Preparation method and application of saussurea involucrate flavonoid capsule

A technology of Saussurea flavonoids and capsules, which can be used in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems that have not been reported yet, and achieve improved survival time, good anti-altitude hypoxia effects, and relieve heart and brain. The effect of tissue damage

Inactive Publication Date: 2013-10-02
贾正平
View PDF1 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It has been reported in the literature that the chemical components of Saussurea sativa include flavonoids, alkaloids, sesquiterpenoids and volatile oils, etc. Among them, flavonoids are the main chemical components of Saussurea sauraceae, which can significantly scavenge superoxide anion free radicals, scavenge hydroxyl free radicals, and resist NADH The biological activity of peroxidase oxidation shows strong anti-oxidation, anti-radiation, and anti-aging effects, but there is no report on the prevention and treatment of acute mountain sickness by the total flavonoids extracted from Saussurea pachyrhiza.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Crush the medicinal materials into coarse powder, add 15 times the amount of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter, combine the filtrate to concentrate into an extract, add micronized silica gel at 10%, and sieve with 20-10 mesh Granulate, dry at 50°C, sieve through a 10-20 mesh sieve, pack into capsules, each weighing about 0.5g. The total flavonoid content is 10% to 20%.

Embodiment 2

[0070] Crush the medicinal materials into coarse powder, add 15 times the amount of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, and load the concentrated solution on HPD400 macroporous adsorption resin The column is loaded at a rate of 20-25 drops per minute. After adsorption for 12 hours, the above-mentioned macroporous resin is washed with distilled water until it is colorless, and then fully eluted with 50% ethanol. The ethanol eluate is collected, dried at 50°C, and pulverized. , after sifting through a 10-20 mesh sieve, pack into capsules, each weighing about 0.5g. The total flavonoid content is 40% to 50%.

Embodiment 3

[0072] Crush the medicinal materials into coarse powder, add 15 times the amount of 70% ethanol to soak overnight, reflux extraction twice, each time for 2 hours, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, and load the concentrated solution on HPD500 macroporous adsorption resin The column is loaded at a rate of 20-25 drops per minute. After adsorption for 12 hours, the above-mentioned macroporous resin is washed with distilled water until it is colorless, and then fully eluted with 50% ethanol. The ethanol eluate is collected, dried at 50°C, and pulverized. , after sifting through a 10-20 mesh sieve, pack into capsules, each weighing about 0.5g. The total flavonoid content is 40% to 50%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a capsule prepared by taking general flavone abstracted from Saussurea involucrata as an active ingredient, and the application of the capsule in preventing and treating acute high altitude diseases, and belongs to the technical field of medicines. According to the invention, through three types of animal anoxia models of normal pressure closed anoxia, acute pressure-relief anoxia and low-pressure oxygen chamber simulation high altitude anoxia, the effect of the Saussurea involucrata flavonoid capsule in resisting high altitude anoxia is investigated. Experimental results show that the Saussurea involucrata flavonoid capsule can obviously prolong the survival time of rats in normal pressure closed anoxia and acute pressure-relief anoxia, damages to heart and brain tissues of rats under a simulation acute high altitude anoxia can be alleviated remarkably, and the capsule has a favorable high altitude anoxia resisting effect, and the mechanism of action of the capsule is concerned with the capabilities of adjusting energy metabolism and improving oxidation resistance.

Description

technical field [0001] The invention relates to the field of pharmaceutical production, in particular to a preparation method and application of Saussurea flavone capsules. Background technique [0002] Acute altitude sickness, including acute altitude sickness, high altitude cerebral edema, and high altitude pulmonary edema, seriously affects the combat effectiveness of troops, high altitude tourism and local economic construction. It is extremely important to develop new anti-altitude hypoxia drugs with small side effects and definite curative effect. Social Significance. Hypobaric hypoxia in a plateau environment can stimulate the body to increase the generation of reactive oxygen species, and reduce the activity of antioxidant enzymes by aggravating lipid peroxidation, thereby causing oxidative damage to organs, tissues, cells and DNA. Therefore, reducing oxidative damage in high altitude environment, improving the function of antioxidant system, improving the body's hy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/285A61K9/48A61P39/06
Inventor 贾正平马慧萍樊鹏程景临林何晓英李琳高荣敏
Owner 贾正平
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap