34 results about "High altitude hypoxia" patented technology

The invention provides a method for screening cattle high altitude hypoxia adaptation specific molecular marker, and furthermore a cattle kind or individual which is suitable for high altitude hypoxiasurvival is screened through the specific marker. The method aims at a high altitude hypoxia adaptation heredity characteristic of a kettle kind, and selects local cattle kinds which are distributedin high altitude regions at aspects of genome evolution, selecting and adapting. Multiple genome selecting signals, a full-genome association analysis method and a strategy are combined. Key genes andmolecular makers which are suitable for high altitude hypoxia are efficiently and accurately screened. Reasonable method designed is realized. The detecting method according to the key gene and marker designing has advantages of high accuracy, and convenient application operation. According to the method of the invention, through analyzing different altitude cattle kinds, a gene ACSS2 which is related with high altitude hypoxia adaptation and a haplotype thereof are found; and furthermore a specific SNP which bears a strongest selecting signal is positioned; and the method realizes an important meaning and a high practicability value for cattle molecule breeding operation.

The invention discloses application of cistanche phenylethanoid glycoside extractive to control altitude sickness. According to the application, experiments prove that the cistanche phenylethanoid glycoside extractive enables an organism to adapt to plateau anoxic environment and prevent encephaledema and pneumonedema from generating through anti-anoxia, anti-inflammatory, anti-oxidative stress and adjusting of aquaporin expression. Additionally, therapy medicine-administration experiments prove that the cistanche phenylethanoid glycoside extractive is capable of reducing incidence rate of limbs edema of a mouse attacked by chronic altitude sickness and mortality, and is capable of effectively reducing the pulmonary artery high pressure and the ventricle hypertrophy degree of a mouse attacked by chronic altitude sickness, and improving cardiopulmonary pathology change. Correspondingly, the invention also discloses a pharmaceutical composition containing the cistanche phenylethanoid glycoside extractive and being capable of controlling altitude sickness.

The invention provides a genetic marker relevant to the high altitude hypoxia adaptability of Tibetan sheep. The genetic marker is positioned on a PPAR (peroxisome proliferator activated receptor) alpha gene, and a concrete nucleotide sequence is as shown in a sequence table SEQ ID No. 1; in the nucleotide sequence of the sequence table SEQ ID No. 1, when an allelic gene is A, the high altitude hypoxia adaptability of the Tibetan sheep is poor; when the allelic gene is B, the high altitude hypoxia adaptability of the Tibetan sheep is good. The Tibetan sheep are taken as research objects, a PCR(Polymerase Chain Reaction)-SSCP (single-stranded conformational polymorphism) method is adopted to combine with DNA (deoxyribonucleic acid) sequencing technology so as to research the genetic variation characteristics of PPAR alpha genes of 2 sheep groups, and in the high altitude hypoxia adaptability, the molecular markers of the Tibetan sheep are initially screened out to provide foundation for subsequent relativity analyses.

The invention discloses a capsule prepared by taking general flavone abstracted from Saussurea involucrata as an active ingredient, and the application of the capsule in preventing and treating acute high altitude diseases, and belongs to the technical field of medicines. According to the invention, through three types of animal anoxia models of normal pressure closed anoxia, acute pressure-relief anoxia and low-pressure oxygen chamber simulation high altitude anoxia, the effect of the Saussurea involucrata flavonoid capsule in resisting high altitude anoxia is investigated. Experimental results show that the Saussurea involucrata flavonoid capsule can obviously prolong the survival time of rats in normal pressure closed anoxia and acute pressure-relief anoxia, damages to heart and brain tissues of rats under a simulation acute high altitude anoxia can be alleviated remarkably, and the capsule has a favorable high altitude anoxia resisting effect, and the mechanism of action of the capsule is concerned with the capabilities of adjusting energy metabolism and improving oxidation resistance.

