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Head chopping device used for acute cerebral anoxia pharmacology experiment

A cerebral hypoxia, acute technology, applied in the fields of application, medical science, autopsy, etc., can solve the problems of animals struggling nervously and biting experimenters, so as to solve the risk of being bitten, reduce experimental errors, control blood The effect of oxygen depletion

Inactive Publication Date: 2019-02-22
黄利 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the shortcomings of the existing guillotine devices and the characteristics of experimental rats who like to drill holes, the present invention provides a guillotine device for acute cerebral hypoxia experiments to solve the problems of nervous struggle of animals and the risk of biting experimenters

Method used

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  • Head chopping device used for acute cerebral anoxia pharmacology experiment
  • Head chopping device used for acute cerebral anoxia pharmacology experiment
  • Head chopping device used for acute cerebral anoxia pharmacology experiment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The subject of guillotine head is healthy Kunming mice that are normally raised. Using the guillotine head method of the present invention, 0 experimental animals struggled, and the mouth breathing time was longer. Only struggle, nervousness and fear, many interference factors, large variance of experimental data (19.32±5.73 seconds), and poor reliability.

[0033] Carry out the guillotine experiment as follows:

[0034] (1) Take 20 healthy Kunming mice with a body weight of 18-19g and normal feeding of SPF, and randomly divide them into two groups: the existing guillotine head group and the present invention group, with 10 mice in each group;

[0035] (2) Normal feeding in a normal feeding environment for 2 days;

[0036] (3) Guillotine head:

[0037] The operation method of the existing guillotine head group: grasp the experimental rat, expose the head, send the head into the guillotine mouth, the guillotine cuts down instantly, and record the breathing time of the ...

Embodiment 2

[0046] The subject of the guillotine head is the Kunming mouse that is normally raised. The experimental mice with the guillotine head of the present invention do not struggle. The variance of the experimental data is small, and the significant effect of the drug on increasing hypoxia tolerance can be effectively counted; the experimental rats struggled to varying degrees with the existing guillotine-guillotine method, and the experimental data obtained had a large variance (21.43±6.01 seconds for the drug-administered group, 21.43±6.01 seconds for the blank control group, group 18.58±5.12 seconds), no statistically significant difference can be found.

[0047] Carry out the guillotine experiment according to the following method:

[0048] (1) Get 40 healthy Kunming mice with a body weight of 18-19gSPF grade normal feeding, and randomly divide them into the existing guillotine head blank control group, the existing guillotine head blank control group and the present invention ...

Embodiment 3

[0053] The subject of guillotine cutting is healthy SD rats of normal feeding SPF level. The existing guillotine-guillotine method is very difficult to grasp the rats by hand, and the experimental rats struggle more violently; the rats of the present invention do not struggle, and the rats are instantly guillotined in a natural state.

[0054] In the present embodiment, the device of the present invention is 20 centimeters except that the length of the cuboid is 20 centimeters, the width of the groove is 7 centimeters, the depth is 4 centimeters, and the length is 20 centimeters; the diameter of the hollow tube is 7 centimeters, and the length is 10 centimeters; Same as implementation 1.

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Abstract

The invention provides a head chopping device used for an acute cerebral anoxia pharmacology experiment. The head chopping device comprises a cuboid (1) with a groove, a hollow pipeline section (2) and a chopper cutter. According to the assembling connection mode, the hollow pipe is transversely arranged at one end of the cuboid groove and closely fits the groove, and the fractured end edge of thehollow pipe and the fractured end edge of the groove coincide and closely fit the cut of the fixed edge of the chopper cutter. The specification of the cuboid is that the length is 4-1000 centimeters, the width is 10-15 centimeters, and the height is 8-15 centimeters; the diameter of the hollow pipe is 3-10 centimeters, and the length of the hollow pipe is 5-10 centimeters; the chopper cutter isprovided with a base, the fixed edge and the movable edge of the chopper cutter are provided with cutter edges, the cutter edges of the upper and lower edges are opened to form a hole shape, the diameter of the hole shape is 4-10 centimeters, and the height of the fixed edge is 6-12 centimeters. The device can solve the problem that in the head chopping process, an animal is nervous and strugglesor bites an experimenter, blood oxygen loss of the experiment animal before head chopping is reduced to the largest extent, it is avoided that the experiment error is caused due to different-degree struggling of the experiment animal, the experiment operation is standard, and experiment data is credible and reliable. The operation is convenient, cost of manufacturing materials is low, and the device is suitable for application and popularization.

Description

technical field [0001] The invention belongs to the field of pharmacological experiment equipment, in particular to a guillotine device for acute cerebral hypoxia pharmacological experiment. Background technique [0002] The body's hypoxia tolerance test is a commonly used drug efficacy evaluation method. According to different hypoxia generation principles, it includes normal pressure hypoxia tolerance test, sodium nitrite poisoning hypoxia test, and acute cerebral hypoxia test. In the evaluation experiment of the effect of drugs or health products on the body's hypoxia tolerance, it is usually required to conduct these three experiments at the same time to explore the principle of their action and confirm the reliability of the experimental results. [0003] The acute cerebral hypoxia experiment is based on the principle that the blood supply to the brain suddenly stops after the head of the experimental animal is cut off, and the oxygen and nutrients in the original blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B16/00
CPCA61B16/00
Inventor 李利民黄利
Owner 黄利
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