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Preparation method of saponin extracts in xanthoceras sorbifolia shells

A technology for saponins and extracts, which is applied in the field of preparation of saponins extracts in husks of Fructus Radix, can solve the problems of incomplete elucidation of pathogenesis, lack of effective prevention and treatment drugs, and the like, and achieves a method that is simple, feasible, easy to operate, and improved. Effects of memory impairment

Inactive Publication Date: 2018-10-26
QIDONG CHUANGLU NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the pathogenesis has not been fully elucidated, there is still a lack of effective prevention and treatment drugs in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method for extracting saponins from sorbiflora sorbifolium husks, comprising the steps of: pulverizing the sorbifolia sorbifolia husks, refluxing and extracting with 75% ethanol solution for 3 times, each extraction for 1.5 hours, the extraction temperature being 70°C, Combine the extracts and concentrate until there is no alcohol smell to obtain the ethanol extract concentrate; dilute the obtained ethanol extract concentrate with water, sequentially extract with petroleum ether, ethyl acetate and water-saturated n-butanol, concentrate under reduced pressure, and obtain petroleum ether extract respectively extracts, ethyl acetate extracts and n-butanol extracts; the ethyl acetate extracts were enriched with AB-8 macroporous resin for active components, first washed with 10% ethanol for 8 column volumes to remove large polar components, and then used Elute 12 column volumes with 80% ethanol, collect 80% eluate, and concentrate under reduced pressure.

[001...

Embodiment 2

[0021] A preparation method for extracting saponins from sorbiflora sorbifolium husks, comprising the following steps: crushing sorbifolia sorbifolia husks, refluxing and extracting twice with 70% ethanol solution, each time for 1 hour, the extraction temperature is 65°C, combining The extract is concentrated until it has no alcohol smell to obtain an ethanol extraction concentrate; the resulting ethanol extraction concentrate is diluted with water, sequentially extracted with petroleum ether, ethyl acetate and water-saturated n-butanol, and concentrated under reduced pressure to obtain petroleum ether extracts , ethyl acetate extract and n-butanol extract; the ethyl acetate extract was enriched with AB-8 type macroporous resin for active components, first washed with 10% ethanol for 8 column volumes to remove large polar components, and then washed with 80 % ethanol for 12 column volumes, collect 80% of the eluent, and concentrate under reduced pressure to obtain the final pro...

Embodiment 3

[0024] A preparation method for extracting saponins from sorbiflora sorbifolium husk, comprising the steps of: pulverizing sorbiflora sorbifolia husk, refluxing and extracting 4 times with 80% ethanol solution, 2 hours each time, the extraction temperature is 75°C, combining The extract is concentrated until it has no alcohol smell to obtain an ethanol extraction concentrate; the resulting ethanol extraction concentrate is diluted with water, sequentially extracted with petroleum ether, ethyl acetate and water-saturated n-butanol, and concentrated under reduced pressure to obtain petroleum ether extracts , ethyl acetate extract and n-butanol extract; the ethyl acetate extract was enriched with AB-8 type macroporous resin for active components, first washed with 10% ethanol for 8 column volumes to remove large polar components, and then washed with 80 % ethanol for 12 column volumes, collect 80% of the eluent, and concentrate under reduced pressure to obtain the final product. ...

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PUM

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Abstract

The invention discloses a preparation method of saponin extracts in xanthoceras sorbifolia shells. The preparation method comprises the following steps: crushing the xanthoceras sorbifolia shells, performing reflux extraction for 2 to 4 times by using 70 to 80 percent ethanol solution, wherein the extraction time is 1 to 2 hours for each time, the extraction temperature is 65 to 75 DEG C, mergingthe extract liquid, concentrating until no alcohol smell exists, and obtaining ethanol extract concentrated liquid; diluting the obtained ethanol extract concentrated liquid by using water, extractingsuccessively by using petroleum ether, vinyl acetate and water saturated n-butyl alcohol, decompression concentrating, and separately obtaining petroleum ether extract, vinyl acetate extract, and n-butyl alcohol extract; and enriching active ingredients from the vinyl acetate extract by using macroporous resin, washing 8 column volumes by using 10 percent ethanol to remove large polarity components, then eluting 12 column volumes by using 80 percent ethanol, collecting 80 percent eluent, and performing decompression concentrating, thus obtaining the saponin extracts. By adopting the preparation method, the saponin components in the xanthoceras sorbifolia shell can be obtained and have the effect for improving the memory disorder and resisting the cerebral anoxia injury.

Description

technical field [0001] The invention relates to a preparation method of a saponin extract from the sorbetia sorbifolium husk. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system that occurs in old age and early old age, mainly with progressive cognitive impairment and memory impairment. Because the pathogenesis has not been fully elucidated, there is still a lack of effective prevention and treatment drugs in clinical practice. [0003] Xanthocerassorbifolium Bunge, Sapindaceae, Xanthoceras genus deciduous shrubs or small trees, up to 5 meters high; the branchlets are brownish red and strong, and the leaves and handles can be up to 30 cm long; the leaflets are opposite, with slightly Asymmetrical, apex acuminate, base cuneate, edge sharply serrated, hermaphrodite inflorescence terminal, male inflorescence axillary, erect, total pedicel short, petals white, base purplish red or yellow, horn-like appendages of flower ...

Claims

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Application Information

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IPC IPC(8): A61K36/77A61P25/28
CPCA61K36/77A61K2236/33A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/55A61P25/28
Inventor 不公告发明人
Owner QIDONG CHUANGLU NEW MATERIAL CO LTD
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