The invention relates to the technical field of brain scientific cognition, and provides a brain cognitive interaction detection system on the basis of plateau hypoxia environments. The brain cognitive interaction detection system comprises a cloud server, an intelligent host and four interaction intelligent terminals. Each interaction intelligent terminal is used for receiving control instructions, executing actions, identifying input action information and generating operation information, and a plurality of test item contents suitable for detecting brain cognitive impairment specificity, objectivity and sensitivity of plateau hypoxia can be formed by the intelligent host; the test item contents are sequentially called and are displayed on the intelligent host for users, test content information is transmitted to the interaction intelligent terminals, the operation information is received and analyzed, or the operation information is acquired, and test item achievement tables are formed; the server is used for calling test item information in response to download requests and receiving and storing the test item achievement tables. The brain cognitive interaction detection system has the advantages that the brain cognition degrees of population in the plateau hypoxia environments can be detected, brain states can be pre-judged, and bases can be provided for targeted treatment, health protection and labor protection.

The invention relates to a community science popularization experience system and an experience method. The system comprises a base plate as well as a sports treadmill and a hypoxia generating systemwhich are arranged on the base plate, wherein the hypoxia generating system comprises a hypoxia helmet component, a chassis as well as a hypoxia generator and a control module which are arranged in the chassis; the hypoxia helmet component comprises a shell, a pair of VR glasses which is arranged on the shell and a hypoxia dispersion device which is arranged in the shell; and the hypoxia dispersion device is connected to a venting connector of the hypoxia generator. According to the community science popularization experience system provided by the invention, a hypoxia environment can be rapidly formed through cooperation between the hypoxia helmet component and the hypoxia generator, so that a user can undergo a high-altitude hypoxia experience within a limited time; meanwhile, videos canbe played in the hypoxia environment via the VR glasses, so that interactions with the user can be achieved, a better experience effect can be achieved on the experiencer (the user) in a motion process and the user can clearly feel adaptive capacity thereof to plateau; and the experience system is also applicable to hypoxia training of sportsmen, troops and the like; therefore, the experience system is relatively good in generalization performance.

The invention discloses a weariness-resistant anoxia-resistant health-care product composition. The weariness-resistant anoxia-resistant health-care product composition comprises hemicellulose, lacquer tree seed oil, soy protein isolate powder, a herbal rhodiola resea extract or herbal rhodiola sacra extract, spirulina, a panax notoginseng root extract, Chinese caterpillar fungus mycelium powder and a ginseng extract. The composition can increase the aerobic metabolism level of organisms, improve the oxygen utilization efficiency of cells, strengthen the altitude acclimatization capacity, and improve operation capacity under high altitude anoxia conditions; besides, the composition can also quickly complement sugar, fat, protein and other nutrients required by the organisms, promote nutrition absorption, rapidly fill carbohydrate and lost nutrients, which are consumed by profuse sweating during movement and particularly high-intensity movement training and exercising, and contribute to alleviating weariness of center and skeleton muscles, besides, is free from any toxic and side effects, and has significant efficacy of resisting weariness, resisting anoxia and adjusting immunity.

The invention discloses application of Codonopsis pilosula oligosaccharide in preparation of a medicine for preventing or treating gastrointestinal injury caused by anoxia. The anoxia is plateau anoxia and / or tissue ischemic anoxia. The invention also provides a preparation method of the Codonopsis pilosula oligosaccharide. The Codonopsis pilosula oligosaccharide has the following advantages: themedicine prepared by adopting the application of the Codonopsis pilosula oligosaccharide in the preparation of the medicine for preventing or treating gastrointestinal injury caused by anoxia has a very good effect, is safe and effective, and has no toxic or side effect; experimental verification shows that the medicine containing the Codonopsis pilosula oligosaccharide can improve spleen atrophyand pulmonary emphysema caused by high-altitude anoxiaof rats, enhance the anti-oxidation level, improve inflammations, relieve intestinal mucosal damage and reduce EPO expression; and protein expression detection further shows that the Codonopsis pilosula oligosaccharide can reduce the expression of HIF-1 alpha in duodenum of a high-altitude hypoxic rat.

The invention relates to the technical field of medicines, in particular to a novel application of a petasites tricholobus franch extract and bakkenolide compounds contained in the petasites tricholobus franch extract in preparing medicines for preventing and treating hypoxic diseases. Results of pharmacodynamic tests show that the extract not only can significantly prolong the survival time of sealed hypoxia mice but also can obviously reduce a death rate of hypobaric hypoxia mice; and the extract can take a significant protecting effect on sealed hypoxia and plateau hypoxia; therefore, the extract can be used for preparing the medicines for preventing and treating altitude sicknesses or hypoxia symptoms such as the plateau hypoxia, the sealed hypoxia and the like.

