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Application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia

A Morinda officinalis oligosaccharide and dysfunctional technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as aggravating brain tissue damage, damage, and increase vascular permeability, and reduce inflammation in the brain. , Improve the effect of fatigue resistance and hypoxia resistance

Active Publication Date: 2021-06-18
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, inflammatory mediators can increase the expression of aquaporin and its downstream target genes, damage the basement membrane of cerebral microvessels, increase vascular permeability, destroy the blood-brain barrier and cause angiogenic cerebral edema, aggravate the damage of brain tissue, and can Decreased learning, memory, and cognitive function

Method used

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  • Application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia
  • Application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia
  • Application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1I

[0021] Embodiment 1IOMO pretreatment improves the rotarod test of the anti-fatigue ability of mice

[0022]After gavage, the next day, the mice were respectively placed on the rotarod fatigue instrument, the speed of the rotarod was adjusted to 30r / min, and the time when the mice fell from the rotarod instrument for the third time was measured. Before the test, the mice were trained 3 days in advance at 10r / min, and trained for 10 minutes every day. The purpose was to let the mice learn to turn the rod to crawl through adaptive training. Such as figure 1 As shown in middle A, the mice were given intragastric administration for 7 days respectively. The experimental groups were Control, IOMO (50mg / kg), IOMO (25mg / kg) and Hongyi Capsules (200mg / kg). Stick test. Mice in the blank control group were given 0.5% sodium carboxymethyl cellulose, and the results were as follows: figure 1 As shown in B, 50mg / kg IOMO was able to improve rod time in mice. With 120min as the end time of...

Embodiment 2I

[0023] Embodiment 2 IOMO pretreatment improves the airtight bottle hypoxia test of mouse survival time

[0024] Select C57BL / 6J, male, 8-week-old healthy adult mice, after adapting to the environment for 3 days, they were randomly divided into groups, 10 mice in each group, and the mice in each group were intragastrically administered once a day, continuously for 7 / 10 days, and 3 hours after the last administration , put the mouse individually in a 250mL jar filled with about 5g of soda lime, smear the bottle mouth with Vaseline, observe and record the death time of the animal with a stopwatch. Such as figure 2 Shown in middle A, give mice gavage treatment respectively, experiment grouping is Control, 10MO (50mg / kg), 10MO (25mg / kg) and positive control group, carry out airtight bottle experiment 3h after finishing gavage for the last time. Such as figure 2 As shown in C, mice in the control group were given 0.5% sodium carboxymethylcellulose, and mice in the treatment grou...

Embodiment 3I

[0025] Example 3 IOMO pretreatment alleviates the inflammatory response test in the brain of mice exposed to plateau hypoxia 1. LPS combined with low pressure and hypoxia treatment

[0026] The mice in the experimental group were intraperitoneally injected with 5 mg / kg of LPS working solution, and the mice in the control group were injected with an equal volume of 0.9% normal saline for injection. After the intraperitoneal injection, it is placed in a low-pressure hypoxic chamber. The principle of the low-pressure hypoxic chamber is to continuously pump air into the chamber through an external air pump to simulate a plateau hypoxic environment. The experimental operation is as follows: the mice in the experimental group were placed in a hypobaric hypoxic chamber, and the parameters were set so that the humidity in the hypobaric hypoxic chamber was maintained at 40%-50%, the temperature was 22-24°C, and the air was pumped continuously at a speed of 30m / s. After 5 minutes, the a...

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Abstract

The invention discloses application of morinda officinalis oligosaccharides in preparation of drugs for treating body dysfunction caused by high-altitude anoxia. The morinda officinalis oligosaccharides can be used for improving anoxic tolerance and fatigue resistance and can also be used for alleviating intracerebral inflammatory reactions; and the morinda officinalis oligosaccharides can also be used for treating body nerve-immunity-endocrine disorders caused by high-altitude brain injury and the high-altitude anoxia and treating body hypofunction and injury caused by the aspects of cognition, emotions and physical performance.

Description

technical field [0001] The invention belongs to the technical field of plateau brain injury, and specifically relates to the application of Morinda officinalis oligosaccharides in the preparation of medicines for treating body dysfunction caused by plateau hypoxia. Background technique [0002] The low pressure and hypoxia in the plateau environment, as a non-specific stimulus, will cause nausea and vomiting, anorexia, fatigue, headache, dizziness, insomnia, and dyspnea in unaccustomed people who enter the plateau rapidly. occur. Studies have shown that the incidence of body dysfunction caused by acute plateau hypoxia at an altitude of 6000m is as high as 75%. It affects the normal work and life of human beings. [0003] Acute high-altitude brain injury in body dysfunction caused by high-altitude hypoxia is mainly caused by the typical hypobaric and hypoxic conditions in high-altitude areas. The mechanism of organ dysfunction caused by hypobaric hypoxia mainly includes th...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P39/00A61P25/00A61P5/00A61P37/02A61P25/28A61K36/746A61K125/00
CPCA61K31/702A61P39/00A61P25/00A61P5/00A61P37/02A61P25/28A61K36/746
Inventor 李云峰朱玲玲张黎明韩莹赵名
Owner ACADEMY OF MILITARY MEDICAL SCI
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