23 results about "High altitude hypoxia" patented technology

The invention discloses application of a stem cell exosome in treating depression-like behaviors caused by high-altitude hypoxia, and belongs to the technical field of biomedicine. The stem cell exosome is an exosome derived from human umbilical cord mesenchymal stem cells, and is used for drugs for preventing and / or treating depression-like behaviors caused by high-altitude hypoxia. The exosome can effectively improve depression-like core behavior symptoms caused by high-altitude hypoxia by regulating a brain-intestinal axis; the method starts from remodeling intestinal flora so as to influence the intracerebral metabolite spectrum, and finally plays a role in neuroprotection by regulating and controlling a 5-HT6 / cAMP-PKA key signal channel. In addition, the combination of the hUC-MSC-exo and probiotics shows synergistic interaction potential, and a potential treatment strategy which is novel in mechanism, remarkable in effect and high in safety is provided for the field.

The invention relates to the technical field of tunnel fire monitoring and early warning internet, in particular to a tunnel fire early warning method and system suitable for high altitude and low oxygen. The method comprises the following steps: firstly, performing environmental data compensation on various sensors in a tunnel, and then obtaining multi-dimensional monitoring data; then, triggering a subsequent fire accurate detection process under the dual conditions that the concentration change of the double gases in the same time period exceeds a threshold value or the characteristics of the double flames in the same space exceed the threshold value; then, in a fire accurate detection process, an abnormal area is positioned, multiple sequences are generated based on an analysis window, an objective abnormal weight is calculated in combination with information entropy, and a static index fire comprehensive confidence coefficient and a dynamic index deterioration speed and a deterioration speed shutter are obtained; and finally, performing graded early warning based on the fire comprehensive confidence coefficient, the fire deterioration speed and the fire deterioration speed trend, accurately matching the coping requirements of different development stages of the high-altitude low-oxygen tunnel fire, and ensuring the accuracy and timeliness of early warning.

The invention relates to the field of medicine, in particular to a preparation method of biphenyl tetrazole derivatives and application of the biphenyl tetrazole derivatives in preparation, prevention or treatment of neurodegenerative diseases and related diseases caused by plateau hypoxia, and the structure of the biphenyl tetrazole derivatives is shown as a formula 8 X in the specification, and R3 is selected from hydrogen, fluorine, chlorine, iodine, methyl, methoxyl, dimethylamino, trifluoromethyl, hydroxyl, carboxyl, nitryl, methoxycarbonyl, acrylate and acrylamide. The biphenyl tetrazole derivative prepared in the invention can destroy Nrf2-Keap1 protein-protein interaction (PPI), and has a very good protection effect on tested cell models of hydrogen peroxide and 6-hydroxydopamine nerve injury and cobalt chloride hypoxia injury. Experimental data show that the biphenyl tetrazole derivative disclosed by the invention is a potential therapeutic molecule, and a certain basis is provided for research and development of drugs.

The application provides a portable two-stage negative feedback pressure automatic control oxygen supply pressure reducing valve, and belongs to the technical field of valves. A first-stage pressure reducing chamber and a second-stage pressure reducing chamber are arranged in the valve body. A first-stage pressure reducing valve assembly is arranged in the first-stage pressure reducing chamber, and a second-stage pressure reducing valve assembly is arranged in the second-stage pressure reducing chamber. The first-stage pressure reducing valve assembly and the second-stage pressure reducing valve assembly are both automatically controlled to output pressure according to the set pressure reducing target pressure through negative feedback, and form two-stage negative feedback pressure reducing output. An air inlet channel is arranged at the lower end of the valve body, and an oxygen supply chamber is arranged at the upper end of the valve body. The air inlet channel is communicated with the input port of the first-stage pressure reducing chamber. The output port of the first-stage pressure reducing chamber is communicated with the input port of the second-stage pressure reducing chamber through a first-stage pressure reducing air passage. The output port of the second-stage pressure reducing chamber is communicated with the oxygen supply chamber through a second-stage pressure reducing air passage. The application controls pressure output through two-stage control pressure negative feedback, and realizes the output of stable pressure oxygen required by the corresponding state under the conditions of medical treatment, old heart, lung and brain hypoxia rescue, sports, mountain climbing and high altitude hypoxia.

1. Name of the product in this design: High Altitude Hypoxia Test Chamber. 2. Purpose of this design: An experimental chamber for simulating a high-altitude environment in biological experiments. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The bottom surface of this product is a part that is not easily seen or cannot be seen during use, so the bottom view is omitted.

This invention discloses a traditional Chinese medicine prebiotic composition for treating high-altitude hypoxia and fatigue, and its preparation method. It belongs to the field of traditional Chinese medicine technology. The prebiotic composition comprises the following raw medicinal materials in parts by weight: 2-20 parts of Polygonatum odoratum, 2-20 parts of chicory, 2-20 parts of wolfberry, 3-30 parts of Codonopsis pilosula, 4-40 parts of Astragalus membranaceus, 2-20 parts of Angelica sinensis, 2-20 parts of jujube, and 2-20 parts of turmeric. The composition of this invention can improve the body's aerobic metabolism, enhance cellular oxygen utilization, strengthen high-altitude adaptability, and improve work capacity under hypoxic conditions. Furthermore, this composition helps relieve central and musculoskeletal fatigue, while having no toxic side effects, and exhibits significant anti-fatigue, hypoxia tolerance, and immune-regulating effects.

This invention discloses a multi-channel PPG wide-range blood oxygen saturation estimation method for high-altitude environments, belonging to the technical field of physiological signal processing and dynamic blood oxygen monitoring. The method first acquires multi-channel PPG signals and reference measurements, and obtains standardized data through preprocessing such as time alignment, invalid data removal, and noise suppression. Then, it constructs an estimation model containing a quality-aware feature extraction module, an attention-based cross-site fusion module, and a regression head. Reliability masks are generated through multi-scale convolution to optimize feature quality, and multi-head self-attention is used to fuse features from multiple sites. Training employs a composite loss function combining MSE and PCC to iteratively optimize parameters. This invention can accurately handle PPG signal noise interference in high-altitude environments, achieving accurate and continuous estimation of blood oxygen saturation over a wide range of 70%-100%, making it suitable for high-altitude hypoxia monitoring scenarios and highly practical.

The invention discloses a cognitive state real-time estimation method driven by physiological data under plateau hypoxia, and belongs to the technical field of physiological signal processing, and the method comprises the following steps: S1, obtaining a physiological signal of an operator in a plateau hypoxia environment, and preprocessing the physiological signal to obtain physiological signal time sequence data; s2, inputting the physiological signal time sequence data into a task-aware hybrid expert model framework; s3, the gating network generates corresponding expert weight distribution through a self-attention mechanism according to the input physiological signal time sequence data; s4, performing parallel feature extraction on the input physiological signal time sequence data by a plurality of heterogeneous expert networks; and S5, according to the expert weight distribution, carrying out weighted summation on the output of the plurality of heterogeneous expert networks, and outputting an estimation result of response time and accuracy of various cognitive dimensions. By adopting the method, the real-time accurate estimation of the multi-dimensional cognitive state of the operator in extreme environments such as plateau hypoxia and the like is realized.

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine composition for invigorating qi, blood, yin and yang and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials: tortoise-shell glue, deer-horn glue, donkey-hide gelatin, ginseng, astragalus membranaceus, codonopsis pilosula and fructus lycii, and is prepared by fermenting the raw materials, and the mass ratio of the tortoise-shell glue to the deer-horn glue to the donkey-hide gelatin to the ginseng to the astragalus membranaceus to the codonopsis pilosula to the fructus lycii is 1: (0.5-2): (0.5-2): (1-4): (2-5): (2-6): (2-6). The fermented product obtained by fermenting the medicine raw materials through probiotics can be used for treating qi-blood yin-yang deficiency syndromes such as fatigue, myocardial ischemia, cerebral hypoxia and kidney essence deficiency and / or treating and preventing leukopenia caused by myelosuppression and / or DNA (deoxyribonucleic acid) reduction after radiation and / or hypoimmunity and plateau hypoxia. The effects of preventing sudden cardiac death and the like are obvious.

The invention relates to the technical field of traditional Chinese medicines, and discloses application of donkey-hide gelatin bone-strengthening oral liquid in prevention and treatment of plateau hypoxic polycythemia. The colla corii asini bone-strengthening oral liquid can be used for preparing medicines for reducing the number of red blood cells in the high altitude polycythemia, improving the form and function of the red blood cells in the high altitude polycythemia and improving pulmonary edema and encephaledema caused by the high altitude polycythemia. The colla corii asini bone-strengthening oral liquid is applied to prevention and treatment of the plateau hypoxic polycythemia, and the problems that at present, traditional Chinese medicine formulas for treating the plateau polycythemia clinically are few, and the plateau polycythemia resisting effect is poor can be solved.

The invention belongs to the technical field of immunology, and discloses a nanoemulsion adjuvant suitable for a plateau hypoxia environment, a preparation method and application. The nano emulsion adjuvant comprises the following components in 100 parts by weight: 0 to 9.4 parts of D / L-alpha-tocopherol, 0.97 to 6 parts of squalene, 1.94 to 20 parts of tween-80, 0 to 4 parts of span-85 or a substitute surfactant, and the balance of distilled water or a PBS (Phosphate Buffer Solution). The preparation method specifically comprises the following steps: S1, mixing: mixing the corresponding parts of the oil phase, the surfactant and the cosurfactant, and stirring until the mixture is fully dissolved; step S2, emulsifying: slowly dropwise adding sterilized pure water to a preset volume while stirring by adopting a low-energy emulsification method; and standing at room temperature and storing in a dark place to obtain the nano emulsion adjuvant. The compound is mainly applied to preparation of a preparation for improving the immune response capacity under the hypoxia condition. The nanoemulsion adjuvant disclosed by the invention can effectively reverse the immunosuppression effect in a chronic hypoxia environment, comprehensively enhance humoral immunity and cellular immunity response, and solve the problem of limitation of a traditional adjuvant in a specific environment.

The application relates to a handheld negative ion generating device and a use method, high-concentration negative ions are generated through a photocatalytic reaction, and the human mouth and nose area is accurately guided. After the negative ions enter the human body through the respiratory tract, the combination of hemoglobin and oxygen can be effectively promoted, the blood oxygen saturation is improved, pure oxygen inhalation is not required, and side effects such as oxygen poisoning are avoided. The negative ions are generated through a photocatalytic reaction, there are no harmful by-products such as ozone, the device is more energy-saving and environment-friendly, and the negative ion release is stable and efficient. The overall structure of the device is compact, handheld and portable, can be flexibly adapted to home daily conditioning, outdoor activities, high-altitude hypoxic environments and the like, and the problem that large blood oxygen improvement equipment is limited in use is solved. The device has negative ion intensity and airflow velocity adjusting functions and is convenient to operate; the device is also integrated with oxygen generation functions and meets hypoxic demands in different degrees. The application has the advantages of high safety, comfortable use, long-lasting endurance and the like and is suitable for daily conditioning and emergency hypoxic use of people with low blood oxygen saturation.

The invention provides a new application of L-theanine in improvement of acute plateau hypoxia tolerance (viability), and finds and verifies that L-theanine can significantly improve the survival rate of mice in an acute hypobaric hypoxia environment and also can relieve brain tissue injury and body oxidative stress injury induced by plateau hypobaric hypoxia for the first time. And the generation of brain energy is promoted. In addition, in an in-vitro cell model, the L-theanine can also effectively improve hypoxia injury of the cobalt chloride induced hippocampal neuron cell line HT22. The invention provides a natural and safe active substance capable of improving the plateau hypoxia tolerance of an organism, provides a scientific basis for research and development of a series of acute physiological and pathological reactions caused by plateau hypoxia, and has a significant application value.