The invention discloses a solid alcohol fuel, which is prepared in two steps at a constant temperature of 70°C by weight percentage from 90.73% industrial alcohol, 4.76% stearic acid, 0.62% NaOH, 1.30% paraffin, and 2.59% distilled water. to make. The solid alcohol fuel of the present invention has the characteristics of easy ignition, high combustion calorific value, no black smoke, no peculiar smell, less residue after combustion, long storage period, no softening and separation, etc., especially under the condition of vacuum anoxic, it can still maintain The combustion is stable, the flame is strong, and it has good combustion performance. It can still burn in the plateau or mountain environment at an altitude of more than 6300 meters. Compared with ordinary solid fuels, the solid alcohol fuel of the present invention has a wider application range, and has obvious advantages in plateau anoxic areas, and is the preferred heat source for home furnishing, travel, sports, or field training for soldiers in plateau areas, as well as plateau and mountain combat.

The invention discloses a biomarker for detecting high altitude hypoxia and an application thereof. The biomarker for detecting the high altitude hypoxia is N-acetylneuraminic acid or a specific antibody thereof and used for preparing diagnostic reagent or a kit for detecting the high altitude hypoxia. The method of determining the degree of the high altitude hypoxia by detecting a serum marker helps to detect or assist in detecting hypoxia so as to help to take appropriate treatment measures as soon as possible, and is easy and fast in operation, easy for patients to accept, and convenient for the dynamical monitor of the progress of hypoxic injury in high altitude population.

The invention provides a method for establishing an acute high altitude anoxia and anxiety stress response animal model. The method comprises the following steps of (1) raising mice at conventional elevation environment, and performing cold water forced swimming adaptability training; (2) and then enabling the mice obtained in the step (1) to be exposed to high-elevation environmental conditions for raising, and performing high-elevation environment composite cold water forced swimming so as to obtain the acute high altitude anoxia and anxiety stress response animal model. The acute high altitude anoxia and anxiety stress response animal model obtained by the method disclosed by the invention has cerebral anoxia pathology characteristics that an aerobic metabolism way of sugar in brain tissues is blocked, so that the supply of ATP energy sources is obviously reduced, and lactic acid is accumulated, and behavioral expression of anorexia and enhanced anxiety behavior, and the induced stimulating factors and clinical pathology behavioral expression of the model both approach the actual situations of acute altitude stress response.

The invention relates to the technical field of natural medicines, and particularly relates to a method for preparing a medicine with an areca-nut component and anti-hypoxic application of the medicine. Overall animal tests show that an areca-nut extract has remarkable anti-hypoxic activity, and can not only prolong the survival time of hypoxia mice in a sealed normal pressure space, but also improve the high altitude anoxia resistance of hypoxia rats acutely entering into a real altitude situation. The mechanism is possibly related to effects that the minute ventilation volumes of the rats are increased, excessive free radicals in tissue are eliminated and the oxidation resistance is improved. The areca-nut extract is a natural component, is free of toxic or side effect on animals and human bodies and is applicable to anti-hypoxic application.

The present invention relates to an application of pyrroloquinoline quinone (PQQ) in the preparation of a medicament used for preventing and treating acute altitude sickness and acute altitude hypoxia injury. Pyrroloquinoline quinone has the effect of preventing and treating acute high altitude hypoxia injury, and as a drug for the prevention and treatment of acute altitude sickness, the efficacy thereof is equivalent to that of acetazolamide, however acetazolamide has many toxic side effects; meanwhile, as a coenzyme, pyrroloquinoline quinone has the advantages of low toxicity and is easily acceptance by patients. In addition, by means of exhaustive swimming experiments of mice under the conditions of hypoxic exposure, PQQ has been shown to have the feature characteristics of improving the working capabilities of a subject at a high altitude, however acetazolamide has not been found to have said effect.

