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Use of lactose-N-tetraose for preventing intestinal leakage

A technology of lactose and the amount of application, which is applied in the application field of food or medicine, can solve problems such as intestinal leakage and intestinal dysplasia, so as to maintain intestinal health, improve intestinal permeability, and improve intestinal Effects of barrier damage

Pending Publication Date: 2022-05-10
INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Infants who are not breastfed have an underdeveloped gut and are more prone to leaky gut than infants who are breastfed

Method used

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  • Use of lactose-N-tetraose for preventing intestinal leakage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This example examines the effects of different types of HMO and their compositions on the function of the small intestinal epithelium under normal conditions, the transport of molecules through the intestinal barrier and FD4 (fluorescein isothiocyanate dextran; FITC-labeled dextran), etc. The indicators reflect the improvement of intercellular intestinal permeability and intestinal barrier (improving paracellular permeability).

[0026] Normal (non-aggressive) condition

[0027] Caco-2 cells were cultured in DMEM medium in transwell system for 21 days to simulate the intestinal epithelial cell layer. Add the tested HMO or HMO composition (final concentration in the culture system: 0.1mg / mL) and incubate for 24 hours, then add FD4 molecules (final surface concentration: 250ug / mL) and continue to incubate. The translocation of FD4 molecules was measured when the culture was continued to 24 hours, and three measurements were taken as biological repetitions. A DMEM medi...

Embodiment 2

[0032] Embodiment 2, the infant formula powder of the added breast milk oligosaccharide

[0033] This embodiment provides a formula milk powder for infants aged 0 to 6 months. The total protein content in the formula milk powder is 11.1g / 100g powder, the fat content is 28.3g / 100g powder, and the carbohydrate content is 52.9g / 100g powder. Oligosaccharide LNT content 0.4g / 100g powder.

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PUM

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Abstract

The invention provides application of lactose-N-tetrasaccharide to prevention of intestinal leakage. Specifically, the invention provides application of lactose-N-tetrasaccharide in preparation of food or medicine for preventing intestinal leakage, and intestinal leakage prevention comprises improvement of intestinal permeability and intestinal barrier between cells. Wherein the prevention of intestinal leakage comprises improvement of intestinal permeability and intestinal barrier between cells.

Description

technical field [0001] The present invention relates to a new application of lactose-N-tetrasaccharide, in particular to the application of lactose-N-tetrasaccharide in the preparation of food or medicine for preventing intestinal leakage. Background technique [0002] Leaky gut refers to the phenomenon that the increased intestinal permeability causes harmful substances in the intestine, such as bacteria and toxins, to pass through the intestinal mucosa and enter other tissues, organs and blood circulation in the human body. Intestinal permeability is related to intestinal barrier function, and normal intestinal permeability depends on the integrity of the intestinal mucosal barrier. The intestinal mucosal barrier is a complex multilayer system, including physical barrier, chemical barrier, biological barrier and immune barrier. The interaction of these barriers allows the gut to maintain an osmotic balance, preventing loss of water and electrolytes and entry of antigens a...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/00A23L33/125A23C9/156A23C9/16
CPCA61K31/715A61P1/00A23L33/125A23C9/156A23C9/16A23V2002/00A23V2200/32A23V2250/28
Inventor 王雯丹吉塞拉·阿德里安娜·怀斯司徒文佑刘彪
Owner INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD
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