Application of liquiritin in preparing medicine for treating cardiovascular and cerebrovascular diseases
A technology for cardiovascular and cerebrovascular diseases, applied in the field of medicine, can solve problems such as no relevant literature reports, achieve no adverse reactions, low cost, prevent or improve the effect of heart and brain damage
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Embodiment 1
[0016] Embodiment 1 Liquiritin anti-simple cerebral ischemia effect
[0017] 1. Materials and Methods
[0018] 1.1 Experimental animals
[0019] Healthy adult male ICR mice, clean grade, weighing 25-30 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and acclimated to the environment in the SPF-level experimental animal room of the Applied Arts and Health Food Functional Testing Center of Beijing Union University for one week before the experiment.
[0020] 1.2 Reagents
[0021] Liquiritin standard substance: Tianjin Jianfeng Natural Products Company (purity ≥ 98%); Edaravone: Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd.; red tetrazolium (2,3,5-triphenyltetrazolium, TTC): Sigma Company.
[0022] 1.3 Instruments
[0023] AR-2140 1 / 10,000 electronic balance: Mettler-Toledo Instrument Co., Ltd.; electric heating constant temperature water bath: Beijing Changfeng Instrument Co., Ltd.
[0024] 1.4 Preparation of permanent cerebral ischemi...
Embodiment 2
[0042] Embodiment 2 Liquiritin anti-cerebral ischemia-reperfusion effect
[0043] 1. Materials and Methods
[0044] 1.1 Experimental animals
[0045]Healthy adult male Wistar rats, clean grade, weighing 200-250 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and acclimatized to the environment for one week in the SPF-level experimental animal room of the Applied Arts, Science and Health Food Functional Testing Center of Beijing Union University before the experiment.
[0046] 1.2 Reagents
[0047] Standard Liquiritin: Tianjin Jianfeng Natural Products Company (purity ≥ 98%); Edaravone: Nanjing Simcere Dongyuan Pharmaceutical Co., Ltd.; MDA, MPO, SOD, Coomassie Brilliant Blue Kit: Nanjing Jiancheng Bioengineering Institute.
[0048] 1.3 Instruments
[0049] AR-2140 1 / 10000 electronic balance: Mettler-Toledo Instrument Co., Ltd.; electric heating constant temperature water bath: Beijing Changfeng Instrument Co., Ltd.; TGL 16M centrifuge: Hu...
Embodiment 3
[0063] Example 3 Liquiritin Anti-Cerebral Hypoxia Effect
[0064] 1. Materials and Methods
[0065] 1.1 Experimental animals
[0066] Healthy adult male ICR mice, clean grade, weighing 18-20 g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and acclimated to the environment in the SPF laboratory animal room of the Applied Arts and Health Food Functional Testing Center of Beijing Union University for one week before the experiment.
[0067] 1.2 Reagents
[0068] Liquiritin standard product: Tianjin Jianfeng Natural Products Company (purity ≥ 98%); Edaravone: Nanjing Xiansheng Dongyuan Pharmaceutical Co., Ltd.; sodium nitrite, Xi'an Chemical Reagent Factory.
[0069] 1.3 Instruments
[0070] AR-2140 1 / 10,000 electronic balance: Mettler-Toledo Instrument Co., Ltd.
[0071] 1.4 Acute cerebral ischemia and hypoxia experiment
[0072] 45 ICR mice were fasted for 12 hours and randomly divided into negative control (0.5% sodium carboxymethylcellu...
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