The invention discloses the application of Codonopsis oligosaccharides in the preparation of drugs for preventing or treating gastrointestinal injury caused by hypoxia, the hypoxia being plateau hypoxia and / or tissue ischemic hypoxia; Methods for the preparation of polysaccharides. The beneficial effects of the present invention are: the application of Codonopsis oligosaccharides provided by the present invention in the preparation of drugs for preventing or treating gastrointestinal damage caused by hypoxia, the prepared drugs have good effects, and the drugs themselves Safe and effective, without toxic and side effects; it has been verified by experiments that drugs containing Codonopsis oligosaccharides can improve spleen atrophy and lung enlargement caused by high-altitude hypoxia in rats, enhance their antioxidant levels, improve inflammation, and relieve intestinal mucosal damage. Reducing EPO expression, and protein expression detection further indicated that Codonopsis oligosaccharides can reduce the expression of HIF-1α in the duodenum of high-altitude hypoxic rats.

The invention discloses application of metformin to an aspect of improving high-altitude hypoxia and anoxia. Under the condition of intraperitoneal injection administration of the metformin, the survival time of rats in a high-altitude low-oxygen environment can be remarkably prolonged. With the adoption of the method disclosed by the invention, a suitable dosage of commonly used drugs is given at proper time, so that a high-altitude anoxia injury resisting capability of animals including the rats and the like can be improved and favorable evidence is provided for human body tests. If application of the metformin to human bodies is popularized, the economic benefits and social benefits are relatively good.

The invention discloses a weariness-resistant anoxia-resistant health-care product composition. The weariness-resistant anoxia-resistant health-care product composition comprises hemicellulose, lacquer tree seed oil, soy protein isolate powder, a herbal rhodiola resea extract or herbal rhodiola sacra extract, spirulina, a panax notoginseng root extract, Chinese caterpillar fungus mycelium powder and a ginseng extract. The composition can increase the aerobic metabolism level of organisms, improve the oxygen utilization efficiency of cells, strengthen the altitude acclimatization capacity, and improve operation capacity under high altitude anoxia conditions; besides, the composition can also quickly complement sugar, fat, protein and other nutrients required by the organisms, promote nutrition absorption, rapidly fill carbohydrate and lost nutrients, which are consumed by profuse sweating during movement and particularly high-intensity movement training and exercising, and contribute to alleviating weariness of center and skeleton muscles, besides, is free from any toxic and side effects, and has significant efficacy of resisting weariness, resisting anoxia and adjusting immunity.

The invention discloses a novel application of sodium sulfite (Na2SO3), that is, an application in preparing medicines, health products, functional drinks or functional food for preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia. According to the invention, by using Na2SO3 as an active component in preparing medicines, health products, functional drinks or functional food for preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia, the body can be in a hypoxia (such as high altitude hypoxia, mine hypoxia, and the like ) preconditioning state, thus the purpose of preventing hypoxia-induced injury and / or diseases related to ischemia-hypoxia (such as high altitude pulmonary edema, high altitude cerebral edema, cerebral ischemia, cardiac ischemia, respiratory distress, and the like) can be achieved. The medicines disclosed herein have the following advantages: 1) obvious curative effect; 2) no toxic and side effect, and high safety; 3) low price of Na2SO3; and 4) convenience in drug use (convenience in carrying and taking).

The invention relates to the technical field of agriculture and agricultural engineering, in particular to a high altitude hypoxia simulating hatching device. The device comprises a hatching box and also comprises an oxygen control system, a carbon dioxide control system, a temperature control system, a humidity control system and an egg turning control system, wherein the oxygen control system comprises an oxygen concentration sensor, a real-time oxygen monitor and a controller I, and the oxygen concentration sensor monitors oxygen concentration in a hatching box body in real time in a diffusion sampling manner in the electrochemical principle. The hypoxia hatching success rate of Tibetan chickens is 75.57% while the hypoxia hatching success rate of white leghorns is only 38.07%, the normoxia hatching success rate of chicken embryos is 98.9%, the hatching effect is completely identical with that of a common hatching box, which indicates that the transformation method which is simple to operate and low in cost can be used for simulating the chicken embryo hatching process under the high altitude hypoxia condition and can meet the requirement of normoxia hatching, one device has multiple purposes, and the transformed hatching box belongs to modular operation and is easy to maintain.