The invention provides application of lactobacillus rhamnosus in preparation of a product for relieving cognitive impairment caused by plateau hypoxia, and belongs to the technical field of prevention and treatment of brain injury caused by plateau hypoxia. According to the application disclosed by the invention, the fact that the lactobacillus rhamnosus can be used for preventing and / or treating cognitive impairment and / or brain injury caused by plateau hypoxia is proposed for the first time, the limitation of the prior art is broken, and a brand new research direction and a brand new product development idea are provided for the field. The lactobacillus rhamnosus is used as a probiotic, has good biological safety and tolerance, is used for food processing, provides a new natural, safe and effective choice for relieving altitude stress and brain injury for people who travel and work in plateau regions, avoids side effects of drug prevention and treatment, and has a good application prospect. The effectiveness of food intervention is improved, and the acceptability and compliance of related products are improved.

The invention discloses a method and a system for conditioning air in a train. The method comprises the following steps: S1, determining a reference air volume according to the total length of a tunnel currently passed by the train and the current altitude of the train; s2, the compensation air volume is determined according to the carbon dioxide concentration in the train; and S3, the total air volume of the fan is set as the sum of the reference air volume and the compensation air volume. Due to the adoption of the technical scheme, compared with the prior art, the three technical problems of plateau oxygen deficit, extra-long tunnel leakage and transient impact are solved, and the comprehensive benefits of energy conservation, cost reduction, comfort and safety are achieved.

The invention discloses an additive for enhancing physical ability for plateau hypoxia as well as a preparation method and application of the additive, and belongs to the technical field of biological medicines. The invention relates to an auxiliary agent for enhancing physical ability due to plateau hypoxia. The auxiliary agent is formed by wrapping a flavonoid compound and a carrier, the molecular weight of a flavonoid compound in the auxiliary agent is not higher than 1500Da; the carrier in the auxiliary agent is a pharmaceutically acceptable carrier. The invention also provides a preparation method and application of the auxiliary agent. Based on a procyanidine core and a synergistic anti-oxidation carrier, the aid for enhancing physical ability due to plateau hypoxia can inhibit reduction of myocardial cell mitochondrial membrane potential caused by hypoxia and reduce physical ability loss caused by hypoxia.

The invention relates to application of a qi-regulating and blood-activating preparation in a medicine for preventing or treating altitude stress, and belongs to the technical field of medicine application. The qi-regulating and blood-activating preparation is prepared by extracting and processing fructus cinnamoii, borneol, ligusticum wallichii and allium macrostemon. Experimental research shows that the qi-regulating and blood-activating preparation can effectively improve plateau hypoxia athletic ability and heart functions, can effectively improve plateau hypoxia lung tissue inflammation infiltration, reduces alveolar wall thickness, reduces lung tissue fibrosis, and reduces myocardial cell LDH release, thereby achieving the effect of effectively preventing and treating acute altitude stress.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving plateau hypoxia reaction, a pharmaceutical preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of sun-dried ginseng, 25-35 parts of radix ophiopogonis, 10-20 parts of schisandra chinensis, 5-15 parts of American ginseng, 5-15 parts of pseudo-ginseng and 15-25 parts of poria cocos. The suncured ginseng, the radix ophiopogonis, the schisandra chinensis, the American ginseng, the pseudo-ginseng and the poria cocos are prepared according to a specific proportion, so that various symptoms caused by plateau hypoxia can be obviously improved, and the traditional Chinese medicine composition has a relatively good application prospect.

The invention belongs to the technical field of blasting, and particularly relates to a blasting oxygenation device and method adaptive to a plateau low-oxygen environment, the device aims at solving the problem that explosive blasting reaction is incomplete in the plateau hypoxia environment, the device comprises a charging bag placed in a blasting hole, an oxygenation device, a partition device and a sealing plug, the oxygenation device is provided with a shell and a liner bag, and the liner bag is provided with an opening. The inner container bag stores oxygen, the partition device is composed of an upper cover plate and an annular air bag, the oxygen increasing device and the partition device are arranged between every two vertically adjacent charging bags, the sealing plug is located at the top of the blast hole, and when the charging bags are detonated, generated shock waves can enable the inner container bag of the oxygen increasing device to be broken to release oxygen, and meanwhile the annular air bag of the partition device is pushed to expand to seal the hole wall. According to the device, oxygen release and sealing are triggered by means of explosion energy, oxygen is supplemented for a reaction area at the moment of explosion, oxygen is prevented from overflowing, and the plateau explosion effect can be improved.

