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Functional vegetated substrate hollow capsule

A hollow capsule and functional technology, which is applied in the fields of capsule delivery, food science, medical preparations with inactive ingredients, etc. Hypoxic capacity, the effect of promoting rehabilitation adjustment, reducing blood viscosity

Active Publication Date: 2014-06-18
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has also been reported that the disintegration time of such capsules is relatively long, and the physical and chemical properties such as low-temperature brittleness and storage at temperatures above 30°C are still unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 80g of hydroxypropyl cellulose was mixed with 0.01g of potassium citrate and 19.99g of gelling agent (the weight percentage of linseed gum and black fungus polysaccharide in the gelling agent was 1:10) to obtain The raw materials of the hollow capsules are prepared, and then the hollow capsules are prepared by adopting a traditional glue-dipping process, so as to obtain the functional plant matrix hollow capsules. The prepared functional plant-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The friability was tested with polytetrafluoroethylene weights. 50 samples were not broken, and their friability The speed can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for disintegration experiments, and the test samples can be completely disintegrated within 10 minutes, and the disintegration time lim...

Embodiment 2

[0019] The hydroxyethyl cellulose of 90g is mixed with the sodium citrate of 0.1g and the gelling agent of 9.9g (the weight percent ratio of linseed gum and black fungus polysaccharide in the gelling agent is 3:7) to obtain The raw materials of the hollow capsules are prepared, and then the hollow capsules are prepared by adopting a traditional glue-dipping process, so as to obtain the functional plant matrix hollow capsules. The prepared functional plant-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The friability was tested with polytetrafluoroethylene weights. 50 samples were not broken, and their friability The speed can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-lE intelligent disintegration instrument is used for the disintegration experiment, and the test samples can be completely disintegrated within 10 minutes, and the disintegration ...

Embodiment 3

[0021] The hydroxymethylcellulose of 85g is mixed with the potassium chloride of 0.5g and the gelling agent of 14.5g (the weight percent ratio of linseed gum and black fungus polysaccharide in the gelling agent is 5:5) to obtain The raw materials of the hollow capsules are prepared, and then the hollow capsules are prepared by adopting a traditional glue-dipping process, so as to obtain the functional plant matrix hollow capsules. The prepared functional plant-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The friability was tested with polytetrafluoroethylene weights. 50 samples were not broken, and their friability The speed can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for disintegration experiments, and the test samples can be completely disintegrated within 10 minutes, and the disintegratio...

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Abstract

The invention relates to a capsule widely applied to medicine, healthcare products and food industries, and in particular relates to a functional vegetated substrate hollow capsule. The functional vegetated substrate hollow capsule is prepared by the steps of mixing cellulose and a coagulant aid which serve as base matrixes with a functional gelatinizing agent which is a mixture of auricularia auricular polysaccharide and flaxseed gum to obtain the raw material of the hollow capsule and preparing the raw material into the hollow capsule through a conventional hollow capsule preparation process. The functional vegetated substrate hollow capsule disclosed by the invention has a remarkable characteristic that the mixture of auricularia auricular polysaccharide and flaxseed gum, having a biological function, is used as the functional gelatinizing agent of the hollow capsule; the functional vegetated substrate hollow capsule prepared from the functional gelatinizing agent, cellulose biological matrix and coagulant aid has obvious functional characteristics unreachable for an existing gelatin hollow capsule; the functional vegetated substrate hollow capsule is widely applicable to medicine, healthcare products and food industries.

Description

technical field [0001] The invention relates to capsules widely used in medicine, health products and food industries, in particular to functional plant matrix hollow capsules. Background technique [0002] It has a long history to prepare medicinal empty capsules by using gelatin hydrolyzed from collagen in animal skin and bone tissue, because the medicinal ingredients wrapped in hollow capsules can avoid the stimulation of the drug itself to the sensory organs of the human body, and achieve The slow-release effect of drugs in the body has long been widely used in the fields of medicine and food by hollow capsules made of gelatin. As the main encapsulation material for medicines and health care products, its defects are also recognized by everyone. Such as its own protein is easily affected by acid and alkali, which limits the use of certain drugs. Gelatin molecules contain more active groups, which are easy to react with the drugs in contact, thus changing the properties...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/46A61K47/38A61K9/48A23L1/29A23P1/04A23L33/00A23P10/30
Inventor 袁国卿闫丰文闫芳
Owner INST OF CHEM CHINESE ACAD OF SCI
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