The invention discloses a high altitude human disease model preparation environment simulation system. The high altitude human disease model preparation environment simulation system comprises a functional equipment integrated base and a feeding cabin arranged on the functional equipment integrated base, wherein the feeding cabin is provided with a stepless regulation micro negative pressure device, a high altitude hypoxia environment simulation device, a high altitude illumination environment simulation device, a high altitude temperature environment simulation device, a high altitude humidity environment simulation device, and an animal behavior remove observation unit; a plurality of metabolism cages are arranged in the feeding cabin; observation windows and a plurality of operation windows on front and rear boxes of the feeding cabin; small object transfer windows and large object transfer windows are arranged on left and right boxes of the feeding cabin respectively; and the metabolism cages also include feeding hoppers and drinking water bottles arranged on the metabolism cages as well as fecal collection hoppers, urine discharge outlets and excrement discharge outlets arranged under the metabolism cages. The high altitude human disease model preparation environment simulation system can simulate the high altitude environment very well, can cultivate various kinds of animals at the same time, and has a plurality of molding animals.

The invention provides a method for establishing an acute high altitude anoxia and anxiety stress response animal model. The method comprises the following steps of (1) raising mice at conventional elevation environment, and performing cold water forced swimming adaptability training; (2) and then enabling the mice obtained in the step (1) to be exposed to high-elevation environmental conditions for raising, and performing high-elevation environment composite cold water forced swimming so as to obtain the acute high altitude anoxia and anxiety stress response animal model. The acute high altitude anoxia and anxiety stress response animal model obtained by the method disclosed by the invention has cerebral anoxia pathology characteristics that an aerobic metabolism way of sugar in brain tissues is blocked, so that the supply of ATP energy sources is obviously reduced, and lactic acid is accumulated, and behavioral expression of anorexia and enhanced anxiety behavior, and the induced stimulating factors and clinical pathology behavioral expression of the model both approach the actual situations of acute altitude stress response.

The invention relates to an alpha D globin gene as a chicken molecular mark with high oxygen carrying capability as well as a detection method and application thereof, belonging to the technical field of auxiliary selection of chicken genetic markers. The nucleotide sequence of the molecular mark provided by the invention is shown as SEQ ID No: 1, wherein the 251 bp in the sequence has an A / C base mutation which is recorded as A251C and causes BSEG I-RFLP Polymorphism. The sequence of a primer for amplifying the molecular marker is shown as SEQ ID No: 2 and SEQ ID No: 3. The method for detecting the molecular marker comprises the steps of extraction of chicken genome DNA in a sample to be detected, PCR amplification and the enzyme digestion of a restriction enzyme BSEGI of the PCR product. When the genotype of a chicken individual to be detected is CC type (478bp+35bp), the chicken individual has high oxygen carrying capability. The invention provides the effective molecule marker for breeding excellent cross-fertilizer chickens which adapt to high altitude hypoxia environments and has high yield and high quality.

The invention belongs to the technical field of genetic biology, and particularly relates to a structural variation molecular marker related to goat hypoxia adaptation and application. The structural variation molecular marker is located at 245bp insertion / deletion at the 42098934th basic group of the 26th chromosome of a goat, particularly insertion / deletion at the 98bp of a nucleotide sequence as shown in SEQ ID No. 1, and the nucleotide sequence of insertion / deletion is as shown in SEQ ID No. 2. The invention also provides a specific primer pair and a detection method for detecting the molecular marker with the structural variation. The sequence of the specific primer pair is shown as SEQ ID No.3 and SEQ ID No.4. The invention also provides a detection method for detecting the molecular marker with the structural variation. The molecular marker with the structural variation is not limited by factors such as age and sex of goats, and can be used for introducing goats with high altitude hypoxia adaptability and breeding varieties.

The invention relates to the technical field of medicines, and in particular to a novel use of a Petasites tricholobus extract and bakkenolides contained in the Petasites tricholobus extract in preparing a medicine for preventing and treating anoxia diseases. Pharmacodynamic test results show that the Petasites tricholobus extract and the bakkenolides can not only significantly prolong survival time of mice with airtight anoxia, but also significantly reduce mortality of mice with decompression anoxia, and have significant protective effect on airtight anoxia and high altitude anoxia, thus canbe used for preparing medicines for preventing and treating high altitude sickness or anoxia such as high altitude anoxia or airtight silo anoxia.