The invention provides a cognitive ability evaluation system and method suitable for a plateau hypoxia environment, and relates to the technical field of cognitive and psychological testing. Comprising a cloud server, an APP test unit, an external portable monitor and a user client. The cloud server is used for generating a cognitive competence assessment task and a questionnaire according to the personal information of each tested user, the altitude environment information and a seven-point scale subjective evaluation method; the APP test unit is used for receiving the cognitive competence assessment task and the questionnaire, obtaining a first test result and a second test result, and obtaining the heart rate and the blood oxygen saturation of each tested user by using an external portable monitor; the cloud server is further used for performing analysis according to the first test result, the second test result, the heart rate and the oxyhemoglobin saturation and generating a test report; and the user client is used for displaying the test report. The special requirements of the plateau anoxic condition can be effectively met, and the oxygen supply strategy in the plateau anoxic environment is further optimized.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for resisting plateau hypoxia sleep disorder and gastrointestinal tract stress and application, the traditional Chinese medicine composition comprises the following raw material medicines: red ginseng, salvia miltiorrhiza, bighead atractylodes rhizome, rhizoma alismatis, Chinese yam, poria cocos, jujube, pericarpium citri reticulatae, astragalus membranaceus, rhodiola rosea, white hyacinth bean, platycodon grandiflorum, ginger processed pinellia and liquorice. Network pharmacology of the traditional Chinese medicine composition shows that the traditional Chinese medicine composition can be used for treating insomnia, gastrointestinal stress and other symptoms caused by plateau hypoxia through multiple components, multiple targets and multiple paths; meanwhile, animal experiments are adopted to detect the influence of the traditional Chinese medicine composition on the normal-pressure hypoxia tolerance of mice, and it is verified that the traditional Chinese medicine composition can indeed improve the hypoxia tolerance and has potential application value and research prospects in intervention of gastrointestinal altitude stress.

The application discloses an individualized highland hypoxia pre-service closed-loop intervention algorithm, relates to the technical field of acute highland disease intervention, and comprises the following steps: S1: continuous data of oxygen supply concentration and blood oxygen saturation during IHT is obtained, and the data set is divided into a training set, a verification set and a test set; S2: based on the training set, a group prediction model of blood oxygen saturation is constructed through a Krylov operator, model updating and prediction are carried out through online iteration, a blood oxygen saturation prediction value is output, and based on the verification set, the group prediction model is used for individualization of the model; S3: blood oxygen saturation is predicted based on the individualized model, a lower-layer optimization cost function taking the low oxygen concentration as a variable is constructed, and upper-layer optimization design of safety constraint self-adaptation is carried out; S4: the training result is evaluated, and the evaluation result is fed back to the step S3; dynamic evaluation indexes are calculated, the low oxygen stimulation intensity of the IHT is adjusted through control optimization strategy, and the rapidity and effectiveness of highland adaptation capability are improved.

The invention provides application of lactobacillus rhamnosus in preparation of a product for relieving anxiety and / or depression caused by plateau hypoxia, and belongs to the technical field of prevention and treatment of diseases caused by plateau hypoxia. According to the application disclosed by the invention, the lactobacillus rhamnosus can be used for preventing and / or treating anxiety and / or depression caused by plateau hypoxia for the first time, the blank of research and product development under a specific application scene of plateau hypoxia is filled up, and a new choice is provided for solving mental health problems related to plateau hypoxia. The lactobacillus rhamnosus is used as a probiotic, has good biological safety and tolerance, is developed into a prevention and treatment product, provides a new natural, safe and effective prevention and treatment choice for tourists and working people in plateau regions, avoids side effects of drug treatment, overcomes defects of traditional modes such as oxygen uptake and the like, and has a good application prospect. And the acceptability and the compliance of a user are improved.