Application of Metformin in Improving Altitude Hypoxia and Hypoxia

A metformin and high-altitude hypoxia technology, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, and inorganic non-active ingredients, can solve the problem of insufficient anti-hypoxic drugs and improve the ability to resist plateau hypoxic damage. The effect of prolonging the survival time, good economic benefit and social benefit

Active Publication Date: 2019-03-19
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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Problems solved by technology

[0004] At present, the prevention of hypoxic injury is mainly improved by drugs, and there is a serious shortage of clinically effective anti-hypoxic drugs. Western medicines with anti-hypoxia mainly include acetazolamide, clonidine hydrochloride, dexamethasone, etc. Various symptoms caused by hypoxia, such as pulmonary edema, cerebral edema, etc., are used to treat hypoxic injury, and there are many side effects of varying degrees

Method used

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  • Application of Metformin in Improving Altitude Hypoxia and Hypoxia

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Embodiment Construction

[0015] The specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0016] Preparation of medicines and animals:

[0017] Metformin, dissolved in 0.9% NaCl solution, stored at 4°C. Rats are qualified test animals, male.

[0018] Administration and high altitude hypoxia injury:

[0019] According to the weight of the rats, metformin was intraperitoneally administered. Three weeks after the administration of metformin, he began to be exposed to high altitude hypoxia.

[0020] The rats were placed in a low-pressure and hypoxic chamber that simulates a plateau environment, and the breathing and limb activities of the rats were detected. After the simulated altitude reached 10,000 meters, it was started as a plateau environment injury, and the survival rate and survival time of the animals were obser...

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Abstract

The invention discloses application of metformin to an aspect of improving high-altitude hypoxia and anoxia. Under the condition of intraperitoneal injection administration of the metformin, the survival time of rats in a high-altitude low-oxygen environment can be remarkably prolonged. With the adoption of the method disclosed by the invention, a suitable dosage of commonly used drugs is given at proper time, so that a high-altitude anoxia injury resisting capability of animals including the rats and the like can be improved and favorable evidence is provided for human body tests. If application of the metformin to human bodies is popularized, the economic benefits and social benefits are relatively good.

Description

Technical field [0001] The invention relates to a medicine for resisting altitude hypoxia, in particular to the application of metformin in improving altitude hypoxia and hypoxia. Background technique [0002] The plateau area of ​​our country is vast, among which plateaus and alpine areas with an average altitude of over 3000 meters account for more than 1 / 4 of the country's land area. Many unfavorable factors in the plateau environment act on the human body, such as low oxygen, low temperature, light radiation, and climate change, but the most important thing is the damage of low oxygen to the human body. When the oxygen required to maintain the body’s life activities cannot be adequately supplied or the oxygen use is impaired, it will cause abnormal changes in the body’s metabolism, function, and even morphology, and eventually cause the body’s heart, brain, kidneys and other important organs to be supplied with energy. Deficiency and exhaustion. [0003] In recent years, as t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/155A61K9/08A61P39/00
CPCA61K9/08A61K31/155A61K47/02
Inventor 赵名朱玲玲吴奎武林霄赵彤范明
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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