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Altitude Anoxia. Also known as “Acute Mountain Sickness”, it typically affects people who are over 2,400 meters or 8,000 feet. Such individuals include mountain climbers, skiers, hikers or tourists at high altitude. The condition arises due to a combination of lower oxygen levels and decreased air pressure at high altitudes.
Application of stem cell exosome in treatment of depression-like behavior caused by high-altitude hypoxia
The invention discloses application of a stem cell exosome in treating depression-like behaviors caused by high-altitude hypoxia, and belongs to the technical field of biomedicine. The stem cell exosome is an exosome derived from human umbilical cord mesenchymal stem cells, and is used for drugs for preventing and / or treating depression-like behaviors caused by high-altitude hypoxia. The exosome can effectively improve depression-like core behavior symptoms caused by high-altitude hypoxia by regulating a brain-intestinal axis; the method starts from remodeling intestinal flora so as to influence the intracerebral metabolite spectrum, and finally plays a role in neuroprotection by regulating and controlling a 5-HT6 / cAMP-PKA key signal channel. In addition, the combination of the hUC-MSC-exo and probiotics shows synergistic interaction potential, and a potential treatment strategy which is novel in mechanism, remarkable in effect and high in safety is provided for the field.
Owner:QINGHAI UNIVERSITY