The invention relates to the technical field of micronutrients in food, in particular to a compound nutritional preparation for improving plateau hypoxia resistance adaptability and a preparation method thereof. It is a soft capsule comprising a capsule core content and a capsule skin, and the capsule core content includes 0.86 parts of vitamin VA , vitamin VB 1 2.0~3.0 parts, vitamin VB 2 2.3-2.8 parts, 40-50 parts of niacin, 50-70 parts of vitamin VC, 15-20 parts of vitamin VE, 3.5-5.5 parts of ginsenoside, 4.5-6.5 parts of jujube seed, 6-8 parts of ganoderma polysaccharide; Gelatin, glycerin, additives, opacifiers and distilled water. The compound nutritional preparation of the present invention has quick onset of drug effects, long duration of action and no side effects, can improve the ability to withstand hypoxia, enhance the immunity of the body, has the effects of strengthening the heart, nourishing blood, calming and calming the nerves, and can regulate the body in hypoxia. Balance in the environment, through human nutrition intervention to improve the ability to adapt to plateau hypoxia.

The invention relates to an ozone reduction device for high altitude hypoxia. The ozone reduction device includes an oxygen reduction unit 2 which consists of two closed containers 9 and 10 having inlets and outlets; the outlet of the first closed container 9 communicates with the inlet of the second closed container 10 through a pipe; a laser irradiator 6 is arranged in the first closed container 9; an ozone reducing agent 8 selected from one or all of iodine and catalyst chloride ions is added in the second closed container 10; and the oxygen reduction unit 2 may be characterized in that the laser irradiator 6 is arranged in a closed container 5 having an inlet and an outlet, a heater 7 is arranged on the closed container 5, and the ozone reducing agent 8 selected from one or all of the iodine and the catalyst chloride ions is added in the closed container 5. The ozone reduction device is compact in structure, is easy to operate, is safe and reliable, is easy to assemble, is low in cost, is portable, can avoid pollutants, can clean air, and can protect an environment.

The invention discloses new application of sodium sulfite (Na2SO3), namely the application in the preparation of medicines and functional beverages for preventing diseases related to hypoxia-induced injury and / or ischemia-hypoxia. By the medicines or the functional beverages for preventing the diseases related to the hypoxia-induced injury and / or the ischemia-hypoxia prepared by taking the Na2SO3 as an active ingredient, an organism is in a hypoxia (such as high altitude hypoxia and mine hypoxia) pre-conditioning state, so that the aims of preventing the diseases (such as high altitude pulmonary edema, high altitude cerebral edema, cerebral ischemia, cardiac ischemia and respiratory distress) related to the hypoxia-induced injury and / or the ischemia-hypoxia are achieved. The medicines disclosed by the invention have the following advantages: 1) obvious treatment effect; 2) no toxic or side effects, and high safety; 3) low cost of Na2SO3; 4) convenience for medication (convenience for carrying and taking).

The invention discloses application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia. The morinda officinalis oligosaccharides can be used for improving anoxic tolerance and fatigue resistance and can also be used for alleviating intracerebral inflammatory reactions; and the morinda officinalis oligosaccharides can also be used for treating body nerve-immunity-endocrine disorders caused by high-altitude brain injury and the high-altitude anoxia and treating body hypofunction and injury caused by the aspects of cognition, emotions and physical performance.

The meldonium of the present invention is used as the prevention or treatment of plateau acute brain injury, and the meldonium is applied to the prevention or treatment of plateau acute brain injury. According to the research of the present invention, it is found that meldonium can effectively reduce or improve the brain injury caused by high altitude hypoxic environment. Therefore, the present invention relates to the use of meldonium for preventing acute brain injury at high altitude. The test shows that Meldonium has a significant protective effect on the damage of brain nerve cells caused by hypobaric hypoxia, and the effect is equivalent to that of the positive control drug acetazolamide. Meldonium can significantly reduce pathological damages such as nerve cell shrinkage, nuclear pyknosis and nuclear fragmentation caused by plateau hypoxia, and can effectively improve brain blood supply deficiency caused by plateau hypoxia; in addition, meldonium can significantly improve Mitochondrial dysfunction in the hippocampus induced by plateau hypoxia reduces oxidative stress damage in brain tissue.