-3 have a better antibacterial effect.

[0208] Example 5: Preparation of antibacterial sanitary napkin

[0209] The antibacterial nonwoven fabric prepared in Example 3 was used to prepare an antibacterial sanitary napkin. The sanitary napkin includes a bottom layer, an absorption layer, a guide layer and a surface layer from bottom to top, and the sanitary napkin is prepared by integral lamination. The bottom layer is a waterproof and breathable polyethylene film, the absorption core is composed of 15 parts of polymer resin, 15 parts of pulp and 70 parts of fluff pulp, and the nonwoven fabrics used in the surface layer and the guide layer are all antibacterial nonwoven fabrics prepared in Example 3.

[0210] Comparative Example 2: Preparation of ordinary sanitary napkin

[0211] The sanitary napkin comprises a bottom layer, an absorption layer, a guide layer and a surface layer from bottom to top, and is made by integral lamination. The bottom layer is a waterproof and breathable polyethylene film, the absorption core is composed of 15 parts of polymer resin, 15 parts of paper pulp and 70 parts of fluff pulp, and the non-woven fabrics used in the surface layer and the guide layer are ordinary non-woven fabrics without special antibacterial treatment.

[0212] Example 6: Sanitary napkin use test

[0213] 40 female volunteers aged 20-40 with sensitive genitalia were recruited and randomly divided into two groups, one for the experimental group and the other for the control group, with 20 people in each group. The experimental group used the antibacterial sanitary napkin prepared in Example 5, and the control group used the ordinary sanitary napkin prepared in Comparative Example 2. The test period covered a two-month physiological period. After the test, the scores of the volunteers on their experience of using the sanitary napkin were collected, including:

[0214] Comfort of use: the skin feel and softness of the sanitary napkin;

[0215] Is the genitals clean: the dry feeling of using sanitary napkins;

[0216] Whether itching occurs in the genital area: record whether itching occurs during use;

[0217] Allergy: Monitor whether allergic reactions occur during use.

[0218] Each item has a full score of 10, and the higher the score, the better the user experience. The average score of each group was calculated, and the results are shown in Table 2.

[0219] Table 2: Sanitary napkin usage test results

[0220] Group Comfort Is the vagina clean? Is the genitals itchy? Are you allergic? Experimental Group 8.5 7.9 8.8 9.5 Control group 7.3 6.7 5.1 9.2

[0221] The results showed that the experimental group using the antibacterial sanitary napkin prepared in Example 5 was superior to the control group in terms of comfort, keeping the genitals clean and relieving itching, and did not cause allergic reactions. This shows that the non-woven fabric made of human milk oligosaccharides can inhibit the growth of harmful bacteria, relieve genital inflammation, and has better softness when used in sanitary napkins, achieving the effect of nourishing the skin.

[0222] It should be understood that the above embodiments are exemplary and are not intended to include all possible implementations included in the claims. Various modifications and changes may be made on the basis of the above embodiments without departing from the scope of the present disclosure. Similarly, the various technical features of the above embodiments may be arbitrarily combined to form other embodiments of the present invention that may not be explicitly described. Therefore, the above embodiments only express several implementations of the present invention and do not limit the scope of protection of the patent of the present invention.

Claims

1. An antibacterial nonwoven fabric, characterized in that: The antibacterial nonwoven fabric comprises a human milk oligosaccharide antibacterial agent.

2. The antibacterial nonwoven fabric according to claim 1, characterized in that: The human milk oligosaccharide antibacterial agent comprises human milk oligosaccharides, a surfactant and / or a thickener; Preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener; More preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener; Further preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

3. The antibacterial nonwoven fabric according to claim 2, characterized in that: The human milk oligosaccharide is selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose; Preferably, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose, and the sialyllactose is selected from 3'-sialyllactose and / or 6'-sialyllactose; Preferably, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate; Preferably, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer.

4. The antibacterial nonwoven fabric according to claim 1, characterized in that: The loading amount of human milk oligosaccharide in the antibacterial nonwoven fabric is 0.5-50g / m 2 ; Preferably, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 1-20 g / m 2 ; More preferably, the loading amount of human milk oligosaccharides in the antibacterial nonwoven fabric is 8 g / m 2 .

5. A method for preparing an antibacterial nonwoven fabric according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: (1) preparing human milk oligosaccharide antibacterial agent; (2) loading the human milk oligosaccharide antibacterial agent prepared in step (1) onto a non-woven fabric; (3) Drying.

6. The preparation method according to claim 5, characterized in that: In parts by weight, the human milk oligosaccharide antibacterial agent comprises: 10-30% human milk oligosaccharide, 0.1-1% surfactant and / or 0.1-1% thickener; Preferably, the human milk oligosaccharide antibacterial agent comprises, by weight: 10-30% human milk oligosaccharide, 0.1-1% surfactant, and 0.1-1% thickener; More preferably, in parts by weight, the human milk oligosaccharide antibacterial agent comprises: 20% human milk oligosaccharide, 0.5% surfactant, and 0.5% thickener.

7. The preparation method according to claim 6, characterized in that: The step (1) comprises adding the human milk oligosaccharide, surfactant and / or thickener to purified water and stirring evenly; Preferably, the human milk oligosaccharide is selected from one or more of fucosyllactose, lactose-N-neotetraose, and sialylated lactose. More preferably, the fucosyllactose is selected from 2'-fucosyllactose and / or 3'-fucosyllactose, and the sialylated lactose is selected from 3'-sialylated lactose and / or 6'-sialylated lactose. Preferably, the surfactant is selected from one or more of Tween-80, cocamidopropyl betaine, lauryl glucoside, and glyceryl stearate; Preferably, the thickener is selected from one or more of xanthan gum, sodium hydroxymethyl cellulose, guar gum, and acrylate copolymer. Preferably, the purified water is warm purified water, and more preferably, the purified water is 40-50°C purified water.

8. The preparation method according to claim 5, characterized in that: The loading in step (2) is to evenly coat the human milk oligosaccharide antibacterial agent onto the non-woven fabric by immersion or spraying, and then perform a roller pressing process; Preferably, the soaking is for 5-15 minutes; Preferably, the spraying amount is 0.5-50g human milk oligosaccharide / m 2 More preferably, the spraying amount is 1-20g human milk oligosaccharide / m 2 Preferably, the spraying amount is 8 g human milk oligosaccharide / m 2 .

9. The preparation method according to claim 5, characterized in that: The drying in step (3) is high-temperature drying until the surface of the non-woven fabric is completely dry; Preferably, the high temperature is 80-120°C, more preferably, the high temperature is 100°C.

10. Use of the antibacterial nonwoven fabric according to any one of claims 1 to 4 in disposable sanitary products.